TWAS hub - CNTN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1348	0.0276	2.2e-16	0.144	0.123	0.163	0.159	0.161	6.9e-21	5.4e-18	1.3e-23	5.1e-23	2.0e-23
2	TCGA	Bladder Urothelial Carcinoma	0.0410	0.0210	7.3e-03	0.016	0.015	0.017	NA	0.014	1.4e-02	1.7e-02	1.3e-02	NA	2.1e-02
3	TCGA	Breast Invasive Carcinoma	0.0355	0.0153	1.7e-04	0.007	0.017	0.009	NA	0.016	9.6e-03	1.5e-04	5.1e-03	NA	1.9e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0323	0.0170	1.0e-02	0.009	0.014	0.000	NA	0.005	3.1e-02	8.7e-03	3.7e-01	NA	7.0e-02
5	TCGA	Prostate Adenocarcinoma	0.0929	0.0341	9.4e-07	0.037	0.073	0.074	NA	0.058	7.9e-05	4.1e-08	3.8e-08	NA	1.1e-06
6	TCGA	Thyroid Carcinoma	0.1370	0.0410	7.1e-10	0.032	0.109	0.088	NA	0.069	4.3e-04	1.0e-10	7.0e-09	NA	2.9e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	24.9	288.9	449.4	-7.1	-20.4	-10.7	-18.9	-18.6	-21.2
Lung FEV1/FVC ratio	7.7	38.9	69.6	0.5	-8.1	-3.6	-6.4	-8.3	-6.6
Illnesses of mother	7.0	8.6	13.1	-2.4	-2.7	-3.4	-3.6	-2.1	-3.1
Serious illness, injury or assault of a close relative in last 2 years	6.0	6.9	9.1	2.5	2.4	3.0	2.8	2.5	2.5
Mouth/teeth dental problems: Loose teeth	6.0	7.1	9.3	2.2	3.1	2.5	2.8	2.7	2.7
Hair Pigment	5.8	165.8	342.2	-6.7	18.5	5.1	12.8	16.4	12.2
Schizophrenia (2018)	5.5	11.5	20.4	4.5	3.3	3.8	2.4	2.7	3.2
Ever had hysterectomy (womb removed)	4.9	5.6	8.9	-0.6	-2.6	-1.7	-2.5	-2.9	-3.0
Tanning	4.5	55.4	114.5	-0.1	-10.7	-3.5	-7.0	-9.5	-8.1
Schizophrenia (2014)	4.2	9.3	13.0	3.6	3.1	3.5	1.6	3.1	3.0
Shortness of breath walking on level ground	4.2	4.9	7.7	0.8	2.8	1.2	2.7	2.2	2.8
Blood Red Count	3.9	38.0	51.8	6.3	6.2	4.3	6.7	5.9	7.2
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	6.6	0.7	2.4	2.5	2.6	2.3	2.2
Ovarian Cancer	3.5	4.7	9.9	0.7	2.9	1.2	2.2	1.8	3.1
Mouth/teeth dental problems	3.3	5.1	11.1	-0.8	-3.3	-1.3	-2.1	-2.9	-2.1
Chronic bronchitis/emphysema (mother)	3.3	3.8	6.7	0.6	2.2	1.9	2.6	1.9	2.0
Medication: Omeprazole	3.3	4.0	6.3	-1.8	-1.5	-2.1	-1.7	-2.5	-2.2
Financial difficulties in last 2 years	3.1	4.1	6.4	-0.0	-2.3	-1.3	-2.4	-2.5	-2.4
Number of live births	3.1	4.4	5.8	-2.1	-1.9	-1.8	-1.9	-2.3	-2.4
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	9.5	1.4	1.3	3.1	2.1	0.8	2.1
Lung cancer (father)	2.7	3.2	5.3	0.8	2.3	2.3	1.6	1.8	1.5
Pain experienced in last month	2.7	4.5	10.5	-1.0	-2.4	-1.9	-3.2	-1.7	-1.7
Pulse rate	2.4	4.1	9.6	1.5	1.4	2.5	2.2	0.1	3.1
Hair/balding pattern: Pattern 4	2.4	5.7	10.8	-1.4	-3.3	-0.7	-2.5	-2.5	-2.9
High blood pressure (siblings)	2.4	3.5	5.7	0.9	2.4	1.8	2.1	1.8	1.9
Current tobacco smoking	2.2	3.6	5.7	2.4	2.4	1.0	1.9	1.4	2.0
Birth weight	2.2	4.7	9.2	-3.0	-1.4	-2.7	-2.2	-0.3	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	3.6	0.2	-1.9	-1.6	-1.7	-1.5	-1.7
Suffer from ‘nerves’	2.1	3.2	6.6	2.6	1.4	2.5	1.6	0.9	0.9
Bipolar Disorder or Schizophrenia	2.0	4.9	10.9	2.9	1.9	3.3	0.9	1.8	1.4
Waist Hip Ratio (WHR)	2.0	8.8	16.0	4.0	-4.0	-0.6	-2.1	-3.4	-2.2
Medication: Atenolol	2.0	2.5	4.0	-0.3	-2.0	-1.7	-1.7	-1.1	-1.9
High blood pressure (mother)	2.0	2.8	8.5	2.0	0.5	2.9	1.8	-0.2	0.8
