TWAS hub - CYP2A7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0463	0.0190	0.00035	0.023	0.012	0.010	NA	0.015	1.3e-05	0.0011	2.8e-03	NA	2.9e-04
2	TCGA	Prostate Adenocarcinoma	0.0688	0.0321	0.00240	0.062	0.008	0.043	NA	0.059	4.7e-07	0.0440	2.7e-05	NA	8.1e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Co-codamol	5.3	6.1	10.7	3.3	1.2
Current tobacco smoking	4.3	7.1	9.4	-3.1	-2.2
Smoking status: Current	4.0	6.4	8.1	-2.8	-2.2
Loneliness, isolation	3.5	4.8	9.6	3.1	0.2
Mouth/teeth dental problems: Loose teeth	3.3	3.9	7.3	-0.7	-2.7
Pain experienced in last month	2.9	4.8	9.6	-3.1	0.1
Loud music exposure frequency	2.8	3.0	6.0	-0.3	2.4
Medication: Metformin	2.6	3.7	6.1	2.5	1.2
Fluid intelligence score	2.6	5.3	8.8	-1.4	-3.0
Pulse wave peak to peak time	2.6	3.1	6.0	-2.4	-0.4
Commuting to job workplace: Public transport	2.6	3.1	4.2	-1.4	-2.1
Pack years adult smoking proportion	2.5	3.8	7.6	2.8	-0.3
Medication: Gliclazide	2.5	2.8	4.5	2.1	-1.1
Ever had prostate specific antigen (PSA) test	2.5	2.8	2.9	-1.7	-1.7
Diabetes (father)	2.4	3.0	5.3	2.3	0.8
Pack years of smoking	2.4	3.5	6.8	2.6	-0.5
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	4.5	0.7	2.1
Headache pain in last month	2.1	3.6	4.2	2.1	1.7
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.3	0.8	2.1
Blood Red Count	2.0	19.1	38.2	-0.1	-6.2
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	5.2	2.3	-0.2
Pulse wave Arterial Stiffness index	2.0	2.4	4.8	2.2	0.2
Eye problems/disorders: None of the above	2.0	2.3	3.8	-2.0	-0.9
Risk taking	2.0	2.9	5.6	2.4	-0.3
Lung FEV1/FVC ratio	1.9	9.5	17.7	-4.2	-1.2
Neck or shoulder pain in last month	1.9	2.7	4.3	2.1	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.0	2.0	-0.2
Eye problems/disorders: Glaucoma	1.9	2.2	4.0	-0.6	2.0
Medication: Simvastatin	1.8	2.6	4.1	2.0	1.1
Falls in the last year	1.8	2.5	4.7	-0.5	-2.2
Depressed Affect (Nagel 2018)	1.7	3.6	4.9	2.2	1.5
Alzheimer’s Disease (in father)	1.7	1.9	3.6	-1.9	-0.4
Length of working week for main job	1.7	1.9	3.7	1.9	-0.3
Cholesterol lowering medication	1.7	2.4	2.6	1.6	1.5
Taking other prescription medications	1.6	2.4	3.2	1.8	1.3
Number of full sisters	1.6	1.9	2.3	1.5	-1.2
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.3	1.8	0.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	2.9	-1.1	-1.7
Alzheimer’s Disease (in mother)	1.5	1.7	3.3	0.4	1.8
Impedance of leg (right)	1.5	7.4	12.5	-3.5	-1.5
Medication: Atenolol	1.5	1.9	3.7	-0.1	1.9
Number of treatments/medications taken	1.4	2.5	3.3	1.8	1.3
Vitamin and mineral supplements	1.4	1.9	3.8	-0.2	1.9
Heart attack	1.4	1.8	2.5	-1.0	-1.6
Medication: Paracetamol	1.4	2.3	3.5	1.9	1.1
High cholesterol (Self-reported)	1.4	2.5	4.3	2.1	0.9
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.6	-1.6	-0.7
Pulse rate	1.3	2.1	3.2	1.1	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	4.7	-2.2	-2.0
