Hub : Genes

SHKBP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2540 0.1020 8.1e-03 0.017 NA 0.052 NA 0.057 9.7e-02 NA 1.2e-02 NA 9.1e-03
2 GTEx Lung 0.1210 0.0365 1.0e-04 0.115 NA 0.091 NA 0.066 4.4e-09 NA 1.8e-07 NA 9.5e-06
3 GTEx Spleen 0.2340 0.0950 6.7e-03 0.021 NA 0.018 NA 0.002 9.2e-02 NA 1.1e-01 NA 2.8e-01
4 GTEx Whole Blood 0.1190 0.0360 5.4e-05 0.093 NA 0.036 NA 0.072 6.9e-09 NA 2.5e-04 NA 3.7e-07
5 NTR Blood 0.0464 0.0117 2.0e-08 0.035 0.033 0.041 0.037 0.038 1.4e-11 4.8e-11 3.1e-13 6.2e-12 2.7e-12
6 ROSMAP Brain Pre-frontal Cortex 0.0769 0.0317 4.0e-03 0.018 0.019 0.039 0.017 0.021 2.0e-03 1.5e-03 8.2e-06 2.4e-03 7.7e-04
7 YFS Blood 0.5064 0.0402 0.0e+00 0.092 0.255 0.270 0.261 0.222 1.3e-28 8.1e-83 1.6e-88 4.0e-85 4.2e-71
8 TCGA Colon Adenocarcinoma 0.0770 0.0400 8.0e-03 -0.004 0.024 -0.004 NA -0.003 6.1e-01 1.5e-02 7.1e-01 NA 5.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.3 2.0 7.9 -0.2 -1.1 -0.7 -1.3 -1.4 2.8 -0.2 -1.6
Bipolar Disorder or Schizophrenia 0.7 1.7 5.2 0.3 -1.1 -1.0 -1.8 -1.5 2.3 0.1 -0.9
Depressed Affect (Nagel 2018) 0.3 0.7 3.2 -0.5 -0.1 -1.3 0.3 -0.1 -0.7 0.3 1.8
Depression (Nagel 2018) 0.4 0.6 3.5 0.3 0.1 -0.7 0.1 -0.2 -0.4 -0.5 1.9
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.7 -1.0 0.6 0.6 1.1 1.3 -0.5 0.9 0.9
Neuroticism (Nagel 2018) 0.2 0.5 1.0 -1.0 -0.7 -0.6 0.1 -0.7 0.7 -0.3 1.0
Schizophrenia (2018) 0.2 0.5 1.4 0.3 -0.5 -0.9 -1.2 -0.7 0.6 0.4 0.1
Schizophrenia vs Biploar Disorder 1.5 2.0 10.2 3.2 0.3 2.3 0.2 0.1 -0.3 0.6 -0.1
Worry (Nagel 2018) 0.3 0.5 1.3 -0.7 0.4 -0.2 0.9 0.2 1.1 -0.5 1.1
Alzheimer’s Disease (in mother) 0.9 1.1 4.2 0.7 0.9 2.0 0.9 1.1 0.7 -0.1 -0.8
Alzheimer’s Disease (in father) 1.1 1.2 4.2 0.8 0.7 1.8 0.5 0.8 2.0 -0.3 -0.4
Alzheimer’s Disease (including proxy) 2.4 3.5 8.9 0.6 2.3 2.7 2.4 3.0 0.5 0.7 0.3
Crohns Disease (2017) 1.3 2.8 16.7 4.1 -0.0 1.0 -0.6 -0.6 2.0 0.2 -0.2
Irritable Bowel Disease (IBD) 1.5 3.7 19.2 4.4 -0.2 1.2 -0.5 -1.1 2.5 -0.1 -1.0
Ulcerative Colitis (UC) 0.9 1.6 8.9 3.0 0.3 1.1 0.3 -0.4 1.3 0.0 -1.0
Major Depression (MDD) 0.9 1.1 3.5 0.7 -1.2 0.3 -0.7 -1.3 -0.2 -1.9 -1.3
Reaction Time 0.6 1.1 4.5 -0.2 -0.7 1.4 -0.8 -0.7 2.1 -0.0 -0.6
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.1 -0.7 0.6 0.6 1.4 1.4 -0.2 0.3 -0.0
Breast Cancer 0.4 0.9 3.9 -1.1 0.2 -0.5 -0.5 0.1 -2.0 0.2 1.3
Ovarian Cancer 0.4 0.6 1.6 -1.3 0.7 -0.8 0.6 0.4 -0.8 0.8 0.2
Prostate Cancer 0.9 1.2 4.9 -0.4 0.4 0.2 0.7 0.6 1.2 1.5 -2.2
Age at First Birth 0.2 0.2 1.3 1.1 0.2 -0.4 0.0 -0.1 0.2 0.3 0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.1 1.4 4.8 -0.7 -1.6 -1.0 -2.2 -0.9 1.4 -0.3 0.0
Coronary Artery Disease (CAD) 0.8 0.9 6.7 2.6 0.2 0.3 -0.0 -0.3 -0.5 0.0 0.0
Crohns Disease (2012) 1.0 1.6 9.0 3.0 1.2 0.9 0.3 0.2 -0.3 1.3 0.2
Mean Putamen Volume 1.1 1.2 2.8 0.8 0.5 1.4 1.2 0.0 1.3 1.0 -1.7
Fasting Glucose 0.5 0.5 1.3 0.2 1.0 1.2 0.5 0.8 0.8 0.6 -0.3
HbA1C 0.3 0.4 1.0 -0.0 0.6 1.0 0.3 0.1 -0.1 0.8 -1.0
HDL Cholesterol 0.6 1.0 3.2 -1.8 -0.5 -0.6 -0.2 -0.7 -1.4 -1.2 0.0
LDL Cholesterol 0.1 0.1 0.2 -0.2 0.4 -0.4 -0.5 -0.1 -0.3 0.4 0.0
Lupus 1.7 2.6 6.2 -0.5 -2.5 -1.2 -1.6 -2.3 0.6 -2.0 -0.5
Neuroticism (2016) 0.7 1.1 2.9 0.2 -1.7 -0.5 -1.1 -1.4 -0.2 -1.3 0.5
Primary Biliary Cirrhosis 0.7 0.9 4.9 0.1 -1.0 0.8 0.2 -0.8 0.4 0.3 -2.2
Rheumatoid Arthritis 1.1 1.5 5.6 -0.0 -0.5 0.7 -0.6 -1.1 2.0 -0.7 -2.4
Schizophrenia (2014) 0.4 0.9 2.2 0.9 -1.0 -0.4 -1.5 -1.1 1.3 -0.3 -0.2
