Hub : Genes

LTBP4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0900	0.0270	1.7e-05	0.051	0.037	0.042	0.041	0.044	7.0e-07	2.4e-05	6.3e-06	9.5e-06	3.9e-06
2	GTEx	Brain Cerebellar Hemisphere	0.6190	0.0810	2.3e-08	0.225	NA	0.467	NA	0.412	1.8e-06	NA	1.3e-13	NA	9.7e-12
3	GTEx	Cells Transformed fibroblasts	0.1230	0.0450	2.0e-03	0.101	NA	0.047	NA	0.077	5.7e-08	NA	1.8e-04	NA	2.0e-06
4	TCGA	Breast Invasive Carcinoma	0.0128	0.0078	6.0e-03	0.005	0.006	-0.001	NA	0.000	3.1e-02	2.0e-02	6.5e-01	NA	2.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.8	4.0	1.6	0.2	0.8	2.0
Bipolar Disorder or Schizophrenia	0.9	2.3	4.7	2.2	-0.1	0.2	2.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-0.4	0.0	-1.6	-0.9
Depression (Nagel 2018)	1.2	1.9	4.4	-0.6	0.6	-2.1	-1.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	-1.4	0.5	1.0	-0.9
Neuroticism (Nagel 2018)	0.2	0.4	1.7	0.2	-0.1	-1.3	-0.1
Schizophrenia (2018)	0.4	0.9	2.2	1.5	-0.3	-0.4	1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.5	-0.3	-0.8	0.0
Worry (Nagel 2018)	0.3	0.6	1.2	-0.5	0.7	-1.1	-0.8
Alzheimer’s Disease (in mother)	2.4	2.8	5.5	-1.1	2.4	-2.0	-0.8
Alzheimer’s Disease (in father)	2.1	2.2	5.7	-0.8	2.4	-1.5	-0.5
Alzheimer’s Disease (including proxy)	6.3	9.2	15.1	-2.4	3.9	-3.4	-2.1
Crohns Disease (2017)	1.0	2.2	3.1	1.3	1.7	-1.8	1.0
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	1.3	1.0	-0.4	1.0
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.3	0.5	0.9	0.1
Major Depression (MDD)	0.1	0.1	0.3	0.0	-0.3	0.5	0.3
Reaction Time	0.7	1.3	2.9	1.6	0.2	0.2	1.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.6	-1.9	0.8	0.9	-0.7
Breast Cancer	0.3	0.6	2.0	0.1	-1.4	0.4	-0.5
Ovarian Cancer	0.3	0.5	1.1	-0.5	-0.3	-1.1	-0.5
Prostate Cancer	0.5	0.8	2.3	-0.2	-0.2	1.5	0.8
Age at First Birth	0.1	0.1	0.3	-0.1	0.3	-0.5	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	2.9	1.6	-0.5	-0.2	1.7
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.5	-0.4	0.5	0.0
Crohns Disease (2012)	0.5	0.9	2.0	-0.0	1.1	-1.4	-0.4
Mean Putamen Volume	0.8	0.9	3.1	-0.6	1.8	-0.3	0.2
Fasting Glucose	0.3	0.3	1.2	-0.1	1.1	-0.2	0.0
HbA1C	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.5
HDL Cholesterol	0.8	1.3	3.7	0.1	-1.9	1.3	0.1
LDL Cholesterol	0.1	0.2	0.4	0.3	0.2	-0.6	0.3
Lupus	3.2	4.8	7.5	2.1	-2.7	2.3	1.5
Neuroticism (2016)	0.9	1.3	3.4	1.2	-0.6	-1.8	0.3
Primary Biliary Cirrhosis	0.5	0.7	1.2	0.3	-0.9	1.1	0.8
Rheumatoid Arthritis	0.3	0.4	0.7	0.2	0.1	0.9	0.8
Schizophrenia (2014)	0.6	1.4	3.0	1.7	-0.1	-0.8	1.3
Triglycerides	0.1	0.1	0.2	0.3	0.4	-0.2	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.2	-0.6	-0.2	0.0