Alcohol intake versus 10 years previously	2.0	2.9	4.0	-1.7	-1.8	-1.9	-1.1	-1.7	-2.0
Pulse wave Arterial Stiffness index	2.0	2.4	3.7	1.7	1.8	1.2	1.9	1.2	1.2
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	6.6	0.7	1.9	1.3	1.4	2.6	1.2
Irritability	2.0	3.4	6.0	1.6	-1.9	-1.3	-1.5	-2.4	-2.0
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.3	0.3	-1.5	-1.6	-1.2	-1.8	-1.8
Supplements: Zinc	1.9	2.1	4.5	0.4	-1.8	-0.4	-1.4	-1.6	-2.1
Pack years adult smoking proportion	1.9	3.0	5.6	-0.7	2.4	0.3	1.9	2.3	1.6
Exposure to tobacco smoke at home	1.9	2.2	4.2	-0.4	-1.4	-0.9	-1.5	-2.1	-1.9
Pulse wave peak to peak time	1.9	2.2	3.6	-1.8	-1.6	-1.2	-1.9	-1.0	-1.2
Age at last live birth	1.9	2.8	5.8	-0.4	-2.4	-0.5	-1.6	-2.1	-1.8
Knee pain experienced in last month	1.9	3.0	5.7	1.1	2.4	1.4	2.2	1.3	1.6
Loneliness, isolation	1.9	2.6	8.5	2.9	0.0	2.1	1.1	-0.8	0.8
Risk taking	1.9	2.8	4.7	-0.8	-1.9	-1.4	-1.2	-2.1	-2.2
Chronotype (morning person)	1.8	4.1	7.7	1.0	-2.8	-1.7	-2.0	-2.3	-2.1
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.8	-1.1	1.6	-0.1	1.5	1.9	1.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.8	-1.5	-1.0	-1.5	-0.8	-2.2	-1.5
Neuroticism (2016)	1.7	2.5	8.8	3.0	0.5	2.2	0.8	-0.6	-0.4
Ulcerative Colitis	1.7	2.5	5.4	1.1	-1.8	-0.4	-2.3	-1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	4.7	1.8	1.9	1.8	2.2	0.6	1.4
Medication: Ibuprofen	1.7	2.1	4.7	0.9	0.9	2.2	1.6	0.6	1.7
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.0	-0.8	-1.5	-1.0	-0.8	-1.2	-2.2
Length of working week for main job	1.6	1.7	3.0	0.7	1.1	1.7	1.3	1.2	1.6
Smoking status: Current	1.6	2.5	4.6	2.1	2.1	0.7	1.3	1.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.2	-2.3	-1.5	-1.2	-2.2	-1.6	-2.0
Basal cell carcinoma (self-reported)	1.6	2.0	3.6	0.0	1.7	1.1	1.5	1.4	1.9
Lupus	1.5	2.3	4.4	1.0	1.0	2.1	2.0	0.7	1.7
Diabetes (mother)	1.5	1.9	7.7	2.8	0.9	0.4	1.0	1.0	0.7
Pain all over the body in last month	1.5	1.6	3.3	0.7	1.8	1.1	1.6	1.0	1.1
Illnesses of siblings	1.5	2.1	4.0	0.0	-2.0	-0.7	-1.9	-1.7	-1.4
Medication: Lansoprazole	1.5	1.8	4.9	2.2	0.5	1.8	1.2	-0.7	0.5
Eye problems/disorders: Glaucoma	1.5	1.7	3.1	0.0	-1.7	-0.9	-0.9	-1.8	-1.7
Commuting to job workplace: Cycle	1.5	1.9	4.6	1.9	0.4	2.1	0.9	-0.1	1.4
Pack years of smoking	1.5	2.1	4.3	-0.9	2.1	-0.1	1.6	1.9	1.3
Irritable Bowel Disease (IBD)	1.4	3.3	6.7	0.9	-2.1	-1.5	-2.6	-1.7	-1.5
Major Depression (MDD)	1.4	1.7	3.5	-1.0	-1.1	-1.5	-1.3	-0.6	-1.9
Triglycerides	1.4	2.2	3.4	-1.0	-1.7	-1.7	-1.8	-1.3	-1.3
Sensitivity / hurt feelings	1.4	2.3	7.1	2.7	0.8	1.8	1.8	-0.2	0.3
Had menopause	1.4	1.8	4.1	-2.0	-0.2	-1.6	-1.0	-0.6	-1.7
Forced vital capacity (FVC)	1.4	5.3	11.4	-2.9	2.3	1.0	1.7	3.4	1.7
Pulse wave reflection index	1.4	1.7	4.2	-0.3	-1.4	-0.9	-1.4	-1.1	-2.0
Pulse rate, automated reading	1.4	4.5	10.4	3.2	0.7	2.7	1.8	-0.2	2.3
Overall health rating	1.4	3.1	5.6	1.3	2.3	1.2	2.4	1.5	1.5
Average weekly champagne plus white wine intake	1.4	2.0	3.3	-0.7	-1.7	-0.2	-1.8	-1.4	-1.8