Triglycerides 0.2 0.3 0.9 -0.0 -0.7 -0.6 -1.0 -0.7 0.2 -0.2 0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.1 0.7 0.9 1.4 -0.0 0.4 -0.8 0.5 0.0
Ulcerative Colitis 0.9 1.4 6.3 2.5 0.1 1.2 0.1 -0.3 1.5 -0.2 -1.0
Blood Eosinophil Count 0.2 1.6 8.0 -2.8 0.0 -1.8 0.7 0.9 0.2 -0.6 -0.6
Blood Platelet Count 0.1 1.3 2.2 -1.4 1.2 0.6 1.5 1.5 -1.0 0.3 0.7
Blood Red Count 2.1 20.0 54.2 -3.4 4.2 3.4 4.8 5.2 -7.4 2.2 3.1
Blood White Count 0.3 1.9 4.9 1.6 -2.0 0.9 -1.1 -2.2 1.0 -0.7 -0.4
Heel T-Score 0.1 1.1 3.1 -0.4 -0.9 1.0 -0.2 -0.3 0.7 1.7 -1.8
BMI 0.1 0.4 1.5 -0.6 -0.8 0.3 -1.2 0.1 -0.2 0.3 0.2
Height 0.7 13.4 29.5 -4.4 3.2 -0.2 5.4 4.7 -0.7 3.8 -3.4
Waist Hip Ratio (WHR) 0.4 1.8 8.1 0.6 1.4 -0.0 1.0 1.2 -0.8 2.9 -1.1
Systolic Blood Pressure 0.8 3.9 9.4 -0.7 1.7 1.8 3.1 2.5 -0.8 1.6 2.3
Smoking Status 2.0 4.7 8.9 2.0 -1.8 -0.4 -2.8 -2.9 2.2 -0.1 -3.0
Allergy or Eczema 0.8 2.1 6.6 0.2 1.9 0.7 2.6 1.8 -1.1 1.2 0.4
Cardiovascular Disease 0.4 1.4 3.6 -0.5 1.0 0.3 1.0 1.6 -0.3 1.9 1.6
Hypothyroidism (self reported) 0.5 1.1 1.7 -1.2 -0.9 -1.3 -1.1 -1.1 0.4 -1.0 -1.1
Respiratory disease 0.7 1.7 3.4 -0.6 1.4 -1.0 1.0 1.8 -1.4 1.7 0.9
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 0.1 -0.7 -0.4 -0.8 -0.6 0.1 -0.1 -0.2
Lung FEV1/FVC ratio 6.8 34.7 63.7 5.4 -7.1 -0.0 -6.7 -8.0 4.7 -6.5 -5.2
Lung FVC 8.3 42.1 96.3 -0.5 8.9 2.8 9.8 9.5 -2.4 6.7 3.5
Neuroticism 0.3 0.7 2.0 -0.7 -0.8 -0.9 -0.0 -1.0 0.6 -1.4 0.1
Chronotype (morning person) 0.4 1.0 3.7 -1.9 -0.2 -1.1 -0.5 0.8 0.3 0.4 1.3
Hair Pigment 0.1 1.7 5.8 0.7 -1.3 -1.1 -2.4 -1.6 -0.2 -1.4 0.5
Tanning 0.1 1.7 4.9 -1.6 -0.3 -1.4 -0.6 -0.8 -2.2 0.5 -1.7
Hand grip strength (left) 0.3 0.9 3.1 -1.8 -0.5 -0.3 -0.7 -0.8 -0.2 0.0 -1.6
Number of treatments/medications taken 0.4 0.7 3.0 -1.7 0.3 -1.2 -0.0 0.1 0.3 0.6 -0.4
Average weekly spirits intake 0.3 0.3 0.6 -0.7 0.6 0.8 0.4 0.5 0.4 0.1 -0.8
Sensitivity / hurt feelings 2.3 3.9 9.4 1.0 -2.3 -0.9 -1.6 -2.9 1.3 -3.1 -1.5
Frequency of depressed mood in last 2 weeks 0.8 1.1 5.0 0.2 1.1 -0.3 0.9 1.2 -0.6 0.1 2.2
Hearing difficulty/problems: Yes 0.4 0.7 3.0 1.7 0.5 -0.6 -0.3 0.2 0.8 0.7 -0.6
Relative age of first facial hair 0.8 1.7 7.3 0.0 -1.3 -0.3 -1.2 -0.7 2.7 -0.1 -1.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 6.4 -0.2 -0.2 -2.5 0.1 -0.8 -0.2 0.7 -1.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 3.0 -0.6 0.5 -0.7 -0.4 0.3 -0.8 -0.2 1.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 0.3 0.9 -1.2 0.5 1.0 0.7 -0.8 0.2
Systolic blood pressure, automated reading 0.9 2.5 6.7 0.4 0.9 2.6 2.3 1.8 -0.4 1.1 1.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.3 1.5 -0.8 -1.1 -1.0 -0.8 -0.0 -0.9 -0.1
Angina 0.4 0.6 1.0 0.8 -0.7 0.2 -1.0 -0.7 1.0 -0.6 -0.6
Medication for hormone replacement therapy 0.6 0.7 2.3 0.9 -0.8 0.2 -0.3 -0.4 1.5 -0.4 -1.1
Vitamin and mineral supplements 0.7 0.9 2.7 0.9 -0.5 0.1 0.3 0.0 1.0 -1.6 -1.6
Supplements: Zinc 1.1 1.2 5.0 1.3 0.2 -1.5 -0.4 -0.3 0.6 2.2 0.3
Medication: Co-codamol 1.5 1.7 4.0 -0.7 -1.3 -1.8 -1.5 -2.0 -0.4 -1.0 -0.9
Medication: Metformin 0.1 0.1 0.6 -0.2 -0.3 -0.8 -0.0 -0.3 -0.1 0.5 0.1
Diabetes (father) 0.7 0.9 2.4 -0.5 -1.1 -0.6 -1.3 -1.5 0.6 0.6 0.3
Diabetes (mother) 0.5 0.6 1.4 -0.8 0.6 1.2 0.6 1.0 0.2 0.9 0.6
Severe depression (siblings) 0.9 1.0 2.4 -0.5 -1.6 -0.2 -0.9 -1.1 1.3 -0.7 -1.1
Pack years adult smoking proportion 1.8 2.7 11.4 -0.5 -2.0 -1.0 -3.4 -1.6 -1.2 -0.8 0.2