Ulcerative Colitis	0.1	0.1	0.3	0.6	0.2	0.2	0.2
Blood Eosinophil Count	0.1	1.1	2.8	-0.4	-1.2	1.7	-0.3
Blood Platelet Count	0.2	2.3	3.5	-1.5	0.4	-1.9	-1.8
Blood Red Count	2.3	22.5	39.9	-6.3	3.3	-0.1	-6.3
Blood White Count	0.4	2.7	4.7	2.2	-1.3	1.5	1.5
Heel T-Score	0.1	0.9	2.0	0.7	-0.4	1.1	1.4
BMI	0.2	1.1	1.7	1.0	-0.5	1.3	1.3
Height	0.4	8.3	23.0	-4.8	1.9	1.9	-1.8
Waist Hip Ratio (WHR)	0.5	2.3	4.8	-1.2	2.2	-1.7	-0.4
Systolic Blood Pressure	0.9	4.3	7.1	-2.7	2.0	-0.2	-2.4
Smoking Status	3.3	8.0	13.3	3.6	-2.0	1.3	3.7
Allergy or Eczema	2.1	5.6	9.4	-3.1	1.9	-0.5	-3.0
Cardiovascular Disease	0.3	1.1	2.4	-0.9	0.7	-1.5	-0.9
Hypothyroidism (self reported)	0.2	0.5	0.7	0.7	-0.3	0.8	0.9
Respiratory disease	0.2	0.5	1.2	-0.8	0.1	-0.4	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.8	1.9	0.9	-1.4	0.2	0.8
Lung FEV1/FVC ratio	8.0	40.6	52.9	7.1	-4.1	6.5	7.3
Lung FVC	12.6	63.9	98.5	-9.9	8.0	-4.5	-8.5
Neuroticism	0.1	0.2	0.5	0.4	-0.6	-0.7	0.0
Chronotype (morning person)	0.5	1.2	2.1	1.0	-1.4	-1.1	0.6
Hair Pigment	0.0	1.4	3.1	1.8	-0.7	-0.8	1.2
Tanning	0.1	1.3	3.6	-0.5	-1.1	1.9	0.3
Hand grip strength (left)	0.4	1.0	1.6	0.8	-1.0	0.9	1.3
Number of treatments/medications taken	0.2	0.4	1.4	0.3	-1.2	0.1	0.3
Average weekly spirits intake	0.1	0.1	0.4	-0.6	0.1	-0.3	-0.3
Sensitivity / hurt feelings	1.3	2.2	3.0	1.7	-1.7	1.0	1.4
Frequency of depressed mood in last 2 weeks	2.6	3.6	5.3	-1.6	1.3	-2.3	-2.2
Hearing difficulty/problems: Yes	1.0	1.5	4.1	-0.8	2.0	-0.9	-0.4
Relative age of first facial hair	0.9	1.9	5.2	1.4	0.1	-0.7	2.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.7	0.5	-0.6	0.3	0.8
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.4	-0.1	1.0	-2.3	-1.0
Ever had hysterectomy (womb removed)	1.3	1.4	2.8	-1.1	1.1	-1.7	-0.6
Systolic blood pressure, automated reading	0.7	2.2	3.2	-1.8	1.6	0.7	-1.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.5	1.6	-1.5	0.6	1.2
Angina	0.5	0.7	1.4	0.9	-0.1	-0.7	1.2
Medication for hormone replacement therapy	0.9	1.1	2.7	0.4	1.7	-0.5	1.1
Vitamin and mineral supplements	0.2	0.3	0.9	-0.6	0.1	1.0	0.3
Supplements: Zinc	1.4	1.5	4.0	1.3	0.0	-2.0	0.7
Medication: Co-codamol	1.3	1.5	3.8	0.6	-1.9	1.2	0.7
Medication: Metformin	0.3	0.5	1.6	0.4	-1.2	-0.2	0.3
Diabetes (father)	1.0	1.3	2.7	1.6	-1.0	0.7	1.0
Diabetes (mother)	0.8	1.0	1.2	-1.1	1.1	-1.0	-0.8
Severe depression (siblings)	2.1	2.3	3.6	1.6	-1.2	1.2	1.9
Pack years adult smoking proportion	3.4	5.1	10.8	3.3	-1.7	-0.9	2.4
Impedance of leg (right)	0.1	0.7	2.4	0.1	1.5	-0.2	0.4