Emphysema/chronic bronchitis	1.3	1.5	2.7	0.5	1.6
Medication: Blood pressure	1.3	2.5	4.9	-0.2	2.2
Respiratory disease	1.2	2.7	4.8	0.8	2.2
Supplements: Zinc	1.2	1.3	2.5	-0.0	1.6
Townsend deprivation index at recruitment	1.2	1.7	2.5	-1.0	-1.6
Fed-up feelings	1.2	2.2	3.1	1.8	1.2
Impedance of leg (left)	1.2	5.7	10.5	-3.2	-1.0
Prospective memory result	1.2	1.5	2.8	0.5	1.7
Birth weight of first child	1.2	2.2	4.0	0.7	2.0
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.6	1.6	0.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.9	-0.2	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.4	-1.6	-0.6
Prostate Cancer	1.1	1.6	2.3	-1.0	-1.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.4	-1.2	-1.0
Qualifications: CSEs or equivalent	1.1	1.5	2.2	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.9	4.1	-1.9	-2.0
Health satisfaction	1.1	1.4	2.7	-1.7	0.0
Heart disease (mother)	1.1	1.3	1.8	-0.9	1.4
Smoking status: Previous	1.1	1.7	1.7	1.3	1.3
Commuting to job workplace: Walk	1.1	1.2	1.5	1.2	-1.0
Medication: Paracetamol	1.1	1.7	2.9	1.7	0.7
Commuting to job workplace: Cycle	1.1	1.4	2.2	1.5	-0.7
Allergy or Eczema	1.0	2.5	5.0	0.2	2.2
Exposure to tobacco smoke at home	1.0	1.1	1.4	0.9	-1.2
Forced vital capacity (FVC), Best measure	1.0	3.6	5.3	-1.4	-2.3
Overall health rating	1.0	2.2	3.9	2.0	0.8
Had major operations	1.0	1.2	1.8	0.8	-1.3
Diabetes diagnosed by doctor	1.0	1.6	3.1	1.8	-0.1
LDL Cholesterol	0.9	1.4	2.7	1.6	0.0
Medication for hormone replacement therapy	0.9	1.0	1.6	-1.3	-0.6
Forced vital capacity (FVC)	0.9	3.3	5.8	-0.9	-2.4
Allergy	0.9	2.1	4.1	0.3	-2.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.6	-0.9	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.4	1.2	-0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.0	1.4	-0.6
Medication: Aspirin	0.9	1.2	2.0	-0.6	-1.4
Long-standing illness, disability or infirmity	0.9	1.3	2.5	1.6	-0.4
Ever taken oral contraceptive pill	0.9	1.0	1.8	-0.5	-1.3
Unable to work because of sickness or disability	0.9	1.2	1.6	0.9	-1.3
Impedance of whole body	0.9	4.6	8.4	-2.9	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	1.6	-0.8	-1.2
Ulcerative Colitis (UC)	0.8	1.5	3.0	-0.2	1.7
Lupus	0.8	1.2	2.4	0.3	1.5
Primary Biliary Cirrhosis	0.8	1.2	2.2	-0.4	1.5
Chronotype (morning person)	0.8	1.8	2.7	1.6	0.9
Sensitivity / hurt feelings	0.8	1.3	2.3	-1.5	-0.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	1.2	0.5
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.4	-0.3	1.9
Multivitamins +/- minerals	0.8	1.0	1.8	0.4	-1.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.1	-0.9	-1.1
High blood pressure (siblings)	0.8	1.1	2.1	-1.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	1.5	0.0
Medication: Omeprazole	0.8	1.0	1.6	1.3	0.6
Medication: Seretide 50 evohaler	0.8	1.0	1.6	0.6	-1.3
Friendships satisfaction	0.8	1.0	2.0	0.0	-1.4
Basal cell carcinoma (self-reported)	0.8	1.0	1.8	-1.4	0.3