Impedance of leg (right) 0.3 1.5 4.3 2.1 -0.1 0.8 -0.7 -0.5 1.7 -0.7 -1.6
Leg fat-free mass (left) 0.6 2.9 6.7 -2.6 1.4 0.5 2.2 2.1 -1.3 1.8 -0.5
Trunk fat percentage 0.3 1.1 2.0 0.2 0.6 1.1 1.3 1.4 0.7 1.1 -1.3
Hand grip strength (right) 0.5 1.3 7.7 -2.8 -0.0 -0.3 0.1 0.2 -1.4 0.5 -0.9
Townsend deprivation index at recruitment 1.6 2.3 5.8 0.1 2.2 -0.4 1.3 2.4 -1.1 1.7 1.4
Current tobacco smoking 0.4 0.7 2.5 1.1 -0.1 -0.3 -0.2 -0.8 1.6 -0.8 -0.3
Average weekly fortified wine intake 0.4 0.5 2.4 -0.3 -0.1 0.0 0.6 0.5 0.9 0.5 -1.5
Maternal smoking around birth 1.4 2.0 9.0 1.7 -0.4 -0.1 -0.4 -1.4 3.0 -0.8 -1.1
Fed-up feelings 0.5 0.9 1.9 1.1 -0.7 -1.4 -0.9 -1.0 -0.2 -0.5 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 1.0 0.2 -0.2 -1.0 -0.4 -0.6 -0.1 -0.5 0.9
Relative age voice broke 1.9 2.9 4.8 2.2 -2.0 0.0 -1.9 -1.6 1.9 -1.4 -1.6
Taking other prescription medications 0.6 0.9 5.0 -1.4 0.5 -2.2 0.0 -0.1 -0.3 0.1 -0.0
Age when periods started (menarche) 1.1 2.6 7.1 0.8 -1.7 0.4 -2.2 -2.0 1.0 0.4 -2.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.0 0.3 1.0 -0.9 0.7 0.2 -1.0 0.0 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 2.0 0.6 0.2 0.1 0.3 -0.0 -0.8 1.4 -0.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 4.3 -1.0 -0.4 2.1 0.2 0.3 0.2 -1.0 0.6
Qualifications: CSEs or equivalent 0.3 0.4 1.3 -1.1 -0.2 0.8 0.1 -0.1 -0.3 -0.3 -1.0
Serious illness, injury or assault to yourself 0.3 0.3 1.1 1.1 0.6 -0.1 -0.3 -0.0 0.8 -0.3 0.7
High blood pressure 0.1 0.1 0.6 -0.3 -0.2 0.1 0.4 0.3 0.8 0.0 -0.3
Hayfever, allergic rhinitis or eczema 0.7 1.5 3.0 -0.6 1.5 0.1 1.7 1.6 -1.4 1.2 0.6
Multivitamins +/- minerals 0.7 0.9 3.2 -0.7 0.6 -0.2 0.1 0.5 -1.4 1.8 0.9
Stomach or abdominal pain in last month 1.1 1.4 3.8 0.5 1.2 1.1 1.8 1.1 -0.2 1.9 0.4
Supplements: Glucosamine 1.5 2.0 4.3 -1.4 -2.1 -1.0 -1.3 -1.7 -0.9 -1.6 -0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.0 -0.6 1.0 0.2 0.9 0.8 -1.0 0.3 -0.1
Medication: Atenolol 0.6 0.8 1.3 -1.1 -0.9 -0.8 -0.7 -0.7 0.7 -1.1 -0.9
Medication: Levothyroxine sodium 1.0 1.8 4.1 -0.4 -1.6 -1.1 -1.6 -2.0 0.1 -1.3 -1.4
Sitting height 0.2 1.1 2.2 -1.5 0.5 -1.3 0.8 0.6 -0.9 0.6 -1.5
Chronic bronchitis/emphysema (father) 0.6 0.7 2.2 0.7 -0.2 -1.5 -1.1 -1.2 -0.5 0.2 -0.5
High blood pressure (mother) 0.7 1.0 3.2 -1.8 -0.8 -0.3 -0.9 -0.7 -0.9 -0.8 1.3
Body mass index (BMI) 0.1 0.3 1.1 -0.2 -1.1 0.1 -0.9 -0.3 0.8 -0.2 -0.3
Impedance of leg (left) 0.2 0.9 3.7 1.9 -0.1 0.3 -0.7 -0.5 1.3 -0.5 -1.0
Leg predicted mass (left) 0.6 3.1 6.8 -2.6 1.5 0.5 2.3 2.2 -1.4 1.8 -0.3
Trunk fat mass 0.3 1.4 2.7 -0.6 0.6 1.0 1.5 1.6 0.5 1.4 -1.5
Waist circumference 0.2 0.7 1.7 -1.3 0.1 0.2 0.7 1.1 0.1 1.1 -0.9
Number of incorrect matches in round 0.6 0.9 2.3 -1.2 0.5 0.4 0.7 1.5 0.4 1.5 0.5
Past tobacco smoking 2.4 4.4 14.4 -1.9 2.1 0.6 2.4 2.4 -0.8 -0.4 3.8
Alcohol usually taken with meals 0.4 0.6 1.6 -1.3 0.2 0.6 1.2 0.5 0.2 0.6 -1.0
Nervous feelings 0.3 0.6 1.8 -0.4 0.9 -0.9 0.8 0.8 -0.4 0.3 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 7.3 0.0 0.7 -0.9 0.0 0.7 -0.8 0.7 2.7
Hearing difficulty/problems with background noise 0.5 0.8 4.5 0.5 -0.0 -0.3 -0.6 0.5 2.1 0.7 0.2
Hair/balding pattern: Pattern 2 0.2 0.2 0.9 -0.4 -0.5 -0.9 0.1 0.4 -0.0 -0.5 0.4
Had menopause 0.5 0.6 1.0 -0.7 -0.9 -0.5 -0.8 -0.5 1.0 -0.8 -0.9
Had other major operations 0.7 0.8 3.2 -0.6 1.1 -0.7 1.8 0.6 -0.6 0.1 -0.7