Leg fat-free mass (left)	0.2	1.2	3.2	-1.8	0.2	1.0	-0.6
Trunk fat percentage	0.4	1.5	3.3	-1.4	0.9	1.8	0.1
Hand grip strength (right)	0.1	0.4	1.0	-0.4	-0.7	1.0	0.3
Townsend deprivation index at recruitment	1.7	2.4	3.5	-1.8	1.9	-0.9	-1.5
Current tobacco smoking	0.2	0.3	0.5	0.3	0.6	0.7	0.5
Average weekly fortified wine intake	0.4	0.5	0.7	-0.8	0.8	0.6	0.5
Maternal smoking around birth	0.9	1.4	2.5	1.5	-0.8	0.3	1.6
Fed-up feelings	0.2	0.3	0.6	0.6	-0.7	-0.8	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.7	-0.3	-0.0	-1.3	-0.7
Relative age voice broke	2.7	4.2	7.6	2.6	-1.4	0.6	2.8
Taking other prescription medications	0.2	0.3	1.3	0.3	-1.1	-0.0	0.1
Age when periods started (menarche)	1.4	3.4	8.4	2.1	-0.7	0.3	2.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.5	0.1	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.2	0.5	-0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	-0.6	1.1	-0.2	-0.7
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.9	0.5	0.3	-1.4	0.0
High blood pressure	0.0	0.0	0.1	0.1	0.1	-0.0	0.2
Hayfever, allergic rhinitis or eczema	1.9	4.2	7.3	-2.7	1.6	-0.6	-2.6
Multivitamins +/- minerals	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.4
Stomach or abdominal pain in last month	1.0	1.3	1.9	-1.4	1.3	0.1	-1.2
Supplements: Glucosamine	2.6	3.3	6.8	1.4	-2.6	1.9	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.9	-0.6	0.5	-0.7
Medication: Atenolol	0.1	0.1	0.2	0.3	-0.5	-0.4	0.2
Medication: Levothyroxine sodium	1.2	2.0	2.6	1.4	-1.6	1.5	1.1
Sitting height	0.0	0.3	1.0	-1.0	-0.2	0.2	0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.8	-0.6	-0.3	0.4
High blood pressure (mother)	0.1	0.1	0.1	-0.1	-0.4	-0.3	-0.3
Body mass index (BMI)	0.2	1.0	1.7	0.8	-0.4	1.3	1.3
Impedance of leg (left)	0.1	0.7	2.1	0.0	1.4	-0.8	0.1
Leg predicted mass (left)	0.2	1.2	3.6	-1.9	0.3	0.9	-0.7
Trunk fat mass	0.4	1.6	3.7	-1.4	0.8	1.9	0.3
Waist circumference	0.1	0.5	0.9	-0.8	0.7	0.9	0.3
Number of incorrect matches in round	0.3	0.4	0.9	0.3	1.0	-0.8	0.3
Past tobacco smoking	4.9	9.0	14.1	-3.5	2.9	-1.0	-3.8
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	0.0	0.4	0.2
Nervous feelings	1.3	2.5	4.1	-1.2	1.3	-2.0	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.6	-0.5	0.3	-2.1	-1.2
Hearing difficulty/problems with background noise	0.6	1.0	2.2	0.2	1.5	-1.3	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	-0.1	-0.3	1.0	0.3
Had menopause	0.9	1.1	1.7	1.0	-1.3	0.7	1.1
Had other major operations	0.8	1.0	2.3	-1.5	-0.2	0.9	-1.0
