Hub : Genes

DIEXF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2210 0.0420 0.0e+00 0.173 0.205 0.212 0.218 0.228 1.3e-20 1.7e-24 2.6e-25 4.4e-26 2.2e-27
2 GTEx Artery Tibial 0.1237 0.0482 6.6e-04 0.072 NA 0.055 NA 0.067 2.7e-06 NA 3.6e-05 NA 6.0e-06
3 GTEx Brain Cortex 0.3680 0.1010 1.4e-03 -0.003 NA 0.052 NA 0.004 3.9e-01 NA 1.5e-02 NA 2.4e-01
4 GTEx Cells EBV-transformed lymphocytes 0.3130 0.0790 1.6e-05 0.278 NA 0.158 NA 0.229 1.2e-09 NA 8.0e-06 NA 5.1e-08
5 GTEx Cells Transformed fibroblasts 0.1940 0.0520 9.6e-07 0.144 NA 0.127 NA 0.134 6.0e-11 NA 9.2e-10 NA 3.3e-10
6 GTEx Lung 0.0873 0.0339 3.9e-03 0.096 NA 0.078 NA 0.077 8.9e-08 NA 1.4e-06 NA 1.7e-06
7 GTEx Nerve Tibial 0.0723 0.0365 9.1e-03 0.001 NA -0.004 NA -0.004 2.9e-01 NA 8.4e-01 NA 8.7e-01
8 GTEx Whole Blood 0.0820 0.0380 9.8e-03 0.026 NA 0.020 NA 0.028 1.6e-03 NA 5.3e-03 NA 1.2e-03
9 METSIM Adipose 0.0464 0.0238 1.6e-02 0.000 0.005 -0.002 0.004 0.003 2.9e-01 5.9e-02 8.6e-01 6.7e-02 1.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.7 1.2 2.5 1.3 -1.1 1.0 -1.3 -1.1 -0.5 0.0 -1.0 -1.6
Bipolar Disorder or Schizophrenia 0.3 0.7 3.8 0.6 -0.5 0.8 -0.5 -0.9 -0.0 0.0 -0.4 -2.0
Depressed Affect (Nagel 2018) 0.3 0.6 1.3 0.8 -0.9 -0.1 -0.7 -1.1 -1.1 0.0 -0.5 -1.1
Depression (Nagel 2018) 0.5 0.8 3.2 -0.0 -0.7 1.8 0.5 -1.5 0.3 0.0 0.9 -0.1
Intelligence (Savage-Jansen 2018) 1.1 3.3 6.8 -2.5 2.6 -1.4 1.9 2.4 1.8 0.0 1.6 0.2
Neuroticism (Nagel 2018) 0.3 0.8 1.9 -0.9 -0.3 -1.2 1.2 -0.6 0.8 0.0 1.4 -0.2
Schizophrenia (2018) 0.1 0.2 1.4 -0.3 0.2 0.1 0.4 -0.2 0.4 0.0 0.3 -1.2
Schizophrenia vs Biploar Disorder 0.7 1.0 2.6 -1.3 1.6 -0.9 0.9 1.6 0.6 0.0 0.4 0.2
Worry (Nagel 2018) 0.9 1.8 4.5 -1.3 -0.2 -1.4 1.9 -0.7 1.6 0.0 2.1 1.2
Alzheimer’s Disease (in mother) 0.9 1.0 2.7 -0.9 0.5 1.0 1.4 -0.0 1.1 0.0 1.6 -1.0
Alzheimer’s Disease (in father) 1.0 1.1 3.4 -1.3 0.9 -1.9 1.1 0.9 0.6 0.0 1.1 -0.4
Alzheimer’s Disease (including proxy) 1.0 1.5 4.4 -1.6 0.8 -0.4 1.8 0.3 1.2 0.0 2.1 -1.1
Crohns Disease (2017) 1.0 2.1 9.2 -0.6 -0.4 -0.5 1.6 -1.0 1.8 0.0 1.7 3.0
Irritable Bowel Disease (IBD) 1.5 3.6 7.2 -0.8 -1.3 0.6 2.2 -2.1 2.4 0.0 2.6 2.7
Ulcerative Colitis (UC) 1.6 2.9 7.6 -1.1 -1.3 0.9 2.1 -2.0 2.3 0.0 2.8 1.2
Major Depression (MDD) 0.5 0.6 2.0 0.8 -0.9 -0.3 -0.8 -1.1 -1.4 0.0 -0.4 0.5
Reaction Time 2.0 3.7 12.3 -1.8 -0.1 -0.4 2.6 -1.0 3.5 0.0 3.2 -0.3
Verbal and Numeric Reasoning (VNR) 1.0 2.3 5.7 -2.1 2.4 -0.7 1.5 2.2 1.3 0.0 1.3 0.2
Breast Cancer 0.5 1.2 4.2 -0.8 1.4 -1.6 0.4 1.1 0.5 0.0 0.3 -2.0
Ovarian Cancer 0.2 0.3 2.0 -0.0 -0.2 1.4 0.1 -0.6 -0.2 0.0 -0.1 -0.1
Prostate Cancer 1.0 1.4 3.3 -1.2 1.5 -1.4 0.9 1.8 0.7 0.0 0.5 1.3
Age at First Birth 3.5 5.0 9.5 -3.1 2.5 -0.9 2.9 1.9 2.8 0.0 3.0 -0.1
Bipolar Disorder (2011) 0.4 0.4 0.9 -0.6 0.2 -0.9 0.6 0.1 1.0 0.0 0.9 0.5
Body Mass Index (BMI) (2010) 0.3 0.4 2.8 0.1 -0.6 1.7 0.0 -0.4 -0.4 0.0 0.1 -0.6
Coronary Artery Disease (CAD) 0.3 0.3 1.3 0.5 -0.9 1.1 -0.5 -0.7 0.1 0.0 -0.3 -0.1
Crohns Disease (2012) 1.1 1.7 7.1 -0.8 0.1 -0.3 1.4 -0.2 1.8 0.0 1.5 2.7
Mean Putamen Volume 0.3 0.3 1.5 -0.4 0.3 -1.2 0.2 0.5 -0.1 0.0 0.1 -0.9
Fasting Glucose 0.6 0.7 1.5 1.0 -0.8 -0.0 -1.1 -0.3 -1.1 0.0 -1.2 -0.9
HbA1C 0.2 0.3 0.7 0.5 -0.4 -0.8 -0.5 -0.7 -0.1 0.0 0.3 0.7
HDL Cholesterol 1.2 1.9 3.9 -2.0 1.6 -0.5 1.8 1.3 1.3 0.0 1.9 -0.6
LDL Cholesterol 1.2 2.0 7.8 -0.7 -0.3 -0.6 1.3 -1.0 1.8 0.0 1.6 2.8
Lupus 0.1 0.1 1.1 -0.1 -0.1 0.1 0.3 -0.1 -0.1 0.0 0.1 1.0
Neuroticism (2016) 0.2 0.3 1.2 -0.4 -0.1 -1.1 0.6 -0.4 0.5 0.0 0.7 -0.3
Primary Biliary Cirrhosis 0.8 1.1 2.8 -1.0 -0.0 -0.2 1.4 -0.4 1.5 0.0 1.4 1.7
Rheumatoid Arthritis 0.3 0.4 1.6 -0.1 0.9 -1.3 0.2 0.5 0.1 0.0 0.5 0.6