Fractured/broken bones in last 5 years	1.4	1.9	5.8	-0.5	-1.5	-0.8	-0.5	-2.4	-1.4
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.3	2.1	-0.2	1.9	0.4	-1.5	0.6
Impedance of whole body	1.4	7.3	13.9	-0.7	-3.7	-1.4	-2.5	-2.7	-3.7
Ulcerative Colitis (UC)	1.3	2.4	4.8	1.2	-1.9	-0.7	-2.2	-1.5	-1.4
Bipolar Disorder (2011)	1.3	1.3	2.7	0.4	-1.1	0.8	-1.6	-0.7	-1.6
Tense / ‘highly strung’	1.3	2.2	9.2	3.0	0.4	1.7	0.7	-0.4	0.0
Crohns Disease (2017)	1.2	2.6	5.3	-0.2	-1.7	-2.2	-2.3	-1.4	-0.8
Impedance of leg (right)	1.2	6.0	11.0	-0.9	-3.3	-1.6	-2.2	-2.7	-3.1
Neuroticism score	1.2	2.4	8.6	2.9	-0.8	1.2	0.3	-1.5	-1.2
Impedance of arm (right)	1.2	5.7	10.6	-1.5	-3.3	-1.3	-2.6	-1.6	-3.2
Noisy workplace	1.2	1.4	3.6	-0.0	-1.2	-1.9	-0.1	-1.1	-1.5
Prospective memory result	1.2	1.5	2.3	1.3	1.5	-0.1	1.0	1.5	1.4
Impedance of arm (left)	1.2	5.7	11.8	-0.3	-3.3	-0.6	-2.6	-2.1	-3.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.3	1.7	1.8	0.8	1.3	1.1	1.0
Health satisfaction	1.2	1.6	2.7	1.3	1.6	0.4	1.2	1.4	1.4
Long-standing illness, disability or infirmity	1.2	1.8	4.0	0.2	1.9	0.5	2.0	1.3	1.1
Neuroticism (Nagel 2018)	1.1	2.5	11.9	3.5	-0.2	0.8	0.3	-1.1	-0.9
Schizophrenia vs Biploar Disorder	1.1	1.5	3.2	1.8	1.2	-0.2	0.6	1.0	1.8
Worry (Nagel 2018)	1.1	2.3	9.8	3.1	-0.1	1.6	0.6	-0.9	-0.7
Alzheimer’s Disease (in mother)	1.1	1.3	1.8	1.2	1.1	1.0	1.3	1.1	1.0
Alzheimer’s Disease (including proxy)	1.1	1.6	3.1	1.2	1.4	0.7	1.8	1.0	1.1
Breast Cancer	1.1	2.6	7.6	-2.0	-1.1	-2.8	-0.9	-0.4	-1.4
Lung FVC	1.1	5.3	13.8	-3.7	2.9	-0.1	0.7	2.7	1.5
Neuroticism	1.1	2.6	8.9	3.0	-1.2	0.3	-0.2	-1.7	-1.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.6	-0.8	-1.2	-1.2	-1.0	-1.3	-1.1
Impedance of leg (left)	1.1	5.4	9.4	-1.1	-3.0	-1.7	-1.9	-2.5	-3.1
Heart attack	1.1	1.3	3.3	1.8	-0.3	1.5	0.3	-1.4	0.6
Worry too long after embarrassment	1.1	1.8	6.1	2.5	0.4	1.9	0.9	-0.2	0.3
Mood swings	1.1	1.9	4.0	2.0	-1.2	-0.9	-0.8	-1.5	-1.5
Ever had bowel cancer screening	1.1	1.3	2.4	0.9	1.5	0.7	1.5	0.9	0.9
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.7	0.9	2.2	0.6	1.0	1.6	1.1
Guilty feelings	1.1	1.7	3.8	1.4	-1.2	-0.1	-0.9	-2.0	-1.5
Depressed Affect (Nagel 2018)	1.0	2.1	6.0	2.5	-1.2	-0.9	-0.7	-1.4	-1.3
Average weekly fortified wine intake	1.0	1.2	1.6	-0.4	1.3	1.2	1.2	1.2	1.0
Maternal smoking around birth	1.0	1.4	2.5	1.6	1.2	0.4	1.5	1.2	0.7
Stomach or abdominal pain in last month	1.0	1.2	2.2	0.1	-1.3	-1.5	-0.7	-1.4	-1.1
Chronic bronchitis/emphysema (father)	1.0	1.2	2.6	-0.5	1.2	0.6	1.0	1.6	1.2
Nervous feelings	1.0	1.8	4.4	2.1	-0.0	2.0	0.8	-0.7	-1.1
Allergy	1.0	2.3	3.4	-1.7	-1.4	-1.8	-1.8	-0.3	-1.4
Worrier / anxious feelings	1.0	1.8	5.9	2.4	-0.1	1.4	0.8	-1.5	-0.4
Number of full brothers	1.0	1.2	2.3	-1.1	-0.8	-1.5	-0.9	-0.6	-1.5
Eye problems/disorders: None of the above	1.0	1.1	3.6	0.3	0.8	1.2	0.5	0.8	1.9
Leg pain on walking	1.0	1.2	2.2	-0.7	1.5	0.9	1.5	1.0	0.9
Average weekly red wine intake	1.0	1.5	3.0	1.7	0.9	0.8	1.5	1.2	0.9
Commuting to job workplace: Walk	1.0	1.1	2.6	1.6	-0.2	1.4	-0.6	-1.2	-0.3