Forced vital capacity (FVC)	6.0	23.0	40.8	-6.4	4.2	-2.0	-5.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.5	-0.7	0.6	-0.7	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	1.2	-0.1	0.6	1.3
Qualifications: None of the above	0.3	0.7	1.9	0.6	0.7	-1.4	0.1
Financial difficulties in last 2 years	0.3	0.4	0.9	-0.3	-0.1	-0.9	-0.8
Mouth/teeth dental problems	0.6	0.9	1.5	-1.1	0.1	-1.0	-1.2
Heart attack	1.0	1.3	2.2	1.5	-0.0	-1.3	1.2
Allergy	3.0	7.0	11.2	3.1	-2.2	1.5	3.3
Pain all over the body in last month	0.6	0.7	1.7	0.7	-0.7	-1.3	0.1
Diabetes (self-reported)	0.9	1.4	2.0	0.9	-1.4	1.0	1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	-0.9	0.1	-0.1	-1.1
Medication: Ramipril	0.5	0.7	1.4	0.3	-1.0	1.2	0.4
Medication: Simvastatin	0.2	0.3	0.5	0.5	-0.4	0.3	0.7
Fluid intelligence score	0.3	0.7	2.5	-0.6	0.1	1.6	0.0
Illnesses of siblings	1.7	2.4	5.4	1.3	-2.3	1.4	0.7
Neuroticism score	0.4	0.9	2.2	0.9	-1.5	-0.5	0.4
Weight	0.2	0.8	1.9	-1.0	0.4	1.4	0.5
Impedance of arm (right)	1.5	7.0	14.1	-3.8	2.6	0.1	-2.7
Arm fat percentage (right)	0.3	1.2	2.7	-1.0	0.9	1.6	0.2
Trunk fat-free mass	0.0	0.2	0.3	-0.5	-0.3	0.6	0.5
Hip circumference	0.2	0.9	2.6	-0.0	-0.2	1.6	1.0
Time employed in main current job	0.3	0.3	0.5	0.2	-0.7	-0.7	0.4
Alcohol intake versus 10 years previously	0.9	1.4	2.5	-1.3	1.6	-0.4	-1.1
Father’s age at death	0.7	0.9	1.8	-0.8	-0.6	1.3	-0.9
Worrier / anxious feelings	0.4	0.8	1.7	-1.3	0.5	0.1	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.9	-0.8	0.9	-0.8	-0.6
Falls in the last year	0.5	0.7	1.3	-1.2	0.8	-0.4	-0.8
Hair/balding pattern: Pattern 3	2.0	2.9	4.7	2.2	-1.1	1.3	2.0
Number of live births	0.3	0.5	0.7	0.8	-0.8	-0.7	0.4
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	16.6	-4.1	3.1	-0.6	-3.3
Pulse rate	0.4	0.6	1.1	0.4	-1.1	0.8	0.7
Happiness	1.9	2.3	3.7	0.9	-1.9	1.7	1.3
Noisy workplace	0.4	0.5	1.5	-0.3	0.2	1.2	-0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.7	-2.2	0.6	1.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.0	-0.4	0.9	-0.0
Mouth/teeth dental problems: Dentures	4.6	7.8	15.0	3.9	-2.1	0.7	3.4
Asthma	0.8	1.5	3.1	-1.6	0.6	-0.0	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	-0.2	-1.0	0.2	-0.2
Medication: Cholesterol lowering	0.1	0.2	0.4	0.1	-0.6	0.3	0.4
Depression (self-reported)	2.1	2.5	5.8	-1.0	0.5	-2.4	-1.7
Medication: Lansoprazole	1.2	1.4	2.9	-1.5	1.7	-0.2	-0.8
Prospective memory result	0.3	0.4	0.8	0.9	-0.0	0.6	0.6
Lung cancer (father)	0.4	0.4	0.9	0.3	1.0	-0.4	0.7
Illnesses of mother	0.6	0.8	1.7	-0.2	-0.1	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.0	21.1	-4.6	3.3	-1.2	-3.9
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	0.3	-0.7	1.6	0.8
