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chr1:203,890,813-205,921,859

Best TWAS P=3.07e-39 · Best GWAS P=5.41e-39 conditioned to 0.000169

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DSTYK	0.05	0.04	blup	67	0.07	6.2e-08	-12.5	-13.1	3.1e-39	0.90	0.05	0.95	TRUE
8	GTEx	Brain Caudate basal ganglia	LRRN2	0.38	0.14	lasso	4	0.07	4.2e-03	-5.5	-5.7	1.6e-08	-0.06	0.10	0.05	TRUE
4	GTEx	Adipose Subcutaneous	DSTYK	0.21	0.18	enet	14	0.18	1.7e-14	-12.2	-12.8	2.0e-37	0.94	0.05	0.95	FALSE
23	GTEx	Nerve Tibial	TMEM81	0.08	0.06	lasso	2	0.05	3.7e-04	-12.5	12.6	2.5e-36	-0.89	0.04	0.94	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DSTYK	0.02	0.01	enet	6	0.01	1.3e-02	9.9	-12.6	3.2e-36	0.82	0.02	0.89	FALSE
22	GTEx	Nerve Tibial	DSTYK	0.20	0.08	lasso	5	0.10	1.6e-07	-12.5	-12.5	5.9e-36	0.89	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	DSTYK	0.04	0.02	enet	7	0.02	2.6e-03	-12.5	-12.5	6.1e-36	0.93	0.02	0.95	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	DSTYK	0.23	0.00	lasso	7	0.00	2.4e-01	-12.5	-12.4	1.9e-35	0.87	0.04	0.80	FALSE
52	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM81	0.06	0.04	lasso	3	0.03	1.7e-03	-12.2	12.4	2.6e-35	-0.78	0.01	0.90	FALSE
5	GTEx	Adipose Subcutaneous	TMEM81	0.10	0.06	enet	5	0.06	8.5e-06	-12.5	12.4	4.6e-35	-0.89	0.08	0.92	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	RBBP5	0.03	0.02	lasso	2	0.03	2.7e-04	-12.5	12.3	5.3e-35	-0.84	0.01	0.98	FALSE
15	GTEx	Esophagus Mucosa	DSTYK	0.15	0.12	lasso	3	0.08	6.0e-06	-12.3	-12.3	8.1e-35	0.83	0.23	0.76	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	DSTYK	0.04	0.01	blup	67	0.02	1.3e-03	-12.5	-12.2	1.7e-34	0.86	0.04	0.92	FALSE
19	GTEx	Lung	RBBP5	0.09	0.08	lasso	2	0.07	2.4e-06	-12.3	12.2	3.6e-34	-0.81	0.56	0.32	FALSE
16	GTEx	Esophagus Mucosa	TMEM81	0.10	0.00	enet	2	0.00	6.2e-01	-12.0	12.1	8.8e-34	-0.90	0.03	0.70	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMCC2	0.17	0.18	lasso	5	0.19	3.0e-22	-12.0	12.1	1.5e-33	-0.90	0.52	0.48	FALSE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	DSTYK	0.06	0.03	lasso	2	0.05	1.6e-04	7.7	-12.0	3.5e-33	0.84	0.02	0.91	FALSE
33	NTR	Blood	TMCC2	0.01	0.00	blup	582	0.00	1.3e-02	-12.3	11.8	6.9e-32	-0.80	0.03	0.87	FALSE
25	GTEx	Skin Sun Exposed Lower leg	DSTYK	0.08	0.05	enet	15	0.05	2.7e-05	9.8	-11.6	2.4e-31	0.82	0.25	0.73	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMEM81	0.07	0.04	lasso	5	0.03	6.4e-05	9.9	11.5	8.7e-31	-0.75	0.44	0.51	FALSE
13	GTEx	Breast Mammary Tissue	DSTYK	0.13	0.02	enet	15	0.02	2.1e-02	-12.0	-11.5	1.4e-30	0.78	0.08	0.67	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM81	0.10	0.05	lasso	3	0.06	6.0e-07	-12.3	11.3	1.2e-29	-0.78	0.01	0.99	FALSE
26	GTEx	Thyroid	RBBP5	0.05	0.02	enet	8	0.04	2.9e-04	9.5	11.3	1.9e-29	-0.66	0.43	0.33	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	DSTYK	0.20	0.04	lasso	7	0.05	1.8e-02	-12.5	-11.1	9.3e-29	0.78	0.03	0.86	FALSE
27	GTEx	Thyroid	TMEM81	0.10	0.05	enet	18	0.06	1.9e-05	-12.2	11.1	9.3e-29	-0.72	0.05	0.94	FALSE
17	GTEx	Esophagus Muscularis	DSTYK	0.20	0.13	enet	21	0.12	6.6e-08	-12.5	-10.7	1.6e-26	0.77	0.09	0.91	FALSE
9	GTEx	Brain Cerebellum	RBBP5	0.19	0.03	enet	6	0.00	3.9e-01	-9.6	10.6	2.0e-26	-0.71	0.05	0.64	FALSE
