TWAS hub - TRAF3IP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.2800	0.1000	1.7e-03	0.170	NA	0.145	NA	0.178	3.9e-05	NA	1.5e-04	NA	2.6e-05
2	GTEx	Testis	0.1510	0.0590	5.3e-03	0.025	NA	0.028	NA	0.021	2.7e-02	NA	2.1e-02	NA	4.0e-02
3	GTEx	Whole Blood	0.2100	0.0480	1.7e-10	0.029	NA	0.111	NA	0.106	9.1e-04	NA	2.0e-10	NA	5.8e-10
4	METSIM	Adipose	0.0395	0.0183	4.6e-03	0.010	0.011	-0.002	NA	0.003	9.3e-03	6.4e-03	8.6e-01	NA	9.4e-02
5	NTR	Blood	0.0506	0.0135	8.1e-13	0.039	0.046	0.048	0.047	0.053	1.5e-12	1.7e-14	3.4e-15	6.6e-15	1.7e-16
6	YFS	Blood	0.2282	0.0354	0.0e+00	0.115	0.189	0.210	0.210	0.205	1.8e-35	1.0e-59	8.3e-67	9.9e-67	3.4e-65
7	TCGA	Breast Invasive Carcinoma	0.0162	0.0115	7.7e-03	0.003	0.007	0.005	NA	0.003	8.3e-02	1.0e-02	3.0e-02	NA	6.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Cholesterol lowering medication	7.1	10.5	21.3	4.3	0.8	1.1	4.2	4.6	1.5	3.3
Ulcerative Colitis (UC)	4.2	7.8	19.0	4.4	2.7	2.0	3.5	2.7	-0.7	2.1
Stomach or abdominal pain in last month	4.2	5.3	10.6	3.0	-0.9	2.2	1.7	2.7	1.2	3.3
Medication: Simvastatin	4.2	6.2	12.5	3.5	1.5	0.1	3.2	3.5	0.9	2.4
Current tobacco smoking	4.1	6.7	13.5	2.6	-0.9	3.7	3.5	2.1	0.2	3.0
Angina	4.0	5.3	9.4	3.1	-1.8	2.0	1.9	2.4	1.8	2.8
Angina (self-reported)	3.8	5.0	8.9	3.0	-1.9	1.9	1.7	2.5	1.7	2.7
Family relationship satisfaction	3.8	4.7	7.4	2.6	-1.5	1.4	2.0	2.7	2.4	2.2
Smoking status: Current	3.8	6.1	11.1	2.5	-1.3	3.3	3.2	2.1	0.4	2.9
Blood Red Count	3.7	36.0	79.7	-8.9	1.3	-4.5	-4.1	-7.6	-3.2	-8.1
Blood White Count	3.6	26.6	40.4	5.7	-1.8	6.3	5.9	5.3	2.8	6.4
Irritable Bowel Disease (IBD)	3.4	8.1	18.8	2.9	4.3	2.7	3.8	1.8	-1.6	1.2
Medication: Blood pressure	3.4	6.4	12.5	2.4	-0.4	2.2	3.0	3.5	1.9	2.9
Bipolar Disorder (2018)	3.3	5.1	9.3	2.7	-1.2	2.2	1.9	2.6	1.8	3.1
Medication: Aspirin	3.2	4.2	9.7	2.4	0.1	2.0	3.1	2.0	0.3	2.5
Hypertension (Self-reported)	3.2	9.0	17.4	2.7	-1.1	3.7	4.2	2.7	1.3	3.8
Noisy workplace	3.0	3.7	6.6	1.6	0.2	1.5	2.5	2.1	2.6	1.8
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	8.2	1.0	-0.6	0.5	1.5	2.6	2.9	1.8
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	4.8	-2.1	-1.0	-2.0	-2.1	-2.1	-1.9	-2.2
Medication for cholesterol	2.9	4.5	11.4	-2.0	0.5	-1.5	-2.2	-3.4	-1.9	-2.2
Systolic Blood Pressure	2.8	13.9	32.5	3.1	0.8	3.2	5.7	4.2	2.9	4.2
Wheeze or whistling in the chest in last year	2.8	5.1	8.7	2.6	-1.6	2.0	3.0	2.2	1.2	2.7
Medication for pain relief, constipation, heartburn	2.7	4.6	10.9	-1.2	1.0	-3.3	-2.6	-2.0	-1.2	-2.6