Impedance of arm (left)	1.8	8.5	18.3	-4.3	2.4	0.1	-3.1
Arm fat mass (right)	0.2	0.6	1.6	-0.6	0.4	1.3	0.5
Trunk predicted mass	0.0	0.2	0.3	-0.5	-0.3	0.6	0.4
Standing height	0.5	4.6	13.5	-3.7	1.4	0.4	-1.6
Length of working week for main job	0.3	0.3	0.7	-0.8	0.6	-0.4	-0.2
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.4	0.3	-0.5	-0.4
Breastfed as a baby	0.9	1.2	2.4	0.6	-0.2	1.4	1.5
Tense / ‘highly strung’	0.2	0.3	0.7	0.4	-0.8	-0.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.6	1.1	-1.9	0.1	0.4
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	-0.1	-0.2	0.0	-0.1
Birth weight of first child	0.5	1.0	1.4	1.2	-1.2	0.6	0.9
Peak expiratory flow (PEF)	0.2	0.5	0.9	0.6	1.0	-0.5	0.6
Pulse wave reflection index	0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.4
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.6	-0.7	0.7	-1.9	-1.1
Loud music exposure frequency	1.2	1.3	2.5	0.7	-1.6	1.5	0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	4.6	-2.1	0.5	0.5	-2.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.7	0.3	-0.9	1.3	0.5
Blood clot in the leg (DVT)	7.4	9.6	14.7	-3.6	2.3	-2.4	-3.8
Medication: Paracetamol	1.4	2.4	6.2	1.5	-2.5	0.4	0.8
Headache pain in last month	0.4	0.8	1.8	-0.6	-0.8	-0.4	-1.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.2	0.7	-0.9	0.0
Glaucoma (self-reported)	0.7	0.8	3.0	-0.4	-0.2	1.7	-0.1
Gout (self-reported)	0.6	0.8	1.3	-1.0	0.8	0.6	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.3	0.6	-0.8	1.1	0.6
Medication: Amlodipine	0.7	0.9	2.0	1.0	-1.4	0.4	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	-0.8	0.4	-1.0	-0.8
Birth weight	0.6	1.4	2.2	-1.5	1.3	-0.4	-1.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.5	-0.1	0.5	-0.2
High blood pressure (siblings)	2.9	4.2	7.3	-2.1	2.7	-1.4	-1.7
Forced vital capacity (FVC), Best measure	8.1	29.8	50.9	-7.1	4.8	-2.9	-6.0
Body fat percentage	0.4	1.4	3.9	-0.9	0.8	2.0	0.5
Leg fat percentage (right)	0.7	2.5	6.2	0.7	0.3	2.5	1.8
Arm fat-free mass (right)	0.1	0.3	0.5	-0.1	-0.6	0.6	0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.5	0.3	-0.7	-0.6	-0.5
Comparative body size at age 10	0.5	1.3	3.0	-0.4	1.7	-1.1	-0.9
Number of full brothers	4.9	6.2	7.7	2.8	-2.5	2.0	2.7
Worry too long after embarrassment	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	1.0	-0.4	-0.0	1.0
Number of children fathered	0.4	0.5	1.2	0.6	-0.2	0.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.3	-0.3	-0.3	-0.5	-1.1
Age at first live birth	0.3	0.5	0.7	-0.9	0.1	0.6	-0.9
Pulse wave peak to peak time	1.0	1.2	2.7	-0.5	0.9	-1.7	-0.9