Neuroticism (Nagel 2018)	0.7	1.6	2.1	1.4	1.1
Alzheimer’s Disease (including proxy)	0.7	1.1	1.4	-0.8	1.2
Major Depression (MDD)	0.7	0.8	1.5	-1.2	0.3
Rheumatoid Arthritis	0.7	0.9	1.7	-0.3	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.1	0.9	1.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	-1.3	0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	0.9	0.9	1.0
Hearing difficulty/problems with background noise	0.7	1.1	2.2	0.2	1.5
Depression (self-reported)	0.7	0.9	1.5	1.2	0.5
Medication: Lansoprazole	0.7	0.8	0.9	-0.8	0.9
Tense / ‘highly strung’	0.7	1.1	1.1	1.0	1.0
Gout (self-reported)	0.7	1.0	1.3	-0.8	-1.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.0	1.0	0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.0	-0.2	-1.7
Coronary Artery Disease (CAD)	0.6	0.7	1.2	-1.1	-0.5
Angina	0.6	0.7	1.1	-1.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.3	1.1	-0.6
Body mass index (BMI)	0.6	2.6	4.6	2.2	0.7
Happiness	0.6	0.8	1.2	1.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.1	1.0	0.9
Wheeze or whistling in the chest in last year	0.6	1.0	1.2	0.9	1.1
Comparative height size at age 10	0.6	3.1	5.9	-0.5	-2.4
Knee pain experienced in last month	0.6	0.9	1.3	1.2	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.5	-1.2	-0.5
Diastolic blood pressure, automated reading	0.6	1.8	2.2	-1.5	-1.2
Bipolar Disorder or Schizophrenia	0.5	1.3	2.0	-1.4	-0.8
Worry (Nagel 2018)	0.5	1.1	1.5	0.8	1.2
Ovarian Cancer	0.5	0.7	1.1	1.0	0.6
Age at First Birth	0.5	0.7	1.4	0.0	1.2
Mean Putamen Volume	0.5	0.6	0.9	-1.0	-0.5
Schizophrenia (2014)	0.5	1.2	1.4	-1.2	-1.0
Ulcerative Colitis	0.5	0.7	1.2	-1.1	0.5
Blood Eosinophil Count	0.5	3.8	6.9	-2.6	-0.8
BMI	0.5	2.6	5.2	2.3	-0.0
Lung FVC	0.5	2.5	3.0	-1.7	-1.4
Average weekly fortified wine intake	0.5	0.6	0.9	-0.9	-0.6
High blood pressure	0.5	1.3	1.4	-1.2	1.1
Medication: Levothyroxine sodium	0.5	0.8	1.5	1.2	0.3
Financial difficulties in last 2 years	0.5	0.6	1.1	1.1	0.4
Mouth/teeth dental problems	0.5	0.8	0.9	-1.0	0.8
Impedance of arm (right)	0.5	2.1	4.0	-2.0	-0.5
Time employed in main current job	0.5	0.6	0.7	-0.9	-0.6
Father’s age at death	0.5	0.6	1.3	0.0	1.1
Glaucoma (self-reported)	0.5	0.6	1.2	0.1	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.1	1.1
Comparative body size at age 10	0.5	1.5	2.2	0.9	-1.5
Medication: Ibuprofen	0.5	0.6	0.8	0.9	0.6
Medication: Allopurinol	0.5	0.7	1.0	-0.7	-1.0
Pulse rate, automated reading	0.5	1.5	1.5	1.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	1.0	0.4
Mood swings	0.5	0.9	1.8	0.3	1.3
Back pain experienced in last month	0.5	0.8	1.0	1.0	-0.8
Wears glasses or contact lenses	0.5	0.6	1.0	0.5	1.0
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.9	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.4	1.5	-1.2	-1.1
Schizophrenia (2018)	0.4	0.7	1.2	-1.1	-0.5
Irritable Bowel Disease (IBD)	0.4	0.9	1.7	0.3	1.3