Forced vital capacity (FVC) 5.5 21.0 45.0 -1.6 6.0 2.3 6.7 6.4 -3.4 4.6 2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.4 -0.0 0.3 -0.1 0.5 0.3 -0.7 1.6 -1.0
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.3 1.4 -1.4 0.2 -1.4 -1.8 0.5 -0.7 -1.5
Qualifications: None of the above 0.2 0.5 1.7 1.3 0.3 -0.6 -0.4 -0.1 0.9 -0.5 0.7
Financial difficulties in last 2 years 0.4 0.6 2.9 0.9 0.2 0.8 0.1 -0.1 -1.7 -0.0 0.7
Mouth/teeth dental problems 0.6 0.9 4.1 -2.0 0.2 -1.0 0.6 0.7 -0.7 -0.7 0.8
Heart attack 0.6 0.8 4.1 2.0 -0.5 0.0 -0.7 -0.7 0.8 -0.0 -0.5
Allergy 1.8 4.1 8.8 0.4 -2.6 0.4 -2.2 -3.0 2.2 -2.1 -1.7
Pain all over the body in last month 1.1 1.2 4.8 0.4 -0.3 -2.0 -0.3 -0.2 0.4 -2.2 0.1
Diabetes (self-reported) 0.3 0.5 1.3 0.3 -0.7 -0.4 -0.8 -0.7 1.1 0.1 -0.8
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.2 -1.0 0.7 -0.0 0.1 1.2 -0.8 0.2 1.5
Medication: Ramipril 0.2 0.3 1.0 -0.5 0.0 -0.4 1.0 0.2 0.9 -0.4 -0.1
Medication: Simvastatin 0.2 0.3 0.8 -0.1 -0.3 -0.9 -0.1 0.0 0.9 0.7 -0.0
Fluid intelligence score 0.1 0.2 0.5 0.1 0.2 -0.7 0.5 0.4 -0.4 0.4 -0.5
Illnesses of siblings 1.2 1.7 5.3 -0.5 -1.2 -0.9 -1.5 -1.9 -0.2 -2.3 0.0
Neuroticism score 1.0 2.1 6.1 0.1 -1.5 -1.7 -1.2 -2.1 0.4 -2.5 -0.1
Weight 0.2 1.2 2.7 -1.6 0.4 0.5 1.2 1.5 0.2 1.2 -1.3
Impedance of arm (right) 1.0 4.7 15.4 1.0 3.1 1.3 3.9 2.5 0.2 1.7 -1.0
Arm fat percentage (right) 0.2 0.8 1.4 0.3 0.4 1.0 1.2 1.1 1.2 0.7 -0.9
Trunk fat-free mass 0.2 1.3 6.5 -2.5 0.3 -0.2 0.8 1.1 -0.4 1.0 -1.0
Hip circumference 0.2 0.8 3.3 -1.8 -0.5 0.1 0.3 0.7 1.0 0.5 -1.0
Time employed in main current job 1.2 1.4 4.0 -1.3 1.4 -0.2 1.3 1.4 0.1 2.0 -0.1
Alcohol intake versus 10 years previously 0.4 0.5 2.5 0.4 0.7 1.6 1.0 0.3 0.0 0.1 -0.1
Father’s age at death 0.3 0.5 1.2 -0.3 -0.4 0.3 0.4 -0.8 -1.1 -1.1 -0.5
Worrier / anxious feelings 0.1 0.1 0.5 -0.2 0.4 -0.3 0.7 -0.3 0.1 -0.4 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 1.0 0.2 -0.4 0.3 0.1 0.6 -0.9 0.4
Falls in the last year 0.2 0.3 0.9 -0.9 0.3 0.3 0.7 0.6 -0.3 -0.1 0.5
Hair/balding pattern: Pattern 3 1.2 1.8 3.5 0.8 -1.6 -0.2 -1.8 -1.7 1.9 -0.1 -1.2
Number of live births 0.2 0.3 0.7 -0.4 -0.8 -0.9 -0.4 -0.1 -0.7 -0.6 0.5
Forced expiratory volume in 1-second (FEV1) 2.2 7.3 15.8 -0.0 3.5 2.5 4.0 3.6 -2.2 2.1 1.4
Pulse rate 0.4 0.7 4.0 -2.0 -0.5 0.6 0.1 -0.6 -0.6 -0.5 -0.3
Happiness 1.3 1.6 4.1 -0.5 -1.8 -0.5 -0.8 -2.0 0.2 -1.1 -1.7
Noisy workplace 0.4 0.6 1.9 0.9 -0.2 0.9 0.2 -0.6 0.5 -1.4 -0.4
Qualifications: A levels/AS levels or equivalent 0.4 0.9 4.1 -0.4 0.9 0.1 2.0 1.1 -0.2 0.7 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 -0.9 0.3 0.7 0.7 0.9 -0.3 0.9 0.6
Mouth/teeth dental problems: Dentures 3.4 5.7 11.2 1.6 -2.7 -1.9 -3.3 -3.3 2.1 -1.9 -1.6
Asthma 0.8 1.6 4.1 -0.3 1.4 -0.5 1.4 2.0 -1.5 1.2 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.0 -0.6 0.0 -1.1 -0.7 -0.4 -1.4 -0.8 0.4
Medication: Cholesterol lowering 0.2 0.4 2.0 0.2 -0.1 -0.3 -0.2 -0.4 0.5 1.4 -0.5
Depression (self-reported) 0.7 0.8 2.6 -0.2 0.9 0.1 0.4 1.0 -1.2 -0.8 1.6
Medication: Lansoprazole 0.9 1.0 2.3 0.0 1.0 1.4 1.3 1.5 1.1 0.3 -0.1
Prospective memory result 0.4 0.5 1.8 1.1 -0.5 0.6 -0.0 0.0 1.3 -0.5 0.3
Lung cancer (father) 0.4 0.4 1.6 0.9 0.4 0.4 0.0 0.5 0.7 1.2 -0.4
Illnesses of mother 1.6 2.0 3.7 1.9 1.5 -0.9 0.6 1.0 -1.9 1.2 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.4 20.2 0.1 4.2 2.4 4.5 4.2 -2.4 2.5 1.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.9 -1.7 -0.4 -0.5 -0.3 0.1 0.5 1.0 -1.3