Health satisfaction	1.1	1.4	2.5	0.8	-0.7	1.4	1.6
Shortness of breath walking on level ground	0.6	0.8	2.0	0.0	1.4	-0.9	0.4
Qualifications: College or University degree	0.4	1.4	2.4	-1.4	-0.3	1.6	-1.1
Eye problems/disorders: None of the above	3.7	4.3	5.6	-2.4	2.3	-1.7	-1.8
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.0
Emphysema/chronic bronchitis	1.3	1.5	3.6	1.1	0.3	-1.9	1.0
Medication for pain relief, constipation, heartburn	0.7	1.1	2.6	-1.1	1.6	0.4	-0.8
Neck or shoulder pain in last month	0.8	1.2	2.6	1.6	-0.4	-0.4	1.3
Medication: Blood pressure	0.4	0.7	1.8	-0.8	-0.3	1.3	-0.2
Angina (self-reported)	0.7	0.9	1.7	1.2	-0.5	-0.6	1.3
Migraine (self-reported)	0.4	0.5	0.9	0.9	-0.8	-0.3	0.6
Medication: Ibuprofen	0.1	0.1	0.3	-0.3	-0.6	0.1	-0.2
Medication: Allopurinol	0.1	0.2	0.4	-0.4	0.6	0.3	-0.1
Medication: Omeprazole	0.2	0.2	0.4	-0.2	-0.6	0.2	-0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	0.1	-0.4	-0.6
Mean time to correctly identify matches	0.6	1.2	2.6	1.4	0.2	0.5	1.6
Heart disease (mother)	0.5	0.6	1.4	0.8	-0.6	-0.4	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	-0.1	-0.9	0.8
Whole body fat mass	0.3	1.1	3.0	-0.9	0.6	1.7	0.5
Leg fat mass (right)	0.4	1.4	3.8	-0.2	0.5	1.9	1.2
Arm predicted mass (right)	0.1	0.3	0.6	0.2	-0.8	0.2	0.7
Pulse rate, automated reading	0.1	0.5	0.8	-0.4	-0.6	0.9	-0.8
Alcohol intake frequency.	1.3	3.1	7.4	-0.4	2.0	-2.7	-0.9
Comparative height size at age 10	0.5	2.9	6.1	-2.5	1.6	-0.5	-1.6
Number of full sisters	0.8	1.0	1.9	0.3	1.4	-1.2	0.8
Suffer from ‘nerves’	0.4	0.6	1.1	-0.5	1.0	-1.0	-0.5
Overall health rating	0.5	1.1	1.5	1.2	-1.2	0.5	1.2
Chest pain or discomfort	1.1	1.6	2.6	1.5	-1.2	-0.2	1.6
Had major operations	0.5	0.5	1.5	-1.2	0.4	-0.6	-0.3
Age at last live birth	0.2	0.2	0.5	-0.5	0.4	0.7	-0.0
Family relationship satisfaction	1.6	1.9	4.7	0.7	-1.1	2.2	1.2
Leg pain on walking	0.6	0.8	1.8	0.1	0.1	1.3	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	0.2	-0.1	-0.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.8	0.3	-0.6	1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.4	0.6	0.5	0.3
Medication: Aspirin	0.4	0.6	1.7	0.4	0.7	-0.3	1.3
Supplements: Vitamin C	0.7	0.8	1.8	1.1	-0.5	0.2	1.3
Knee pain experienced in last month	0.0	0.0	0.0	-0.2	0.2	0.1	0.2
Hypertension (Self-reported)	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.8	-1.5	0.7	-1.3	-1.9
Illnesses of father: Heart disease	0.5	0.7	2.0	0.3	0.1	1.4	0.8
Illnesses of siblings: Diabetes	1.9	2.3	6.0	-0.5	1.7	-2.5	-0.3
Smoking status: Previous	3.6	5.4	9.9	2.7	-1.9	0.6	3.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.4	-1.5	-0.4	1.8	-1.2