Reaction Time	0.4	0.7	1.1	-1.0	0.6
HDL Cholesterol	0.4	0.6	1.1	0.3	1.1
Smoking Status	0.4	0.9	1.4	-1.2	-0.7
Supplements: Glucosamine	0.4	0.5	0.8	-0.4	-0.9
Waist circumference	0.4	1.4	2.8	1.7	-0.0
Hair/balding pattern: Pattern 2	0.4	0.6	0.6	0.8	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	0.6	0.7
Medication: Cholesterol lowering	0.4	0.6	1.2	0.3	-1.1
Illnesses of mother	0.4	0.5	0.6	0.8	-0.6
Impedance of arm (left)	0.4	2.0	3.8	-1.9	-0.6
Breastfed as a baby	0.4	0.5	0.9	0.2	-0.9
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.9	-0.4
Migraine (self-reported)	0.4	0.5	0.7	-0.6	0.8
Mean time to correctly identify matches	0.4	0.8	1.3	-0.5	1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	1.1	-0.7
Arm fat percentage (left)	0.4	1.5	2.6	1.6	0.7
Qualifications: nursing, teaching	0.4	0.6	0.7	0.6	-0.9
Osteoporosis (self-reported)	0.4	0.5	0.9	0.4	1.0
Medication: Aspirin	0.4	0.6	1.1	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.1	-1.1	-0.7
Arm fat mass (left)	0.4	1.7	2.8	1.7	0.7
Average weekly champagne plus white wine intake	0.4	0.5	0.7	-0.8	-0.5
Medication: Bendroflumethiazide	0.4	0.6	0.7	0.7	0.8
Alcohol drinker status: Never	0.4	0.5	0.7	-0.5	0.9
Age started oral contraceptive pill	0.4	0.4	0.9	0.9	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	0.9	0.4
Breast Cancer	0.3	0.8	1.0	0.7	-1.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.2	0.8
Hypothyroidism (self reported)	0.3	0.6	1.1	1.1	-0.3
Average weekly spirits intake	0.3	0.3	0.6	-0.2	-0.8
Hearing difficulty/problems: Yes	0.3	0.4	0.6	0.5	0.8
Age when periods started (menarche)	0.3	0.7	1.3	1.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	0.3	-0.8
Stomach or abdominal pain in last month	0.3	0.3	0.5	-0.4	0.7
Past tobacco smoking	0.3	0.6	0.9	-0.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	1.0	0.1
Had menopause	0.3	0.4	0.6	0.4	0.7
Qualifications: None of the above	0.3	0.7	1.1	0.6	1.1
Diabetes (self-reported)	0.3	0.5	0.9	0.9	0.4
Arm fat percentage (right)	0.3	1.2	1.9	1.4	0.7
Hip circumference	0.3	1.2	2.2	1.5	0.4
Worrier / anxious feelings	0.3	0.5	1.1	-0.1	1.0
Asthma	0.3	0.5	0.6	-0.8	0.7
Arm fat mass (right)	0.3	1.3	2.1	1.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.3	1.1	-0.2
Medication: Amlodipine	0.3	0.5	0.9	0.2	1.0
Birth weight	0.3	0.6	0.9	0.9	0.5
Number of full brothers	0.3	0.3	0.6	0.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.0	0.8
Medication for pain relief, constipation, heartburn	0.3	0.6	0.7	-0.8	-0.6
Chest pain or discomfort	0.3	0.4	0.7	0.2	0.8
Family relationship satisfaction	0.3	0.4	0.7	0.8	0.1
Supplements: Vitamin C	0.3	0.4	0.5	0.5	-0.7
Hypertension (Self-reported)	0.3	0.9	1.3	-0.7	1.1
Illnesses of father: Heart disease	0.3	0.4	0.4	0.7	0.7
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.3	0.7
Leg fat-free mass (right)	0.3	1.5	3.0	1.7	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	-0.3	0.7