Medication: Metformin	2.5	3.5	11.7	2.1	0.0	1.3	3.4	1.9	0.4	1.7
Neuroticism	2.4	5.7	12.1	-1.2	1.4	-3.3	-3.5	-1.6	-1.0	-3.2
Age at last live birth	2.4	3.4	5.2	-1.0	1.8	-2.3	-1.9	-1.9	-1.7	-2.1
High cholesterol (Self-reported)	2.4	4.3	10.2	3.0	0.9	1.1	3.2	2.5	-0.0	1.7
Medication: Atorvastatin	2.4	2.9	6.8	1.5	-1.7	2.6	1.9	0.9	0.1	2.0
Neuroticism (Nagel 2018)	2.3	5.4	12.6	-0.7	1.6	-3.5	-3.5	-1.1	-0.3	-2.9
Cardiovascular Disease	2.3	7.5	15.7	2.2	-1.7	3.8	4.0	2.0	0.7	3.1
Medication: Lisinopril	2.3	3.0	5.1	1.4	-1.4	1.9	1.9	1.7	1.3	2.3
High blood pressure	2.2	6.1	13.8	2.4	-0.4	3.0	3.7	2.1	0.7	2.9
Medication: Atenolol	2.2	2.8	5.2	2.0	-0.2	1.7	2.3	1.8	-0.2	2.1
Mean time to correctly identify matches	2.2	4.1	11.0	2.9	3.3	-1.0	1.2	1.3	-2.3	0.4
Medication: Aspirin	2.2	2.9	6.9	1.9	0.1	1.7	2.6	1.7	0.2	2.0
Blood Platelet Count	2.1	23.8	37.6	5.6	0.2	4.3	6.1	5.7	3.7	5.8
Hair/balding pattern: Pattern 3	2.1	3.2	7.1	-1.5	1.6	-0.6	-0.7	-2.7	-2.5	-1.7
Prospective memory result	2.1	2.6	7.8	-1.0	1.0	-0.6	-1.7	-1.7	-1.5	-2.8
Hearing aid user	2.1	2.3	4.7	1.6	-0.9	1.3	2.2	1.5	1.0	1.9
Basal cell carcinoma (self-reported)	2.1	2.5	6.6	-0.3	2.1	-1.3	-0.3	-1.2	-2.6	-1.7
Heart disease (siblings)	2.1	2.6	5.7	0.9	-2.4	1.0	0.9	1.8	2.2	1.5
Ulcerative Colitis	2.0	2.9	8.8	1.8	3.0	0.3	2.1	0.6	-1.9	-0.2
Smoking Status	2.0	4.9	7.6	1.8	-2.8	2.0	1.9	2.4	1.5	2.8
Worrier / anxious feelings	2.0	3.8	10.7	-1.1	0.3	-2.8	-3.3	-1.3	-0.3	-2.2
Lung cancer (father)	2.0	2.4	5.7	1.2	0.2	2.0	2.4	1.4	1.3	1.4
Age at first live birth	2.0	3.6	5.9	-1.6	0.9	-2.0	-1.5	-2.4	-2.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.2	-1.2	-2.0	-0.8	-2.1	-1.7	-0.4	-1.3
Medication: Gliclazide	2.0	2.3	5.7	1.6	-0.4	1.6	2.4	1.4	0.3	1.7
Guilty feelings	2.0	3.0	7.8	-1.0	0.8	-2.4	-2.0	-1.0	-0.8	-2.8
Crohns Disease (2017)	1.9	4.2	17.8	0.3	4.2	1.8	2.2	0.1	-1.9	-0.2
Medication: Ramipril	1.9	2.5	3.9	0.9	-2.0	1.9	1.4	1.7	1.1	1.7
Shortness of breath walking on level ground	1.9	2.2	5.0	2.2	-0.2	1.3	1.6	1.7	0.8	1.6
Suffer from ‘nerves’	1.9	2.9	5.3	-1.7	2.0	-2.2	-1.1	-1.4	-0.3	-2.3
Vascular/heart problems diagnosed by doctor	1.9	5.1	9.5	-2.4	1.0	-2.6	-3.1	-2.1	-0.9	-2.7
Alzheimer’s Disease (including proxy)	1.8	2.6	7.7	-0.2	2.3	-2.8	0.3	-1.0	-1.7	-1.0
Crohns Disease (2012)	1.8	2.9	6.2	0.5	2.5	1.8	2.4	-0.2	-2.1	0.0
Systolic blood pressure, automated reading	1.8	5.2	19.0	1.3	1.9	1.2	4.4	2.0	1.6	2.1
Chronic bronchitis/emphysema (father)	1.8	2.1	4.5	1.4	-1.4	0.4	0.2	2.1	2.1	1.4