34	YFS	Blood	TMCC2	0.03	0.02	blup	582	0.02	2.5e-06	-12.9	10.3	5.3e-25	-0.75	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	DSTYK	0.13	0.11	lasso	5	0.08	6.6e-07	9.8	-10.2	2.1e-24	0.70	0.76	0.22	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	DSTYK	0.04	0.01	enet	20	0.01	2.1e-03	-12.5	-10.0	1.4e-23	0.64	0.03	0.65	FALSE
18	GTEx	Heart Atrial Appendage	DSTYK	0.14	0.03	enet	10	0.06	1.1e-03	-12.2	-10.0	2.4e-23	0.77	0.03	0.91	FALSE
31	METSIM	Adipose	RBBP5	0.06	0.02	bslmm	603	0.02	8.2e-04	-9.6	9.8	1.4e-22	-0.56	0.43	0.24	FALSE
32	METSIM	Adipose	TMEM81	0.03	0.01	blup	584	0.01	5.0e-03	-12.5	9.7	2.3e-22	-0.75	0.02	0.98	FALSE
7	GTEx	Artery Tibial	DSTYK	0.25	0.08	enet	32	0.14	1.1e-10	-12.5	-9.5	2.5e-21	0.74	0.15	0.85	FALSE
21	GTEx	Muscle Skeletal	TMCC2	0.04	0.04	lasso	1	0.03	4.4e-04	9.5	-9.5	2.6e-21	0.62	0.16	0.76	FALSE
6	GTEx	Artery Aorta	DSTYK	0.15	0.11	lasso	3	0.07	6.8e-05	9.8	-8.9	3.7e-19	0.65	0.44	0.45	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	RBBP5	0.03	0.01	blup	79	0.02	1.2e-03	-9.6	8.6	7.0e-18	-0.64	0.02	0.84	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DSTYK	0.06	0.00	blup	67	0.02	1.2e-03	9.9	-8.6	1.0e-17	0.67	0.02	0.63	FALSE
28	GTEx	Uterus	RBBP5	0.46	-0.01	lasso	12	0.01	2.0e-01	-13.1	8.4	3.2e-17	-0.58	0.04	0.59	FALSE
20	GTEx	Lung	TMEM81	0.13	0.05	enet	25	0.05	6.9e-05	-11.9	7.9	2.6e-15	-0.73	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	DSTYK	0.08	0.04	blup	67	0.05	4.9e-06	4.1	-7.9	3.7e-15	0.66	0.64	0.33	FALSE
30	METSIM	Adipose	DSTYK	0.06	0.02	bslmm	614	0.02	7.5e-04	9.8	-7.7	1.6e-14	0.57	0.05	0.89	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RBBP5	0.15	0.07	bslmm	617	0.10	2.3e-12	4.1	7.5	4.9e-14	-0.43	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	CNTN2	0.14	0.03	blup	98	0.11	1.0e-10	6.3	7.2	6.1e-13	-0.57	0.03	0.97	FALSE
10	GTEx	Brain Cerebellum	TMEM81	0.25	0.02	enet	21	0.11	3.0e-04	4.4	7.0	3.6e-12	-0.52	0.09	0.63	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	RBBP5	0.25	0.00	enet	16	0.04	3.5e-02	-2.5	6.8	1.4e-11	-0.56	0.10	0.29	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CNTN2	0.03	0.01	blup	98	0.01	8.7e-03	7.0	6.7	2.8e-11	-0.55	0.03	0.26	FALSE
29	METSIM	Adipose	CNTN2	0.13	0.14	enet	16	0.16	1.3e-23	4.2	6.3	2.1e-10	-0.48	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CNTN2	0.04	0.02	enet	8	0.02	1.3e-02	4.3	6.2	6.4e-10	-0.45	0.07	0.32	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	CNTN2	0.09	0.04	enet	16	0.07	3.8e-08	4.1	5.9	4.1e-09	-0.38	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMCC2	0.03	0.03	lasso	2	0.03	5.4e-04	4.1	-5.7	1.3e-08	0.56	0.04	0.29	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	RBBP5	0.09	0.04	blup	80	0.05	4.8e-06	4.1	5.7	1.6e-08	-0.25	0.64	0.06	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMCC2	0.07	0.00	blup	65	0.01	8.1e-04	-2.3	-5.6	2.5e-08	0.52	0.03	0.23	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLEKHA6	0.06	0.02	enet	12	0.04	3.0e-05	-5.9	5.5	3.4e-08	0.06	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PLEKHA6	0.11	0.06	lasso	3	0.06	2.5e-04	-4.2	5.3	1.1e-07	0.07	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RBBP5	0.22	0.06	blup	79	0.14	1.3e-04	9.8	5.3	1.1e-07	-0.19	0.09	0.08	FALSE