Schizophrenia (2014) 0.2 0.5 2.9 0.3 -0.1 -0.3 -0.4 -0.3 -0.6 0.0 -0.5 -1.7
Triglycerides 2.1 3.5 5.7 2.4 -2.0 2.0 -2.2 -1.8 -2.2 0.0 -2.2 0.1
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.8 1.5 -1.7 0.7 -1.4 -1.1 -1.2 0.0 -1.3 -0.2
Ulcerative Colitis 2.5 3.6 9.2 -1.8 -0.4 0.6 2.8 -1.1 2.6 0.0 3.0 1.8
Blood Eosinophil Count 0.1 0.5 1.7 0.2 -1.0 1.3 -0.1 -0.8 0.7 0.0 0.3 0.6
Blood Platelet Count 0.6 7.0 13.0 3.0 -3.6 3.0 -2.7 -3.3 -2.2 0.0 -2.1 -2.2
Blood Red Count 0.9 8.9 26.7 -2.3 4.5 -3.8 1.6 5.2 0.6 0.0 0.3 3.2
Blood White Count 1.3 9.4 17.6 4.2 -4.2 2.8 -3.7 -3.8 -2.3 0.0 -3.0 0.4
Heel T-Score 0.8 6.0 25.6 1.5 -3.2 5.1 -0.5 -3.8 0.1 0.0 0.3 0.6
BMI 1.2 7.1 18.2 1.7 -0.0 3.8 -2.6 0.6 -3.5 0.0 -3.1 -4.3
Height 0.2 3.1 11.2 2.0 -1.6 1.0 -1.1 -2.0 -1.2 0.0 -1.5 3.3
Waist Hip Ratio (WHR) 0.3 1.3 3.5 0.9 -1.8 1.8 -0.2 -1.9 0.1 0.0 0.2 1.1
Systolic Blood Pressure 2.8 14.0 30.7 4.7 -5.5 3.2 -3.2 -5.5 -2.7 0.0 -2.5 2.9
Smoking Status 3.4 8.1 14.8 3.8 -3.5 3.2 -3.2 -3.3 -2.2 0.0 -3.0 -0.1
Allergy or Eczema 0.1 0.3 0.6 -0.7 0.7 -0.6 0.3 0.7 0.2 0.0 0.2 -0.7
Cardiovascular Disease 1.5 4.9 9.2 2.9 -2.9 3.0 -2.4 -2.2 -1.6 0.0 -2.1 1.1
Hypothyroidism (self reported) 0.4 0.9 3.3 0.3 -1.6 0.4 0.7 -1.8 0.5 0.0 0.8 0.7
Respiratory disease 0.5 1.1 3.2 -1.3 1.6 0.0 0.6 1.8 0.4 0.0 0.3 -1.4
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.5 -0.2 0.2 1.2 -0.2 0.7 -0.0 0.0 -0.3 -1.2
Lung FEV1/FVC ratio 0.4 2.3 5.3 -1.8 0.5 -0.7 2.1 0.5 2.3 0.0 2.2 1.4
Lung FVC 0.1 0.7 1.4 -0.5 -0.2 1.1 0.9 -0.7 1.2 0.0 1.1 1.0
Neuroticism 0.8 1.9 4.0 -1.5 0.4 -2.0 1.9 -0.1 1.6 0.0 2.0 -0.1
Chronotype (morning person) 0.2 0.4 0.7 -0.6 0.7 -0.8 0.7 0.4 0.7 0.0 0.8 0.4
Hair Pigment 0.0 1.4 3.3 -1.1 0.6 -0.0 1.6 -0.2 1.6 0.0 1.6 1.8
Tanning 0.1 1.6 3.0 1.5 -1.6 -0.2 -1.4 -1.4 -1.7 0.0 -1.4 -0.7
Hand grip strength (left) 0.3 0.9 1.5 1.1 -1.0 0.9 -0.6 -1.2 -1.1 0.0 -0.9 1.1
Number of treatments/medications taken 1.4 2.5 4.5 2.1 -1.9 1.9 -1.8 -1.5 -1.5 0.0 -1.7 0.6
Average weekly spirits intake 0.3 0.3 0.8 0.7 0.3 -0.0 -0.7 0.3 -0.9 0.0 -0.8 0.5
Sensitivity / hurt feelings 0.5 0.9 2.6 0.7 -0.8 0.9 -0.8 -0.7 -1.3 0.0 -0.7 -1.6
Frequency of depressed mood in last 2 weeks 0.7 1.0 4.8 -0.8 0.6 2.2 0.8 0.1 0.7 0.0 1.0 -0.9
Hearing difficulty/problems: Yes 0.4 0.6 2.4 -0.1 -0.6 0.9 0.2 -1.2 -0.0 0.0 0.5 -1.5
Relative age of first facial hair 1.0 2.0 6.4 -1.1 0.4 -0.8 1.7 -0.2 1.4 0.0 2.1 2.5
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 6.4 -0.0 0.5 0.7 -0.7 0.7 -1.0 0.0 -0.8 -2.5
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 -0.2 0.4 0.4 -0.1 0.6 -0.2 0.0 -0.2 0.1
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 0.6 0.2 -0.0 -0.8 0.2 -0.8 0.0 -0.7 -0.9
Systolic blood pressure, automated reading 3.0 8.6 18.1 3.8 -4.1 2.1 -2.6 -4.2 -2.8 0.0 -2.2 2.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 0.5 -0.3 0.7 -0.6 -0.6 -0.9 0.0 -0.6 -0.6
Angina 1.7 2.3 4.6 2.0 -2.1 1.2 -1.9 -1.8 -1.0 0.0 -1.6 -0.3
Medication for hormone replacement therapy 0.2 0.2 1.1 0.2 0.1 -1.1 -0.3 0.0 0.1 0.0 -0.3 0.4
Vitamin and mineral supplements 0.8 1.1 2.2 -1.0 0.9 -1.2 1.2 0.7 1.0 0.0 1.3 1.5
Supplements: Zinc 0.5 0.5 1.6 0.3 -1.2 1.2 -0.1 -1.1 0.2 0.0 0.1 0.5
Medication: Co-codamol 0.1 0.2 1.1 0.0 -0.0 1.0 0.3 -0.3 0.1 0.0 0.5 0.2
Medication: Metformin 1.4 2.0 9.3 1.2 -1.6 3.0 -0.7 -1.7 -0.4 0.0 -0.4 0.9
Diabetes (father) 1.1 1.4 4.5 1.1 -1.6 2.1 -0.8 -1.3 -0.7 0.0 -0.6 -0.8
Diabetes (mother) 0.4 0.5 2.7 -0.6 0.8 0.4 0.3 0.5 -0.2 0.0 0.2 -1.6
Severe depression (siblings) 0.1 0.2 0.5 0.1 -0.2 0.6 -0.4 0.2 -0.5 0.0 -0.5 -0.7