Ever had bowel cancer screening	0.3	0.4	0.6	-0.8	0.3
Asthma (self-reported)	0.3	0.7	0.8	-0.9	0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	-0.7	0.3
Leg predicted mass (right)	0.3	1.5	3.0	1.7	0.2
Miserableness	0.3	0.5	0.5	0.7	0.7
Mother’s age at death	0.3	0.4	0.7	0.9	-0.1
Ever depressed for a whole week	0.3	0.3	0.6	-0.2	0.8
Heart disease (siblings)	0.3	0.3	0.4	-0.5	0.6
Blood Platelet Count	0.2	2.2	2.4	1.4	1.6
Blood White Count	0.2	1.4	1.8	-1.4	-1.0
Height	0.2	3.0	6.0	0.3	-2.5
Waist Hip Ratio (WHR)	0.2	0.7	1.4	0.0	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.9	0.1
Hand grip strength (left)	0.2	0.6	1.3	-0.0	-1.1
Systolic blood pressure, automated reading	0.2	0.5	1.0	-1.0	0.2
Diabetes (mother)	0.2	0.3	0.6	0.8	-0.1
Severe depression (siblings)	0.2	0.2	0.4	0.0	-0.7
Leg fat-free mass (left)	0.2	1.1	2.2	1.5	-0.1
Hand grip strength (right)	0.2	0.6	1.2	0.1	-1.1
High blood pressure (mother)	0.2	0.3	0.6	0.4	-0.7
Leg predicted mass (left)	0.2	1.1	2.2	1.5	-0.2
Nervous feelings	0.2	0.4	0.8	0.1	0.9
Medication: Ramipril	0.2	0.2	0.5	-0.7	-0.0
Illnesses of siblings	0.2	0.3	0.7	0.0	0.8
Weight	0.2	1.0	1.9	1.4	-0.1
Number of live births	0.2	0.2	0.4	0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	0.9	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.3	0.6	0.5
Lung cancer (father)	0.2	0.3	0.5	-0.7	-0.1
Standing height	0.2	2.4	3.3	-1.2	-1.8
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	-0.9	-0.5
Pulse wave reflection index	0.2	0.3	0.4	-0.3	0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.5	0.3	-0.7
Number of children fathered	0.2	0.2	0.3	0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.5	0.4
Whole body fat mass	0.2	0.6	1.3	1.1	-0.0
Leg fat mass (right)	0.2	0.6	1.3	1.1	0.1
Alcohol intake frequency.	0.2	0.4	0.4	0.6	0.6
Age at last live birth	0.2	0.3	0.5	-0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.3	0.6
Mineral and other dietary supplements	0.2	0.3	0.4	0.6	-0.4
Breast cancer (self-reported)	0.2	0.2	0.5	-0.1	-0.7
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	0.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	0.7	0.2
Medication: Atorvastatin	0.2	0.3	0.5	0.7	-0.3
Leg fat percentage (left)	0.2	0.6	0.7	0.8	0.7
Myopia	0.2	0.3	0.6	-0.0	-0.8
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.3	1.1	-0.2
Supplements: Calcium	0.2	0.2	0.4	-0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	0.5	-0.6
Leg fat mass (left)	0.2	0.8	1.4	1.2	0.4
Crohns Disease (2017)	0.1	0.1	0.1	0.4	-0.3
HbA1C	0.1	0.1	0.2	-0.0	-0.4
Systolic Blood Pressure	0.1	0.6	1.0	-0.4	1.0
Cardiovascular Disease	0.1	0.2	0.2	0.5	0.5
Tanning	0.1	1.4	2.8	-0.2	-1.7
Relative age of first facial hair	0.1	0.1	0.2	0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	-0.3
Maternal smoking around birth	0.1	0.1	0.2	-0.5	0.2
Relative age voice broke	0.1	0.2	0.3	0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.7	-0.0