Impedance of arm (left) 1.3 5.9 20.1 0.4 3.3 1.3 4.5 3.1 -0.6 2.0 -0.2
Arm fat mass (right) 0.1 0.4 0.9 -0.5 0.1 0.5 0.7 0.9 0.6 0.8 -0.9
Trunk predicted mass 0.2 1.4 7.0 -2.6 0.3 -0.2 0.9 1.1 -0.5 1.0 -1.0
Standing height 0.8 8.3 17.1 -3.2 2.9 0.8 4.1 3.7 -1.4 3.1 -2.1
Length of working week for main job 0.9 1.0 2.9 -1.7 1.0 0.8 0.8 1.0 -0.5 1.3 -0.4
Exposure to tobacco smoke at home 0.4 0.5 1.5 0.7 -0.1 1.1 -0.5 0.1 -0.1 -0.5 1.2
Breastfed as a baby 1.0 1.2 4.1 -1.1 -0.7 1.6 0.5 1.1 0.3 2.0 -0.4
Tense / ‘highly strung’ 0.2 0.3 1.4 0.1 -0.0 -0.7 -0.5 -0.1 0.3 -0.6 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.8 4.1 -0.4 -1.2 -1.5 -1.5 -2.0 -0.6 -1.9 -0.3
Hair/balding pattern: Pattern 4 0.1 0.3 1.0 1.0 0.1 -0.7 -0.4 -0.4 -0.9 -0.1 -0.4
Birth weight of first child 0.7 1.3 3.1 1.2 -0.8 -0.3 -1.2 -1.8 1.4 -0.9 -1.0
Peak expiratory flow (PEF) 0.3 0.6 3.1 1.8 0.0 0.5 -1.0 -0.2 -0.0 -0.4 0.5
Pulse wave reflection index 0.1 0.1 0.2 -0.0 0.2 -0.4 -0.0 0.5 -0.5 0.4 -0.1
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.4 0.3 0.6 -0.6 0.3 1.0 -1.3 1.5 1.5
Loud music exposure frequency 1.3 1.5 3.6 -1.2 -1.5 -1.9 -0.5 -1.3 0.6 -1.5 -0.4
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.5 -0.6 1.0 0.1 1.9 1.3 -1.2 1.4 1.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.6 0.3 0.5 0.7 0.3 0.3 0.4 0.5 0.2
Blood clot in the leg (DVT) 5.6 7.2 12.1 -1.2 3.3 1.3 2.7 3.5 -3.0 2.5 3.0
Medication: Paracetamol 1.6 2.7 7.8 -0.6 -1.1 -2.8 -2.1 -2.0 -0.2 -1.9 -0.0
Headache pain in last month 0.6 1.1 3.6 -1.9 0.5 -1.3 0.3 0.0 -1.6 0.5 0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.5 0.1 0.3 -0.7 -0.6 -0.1 -1.2 -0.6 0.2
Glaucoma (self-reported) 0.1 0.1 0.3 0.3 -0.5 0.4 0.3 -0.3 0.1 -0.6 -0.1
Gout (self-reported) 0.4 0.5 3.1 0.6 0.3 1.8 0.7 -0.2 -0.2 -0.2 0.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 2.3 -1.0 -0.9 -1.0 -1.1 -1.5 -0.3 -1.1 -1.5
Medication: Amlodipine 0.3 0.4 2.0 -0.3 -0.6 -1.4 -0.3 -0.5 -0.5 -0.4 -0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.8 -0.7 0.9 0.9 0.2 1.3 -0.3 1.0 0.7
Birth weight 0.9 1.9 4.5 0.5 2.1 0.5 2.0 1.7 -0.8 1.6 -0.2
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.8 -1.4 0.3 -0.7 0.7 0.3 0.6 0.2 -0.4
High blood pressure (siblings) 1.6 2.3 4.9 -0.1 1.8 0.4 2.2 2.1 -0.5 2.2 0.7
Forced vital capacity (FVC), Best measure 6.9 25.3 53.9 -1.7 6.8 2.5 7.3 7.1 -3.4 5.1 2.2
Body fat percentage 0.2 0.8 1.9 0.3 0.1 1.1 0.8 1.0 1.2 0.5 -1.4
Leg fat percentage (right) 0.5 1.7 4.9 0.3 -1.5 0.8 -1.0 -0.5 2.2 -0.8 -1.9
Arm fat-free mass (right) 0.2 1.3 7.7 -2.8 -0.0 -0.3 0.3 0.9 -0.6 0.9 -0.6
Exposure to tobacco smoke outside home 0.9 1.2 4.5 -0.2 -0.3 -0.5 -0.5 -0.2 -2.1 -0.2 2.0
Comparative body size at age 10 1.1 3.0 7.1 1.5 1.7 1.6 1.5 1.8 -1.6 2.7 1.2
Number of full brothers 1.5 1.8 6.2 -0.1 -2.5 0.1 -2.1 -1.1 1.1 -1.4 0.1
Worry too long after embarrassment 0.6 1.0 3.9 -1.3 -1.1 -0.4 -0.5 -1.0 0.3 -2.0 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.5 -0.7 0.3 0.2 0.1 -0.4 -1.2 0.3 0.8
Wheeze or whistling in the chest in last year 0.5 1.0 4.0 -0.0 0.1 -1.2 -0.2 0.6 1.4 2.0 0.0
Number of children fathered 1.1 1.3 3.7 1.9 -0.7 1.0 -0.9 -0.2 1.8 0.4 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 -0.8 0.1 -0.7 0.1 -0.1 0.1 -0.5 0.9
Age at first live birth 0.2 0.4 1.2 1.1 0.4 0.8 0.7 0.3 -0.3 0.4 -0.2