Pack years adult smoking proportion 0.3 0.5 1.4 -0.3 0.6 0.8 0.5 0.7 1.0 0.0 0.5 1.2
Impedance of leg (right) 0.5 2.3 14.2 0.3 -1.1 -0.9 0.6 -1.6 0.8 0.0 1.1 3.8
Leg fat-free mass (left) 0.6 3.1 9.9 0.7 0.9 2.0 -1.5 1.3 -2.0 0.0 -2.2 -3.1
Trunk fat percentage 1.7 6.9 14.6 2.2 -0.4 2.7 -3.2 0.1 -3.7 0.0 -3.5 -3.8
Hand grip strength (right) 0.1 0.4 1.8 0.5 -0.5 0.5 -0.0 -0.8 -0.5 0.0 -0.4 1.4
Townsend deprivation index at recruitment 0.6 0.8 1.7 -0.4 -0.9 1.0 1.0 -1.2 1.3 0.0 1.2 0.2
Current tobacco smoking 1.7 2.7 5.5 1.9 -2.0 2.3 -1.2 -2.0 -0.6 0.0 -0.8 2.3
Average weekly fortified wine intake 0.4 0.4 1.4 -0.5 0.5 0.1 0.8 0.4 0.8 0.0 0.8 1.2
Maternal smoking around birth 0.1 0.2 1.4 0.1 -0.2 -1.2 -0.0 0.1 -0.3 0.0 0.1 -0.6
Fed-up feelings 1.6 2.9 5.2 2.1 -2.1 1.2 -1.8 -2.0 -2.3 0.0 -1.7 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 6.7 0.7 -0.8 2.6 -0.4 -1.4 -0.7 0.0 -0.0 -0.9
Relative age voice broke 3.5 5.4 11.6 -2.2 1.3 -1.9 2.8 0.6 3.0 0.0 3.1 3.4
Taking other prescription medications 0.3 0.5 1.0 -0.9 0.8 -0.5 0.7 1.0 1.0 0.0 0.6 0.5
Age when periods started (menarche) 0.4 0.8 2.4 0.8 -0.3 -0.2 -1.2 0.8 -1.6 0.0 -1.4 -0.8
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 3.9 1.4 -1.8 1.2 -0.8 -2.0 -1.1 0.0 -0.5 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 3.4 0.4 -0.6 1.9 -0.5 -0.5 -0.4 0.0 -0.5 -1.2
Tinnitus: Yes, but not now, but have in the past 6.3 6.8 12.3 3.4 -3.5 2.0 -2.8 -3.4 -2.5 0.0 -2.6 -0.9
Qualifications: CSEs or equivalent 1.7 2.2 7.0 0.1 1.0 1.9 -0.9 1.6 -1.9 0.0 -1.3 -2.6
Serious illness, injury or assault to yourself 0.4 0.4 1.7 -0.7 0.4 0.6 0.5 0.7 0.4 0.0 0.4 -1.3
High blood pressure 1.4 4.0 7.6 2.7 -2.8 1.8 -2.0 -2.6 -1.4 0.0 -1.6 1.5
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.7 -0.3 0.8 -0.4 -0.1 0.8 -0.1 0.0 -0.3 -0.5
Multivitamins +/- minerals 0.4 0.5 2.0 -0.0 -0.5 1.2 -0.0 -0.6 0.1 0.0 0.0 -1.4
Stomach or abdominal pain in last month 3.1 3.8 5.8 2.3 -2.4 1.4 -2.4 -1.8 -2.3 0.0 -2.2 -1.6
Supplements: Glucosamine 0.1 0.1 0.5 -0.1 0.1 0.6 -0.0 0.1 0.1 0.0 -0.2 -0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.5 0.1 -1.2 1.1 0.2 -1.1 0.0 0.0 0.4 0.4
Medication: Atenolol 0.8 1.0 3.1 1.3 -1.8 0.4 -0.6 -1.7 0.2 0.0 -0.1 1.0
Medication: Levothyroxine sodium 0.8 1.3 3.5 -0.9 -0.4 0.8 1.7 -0.8 1.6 0.0 1.9 1.0
Sitting height 0.2 1.3 4.2 1.2 -0.5 -0.1 -1.5 0.0 -1.7 0.0 -2.0 0.0
Chronic bronchitis/emphysema (father) 0.8 1.0 1.8 1.1 -1.1 0.6 -1.1 -1.3 -0.8 0.0 -0.8 -1.4
High blood pressure (mother) 0.2 0.2 1.7 -0.0 0.4 1.3 0.1 -0.0 0.0 0.0 0.2 0.2
Body mass index (BMI) 1.7 7.1 19.4 1.8 0.1 3.2 -2.8 0.6 -3.6 0.0 -3.2 -4.4
Impedance of leg (left) 0.4 2.0 10.5 0.7 -1.7 -0.4 0.0 -2.0 0.4 0.0 0.5 3.2
Leg predicted mass (left) 0.6 3.2 10.1 0.8 0.8 2.1 -1.6 1.2 -2.1 0.0 -2.2 -3.2
Trunk fat mass 1.6 6.8 13.2 2.1 -0.3 3.0 -3.0 0.2 -3.6 0.0 -3.4 -3.6
Waist circumference 1.3 4.6 10.6 1.4 -0.1 3.1 -2.2 0.1 -2.9 0.0 -2.4 -3.2
Number of incorrect matches in round 0.7 1.1 2.3 1.3 -1.3 -0.2 -1.4 -0.8 -0.9 0.0 -1.5 -0.9
Past tobacco smoking 2.7 4.9 11.6 -2.5 2.6 -3.4 2.1 2.5 1.4 0.0 2.0 1.7
Alcohol usually taken with meals 0.3 0.5 2.7 0.2 0.2 -0.7 -0.4 0.5 -0.4 0.0 -0.6 1.6
Nervous feelings 0.4 0.7 2.5 -0.5 -0.4 -1.6 1.0 -0.7 0.8 0.0 1.0 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.9 -0.6 -0.7 1.3 1.1 -1.1 1.3 0.0 1.4 0.2
Hearing difficulty/problems with background noise 0.8 1.3 3.5 -0.9 -0.1 -1.9 1.3 -0.5 1.2 0.0 1.5 1.4
Hair/balding pattern: Pattern 2 0.4 0.5 1.4 0.2 -1.0 0.6 0.1 -1.2 0.3 0.0 0.5 -1.1
Had menopause 0.1 0.2 0.7 0.4 -0.8 -0.1 -0.3 -0.7 -0.1 0.0 -0.1 0.2
