Best TWAS P=4.44e-19 · Best GWAS P=7.41e-21 conditioned to 0.000605
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | DIEXF | 0.19 | 0.14 | lasso | 6 | 0.13 | 3.3e-10 | 4.3 | 5.2 | 2.4e-07 | 0.55 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Spleen | TRAF3IP3 | 0.28 | 0.17 | lasso | 5 | 0.18 | 2.6e-05 | 9.3 | -8.9 | 4.4e-19 | -0.84 | 0.03 | 0.90 | TRUE |
| 3 | NTR | Blood | TRAF3IP3 | 0.05 | 0.04 | lasso | 10 | 0.05 | 1.7e-16 | 8.9 | -7.6 | 2.8e-14 | -0.80 | 0.09 | 0.91 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C1orf107 | 0.06 | 0.00 | blup | 79 | 0.01 | 8.1e-02 | -4.0 | 5.2 | 2.2e-07 | 0.38 | 0.01 | 0.10 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRAF3IP3 | 0.02 | 0.00 | blup | 86 | 0.01 | 1.0e-02 | 9.2 | -8.1 | 8.0e-16 | -0.92 | 0.02 | 0.63 | FALSE |
| 6 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | HSD11B1 | 0.18 | 0.00 | blup | 91 | 0.04 | 3.0e-02 | 9.3 | 8.0 | 9.0e-16 | 0.81 | 0.02 | 0.46 | FALSE |