Heart attack	1.8	2.3	3.2	1.8	-1.5	1.2	1.3	1.7	1.3	1.8
High blood pressure (siblings)	1.8	2.6	6.3	2.5	-0.6	1.0	1.5	2.0	0.8	1.9
Worry (Nagel 2018)	1.7	3.7	8.9	-0.6	2.1	-3.0	-1.9	-1.1	-0.9	-2.6
Mood swings	1.7	3.0	10.3	-1.2	-0.0	-1.9	-3.2	-1.1	0.3	-2.1
Heart attack/myocardial infarction (self-reported)	1.7	2.2	3.1	1.7	-1.6	1.1	1.3	1.7	1.2	1.8
Age at First Birth	1.6	2.4	5.0	-0.3	1.4	-2.2	-1.8	-1.1	-1.7	-1.5
Diabetes (father)	1.6	1.9	2.9	1.4	-1.2	1.2	1.6	1.7	1.0	1.5
Hair/balding pattern: Pattern 2	1.6	2.0	4.4	2.1	-0.7	-0.2	1.4	2.1	0.7	1.4
Illnesses of siblings	1.6	2.2	3.2	-1.8	1.8	-1.0	-1.2	-1.5	-1.2	-1.8
Friendships satisfaction	1.6	1.9	5.0	2.0	-0.1	-0.4	0.8	2.2	1.5	1.0
Alzheimer’s Disease (in father)	1.5	1.6	7.3	-0.6	0.5	-2.7	-1.1	-1.0	-0.6	-0.8
Breast Cancer	1.5	3.6	9.7	-1.8	-1.7	-1.7	-3.1	-1.6	-0.1	-1.9
Ever had hysterectomy (womb removed)	1.5	1.7	4.1	0.5	-0.2	2.0	1.9	0.6	0.3	1.8
Mouth/teeth dental problems: Dentures	1.5	2.5	3.3	1.4	-1.4	1.4	1.8	1.6	1.6	1.8
Birth weight of first child	1.5	2.7	4.2	-1.9	-0.7	-1.4	-1.8	-2.0	-1.4	-1.8
Worry too long after embarrassment	1.5	2.4	7.8	1.2	1.4	-2.8	-1.9	-0.0	-1.2	-1.0
Neck or shoulder pain in last month	1.5	2.2	8.4	1.3	-2.9	1.0	0.3	0.8	1.4	1.2
Overall health rating	1.5	3.1	6.9	2.6	0.3	1.3	2.3	2.2	0.8	1.6
Leg pain on walking	1.5	1.9	3.5	1.6	0.5	0.5	1.2	1.9	1.6	1.8
Eye problems/disorders: Cataract	1.5	1.8	4.7	1.7	-0.7	-0.2	0.7	2.2	1.4	1.3
Ovarian Cancer	1.4	1.8	4.0	-1.4	1.0	-2.0	-1.4	-0.4	0.4	-1.9
Waist Hip Ratio (WHR)	1.4	6.2	11.2	3.0	0.2	2.9	3.4	2.9	1.0	2.4
Happiness	1.4	1.7	4.2	0.1	-1.6	-2.0	-1.9	0.4	0.7	-0.8
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.4	-1.2	0.1	-0.2	-2.3	-1.2	-0.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	6.0	0.6	2.4	0.3	1.4	-0.1	-1.7	-0.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	6.8	1.4	-0.4	2.6	1.3	0.7	0.2	0.9
Chest pain or discomfort	1.4	2.0	4.0	2.0	-0.5	1.4	1.8	1.3	0.9	1.3
Long-standing illness, disability or infirmity	1.4	2.1	3.6	1.8	-0.2	0.3	1.6	1.9	1.4	1.7
Ever taken oral contraceptive pill	1.4	1.6	4.0	-0.9	-0.3	-1.9	-2.0	-0.1	0.6	-1.4
Financial situation satisfaction	1.4	1.7	6.5	0.9	-0.7	-2.5	-1.6	0.1	0.6	-1.1
Reaction Time	1.3	2.6	6.3	2.4	2.5	-1.1	0.2	0.8	-1.9	-0.1
Fasting Glucose	1.3	1.6	4.3	1.2	-2.1	1.2	0.1	1.0	1.3	1.2
Sensitivity / hurt feelings	1.3	2.3	7.2	0.0	-1.0	-2.5	-2.7	-0.3	0.8	-0.9
Qualifications: CSEs or equivalent	1.3	1.7	2.9	-1.3	-1.7	-0.9	-1.5	-1.2	1.1	-1.2