Had other major operations 0.5 0.6 1.2 0.4 0.4 -1.0 -0.8 0.4 -1.1 0.0 -0.9 -0.9
Forced vital capacity (FVC) 0.1 0.4 1.6 0.4 -0.5 1.3 -0.2 -0.6 -0.1 0.0 -0.2 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 4.9 0.3 -0.5 2.0 -0.6 -0.4 -0.2 0.0 -0.5 -2.2
Ever unenthusiastic/disinterested for a whole week 3.4 4.1 6.6 2.6 -2.6 0.9 -2.4 -2.2 -2.5 0.0 -2.4 -1.0
Qualifications: None of the above 0.7 1.5 4.4 1.3 -1.0 0.7 -1.3 -0.9 -1.4 0.0 -1.3 -2.1
Financial difficulties in last 2 years 0.6 0.8 5.9 -0.0 0.1 0.1 -0.5 0.8 -0.6 0.0 -0.5 -2.4
Mouth/teeth dental problems 0.5 0.7 4.3 -0.6 0.6 -2.1 0.4 1.0 0.1 0.0 0.2 -0.5
Heart attack 0.4 0.5 0.8 0.8 -0.6 0.9 -0.8 -0.5 -0.4 0.0 -0.6 -0.9
Allergy 0.3 0.8 2.5 0.8 -1.4 -0.2 -0.0 -1.6 0.3 0.0 0.4 1.3
Pain all over the body in last month 1.0 1.0 2.1 1.3 -1.4 0.3 -1.1 -1.2 -1.1 0.0 -1.0 -0.7
Diabetes (self-reported) 0.4 0.6 4.8 0.4 -0.2 2.2 -0.4 -0.3 -0.3 0.0 -0.4 0.4
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 3.2 -1.6 1.7 -1.6 1.3 1.8 1.4 0.0 1.1 0.3
Medication: Ramipril 1.4 1.8 3.4 1.7 -1.5 1.2 -1.7 -0.8 -1.5 0.0 -1.9 0.7
Medication: Simvastatin 3.4 4.9 17.6 1.9 -3.8 2.5 -0.7 -4.2 -0.4 0.0 -0.0 1.5
Fluid intelligence score 0.7 1.4 2.9 -1.6 1.7 -0.6 1.2 1.6 1.1 0.0 1.1 0.8
Illnesses of siblings 1.5 2.2 3.1 -1.8 1.6 -1.6 1.8 1.4 1.5 0.0 1.7 0.9
Neuroticism score 0.4 0.8 2.3 -1.0 0.3 -0.9 1.3 -0.1 1.1 0.0 1.5 -0.4
Weight 1.2 5.7 12.0 1.7 0.3 2.5 -2.7 0.8 -3.5 0.0 -3.3 -3.4
Impedance of arm (right) 0.3 1.3 4.5 -0.5 -0.4 -1.2 1.0 -0.6 1.4 0.0 1.4 2.1
Arm fat percentage (right) 1.4 5.5 14.8 1.7 -0.1 2.8 -2.5 0.3 -3.2 0.0 -2.8 -3.9
Trunk fat-free mass 0.1 0.6 1.2 0.0 1.0 1.1 -0.4 1.0 -0.9 0.0 -0.9 -0.8
Hip circumference 0.7 3.1 9.2 0.5 1.3 1.6 -1.5 1.4 -2.4 0.0 -2.1 -3.0
Time employed in main current job 1.0 1.1 2.6 -1.6 0.8 -0.7 1.5 0.5 1.2 0.0 1.6 -0.2
Alcohol intake versus 10 years previously 0.6 0.9 2.2 1.0 -0.4 0.0 -1.4 0.4 -1.4 0.0 -1.5 -0.5
Father’s age at death 0.2 0.2 1.2 0.1 -0.3 1.1 -0.1 0.0 -0.6 0.0 -0.4 -0.4
Worrier / anxious feelings 0.2 0.4 2.6 -0.4 0.0 -1.6 0.5 -0.3 0.2 0.0 0.6 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.5 -0.1 0.1 1.2 0.5 -0.4 0.7 0.0 0.7 -0.4
Falls in the last year 1.2 1.6 2.9 -1.7 1.7 -0.0 1.5 1.3 1.4 0.0 1.5 -0.6
Hair/balding pattern: Pattern 3 1.7 2.6 5.0 -1.8 1.5 -1.0 1.9 1.6 1.7 0.0 1.7 2.2
Number of live births 1.0 1.4 3.6 1.2 -0.6 -0.8 -1.7 0.3 -1.8 0.0 -1.9 0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.3 -0.1 -0.3 1.5 0.4 -0.4 0.4 0.0 0.3 1.2
Pulse rate 0.1 0.3 0.8 0.7 -0.3 -0.5 -0.5 -0.2 -0.3 0.0 -0.4 0.9
Happiness 0.7 0.8 3.2 0.4 -1.3 0.4 -0.1 -1.5 0.4 0.0 0.1 -1.8
Noisy workplace 1.1 1.3 2.8 1.4 -1.7 1.1 -0.9 -1.6 -0.8 0.0 -0.8 -1.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.5 -0.9 1.1 0.4 0.6 1.2 0.9 0.0 0.5 0.6
Serious illness, injury or assault of a close relative in last 2 years 2.5 2.9 5.4 -2.1 2.3 -1.1 1.7 2.2 2.3 0.0 1.4 -0.7
Mouth/teeth dental problems: Dentures 3.1 5.3 9.4 3.1 -2.5 1.9 -3.0 -2.1 -2.5 0.0 -3.0 -0.5
Asthma 0.8 1.6 5.2 -1.7 2.2 -0.5 0.8 2.3 0.4 0.0 0.4 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 3.4 0.0 0.8 1.8 -0.3 1.1 -0.4 0.0 -0.4 -1.1
Medication: Cholesterol lowering 0.5 0.8 2.1 0.7 -1.3 1.4 -0.2 -1.4 0.4 0.0 -0.0 0.7
Depression (self-reported) 0.4 0.4 1.1 -0.3 -0.1 0.6 0.6 -0.6 1.0 0.0 0.8 -1.0
Medication: Lansoprazole 0.3 0.3 1.1 0.6 -0.6 1.1 -0.6 -0.6 -0.3 0.0 -0.5 -0.4
Prospective memory result 3.0 3.7 6.1 -2.5 2.1 -1.2 2.4 1.8 2.2 0.0 2.3 1.5
Lung cancer (father) 0.6 0.8 3.4 0.7 -0.9 0.9 -0.4 -1.0 -0.2 0.0 -0.2 1.8