Whole body fat-free mass	0.1	0.4	0.7	-0.8	-0.3	0.8	0.1
Leg fat-free mass (right)	0.2	1.2	3.7	-1.9	0.1	0.5	-1.0
Arm fat percentage (left)	0.4	1.4	2.4	-1.6	1.0	1.5	-0.3
Average weekly red wine intake	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.3	-0.5	-0.1	-0.2
Mood swings	0.4	0.8	1.6	-0.5	-0.2	-1.3	-1.1
Loneliness, isolation	1.4	2.0	5.3	1.3	-2.3	-0.3	1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.3	0.8	-0.0	0.3
Ever had bowel cancer screening	0.1	0.1	0.2	-0.2	-0.5	0.4	-0.0
Diabetes diagnosed by doctor	0.3	0.4	0.7	0.7	-0.8	0.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.6	-0.6	0.1	-1.3	-1.1
Friendships satisfaction	0.6	0.7	1.4	1.2	-0.1	0.7	1.1
Qualifications: nursing, teaching	0.3	0.5	1.2	-0.8	-0.3	1.1	-0.4
Commuting to job workplace: Walk	1.3	1.4	2.0	-0.9	1.4	-1.3	-1.1
Eye problems/disorders: Cataract	1.0	1.2	2.5	1.6	-0.7	-0.1	1.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.1	-1.3	1.8	-0.1	-0.5
Medication for cholesterol	0.4	0.7	0.7	-0.8	-0.8	0.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	0.6	0.5	-1.0	1.2
Back pain experienced in last month	1.7	2.5	3.3	-1.8	1.7	-1.1	-1.6
Mineral and other dietary supplements	1.2	1.6	2.2	-1.1	1.2	-1.5	-1.2
Breast cancer (self-reported)	0.2	0.3	0.7	0.6	-0.2	0.1	0.9
Asthma (self-reported)	0.7	1.3	2.9	-1.5	0.4	-0.1	-1.7
Osteoporosis (self-reported)	1.3	1.6	4.3	0.3	-2.1	1.4	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.4	-0.3	1.1	0.7
Medication: Aspirin	0.2	0.2	0.6	0.0	0.5	-0.2	0.8
Medication: Gliclazide	0.5	0.6	0.9	-0.8	0.0	-0.9	-1.0
Illnesses of father: None of the above (group 1)	0.3	0.4	1.2	0.3	-0.4	-1.1	-0.2
Smoking status: Current	0.2	0.3	0.6	0.4	0.2	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.7	9.9	-3.1	2.8	0.9	-2.1
Whole body water mass	0.1	0.3	0.7	-0.8	-0.3	0.7	0.2
Leg predicted mass (right)	0.2	1.2	3.7	-1.9	0.1	0.5	-1.0
Arm fat mass (left)	0.2	0.6	1.4	-0.9	0.5	1.2	0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.4	-0.5	-0.3	-0.6
Average weekly champagne plus white wine intake	0.3	0.3	0.9	0.6	-0.9	0.4	0.1
Miserableness	0.6	1.0	2.5	-0.5	0.6	-1.6	-0.8
Guilty feelings	0.9	1.4	2.3	1.4	-1.5	-1.1	0.7
Wears glasses or contact lenses	0.7	0.8	1.6	0.3	-1.2	1.2	0.3
Ever taken oral contraceptive pill	1.6	1.8	3.8	1.0	-1.2	1.9	1.0
Hearing aid user	0.3	0.3	0.6	-0.5	0.5	-0.4	-0.8
Mother’s age at death	0.8	1.0	2.0	0.1	-1.3	1.4	0.3
Financial situation satisfaction	0.4	0.5	0.8	0.2	-0.9	0.9	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.6	-0.4	0.1	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.4	0.2	-1.2	0.1	-1.0