Pulse wave peak to peak time 0.7 0.8 2.6 1.6 0.6 0.4 0.4 0.2 -0.7 -0.9 1.2
Health satisfaction 1.7 2.2 7.5 -0.2 -1.1 -1.2 -1.1 -1.3 1.6 -1.1 -2.7
Shortness of breath walking on level ground 0.9 1.0 4.8 -1.2 -0.7 2.2 -0.2 0.8 0.0 0.6 -0.5
Qualifications: College or University degree 0.3 1.1 4.1 -1.1 1.0 -0.4 2.0 0.9 -1.1 -0.1 -0.1
Eye problems/disorders: None of the above 3.1 3.6 9.5 -0.4 2.6 2.1 2.1 3.1 -0.7 1.6 0.8
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.6 1.2 0.8 -0.1 0.6 0.1 -0.1 0.6 -0.8
Emphysema/chronic bronchitis 0.4 0.5 1.6 -0.2 0.2 -0.9 -0.8 0.1 0.8 1.3 -0.3
Medication for pain relief, constipation, heartburn 0.7 1.1 2.9 0.6 0.6 1.7 1.4 1.2 -0.5 1.4 0.2
Neck or shoulder pain in last month 1.2 1.7 4.7 0.7 -1.8 -1.3 -2.2 -1.7 0.1 0.1 -0.1
Medication: Blood pressure 0.5 0.9 3.1 -0.3 -0.1 1.8 1.4 0.8 1.0 0.8 -0.4
Angina (self-reported) 0.5 0.7 1.3 0.5 -1.0 -0.0 -1.1 -1.0 0.9 -0.7 -0.6
Migraine (self-reported) 0.8 1.0 6.1 -0.1 -0.6 -2.5 -0.8 -0.6 0.7 -0.4 0.0
Medication: Ibuprofen 0.3 0.4 1.6 -0.6 0.1 -0.7 -0.4 -0.2 -1.3 -0.6 0.3
Medication: Allopurinol 0.7 1.0 3.2 1.1 -0.7 1.8 0.1 -1.0 0.8 -0.8 -0.6
Medication: Omeprazole 1.2 1.4 4.5 -2.1 0.2 -1.3 0.2 0.1 -2.0 0.1 1.0
Medication: Seretide 50 evohaler 0.6 0.7 1.4 -1.2 0.5 0.8 0.5 1.1 -0.8 1.1 -0.1
Mean time to correctly identify matches 0.7 1.3 5.8 0.4 -0.9 0.9 -0.9 -0.9 2.4 -0.7 -0.9
Heart disease (mother) 0.8 1.0 6.2 -0.5 -0.7 0.3 -0.3 -0.5 2.5 -0.6 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.4 0.6 -0.4 1.6 -0.9 -0.6 1.0 -0.2 -0.6
Whole body fat mass 0.2 0.7 1.8 -0.6 0.1 0.8 0.9 1.1 0.8 0.8 -1.4
Leg fat mass (right) 0.2 0.7 2.5 -0.4 -0.6 0.6 -0.1 0.3 1.3 0.1 -1.6
Arm predicted mass (right) 0.2 1.1 7.0 -2.6 -0.2 -0.6 -0.2 0.6 -0.9 0.7 -0.1
Pulse rate, automated reading 0.7 2.2 9.4 -3.1 0.3 0.1 0.9 0.2 -2.4 0.1 1.3
Alcohol intake frequency. 1.1 2.6 4.1 1.6 2.0 -1.7 1.5 1.6 -0.2 1.7 2.0
Comparative height size at age 10 1.4 7.8 16.6 -2.2 2.9 0.9 4.0 4.1 -1.5 3.7 0.0
Number of full sisters 0.7 0.8 2.9 -0.3 0.6 0.7 0.3 1.1 1.3 1.7 0.2
Suffer from ‘nerves’ 0.3 0.5 2.3 0.2 0.1 -0.3 0.6 0.3 1.5 -1.1 0.0
Overall health rating 0.9 1.9 7.3 0.4 -1.1 -2.7 -1.2 -1.5 0.7 -1.3 -0.9
Chest pain or discomfort 1.2 1.8 5.8 0.1 -0.3 -2.4 -0.9 0.1 2.3 1.1 -0.8
Had major operations 1.0 1.2 2.9 -1.5 1.1 -0.4 1.0 0.5 0.6 1.7 -1.3
Age at last live birth 0.3 0.5 1.1 1.0 -0.3 0.9 0.7 0.1 0.4 0.5 -1.0
Family relationship satisfaction 0.7 0.8 3.3 -1.2 -1.1 -0.7 -0.0 -0.2 1.8 -0.4 -0.3
Leg pain on walking 0.8 1.0 4.5 0.5 -0.8 0.1 -0.6 -0.3 1.3 -0.2 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.7 -0.0 0.0 0.2 -0.4 0.3 -1.0 0.5 1.3
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.4 1.6 -1.0 1.8 -0.4 -1.0 1.4 -0.5 -1.7
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 3.2 -1.8 0.1 0.3 0.3 0.4 1.2 1.3 -0.7
Medication: Aspirin 0.6 0.8 3.7 -0.3 -0.5 1.0 -0.7 -0.0 1.9 0.3 -1.0
Supplements: Vitamin C 0.6 0.7 2.2 0.2 -0.5 -1.0 -0.5 -0.7 1.3 1.5 0.1
Knee pain experienced in last month 0.4 0.7 2.1 -1.1 0.2 -1.4 -0.4 0.3 -0.8 1.1 0.2
Hypertension (Self-reported) 0.1 0.2 0.6 -0.4 0.1 0.3 0.8 0.7 0.6 0.3 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 6.6 -2.6 0.3 -0.1 0.4 0.7 -2.0 -0.6 1.4
Illnesses of father: Heart disease 0.7 0.9 4.2 2.1 -0.7 -0.8 -0.3 -0.8 0.5 0.0 -1.1
Illnesses of siblings: Diabetes 1.5 1.8 4.2 1.6 1.1 1.6 0.7 1.5 -0.8 2.1 0.6