Illnesses of mother 0.2 0.3 0.7 0.2 -0.3 -0.6 -0.6 0.2 -0.8 0.0 -0.8 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.0 0.4 -0.8 1.0 0.1 -0.8 0.3 0.0 0.1 0.9
Pulse wave Arterial Stiffness index 0.5 0.6 1.6 0.7 0.4 -0.9 -1.0 0.5 -1.0 0.0 -1.3 0.4
Impedance of arm (left) 0.1 0.7 2.6 0.1 -0.6 -1.6 0.1 -0.5 0.5 0.0 0.4 1.6
Arm fat mass (right) 1.5 6.3 14.1 1.8 0.0 3.0 -2.8 0.5 -3.4 0.0 -3.2 -3.8
Trunk predicted mass 0.1 0.7 1.3 0.1 1.0 1.1 -0.4 1.0 -0.9 0.0 -0.9 -0.9
Standing height 0.0 0.4 2.5 0.3 0.3 -0.8 -0.2 0.3 -0.2 0.0 -0.7 1.6
Length of working week for main job 1.0 1.1 5.2 -0.7 1.9 -0.6 0.3 2.3 0.4 0.0 -0.1 0.3
Exposure to tobacco smoke at home 2.0 2.3 6.0 -1.8 1.2 -0.5 1.9 0.9 2.5 0.0 2.1 0.8
Breastfed as a baby 0.2 0.2 0.6 -0.3 0.8 0.3 0.3 0.8 0.5 0.0 0.1 0.6
Tense / ‘highly strung’ 1.6 2.6 7.2 -1.9 0.8 -0.8 2.4 0.4 2.3 0.0 2.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.7 0.4 -0.4 1.3 -0.0 -1.1 -0.1 0.0 0.1 -0.2
Hair/balding pattern: Pattern 4 1.2 3.0 7.1 -0.4 -1.4 1.5 1.9 -2.7 1.8 0.0 2.4 1.8
Birth weight of first child 1.4 2.5 6.4 -2.0 2.4 -1.5 1.5 2.5 0.8 0.0 1.2 0.2
Peak expiratory flow (PEF) 0.1 0.3 0.9 -0.4 0.7 0.9 0.2 0.9 -0.1 0.0 -0.1 0.5
Pulse wave reflection index 0.4 0.5 1.8 -0.6 1.3 -1.1 0.3 1.0 0.4 0.0 0.0 0.3
Ever highly irritable/argumentative for 2 days 1.5 1.8 2.9 -1.7 1.7 -1.6 1.6 1.4 1.2 0.0 1.3 -0.5
Loud music exposure frequency 0.5 0.5 1.0 -0.5 1.0 0.5 0.7 0.9 0.8 0.0 0.6 0.9
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.3 -0.3 0.4 0.8 0.5 0.1 0.3 0.0 0.5 1.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.3 -0.7 -0.1 0.6 1.0 -0.5 0.7 0.0 1.1 0.3
Blood clot in the leg (DVT) 0.0 0.0 0.2 0.1 -0.1 0.1 0.1 -0.2 -0.3 0.0 0.2 0.5
Medication: Paracetamol 1.4 2.3 5.2 1.9 -0.8 0.5 -2.1 0.0 -2.2 0.0 -2.3 -1.1
Headache pain in last month 0.2 0.4 2.9 0.4 -0.1 1.7 -0.3 -0.2 -0.0 0.0 -0.3 0.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.3 -1.1 0.9 -1.1 0.8 0.7 0.3 0.0 0.8 -0.9
Glaucoma (self-reported) 0.2 0.3 0.5 -0.2 0.5 -0.5 -0.3 0.7 -0.7 0.0 -0.4 -0.7
Gout (self-reported) 0.1 0.2 0.6 -0.3 0.2 0.7 0.5 0.2 0.7 0.0 0.4 0.4
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 4.7 -0.7 -1.1 1.0 1.9 -1.6 1.8 0.0 2.2 1.4
Medication: Amlodipine 0.5 0.7 2.1 1.1 -1.5 0.8 -0.7 -1.1 -0.4 0.0 -0.6 -0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.7 0.5 -0.4 1.3 -0.7 -0.1 -0.7 0.0 -0.7 -0.6
Birth weight 1.2 2.6 6.7 -2.0 0.8 0.3 2.5 0.3 1.6 0.0 2.6 1.8
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.9 0.2 -0.2 -0.5 -0.6 0.4 -0.2 0.0 -0.6 -0.9
High blood pressure (siblings) 1.4 2.0 5.1 1.6 -2.2 1.3 -1.3 -2.2 -1.0 0.0 -0.9 0.2
Forced vital capacity (FVC), Best measure 0.1 0.3 0.8 0.7 -0.9 0.7 -0.4 -0.8 -0.1 0.0 -0.5 0.4
Body fat percentage 1.7 6.8 13.4 2.1 -0.5 3.2 -3.0 -0.1 -3.6 0.0 -3.2 -3.7
Leg fat percentage (right) 1.9 6.9 14.3 2.3 -0.8 3.8 -3.0 -0.5 -3.6 0.0 -3.1 -3.2
Arm fat-free mass (right) 0.5 2.5 5.5 1.1 0.5 1.7 -1.7 0.8 -2.2 0.0 -2.4 -1.9
Exposure to tobacco smoke outside home 0.3 0.4 1.0 0.6 -0.5 0.8 -0.5 -0.6 -0.1 0.0 -0.5 -1.0
Comparative body size at age 10 0.5 1.3 5.9 -0.0 0.1 2.4 -0.2 -0.0 -0.6 0.0 -0.3 -2.4
Number of full brothers 1.2 1.5 6.8 0.3 -0.3 1.9 -0.6 -0.5 -1.3 0.0 -0.5 -2.6
Worry too long after embarrassment 1.1 1.9 4.7 -1.0 -0.7 -0.2 1.8 -1.3 2.0 0.0 2.2 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 4.6 1.1 -1.9 1.3 -0.7 -2.1 -0.5 0.0 -0.3 -1.5
Wheeze or whistling in the chest in last year 2.0 3.6 7.8 2.0 -2.1 2.8 -2.2 -1.7 -1.8 0.0 -2.1 -0.4
Number of children fathered 2.2 2.5 7.2 1.6 -0.1 0.7 -2.3 0.5 -2.7 0.0 -2.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 6.3 -1.0 -0.4 0.9 1.8 -1.1 1.9 0.0 2.1 2.5