Osteoporosis (self-reported)	1.0	1.2	2.2	-0.9	1.5	-0.2	1.2	1.3	1.1
Miserableness	1.0	1.7	2.7	1.5	-1.4	-0.1	-1.1	-1.6	-1.4
Number of operations (self-reported)	1.0	1.6	3.6	-1.9	-0.3	-1.3	-0.9	-0.7	-1.6
Blood White Count	0.9	6.6	20.9	4.6	-2.9	1.8	-0.1	-2.4	-1.2
Smoking Status	0.9	2.2	6.8	2.6	1.9	0.3	1.3	0.4	1.1
Alcohol usually taken with meals	0.9	1.4	3.8	1.9	-1.1	0.8	0.3	-1.6	-0.4
Hearing difficulty/problems with background noise	0.9	1.4	2.2	1.1	-1.4	-0.9	-1.2	-1.5	-0.8
Breastfed as a baby	0.9	1.1	2.6	-0.8	-0.8	-1.6	-1.1	-1.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.0	1.2	1.4	1.0	1.0	1.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.8	-1.4	1.0	0.0	-0.0	1.7	0.9
Supplements: Vitamin C	0.9	1.1	3.2	1.8	-0.7	-0.4	-0.5	-0.8	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.0	-0.5	-0.8	-1.0	-0.6	-1.4	-1.3
Qualifications: nursing, teaching	0.9	1.3	4.3	1.4	-0.3	2.1	0.5	-0.6	1.0
Hearing aid user	0.9	1.0	2.7	1.3	-0.2	1.6	0.5	-0.8	0.8
Myopia	0.9	1.3	2.7	1.5	0.4	1.6	0.7	0.0	1.4
Bipolar Disorder (2018)	0.8	1.3	3.3	-1.0	-1.0	0.4	-1.5	-0.5	-1.8
Prostate Cancer	0.8	1.2	1.7	-1.3	-1.1	-0.8	-1.0	-1.0	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.5	0.6	1.6	0.9	1.0	0.9	1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	8.8	-3.0	1.5	0.7	0.7	2.0	0.7
Leg fat-free mass (right)	0.8	4.1	8.5	0.2	2.7	0.6	1.6	2.9	2.4
Mean Putamen Volume	0.7	0.8	2.6	-1.3	0.6	-0.4	0.6	1.6	0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.9	1.7	-0.9	0.2	-0.4	-0.7	-0.6
Leg fat-free mass (left)	0.7	3.5	7.1	0.5	2.5	0.6	1.4	2.7	2.3
Leg predicted mass (left)	0.7	3.8	7.8	0.5	2.6	0.7	1.5	2.8	2.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.9	2.0	-0.0	0.7	0.1	-0.9	-0.1
Trunk fat-free mass	0.7	4.0	8.6	-0.4	2.7	0.1	1.4	2.9	2.4
Hair/balding pattern: Pattern 3	0.7	1.0	5.1	2.3	0.2	0.1	0.4	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	9.7	-3.1	-0.9	-0.5	-1.3	-0.2	-1.2
Trunk predicted mass	0.7	3.9	8.5	-0.5	2.7	-0.0	1.4	2.9	2.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	5.6	-2.4	-0.7	0.1	-0.8	-0.0	-0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.0	-0.3	1.4	-0.0	1.1	1.2	0.9
Comparative body size at age 10	0.7	2.0	6.9	2.6	1.0	1.1	0.4	0.3	1.6
Neck or shoulder pain in last month	0.7	1.0	2.1	0.3	1.4	0.7	1.4	0.9	0.3
Comparative height size at age 10	0.7	4.0	12.6	-3.5	1.7	-0.9	0.1	2.8	-0.0
Medication: Aspirin	0.7	0.9	3.2	0.5	-0.7	-0.8	-0.5	-1.8	-0.7
Whole body fat-free mass	0.7	3.8	8.1	-0.1	2.7	0.2	1.4	2.8	2.3
Leg predicted mass (right)	0.7	4.0	8.2	0.2	2.7	0.6	1.6	2.9	2.4
Average weekly beer plus cider intake	0.7	1.1	4.0	2.0	0.9	0.6	0.9	0.4	0.5
Ever depressed for a whole week	0.7	0.9	1.9	-0.0	-0.6	-1.0	-0.8	-1.4	-1.2
Body Mass Index (BMI) (2010)	0.6	0.8	4.0	2.0	0.5	-0.5	0.2	0.5	0.5
Primary Biliary Cirrhosis	0.6	0.8	2.5	-1.4	0.2	-1.6	-0.6	0.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	5.1	2.2	-0.7	-0.9	-0.1	0.2	0.6
Average weekly spirits intake	0.6	0.8	2.5	-1.6	-0.1	-1.2	-0.6	-0.0	-0.5
Vitamin and mineral supplements	0.6	0.8	1.1	-0.8	0.4	0.8	1.1	1.1	0.9