Smoking status: Previous 2.2 3.3 12.6 1.9 -1.4 -0.0 -1.7 -1.8 1.0 1.1 -3.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 5.2 -2.0 1.4 1.8 2.3 2.0 -1.2 1.8 -0.3
Whole body fat-free mass 0.3 1.9 7.9 -2.8 0.7 -0.0 1.3 1.4 -0.9 1.4 -0.7
Leg fat-free mass (right) 0.7 3.5 8.2 -2.9 1.6 0.2 2.4 2.2 -1.7 2.0 0.0
Arm fat percentage (left) 0.2 0.9 2.6 0.0 0.7 1.0 1.6 1.5 0.6 1.0 -0.4
Average weekly red wine intake 0.7 1.1 3.1 -1.8 0.2 -1.3 0.7 1.3 -0.3 0.9 0.6
Handedness (chirality/laterality): Left-handed 0.2 0.3 1.1 1.1 0.1 -0.2 0.5 -0.2 0.6 0.2 -0.2
Mood swings 0.3 0.5 1.8 -0.3 -0.3 -0.7 -0.4 -0.7 -0.4 -0.9 1.3
Loneliness, isolation 1.9 2.7 7.1 -0.7 -1.6 -2.7 -2.0 -1.7 -1.0 -1.6 1.0
Long-standing illness, disability or infirmity 0.5 0.8 2.9 1.3 0.2 -1.7 0.1 -0.2 0.1 1.0 -1.0
Ever had bowel cancer screening 0.6 0.8 2.0 -1.4 -0.6 -0.7 -0.7 -0.6 -0.2 -1.4 -0.6
Diabetes diagnosed by doctor 0.1 0.1 0.2 0.4 -0.1 -0.1 -0.4 0.0 0.5 0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 6.6 0.0 0.7 -1.7 0.2 -0.0 -2.6 0.4 1.4
Friendships satisfaction 0.6 0.7 1.7 -0.0 -1.3 -0.3 -1.1 -1.0 1.1 -0.4 -0.4
Qualifications: nursing, teaching 0.4 0.6 3.2 -1.8 -0.5 0.2 0.1 -0.6 -0.6 -0.5 -0.4
Commuting to job workplace: Walk 2.1 2.2 5.4 0.7 1.5 1.2 0.9 1.2 -1.0 2.3 2.3
Eye problems/disorders: Cataract 1.1 1.3 2.7 0.0 -1.4 -1.4 -1.6 -1.6 0.4 -1.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 7.8 2.8 1.4 0.1 1.8 0.8 -0.1 1.9 -1.2
Medication for cholesterol 0.5 0.7 2.2 0.1 0.9 1.5 1.2 0.6 -0.6 0.6 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.5 0.3 -0.4 -0.3 -0.6 -0.3 1.2 -0.7 -1.9
Back pain experienced in last month 1.6 2.3 5.3 -0.7 1.6 0.1 1.8 2.3 -1.0 2.1 1.2
Mineral and other dietary supplements 0.3 0.4 1.2 0.3 1.1 0.3 0.4 0.6 -0.7 -0.3 0.9
Breast cancer (self-reported) 0.4 0.5 2.5 1.6 -0.0 -0.7 -0.6 -0.1 0.8 0.1 -0.5
Asthma (self-reported) 0.9 1.7 4.4 -0.4 1.4 -0.2 1.3 2.1 -1.7 1.2 1.1
Osteoporosis (self-reported) 0.1 0.1 0.7 -0.2 -0.1 -0.2 0.1 -0.8 -0.1 -0.6 -0.1
Osteoarthritis (self-reported) 0.5 0.6 2.0 -0.4 -0.3 1.1 0.1 -0.5 1.4 -0.9 -0.7
Medication: Aspirin 0.5 0.6 2.4 -0.3 -0.1 1.3 -0.3 0.2 1.6 0.5 -0.7
Medication: Gliclazide 0.9 1.0 3.0 -1.7 1.0 -0.4 1.3 0.5 -0.7 1.0 0.4
Illnesses of father: None of the above (group 1) 0.2 0.3 1.2 -0.2 0.5 -0.1 0.3 0.8 0.1 -0.2 1.1
Smoking status: Current 0.3 0.5 1.8 0.7 -0.3 -0.5 -0.4 -0.8 1.3 -0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 9.3 1.1 1.9 2.3 3.0 2.3 1.0 0.6 0.5
Whole body water mass 0.3 1.8 7.6 -2.8 0.6 0.0 1.2 1.4 -0.7 1.3 -0.7
Leg predicted mass (right) 0.7 3.6 8.3 -2.9 1.6 0.2 2.4 2.2 -1.7 2.1 0.0
Arm fat mass (left) 0.1 0.5 1.2 -0.7 0.2 0.4 0.9 1.1 0.4 0.9 -0.8
Number of self-reported non-cancer illnesses 0.5 1.0 2.5 -1.6 0.7 -1.5 -0.0 1.1 -0.8 -0.0 0.7
Average weekly champagne plus white wine intake 0.2 0.3 1.4 0.2 -0.1 -0.1 -0.7 -0.4 -1.2 -0.0 0.1
Miserableness 0.2 0.3 0.8 0.9 0.6 -0.7 0.2 0.3 -0.7 0.1 0.7
Guilty feelings 0.9 1.4 2.8 -0.8 -1.5 -1.3 -1.7 -1.5 0.1 -1.0 0.6
Wears glasses or contact lenses 0.2 0.2 0.6 -0.6 -0.6 -0.0 -0.1 -0.4 0.4 -0.4 -0.8
Ever taken oral contraceptive pill 1.6 1.8 4.4 1.0 -1.5 1.2 -1.8 -2.1 -0.8 -1.0 -0.9
Hearing aid user 0.5 0.6 2.1 1.0 0.7 1.4 0.7 0.4 -0.6 0.1 0.3
Mother’s age at death 0.8 1.0 3.8 -1.9 -0.6 -1.2 -0.4 -0.7 -1.2 0.2 -0.5
Financial situation satisfaction 0.7 0.9 1.5 -0.3 -1.0 -1.1 -0.8 -1.0 0.2 -1.2 -1.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.6 1.6 0.9 0.4 0.3 -0.0 -0.4 -0.0 -1.6