Trunk fat mass	0.1	0.4	0.8	0.9	-0.2
Number of incorrect matches in round	0.1	0.1	0.2	0.4	-0.2
Alcohol usually taken with meals	0.1	0.2	0.3	-0.6	-0.1
Had other major operations	0.1	0.1	0.1	-0.0	0.4
Pain all over the body in last month	0.1	0.1	0.2	0.3	0.4
Neuroticism score	0.1	0.2	0.3	0.4	0.5
Trunk fat-free mass	0.1	0.3	0.4	0.6	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	0.4	0.4
Peak expiratory flow (PEF)	0.1	0.3	0.4	0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.4	0.4
Arm fat-free mass (right)	0.1	0.6	0.9	1.0	-0.5
Worry too long after embarrassment	0.1	0.2	0.3	-0.6	0.2
Age at first live birth	0.1	0.2	0.3	-0.6	0.3
Shortness of breath walking on level ground	0.1	0.2	0.2	-0.5	-0.3
Qualifications: College or University degree	0.1	0.2	0.2	0.4	-0.5
Medication: Blood pressure	0.1	0.2	0.3	-0.6	-0.2
Angina (self-reported)	0.1	0.2	0.4	-0.6	-0.1
Arm predicted mass (right)	0.1	0.7	1.3	1.1	-0.2
Suffer from ‘nerves’	0.1	0.2	0.4	0.1	-0.6
Leg pain on walking	0.1	0.2	0.3	-0.5	-0.0
Whole body fat-free mass	0.1	0.6	1.1	1.1	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.4	0.3
Medication for cholesterol	0.1	0.2	0.4	0.2	-0.6
Whole body water mass	0.1	0.4	0.8	0.9	-0.2
Guilty feelings	0.1	0.2	0.2	0.5	-0.3
Hearing aid user	0.1	0.1	0.1	-0.2	-0.3
Financial situation satisfaction	0.1	0.1	0.2	0.3	-0.4
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.2	-0.5
Ever smoked	0.1	0.1	0.3	-0.0	0.5
Basal metabolic rate	0.1	0.5	1.0	1.0	-0.1
Arm fat-free mass (left)	0.1	0.4	0.7	0.9	0.1
Number of operations (self-reported)	0.1	0.2	0.4	-0.2	0.6
Arm predicted mass (left)	0.1	0.3	0.6	0.8	0.0
Depression (Nagel 2018)	0.0	0.0	0.1	0.3	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	-0.1	-0.1
Fasting Glucose	0.0	0.0	0.0	-0.1	-0.0
Neuroticism (2016)	0.0	0.0	0.0	0.1	0.2
Triglycerides	0.0	0.1	0.1	-0.4	0.1
Heel T-Score	0.0	0.2	0.4	0.1	0.6
Neuroticism	0.0	0.1	0.1	0.3	0.3
Hair Pigment	0.0	0.5	0.6	0.8	-0.7
Trunk fat percentage	0.0	0.2	0.3	0.6	-0.2
Serious illness, injury or assault to yourself	0.0	0.1	0.1	-0.3	-0.1
Sitting height	0.0	0.3	0.5	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.0	0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.3	-0.1
Noisy workplace	0.0	0.0	0.0	0.0	0.2
Trunk predicted mass	0.0	0.2	0.3	0.6	-0.4
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.2	0.2
Body fat percentage	0.0	0.1	0.2	0.4	-0.0
Leg fat percentage (right)	0.0	0.2	0.3	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	-0.2
Average weekly red wine intake	0.0	0.0	0.1	0.1	-0.3
Medication: Lisinopril	0.0	0.0	0.1	-0.0	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.1	0.1	0.2
Irritability	0.0	0.1	0.1	-0.1	-0.4
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.0	0.1
Alcohol drinker status: Previous	0.0	0.0	0.1	0.0	-0.2

Hub : Genes

CYP2A7

Models

Trait associations