Age at first live birth 1.8 3.1 5.2 -2.3 2.2 -1.8 2.0 2.0 1.8 0.0 1.8 0.3
Pulse wave peak to peak time 0.4 0.4 1.1 -0.5 -0.4 0.8 0.8 -0.6 0.8 0.0 1.0 -0.4
Health satisfaction 1.0 1.3 3.5 1.1 -1.7 1.6 -0.8 -1.9 -0.3 0.0 -0.6 -0.3
Shortness of breath walking on level ground 1.3 1.6 2.9 1.6 -1.7 0.9 -1.4 -1.3 -1.5 0.0 -1.3 -0.6
Qualifications: College or University degree 0.2 0.5 2.7 0.3 0.2 -1.1 -0.5 0.3 0.2 0.0 -0.7 1.6
Eye problems/disorders: None of the above 0.9 1.1 3.2 -1.1 1.1 -0.6 1.2 1.0 1.8 0.0 1.2 0.0
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.9 -0.8 0.3 0.3 0.9 0.3 1.7 0.0 1.1 1.2
Emphysema/chronic bronchitis 0.3 0.3 1.3 -0.4 0.3 1.1 0.1 0.5 0.2 0.0 0.1 -1.1
Medication for pain relief, constipation, heartburn 1.5 2.5 4.0 -2.0 1.6 -1.9 2.0 0.8 1.8 0.0 1.9 1.1
Neck or shoulder pain in last month 0.4 0.5 1.4 0.6 -0.3 0.9 -1.0 0.2 -0.6 0.0 -1.0 -1.2
Medication: Blood pressure 0.7 1.2 2.4 1.6 -1.0 0.9 -1.5 -0.5 -0.8 0.0 -1.5 1.0
Angina (self-reported) 1.7 2.3 4.5 2.0 -2.1 0.9 -1.9 -1.8 -1.0 0.0 -1.7 -0.3
Migraine (self-reported) 2.2 2.7 5.8 2.2 -1.0 1.1 -2.2 -1.0 -2.2 0.0 -2.4 -0.9
Medication: Ibuprofen 0.8 0.9 2.7 -0.5 1.4 1.5 0.1 1.7 -0.1 0.0 -0.0 -0.9
Medication: Allopurinol 0.4 0.5 0.9 -0.5 0.3 0.9 0.9 0.0 0.9 0.0 1.0 0.7
Medication: Omeprazole 0.4 0.5 1.2 1.0 -1.1 0.1 -0.7 -0.9 -0.6 0.0 -0.5 0.9
Medication: Seretide 50 evohaler 0.4 0.4 2.3 -0.4 1.0 0.2 -0.0 1.5 0.4 0.0 -0.3 0.3
Mean time to correctly identify matches 2.0 3.9 11.6 -1.5 -0.7 0.2 2.6 -1.8 3.4 0.0 3.3 0.1
Heart disease (mother) 1.0 1.2 2.5 1.6 -0.9 1.0 -1.4 -0.8 -1.2 0.0 -1.3 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.1 3.7 9.6 2.4 -1.4 1.0 -2.6 -0.7 -3.1 0.0 -2.7 -0.8
Whole body fat mass 1.7 7.3 14.3 2.1 -0.3 3.5 -3.1 0.2 -3.6 0.0 -3.5 -3.8
Leg fat mass (right) 1.9 7.4 15.1 2.2 -0.3 3.9 -3.0 -0.0 -3.7 0.0 -3.4 -3.6
Arm predicted mass (right) 0.4 2.2 4.3 0.9 0.7 1.9 -1.4 0.9 -2.0 0.0 -2.1 -1.8
Pulse rate, automated reading 0.4 1.3 5.2 1.3 -1.1 0.3 -0.8 -1.2 -0.7 0.0 -0.7 2.3
Alcohol intake frequency. 0.7 1.7 3.9 1.6 -0.8 0.6 -2.0 -0.1 -1.7 0.0 -1.9 -1.3
Comparative height size at age 10 0.1 0.8 2.8 1.2 -0.2 0.8 -1.2 -0.2 -1.0 0.0 -1.7 -0.3
Number of full sisters 1.1 1.3 3.2 1.6 -1.1 -0.2 -1.5 -0.5 -1.8 0.0 -1.5 -0.6
Suffer from ‘nerves’ 0.4 0.6 2.7 -0.5 0.1 -0.3 1.0 -0.4 0.7 0.0 1.0 1.6
Overall health rating 1.8 3.8 9.8 2.1 -2.8 2.9 -1.3 -3.1 -1.1 0.0 -0.8 0.7
Chest pain or discomfort 1.1 1.6 4.0 1.5 -2.0 1.4 -1.2 -1.7 -0.9 0.0 -0.9 0.4
Had major operations 0.2 0.3 2.1 -0.1 0.0 1.4 -0.0 0.2 -0.2 0.0 -0.1 0.3
Age at last live birth 2.7 3.9 6.9 -2.6 2.4 -1.8 2.4 2.1 2.0 0.0 2.2 0.4
Family relationship satisfaction 3.6 4.4 7.0 2.3 -2.6 2.5 -1.9 -2.6 -1.2 0.0 -1.6 -2.5
Leg pain on walking 1.8 2.2 5.7 1.7 -1.9 2.4 -1.2 -1.9 -1.4 0.0 -1.1 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 7.0 0.8 -0.8 2.6 -0.6 -0.8 -0.3 0.0 -0.5 -0.8
Commuting to job workplace: Car/motor vehicle 0.7 0.8 5.1 -0.7 0.6 2.3 0.6 0.3 -0.7 0.0 0.5 0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.5 0.2 -0.4 -1.0 0.2 -0.7 -0.2 0.0 0.3 1.6
Medication: Aspirin 1.6 2.1 4.9 1.5 -2.2 2.0 -0.8 -2.2 -0.2 0.0 -0.4 1.4
Supplements: Vitamin C 1.6 1.9 4.1 1.5 -1.3 0.1 -1.7 -0.9 -2.0 0.0 -1.7 -1.4
Knee pain experienced in last month 0.6 0.9 3.3 0.3 -0.9 1.8 0.3 -1.1 0.6 0.0 0.7 1.4
Hypertension (Self-reported) 1.9 5.4 10.6 3.2 -3.0 2.3 -2.7 -2.6 -1.9 0.0 -2.3 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 1.0 -0.1 0.3 0.6 0.0 0.4 -0.0 0.0 0.1 1.0
Illnesses of father: Heart disease 0.2 0.3 0.9 -0.4 0.6 0.9 0.3 0.5 0.1 0.0 0.3 0.9