Diabetes (father)	0.6	0.8	1.3	-0.8	-1.1	-0.9	-1.1	-0.2	-0.7
Hip circumference	0.6	2.7	5.7	0.4	2.3	0.0	1.2	2.4	1.9
Time employed in main current job	0.6	0.6	1.4	0.7	0.3	-1.2	-0.9	0.9	0.6
Gout (self-reported)	0.6	0.8	1.5	0.4	1.2	0.3	1.0	1.2	0.8
Exposure to tobacco smoke outside home	0.6	0.9	1.9	0.5	-1.0	-1.1	-0.4	-0.9	-1.4
Qualifications: College or University degree	0.6	1.9	7.6	0.7	0.7	2.8	0.7	0.5	1.5
Angina (self-reported)	0.6	0.8	1.4	1.2	-0.5	-0.2	-0.9	-1.1	-0.9
Arm predicted mass (right)	0.6	3.2	6.5	0.3	2.5	0.2	1.5	2.3	2.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.5	0.5	0.6	-0.2	1.6	1.0	0.5
Whole body water mass	0.6	3.6	7.8	-0.2	2.6	0.2	1.4	2.8	2.2
Financial situation satisfaction	0.6	0.7	2.9	1.7	-0.4	0.2	-0.3	-1.0	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	1.5	0.4	1.0	0.8	0.1	0.5
Arm fat-free mass (left)	0.6	3.1	6.1	-0.4	2.4	-0.2	1.4	2.5	2.1
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.4	0.0	0.8	0.9	0.9	1.2	0.5
Arm predicted mass (left)	0.6	2.8	5.7	-0.1	2.3	-0.1	1.3	2.4	2.0
Reaction Time	0.5	0.9	1.4	0.9	1.2	1.0	0.6	0.7	1.1
Age at First Birth	0.5	0.8	1.7	0.6	1.0	0.6	1.0	0.4	1.3
Coronary Artery Disease (CAD)	0.5	0.6	1.1	1.1	-0.6	0.9	-0.7	-0.6	-0.7
Allergy or Eczema	0.5	1.4	4.5	2.1	-0.5	1.0	0.3	-1.5	-0.5
Angina	0.5	0.6	1.4	1.2	-0.4	0.0	-0.7	-1.0	-0.9
Medication for hormone replacement therapy	0.5	0.6	1.8	0.6	0.7	1.4	0.8	0.2	0.5
Taking other prescription medications	0.5	0.8	1.8	1.3	1.3	0.1	1.2	0.5	0.3
Age when periods started (menarche)	0.5	1.1	3.6	0.7	0.9	1.9	0.7	0.9	0.7
Hayfever, allergic rhinitis or eczema	0.5	1.2	4.4	2.1	-0.1	1.1	0.7	-0.9	0.0
Multivitamins +/- minerals	0.5	0.7	1.3	-0.6	-0.4	-0.7	-1.0	-0.8	-1.1
Sitting height	0.5	3.4	8.9	-1.9	2.0	-0.9	1.2	3.0	1.3
Number of incorrect matches in round	0.5	0.8	2.3	-0.8	-1.2	-0.2	-0.5	-1.5	-0.5
Hair/balding pattern: Pattern 2	0.5	0.6	3.2	-0.0	0.2	1.8	0.4	-0.3	-0.3
Medication: Ramipril	0.5	0.7	1.8	1.3	-0.3	0.8	0.3	-1.1	-0.3
Asthma	0.5	0.9	2.3	-0.3	1.0	0.3	1.4	0.1	1.5
Medication: Cholesterol lowering	0.5	0.8	2.0	1.3	-0.9	-0.5	-0.3	-1.4	-0.1
Depression (self-reported)	0.5	0.6	1.0	-0.7	-0.7	-1.0	-0.8	-0.6	-0.9
Arm fat-free mass (right)	0.5	2.7	5.4	0.2	2.3	-0.1	1.3	2.2	2.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.4	0.3	1.3	-0.4	1.6	0.5	0.9
Had major operations	0.5	0.6	1.0	-0.4	-0.9	-1.0	-0.6	-0.7	-1.0
Illnesses of father: Heart disease	0.5	0.7	1.6	0.2	-1.2	-0.6	-0.7	-0.7	-1.3
Ever taken oral contraceptive pill	0.5	0.5	2.8	-1.7	-0.4	-0.4	0.3	-0.2	-0.2
Commuting to job workplace: Public transport	0.5	0.6	2.5	1.6	-0.2	0.6	-0.0	-0.5	0.6
Medication: Bendroflumethiazide	0.5	0.8	1.2	-0.7	-0.8	-0.9	-0.7	-1.0	-1.1
Basal metabolic rate	0.5	2.9	6.4	0.1	2.3	0.1	1.2	2.5	2.1
Alcohol drinker status: Previous	0.5	0.6	1.0	0.6	1.0	1.0	0.6	0.3	-0.7
Crohns Disease (2012)	0.4	0.7	2.1	-0.8	-0.4	-1.4	-1.0	-0.5	-0.2
HDL Cholesterol	0.4	0.7	2.5	-0.2	0.7	1.6	0.8	0.2	0.9
Cardiovascular Disease	0.4	1.2	2.8	1.1	-1.2	-0.3	-0.5	-1.7	-1.2