Commuting to job workplace: Public transport 1.0 1.1 4.5 -0.9 0.2 -1.0 -0.0 -0.2 -2.1 -0.5 1.6
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 -0.5 -1.0 0.5 -0.0 -0.8 0.3 -0.8 -0.4
Medication: Blood pressure 1.0 2.0 4.9 -0.9 -1.5 -2.2 -1.7 -1.3 0.6 -1.7 0.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.6 -0.5 0.3 -0.8 -0.1 -0.2 -0.2 0.4 0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.6 0.6 -0.9 -0.6 -0.6 -0.9 1.0 1.3 -0.9
High cholesterol (Self-reported) 0.3 0.6 1.7 0.2 -0.6 -1.3 -0.9 -0.4 0.7 0.9 -0.2
Medication: Bendroflumethiazide 0.8 1.2 3.3 0.4 1.5 0.1 1.8 0.9 -0.6 1.7 0.0
Medication: Paracetamol 1.8 2.8 6.2 -0.5 -1.3 -2.2 -2.5 -1.9 -1.2 -1.9 1.0
Medication: Lisinopril 0.4 0.5 1.8 -0.1 -0.2 1.3 0.1 0.2 0.4 0.6 -1.3
Medication: Atorvastatin 0.2 0.3 1.2 0.6 0.4 0.6 0.5 0.0 0.2 1.1 0.1
Illnesses of father: High blood pressure 0.4 0.5 1.9 -0.7 -0.3 1.4 -0.9 -0.3 -0.3 1.0 -0.1
Alcohol drinker status: Never 0.8 1.0 2.9 -0.2 1.2 -1.7 1.0 0.5 0.1 0.6 1.3
Ever smoked 1.6 2.8 8.8 1.7 -1.5 -0.5 -2.2 -1.9 0.1 0.1 -3.0
Basal metabolic rate 0.3 1.8 6.4 -2.5 0.7 0.2 1.4 1.6 -0.7 1.4 -0.8
Leg fat percentage (left) 0.4 1.4 3.9 0.2 -1.5 0.5 -1.0 -0.6 2.0 -0.6 -1.7
Arm fat-free mass (left) 0.2 1.2 7.4 -2.7 -0.6 -0.6 -0.4 0.3 -0.1 0.3 -0.9
Number of operations (self-reported) 0.8 1.1 2.7 -1.4 1.6 -0.6 1.3 1.1 -0.7 0.6 0.7
Average weekly beer plus cider intake 1.1 1.5 5.1 0.4 -1.2 0.7 -1.8 -2.2 0.3 -1.3 -0.2
Irritability 0.3 0.5 1.6 -0.3 -0.5 1.3 -0.7 -1.1 0.4 0.5 0.1
Risk taking 0.4 0.6 2.0 -0.8 -0.7 -1.4 -0.7 -0.8 -0.7 0.6 -0.1
Ever had prostate specific antigen (PSA) test 1.4 1.7 6.6 1.0 -0.4 0.1 0.6 -0.5 2.2 -0.4 -2.6
Fractured/broken bones in last 5 years 0.7 0.9 1.8 -1.1 -0.8 -1.0 -0.6 -1.4 -0.8 -1.1 0.1
Age started oral contraceptive pill 0.8 1.0 2.9 -1.7 -0.0 -1.4 -0.7 -0.6 -1.1 0.8 0.0
Diastolic blood pressure, automated reading 1.3 3.9 12.8 -0.1 1.8 0.9 2.0 0.8 -3.6 -1.0 3.0
Ever depressed for a whole week 2.4 3.0 6.2 1.2 -1.8 0.4 -1.4 -2.0 1.1 -2.5 -2.4
Unable to work because of sickness or disability 0.4 0.5 1.2 1.1 0.4 1.1 -0.6 -0.2 -0.7 0.4 0.6
Commuting to job workplace: Cycle 1.4 1.7 6.2 -0.6 1.7 -0.3 0.8 0.7 -2.5 0.5 1.7
Myopia 1.1 1.6 4.9 -1.4 -0.4 -1.2 -1.1 -1.0 -2.2 -0.9 1.3
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.2 -0.1 0.4 0.1 0.1 0.0 -0.3 0.2 -0.1
Cholesterol lowering medication 0.2 0.3 1.3 -0.1 0.3 -0.7 -0.4 0.3 -0.0 0.7 1.1
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.2 -1.3 -0.3 -1.7 -0.3 -0.2 -1.8 0.1 0.5
Pain experienced in last month 1.5 2.6 8.4 2.1 -0.6 2.9 0.0 -0.6 2.2 -1.0 -1.3
Supplements: Calcium 0.2 0.2 0.5 -0.7 0.1 -0.4 0.2 -0.5 -0.3 0.4 -0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 0.1 -0.0 0.3 -0.6 -0.3 0.4 0.0 -0.2
Heart attack/myocardial infarction (self-reported) 0.7 0.8 4.6 2.1 -0.5 0.1 -0.7 -0.7 0.8 -0.0 -0.6
Deep venous thrombosis (DVT) (self-reported) 5.1 6.5 11.6 -1.4 3.1 1.3 2.5 3.4 -2.8 2.1 3.0
Heart disease (siblings) 0.3 0.4 2.2 -0.1 -0.7 -0.3 -0.3 -0.2 1.5 -0.3 -0.1
Alcohol drinker status: Previous 0.9 1.0 6.2 -0.4 -1.0 -2.5 -0.2 -0.6 0.8 -0.2 -0.1
Pack years of smoking 1.5 2.2 10.5 -0.4 -1.8 -0.8 -3.2 -1.4 -1.1 -0.6 0.2
Impedance of whole body 0.4 1.8 4.7 1.4 1.9 1.0 2.2 1.5 0.6 0.7 -0.8
Leg fat mass (left) 0.2 0.6 2.4 -0.5 -0.6 0.6 0.0 0.3 1.3 0.2 -1.5
Arm predicted mass (left) 0.2 0.8 5.2 -2.3 -0.5 -0.3 -0.3 0.4 -0.2 0.3 -0.7