Illnesses of siblings: Diabetes 0.6 0.7 1.4 -1.1 0.7 0.4 1.1 0.5 1.2 0.0 1.1 0.4
Smoking status: Previous 1.8 2.7 4.2 1.7 -1.6 2.1 -1.7 -1.5 -1.4 0.0 -1.8 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.7 1.0 -0.4 -1.4 -1.3 0.4 -1.4 0.0 -1.9 -0.7
Whole body fat-free mass 0.3 1.6 3.6 0.5 0.8 1.6 -1.0 1.0 -1.5 0.0 -1.6 -1.9
Leg fat-free mass (right) 0.6 3.4 11.5 0.8 0.7 2.1 -1.6 1.1 -2.1 0.0 -2.3 -3.4
Arm fat percentage (left) 1.6 6.5 15.5 1.9 -0.2 2.9 -2.9 0.4 -3.6 0.0 -3.2 -3.9
Average weekly red wine intake 0.9 1.3 3.0 -1.4 0.6 -0.1 1.6 0.1 1.7 0.0 1.7 1.1
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.5 0.1 -0.6 -0.7 0.3 -1.0 1.1 0.0 0.4 1.2
Mood swings 0.1 0.3 1.1 -0.6 0.7 -0.0 0.4 0.5 -0.1 0.0 0.3 -1.0
Loneliness, isolation 1.4 2.0 7.2 1.4 -0.7 0.6 -1.6 -0.7 -1.4 0.0 -1.7 -2.7
Long-standing illness, disability or infirmity 1.1 1.6 3.5 1.4 -1.9 1.5 -1.1 -1.8 -1.3 0.0 -0.8 0.2
Ever had bowel cancer screening 0.1 0.1 0.3 -0.1 0.2 -0.6 -0.0 0.2 -0.5 0.0 0.1 0.2
Diabetes diagnosed by doctor 0.4 0.7 5.5 0.4 -0.4 2.4 -0.4 -0.3 -0.2 0.0 -0.4 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.8 -1.3 2.1 -2.2 0.7 2.0 0.9 0.0 0.5 -0.8
Friendships satisfaction 0.9 1.2 4.5 0.8 -1.6 1.0 -0.3 -2.1 0.2 0.0 0.1 -1.3
Qualifications: nursing, teaching 0.2 0.4 1.8 0.2 0.2 1.4 -0.2 0.1 -0.1 0.0 -0.2 1.1
Commuting to job workplace: Walk 0.7 0.8 5.1 -0.4 -0.1 -2.3 0.6 -0.2 0.9 0.0 0.7 0.0
Eye problems/disorders: Cataract 1.9 2.2 4.1 1.7 -2.0 0.2 -1.6 -2.0 -1.9 0.0 -1.2 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.7 -0.5 0.9 -0.6 0.1 0.5 0.5 0.0 0.1 -0.5
Medication for cholesterol 3.5 5.2 10.3 -3.0 3.2 -2.2 2.4 3.0 2.0 0.0 2.1 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.7 0.6 -0.2 0.6 0.8 0.2 0.0 0.6 -0.8
Back pain experienced in last month 0.9 1.3 4.7 1.1 -0.1 -0.7 -1.3 0.3 -2.2 0.0 -1.6 -1.2
Mineral and other dietary supplements 0.5 0.7 1.1 -0.8 1.0 -1.1 0.7 1.0 0.8 0.0 0.7 0.9
Breast cancer (self-reported) 0.1 0.1 0.4 -0.2 -0.3 -0.7 0.1 -0.3 0.2 0.0 0.3 0.3
Asthma (self-reported) 0.9 1.8 5.1 -1.8 2.3 -0.4 1.1 2.2 0.6 0.0 0.7 -0.5
Osteoporosis (self-reported) 1.5 1.9 6.8 -1.5 2.1 -1.6 0.6 2.6 0.3 0.0 0.3 -1.0
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.2 0.2 -0.2 0.2 0.3 0.4 0.0 0.4 0.6
Medication: Aspirin 1.3 1.7 3.6 1.4 -1.9 1.9 -0.7 -1.9 -0.3 0.0 -0.3 1.4
Medication: Gliclazide 1.3 1.5 2.9 1.6 -1.4 1.7 -1.4 -1.0 -1.2 0.0 -1.2 -0.4
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 -0.7 0.8 -0.3 0.7 0.6 0.7 0.0 0.6 1.1
Smoking status: Current 1.3 2.1 4.1 1.8 -1.7 2.0 -1.2 -1.7 -0.6 0.0 -0.9 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 -0.9 0.7 -0.3 1.0 0.5 0.8 0.0 1.1 0.1
Whole body water mass 0.3 1.7 3.8 0.5 0.9 1.6 -1.0 1.1 -1.6 0.0 -1.7 -1.9
Leg predicted mass (right) 0.6 3.4 11.4 0.8 0.7 2.1 -1.6 1.1 -2.1 0.0 -2.3 -3.4
Arm fat mass (left) 1.8 7.6 16.0 2.1 -0.1 3.2 -3.1 0.5 -3.9 0.0 -3.6 -4.0
Number of self-reported non-cancer illnesses 0.2 0.3 1.0 -0.4 0.5 0.1 0.2 1.0 0.2 0.0 0.1 1.0
Average weekly champagne plus white wine intake 1.1 1.5 3.1 -1.5 1.8 0.6 1.3 1.3 1.3 0.0 1.1 1.2
Miserableness 0.2 0.3 0.8 -0.5 -0.2 -0.5 0.8 -0.4 0.5 0.0 0.9 -0.7
Guilty feelings 1.2 1.9 3.6 -1.7 1.1 -1.1 1.9 0.5 1.8 0.0 1.9 -1.0
Wears glasses or contact lenses 0.4 0.5 1.0 -1.0 0.8 -0.0 0.8 0.4 1.0 0.0 0.9 0.3
Ever taken oral contraceptive pill 0.1 0.1 0.3 -0.6 0.5 0.1 0.2 0.5 -0.4 0.0 0.1 -0.3
Hearing aid user 1.0 1.1 3.2 1.0 -0.8 1.8 -1.2 -0.7 -0.9 0.0 -1.0 -1.3
Mother’s age at death 1.2 1.5 4.0 -1.3 1.3 -2.0 1.0 1.7 1.1 0.0 0.8 0.6
Financial situation satisfaction 0.6 0.7 1.8 -0.7 -0.2 -1.4 0.8 -0.2 1.0 0.0 0.7 -1.3