Hearing difficulty/problems: Yes	0.4	0.7	2.7	1.6	-0.7	0.3	-0.3	-0.6	-0.7
Fed-up feelings	0.4	0.7	2.6	1.6	-0.4	0.1	0.2	-1.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	-1.0	-0.5	-0.3	-0.3	-1.0	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.9	0.7	-0.2	-1.4	0.2	-0.7	-0.2
Supplements: Glucosamine	0.4	0.5	1.0	0.1	0.3	-1.0	-0.5	-1.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	1.1	1.1	0.4	0.8	0.4	0.2
Diabetes (self-reported)	0.4	0.6	2.2	1.5	-0.4	-1.1	0.0	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	6.7	-2.6	-0.6	0.1	-0.6	0.6	-0.5
Happiness	0.4	0.5	1.5	1.2	0.7	0.1	-0.2	0.5	0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	1.5	-0.2	1.2	-0.8	0.6	0.8	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.1	0.2	0.3	0.6	1.4	-0.6	-0.3
Loud music exposure frequency	0.4	0.4	1.1	-0.5	0.7	-0.9	-0.1	1.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	-0.9	0.7	1.1	0.3	1.1	0.4
Medication: Allopurinol	0.4	0.5	1.1	0.4	1.1	0.5	0.9	0.9	0.3
Medication: Seretide 50 evohaler	0.4	0.4	1.3	-0.1	0.8	0.6	1.1	0.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.9	0.5	-0.3	-0.1	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	1.1	0.1	1.7	1.0	0.2	0.4
Diabetes diagnosed by doctor	0.4	0.6	2.9	1.7	0.2	-0.3	0.7	0.0	0.5
Friendships satisfaction	0.4	0.5	1.3	1.1	-0.2	-0.5	-0.9	-0.0	-0.6
Mineral and other dietary supplements	0.4	0.5	1.4	-0.0	-1.2	1.0	-0.2	-0.8	-0.2
Asthma (self-reported)	0.4	0.7	1.8	0.1	1.0	0.2	1.4	-0.0	1.3
Osteoarthritis (self-reported)	0.4	0.6	1.5	-1.2	1.1	-0.2	0.6	0.4	0.4
Medication: Gliclazide	0.4	0.5	2.3	0.0	-0.2	-1.5	-0.5	-0.2	-0.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.5	0.6	1.2	0.4	1.2	0.6	0.4
Wears glasses or contact lenses	0.4	0.5	1.3	1.1	0.8	0.3	0.5	0.5	0.6
High cholesterol (Self-reported)	0.4	0.8	1.4	0.3	-1.1	-1.2	-0.4	-0.7	-1.1
Alcohol drinker status: Never	0.4	0.4	1.2	0.8	0.2	1.1	0.4	-0.8	-0.2
BMI	0.3	1.7	4.2	2.0	1.4	0.8	0.8	1.1	1.3
Hand grip strength (left)	0.3	0.8	1.9	-0.8	-1.4	-0.6	-1.0	-0.2	-1.0
Medication: Co-codamol	0.3	0.3	0.5	0.5	0.6	-0.5	0.7	-0.2	0.7
Medication: Metformin	0.3	0.4	1.4	1.2	-0.2	-0.9	0.1	0.1	0.1
Severe depression (siblings)	0.3	0.4	1.8	-0.2	0.4	1.3	0.2	-0.1	-0.4
Trunk fat percentage	0.3	1.1	2.0	0.8	-1.0	-1.4	-1.2	-0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.1	1.0	-0.4	0.5	0.1	0.9
Relative age voice broke	0.3	0.5	1.5	-1.2	-0.0	-1.0	-0.1	0.6	-0.0
Fluid intelligence score	0.3	0.7	1.9	-1.4	-0.2	-0.4	-1.4	0.3	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.8	-1.3	0.4	1.2	0.4	0.5	0.8
Birth weight of first child	0.3	0.5	1.3	-0.0	-0.7	-1.1	-0.7	-0.7	-0.5
Medication: Amlodipine	0.3	0.4	1.2	0.9	-0.2	0.1	0.3	-1.1	-0.3
Leg fat percentage (right)	0.3	1.0	2.5	0.4	-0.7	-1.6	-1.2	-1.1	-0.5
Migraine (self-reported)	0.3	0.4	1.0	-1.0	0.6	0.4	0.6	0.3	0.8
Heart disease (mother)	0.3	0.4	1.1	0.5	0.7	1.1	0.3	0.4	0.5
Alcohol intake frequency.	0.3	0.6	1.6	1.3	-0.3	0.7	-0.2	-0.8	-0.9
Number of full sisters	0.3	0.3	0.7	-0.1	0.7	0.8	0.8	-0.2	0.4
Chest pain or discomfort	0.3	0.4	1.5	1.2	0.7	0.4	0.6	-0.3	0.2