Eye problems/disorders: Glaucoma	0.8	1.0	2.9	0.2	-0.9	1.7	0.3
Medication: Blood pressure	0.4	0.8	1.8	1.3	-0.3	-0.6	0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	0.1	-0.1	-0.7	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.4	0.8	-0.1	1.0	1.2
High cholesterol (Self-reported)	0.3	0.4	0.9	0.9	-0.6	0.1	0.8
Medication: Bendroflumethiazide	1.3	2.0	3.5	-1.9	0.8	-0.8	-1.8
Medication: Paracetamol	2.2	3.3	7.5	2.2	-2.7	-0.0	0.9
Medication: Lisinopril	0.3	0.4	1.1	-0.4	1.1	-0.3	0.2
Medication: Atorvastatin	0.3	0.4	0.9	-0.7	0.9	0.1	-0.4
Illnesses of father: High blood pressure	0.3	0.4	1.0	1.0	-0.4	0.2	0.7
Alcohol drinker status: Never	0.6	0.7	1.4	-0.6	0.6	-0.9	-1.2
Ever smoked	2.6	4.6	7.6	2.5	-2.1	0.5	2.8
Basal metabolic rate	0.1	0.4	1.0	-1.0	-0.0	0.9	0.1
Leg fat percentage (left)	0.6	2.1	5.1	0.7	0.1	2.3	1.7
Arm fat-free mass (left)	0.2	0.9	1.6	0.6	-0.9	0.8	1.3
Number of operations (self-reported)	0.8	1.2	2.3	-1.3	0.4	-0.9	-1.5
Average weekly beer plus cider intake	0.3	0.5	1.0	1.0	-0.8	0.4	0.3
Irritability	0.2	0.4	0.5	0.7	-0.7	-0.6	0.3
Risk taking	0.5	0.8	1.7	0.6	-1.3	0.9	0.5
Ever had prostate specific antigen (PSA) test	1.1	1.2	3.2	0.0	0.1	1.8	1.3
Fractured/broken bones in last 5 years	1.4	1.8	5.9	0.7	-2.4	0.9	0.1
Age started oral contraceptive pill	0.1	0.2	0.5	0.1	-0.7	0.4	-0.1
Diastolic blood pressure, automated reading	1.4	4.4	13.4	-2.0	-0.0	-0.3	-3.7
Ever depressed for a whole week	2.1	2.5	4.1	1.4	-1.0	1.7	2.0
Unable to work because of sickness or disability	0.7	0.9	2.5	1.0	-0.2	-1.6	0.3
Commuting to job workplace: Cycle	1.2	1.4	3.5	-1.0	-0.8	-0.8	-1.9
Myopia	0.4	0.6	1.4	-0.0	-0.6	-1.2	-0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.5	-0.2	0.7	-0.3
Cholesterol lowering medication	0.5	0.8	1.7	0.2	1.2	-1.3	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.5	-0.9	0.3	0.1
Pain experienced in last month	0.6	1.0	1.9	0.9	0.5	1.0	1.4
Supplements: Calcium	0.8	0.9	2.1	0.9	-1.5	0.6	0.6
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.3	-0.4	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.0	1.4	-0.0	-1.2	1.2
Deep venous thrombosis (DVT) (self-reported)	6.8	8.8	13.2	-3.3	2.3	-2.4	-3.6
Heart disease (siblings)	0.1	0.2	0.2	0.5	0.5	0.3	0.4
Alcohol drinker status: Previous	0.6	0.7	1.0	0.9	-1.0	0.0	1.0
Pack years of smoking	3.3	4.8	10.3	3.2	-1.4	-1.1	2.4
Impedance of whole body	0.7	3.5	5.6	-2.4	2.2	-0.5	-1.7
Leg fat mass (left)	0.3	1.2	3.5	-0.2	0.4	1.9	1.1
Arm predicted mass (left)	0.1	0.6	1.1	0.5	-0.8	0.5	1.1