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.1 -1.1 0.4 -0.4 1.6 -0.5 0.9 0.0 1.8 0.1
Commuting to job workplace: Public transport 2.7 3.2 7.6 -1.7 1.1 -2.8 1.9 0.7 2.6 0.0 1.9 1.7
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 0.1 0.3 -0.6 -0.4 0.5 -0.6 0.0 -0.6 -0.4
Medication: Blood pressure 2.1 3.9 8.4 2.6 -2.9 1.8 -2.2 -2.5 -1.5 0.0 -1.9 0.5
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.6 1.5 -0.7 0.3 -1.7 0.0 -1.6 0.0 -1.9 -1.1
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.7 1.0 -1.3 1.5 -0.5 -1.6 -0.8 0.0 -0.4 -0.7
High cholesterol (Self-reported) 1.9 3.4 9.5 1.4 -2.7 3.1 -0.2 -3.0 0.5 0.0 0.4 1.7
Medication: Bendroflumethiazide 0.2 0.3 1.2 0.4 -0.6 0.1 -0.2 -0.5 0.6 0.0 -0.0 1.1
Medication: Paracetamol 1.3 2.0 4.7 1.6 -0.6 0.4 -1.9 0.1 -2.2 0.0 -2.1 -1.3
Medication: Lisinopril 2.8 3.6 7.1 2.7 -2.1 1.2 -2.5 -1.9 -2.0 0.0 -2.3 0.1
Medication: Atorvastatin 1.2 1.5 3.2 1.8 -0.9 1.4 -1.7 -0.5 -1.1 0.0 -1.7 -0.6
Illnesses of father: High blood pressure 0.8 1.0 1.7 1.3 -1.3 0.9 -1.2 -0.8 -1.0 0.0 -1.1 -0.2
Alcohol drinker status: Never 0.5 0.6 1.2 -0.8 0.9 -1.1 0.6 1.1 0.8 0.0 0.6 0.3
Ever smoked 1.6 2.8 8.5 1.9 -2.3 2.9 -1.4 -2.1 -0.4 0.0 -1.2 -0.1
Basal metabolic rate 0.5 2.7 6.2 0.8 0.8 2.0 -1.5 1.1 -2.2 0.0 -2.2 -2.5
Leg fat percentage (left) 2.2 8.0 15.8 2.5 -1.1 4.0 -3.2 -0.7 -3.8 0.0 -3.4 -3.4
Arm fat-free mass (left) 0.4 1.9 4.1 0.6 0.8 2.0 -1.1 0.9 -1.8 0.0 -1.8 -1.9
Number of operations (self-reported) 0.5 0.7 3.7 -0.4 0.5 1.9 0.5 0.3 0.3 0.0 0.6 1.4
Average weekly beer plus cider intake 0.1 0.1 0.8 0.0 -0.2 -0.3 -0.0 0.1 -0.5 0.0 -0.1 -0.9
Irritability 0.3 0.6 1.1 -0.8 0.5 0.8 0.9 0.1 0.7 0.0 1.1 -1.0
Risk taking 1.2 1.7 6.2 -1.1 2.4 -0.3 0.3 2.5 -0.2 0.0 -0.2 -1.3
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.7 -1.5 1.6 -1.6 1.1 1.5 1.1 0.0 0.9 0.3
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.4 0.2 0.4 0.4 0.1 0.2 0.0 0.4 0.1
Age started oral contraceptive pill 0.3 0.4 3.0 -0.2 0.1 -1.7 0.2 0.2 0.3 0.0 0.3 0.8
Diastolic blood pressure, automated reading 1.8 5.5 9.1 2.9 -3.0 2.0 -2.0 -3.0 -2.3 0.0 -1.8 2.7
Ever depressed for a whole week 1.5 1.8 3.2 1.8 -1.8 1.0 -1.7 -1.5 -1.0 0.0 -1.7 -0.3
Unable to work because of sickness or disability 0.7 0.9 5.4 0.5 0.0 0.9 -0.7 0.0 -0.6 0.0 -0.8 -2.3
Commuting to job workplace: Cycle 0.4 0.5 1.6 0.7 -0.5 -0.2 -0.8 -0.5 -0.8 0.0 -0.8 -1.2
Myopia 0.2 0.3 0.9 -0.3 0.5 -0.3 0.3 0.4 0.5 0.0 0.6 -1.0
Vascular/heart problems diagnosed by doctor 1.3 3.6 7.6 -2.6 2.8 -1.5 1.9 2.4 1.3 0.0 1.5 -1.5
Cholesterol lowering medication 5.7 8.4 21.8 3.4 -4.5 3.3 -2.2 -4.7 -1.8 0.0 -1.4 0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.1 1.0 -0.8 -0.5 -1.1 -0.3 -0.9 0.0 -0.9 0.0
Pain experienced in last month 0.3 0.5 1.0 -0.5 0.0 -0.1 0.9 -0.5 1.0 0.0 1.0 0.9
Supplements: Calcium 0.1 0.1 0.5 -0.2 0.1 -0.7 0.2 0.1 0.2 0.0 0.3 0.0
Basal cell carcinoma (self-reported) 2.5 3.0 5.6 -1.4 0.5 -2.3 2.0 -0.2 2.4 0.0 2.3 2.1
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.9 0.8 -0.6 0.8 -0.9 -0.5 -0.5 0.0 -0.7 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.3 -0.0 -0.0 -0.3 0.2 -0.2 -0.1 0.0 0.3 0.5
Heart disease (siblings) 2.0 2.4 3.8 1.9 -1.6 1.6 -1.9 -1.4 -1.7 0.0 -1.9 -0.9
Alcohol drinker status: Previous 0.9 1.1 3.1 0.1 -1.0 1.1 0.8 -1.8 1.3 0.0 1.2 0.7
Pack years of smoking 0.4 0.5 1.6 -0.3 0.5 0.8 0.5 0.4 1.1 0.0 0.6 1.2
Impedance of whole body 0.2 1.1 4.8 0.7 -1.3 -0.9 -0.1 -1.3 0.2 0.0 0.2 2.2
Leg fat mass (left) 2.2 8.8 16.7 2.4 -0.6 4.1 -3.3 -0.2 -4.0 0.0 -3.7 -3.9
Arm predicted mass (left) 0.5 2.3 5.2 0.8 0.6 2.3 -1.3 0.8 -2.0 0.0 -1.9 -2.1