Family relationship satisfaction	0.3	0.4	0.8	0.9	0.3	0.5	-0.9	0.5	-0.2
Illnesses of siblings: Diabetes	0.3	0.3	1.1	-0.3	0.3	-1.1	0.5	0.7	-0.1
Breast cancer (self-reported)	0.3	0.3	1.1	-0.7	0.0	-1.1	-0.2	-0.2	-0.5
Medication: Aspirin	0.3	0.4	1.6	0.4	-0.3	-0.6	-0.2	-1.3	-0.5
Medication: Lisinopril	0.3	0.4	1.4	-0.6	0.6	0.5	0.4	0.3	1.2
Diastolic blood pressure, automated reading	0.3	0.9	2.3	0.0	1.5	0.8	1.0	1.0	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.8	-1.9	-0.0	-0.8	-0.8	0.8	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.5	-0.9	0.5	-0.2	-0.9	1.2	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-0.6	0.3	0.2	-1.1	1.2	0.1
HbA1C	0.2	0.2	0.4	-0.7	0.4	-0.3	0.7	-0.0	0.2
LDL Cholesterol	0.2	0.3	0.7	0.1	0.4	0.4	0.3	0.8	0.7
Rheumatoid Arthritis	0.2	0.3	1.2	0.3	-0.4	1.1	0.3	0.3	0.3
Blood Eosinophil Count	0.2	1.2	3.6	1.9	-0.2	1.8	0.3	0.1	-0.3
Heel T-Score	0.2	1.2	3.3	1.8	1.2	0.8	0.8	1.1	0.1
Height	0.2	3.3	16.2	-4.0	-0.7	-1.1	-0.8	0.2	-1.1
Systolic Blood Pressure	0.2	1.0	2.7	1.1	0.1	1.1	1.6	-0.2	0.8
Relative age of first facial hair	0.2	0.4	0.9	-0.8	0.4	0.4	0.7	1.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.1	0.5	-0.4	-0.5	-0.3	-0.7
High blood pressure	0.2	0.7	1.9	1.4	0.3	0.7	1.1	-0.5	0.3
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.5	0.8	0.1	0.8	0.4	0.2
Body mass index (BMI)	0.2	0.7	1.6	1.2	0.9	-0.6	0.2	0.6	1.1
Waist circumference	0.2	0.9	4.9	2.2	0.2	-0.4	-0.0	0.2	0.6
Qualifications: None of the above	0.2	0.5	0.8	0.7	0.6	-0.9	0.9	-0.5	0.3
Medication: Simvastatin	0.2	0.2	0.4	0.6	-0.4	-0.5	0.0	-0.7	-0.5
Weight	0.2	1.0	2.4	0.2	1.3	-0.7	0.4	1.6	1.0
Arm fat percentage (right)	0.2	0.6	1.5	0.5	-0.7	-1.2	-1.1	-0.3	-0.4
Father’s age at death	0.2	0.3	0.6	-0.3	-0.2	-0.2	-0.8	-0.7	-0.5
Falls in the last year	0.2	0.2	0.7	0.9	0.4	-0.7	-0.1	-0.0	0.2
Peak expiratory flow (PEF)	0.2	0.4	1.1	-0.6	-1.0	-0.3	-0.6	-0.3	0.5
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.7	0.6	0.5	-0.4	-0.0	0.2
Glaucoma (self-reported)	0.2	0.3	0.7	0.3	-0.5	-0.2	-0.2	-0.6	-0.8
Body fat percentage	0.2	0.8	1.7	0.7	-0.8	-1.3	-1.0	-0.7	-0.8
Number of children fathered	0.2	0.3	1.1	-1.0	0.3	0.1	0.3	0.5	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.0	0.3	0.4	-0.3	0.5	0.2	1.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	-0.2	-0.5	-0.4	-1.0	0.3	-0.4
Medication: Blood pressure	0.2	0.3	0.6	0.7	-0.2	-0.5	0.4	-0.8	-0.3
Mean time to correctly identify matches	0.2	0.4	1.7	1.3	0.1	0.0	-0.6	-0.6	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	0.1	-0.5	-0.2	-0.7	-0.5	-0.7
Medication for cholesterol	0.2	0.3	1.1	-0.5	0.4	0.4	0.1	1.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.4	-0.4	-0.7	0.0	-0.2	-0.7
Back pain experienced in last month	0.2	0.3	0.7	-0.8	0.6	0.8	0.6	-0.1	0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	1.0	1.0	0.1	0.1	-0.0	-0.5	0.2
Mother’s age at death	0.2	0.3	0.7	0.6	-0.4	-0.4	-0.8	-0.5	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	-0.9	0.7	-0.0	0.4	0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.1	1.0	-0.4	0.3	0.6	0.1
Medication: Atorvastatin	0.2	0.2	0.9	1.0	0.1	0.2	0.2	0.0	0.6
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.6	-0.8	0.3	-0.3	-0.3	-0.5
Leg fat percentage (left)	0.2	0.7	2.6	0.3	-0.4	-1.6	-0.8	-0.8	-0.3
Age started oral contraceptive pill	0.2	0.3	0.5	0.6	0.3	-0.5	0.4	-0.7	0.4
Unable to work because of sickness or disability	0.2	0.2	0.6	0.8	0.8	-0.2	0.4	0.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.6	0.7	0.6	-0.0	0.3	0.2
Depression (Nagel 2018)	0.1	0.2	0.5	0.7	-0.1	-0.2	-0.1	-0.7	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	0.1	-0.5	0.1	-0.4	-0.0
Fasting Glucose	0.1	0.1	0.4	0.1	0.2	-0.6	-0.3	0.1	0.2
Hypothyroidism (self reported)	0.1	0.2	0.7	0.6	0.9	-0.2	0.4	0.2	0.2
Respiratory disease	0.1	0.2	0.6	0.2	0.2	-0.3	0.4	-0.8	0.5
Number of treatments/medications taken	0.1	0.2	0.5	-0.2	0.7	-0.6	0.3	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	0.5	0.1	-0.1	-0.2	-0.8	-0.5
Systolic blood pressure, automated reading	0.1	0.4	1.0	-0.4	-0.3	-1.0	-0.4	-0.8	-0.6
Hand grip strength (right)	0.1	0.2	0.5	0.1	-0.5	0.4	0.1	0.7	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.3	0.0	0.1	0.4	-0.5	-0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.3	-0.7	-0.3	0.0	-0.1	-0.5
Trunk fat mass	0.1	0.5	1.6	0.6	-0.3	-1.3	-0.8	0.0	-0.4
Past tobacco smoking	0.1	0.1	0.4	0.1	-0.6	0.2	-0.6	0.1	-0.3
Had other major operations	0.1	0.1	0.6	-0.3	0.3	-0.0	-0.3	-0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.8	-0.5	-0.7	-0.4	-0.6	0.1
Arm fat mass (right)	0.1	0.3	1.3	0.5	0.1	-1.1	-0.4	0.4	0.2
Standing height	0.1	1.3	4.1	-1.7	0.6	-0.4	0.2	2.0	-0.1
Medication: Paracetamol	0.1	0.2	0.4	-0.2	0.6	0.3	0.5	0.6	0.5
Headache pain in last month	0.1	0.3	0.5	0.3	-0.3	0.7	0.7	-0.5	-0.4
Age at first live birth	0.1	0.2	0.5	0.7	-0.3	0.4	-0.3	-0.2	0.6
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.0	0.4	0.1	0.6	-0.3	0.4
Whole body fat mass	0.1	0.3	1.6	0.4	0.1	-1.3	-0.4	0.4	0.1
Leg fat mass (right)	0.1	0.4	1.5	0.5	0.2	-1.2	-0.4	0.1	0.4
Hypertension (Self-reported)	0.1	0.4	1.3	1.1	-0.1	0.1	0.5	-0.9	-0.1
Smoking status: Previous	0.1	0.1	0.5	-0.1	-0.1	-0.2	0.2	-0.7	-0.3
Arm fat percentage (left)	0.1	0.5	0.9	0.9	-0.5	-1.0	-0.9	-0.4	-0.3
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.4	0.3	0.1	0.5	0.5	-0.3
Arm fat mass (left)	0.1	0.3	0.8	0.9	0.1	-0.9	-0.4	0.4	0.3
Medication: Blood pressure	0.1	0.2	0.8	0.9	-0.0	-0.1	0.1	-0.8	0.0
Medication: Paracetamol	0.1	0.2	0.7	-0.1	0.8	-0.1	0.3	0.6	0.2
Ever smoked	0.1	0.3	0.7	0.9	0.6	-0.0	0.5	0.1	0.4
Cholesterol lowering medication	0.1	0.1	0.4	0.6	0.1	-0.5	0.1	0.0	-0.2
Supplements: Calcium	0.1	0.1	0.1	0.3	-0.1	-0.2	-0.2	-0.4	-0.3
Heart disease (siblings)	0.1	0.1	0.5	-0.0	0.6	0.2	0.7	-0.1	0.1
Leg fat mass (left)	0.1	0.4	1.5	0.5	0.4	-1.2	-0.2	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.1	-0.2	0.1	0.0	-0.4	0.4
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	-0.1	0.5	-0.2	0.1	0.0	-0.5

Hub : Genes

CNTN2

Models

Trait associations