Past tobacco smoking	1.3	2.4	8.8	-0.8	3.0	0.8	0.0	-1.7	-1.7	-1.1
Neuroticism score	1.3	2.7	6.3	-0.6	0.6	-2.5	-2.3	-1.2	-0.4	-2.2
Breastfed as a baby	1.3	1.6	3.7	-1.9	0.5	-1.4	-0.7	-1.4	-0.7	-1.5
Alcohol intake frequency.	1.3	2.9	5.5	1.7	-0.0	2.3	1.7	1.7	1.5	2.0
Illnesses of father: None of the above (group 1)	1.3	1.6	3.2	-1.5	1.8	-0.2	-1.0	-1.4	-1.1	-1.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	7.0	0.2	2.6	-1.5	0.2	0.1	-1.0	-0.8
Number of incorrect matches in round	1.2	1.9	4.2	1.1	-1.2	2.0	0.3	1.7	1.6	1.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.6	0.7	-1.1	0.7	-1.3	1.5	1.9	0.9
Medication: Lansoprazole	1.2	1.4	2.9	0.7	-1.2	1.7	0.5	1.6	1.0	1.1
Number of full brothers	1.2	1.5	3.3	1.5	-0.7	-0.3	0.6	1.8	1.7	1.1
Number of children fathered	1.2	1.3	2.8	0.1	-1.5	1.1	1.3	0.5	0.9	1.7
Medication: Blood pressure	1.2	2.1	7.1	0.7	-1.3	2.7	1.3	0.7	0.9	1.5
Illnesses of father: High blood pressure	1.2	1.5	3.9	1.0	-0.9	2.0	1.3	0.9	0.2	1.5
Alcohol drinker status: Previous	1.2	1.4	2.7	1.6	1.1	0.5	1.6	0.7	-1.3	0.9
Schizophrenia vs Biploar Disorder	1.1	1.5	3.1	-1.6	0.3	-0.6	-0.9	-1.5	-1.1	-1.8
Alzheimer’s Disease (in mother)	1.1	1.2	4.1	-0.6	2.0	-0.8	0.7	-0.8	-1.4	-0.7
Verbal and Numeric Reasoning (VNR)	1.1	2.5	4.9	-1.5	-0.4	-1.9	-2.1	-2.2	-1.1	-1.1
Prostate Cancer	1.1	1.6	4.5	-2.1	0.5	-0.2	-0.8	-1.3	-0.9	-1.7
HDL Cholesterol	1.1	1.9	4.3	-0.4	1.5	-2.1	-1.0	-1.4	-1.4	-1.1
Number of treatments/medications taken	1.1	2.0	3.6	0.5	-0.4	1.8	1.9	1.7	0.8	1.9
Relative age voice broke	1.1	1.6	5.9	0.7	1.1	-1.2	0.6	-1.1	-2.4	-0.7
Father’s age at death	1.1	1.5	3.6	-1.9	0.8	-1.0	-0.8	-1.1	-0.3	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.0	-0.6	-0.7	-1.5	-1.4	-1.1	0.1	-1.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.1	0.6	-1.2	1.5	1.4	1.3	0.8	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.6	1.8	-0.9	0.3	0.6	1.9	1.1	0.7
Emphysema/chronic bronchitis	1.1	1.3	3.9	2.0	-1.3	0.8	0.9	0.9	0.6	0.8
Number of full sisters	1.1	1.4	2.9	1.0	-1.1	0.5	0.5	1.0	1.7	1.7
Smoking status: Previous	1.1	1.6	4.2	-0.6	-2.0	-1.9	-1.2	0.4	1.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	6.5	-2.5	-0.8	-0.9	-1.8	-1.7	0.5	-1.4
Diabetes diagnosed by doctor	1.1	1.8	8.5	1.1	-0.4	1.1	2.9	0.9	-0.1	0.9
Ever depressed for a whole week	1.1	1.4	2.8	0.5	-1.7	1.7	-0.7	1.2	1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.8	1.3	-1.1	1.7	0.6	1.3	0.5	1.1
LDL Cholesterol	1.0	1.6	4.1	2.0	1.6	-0.9	0.6	0.2	-1.8	0.3
Lupus	1.0	1.5	3.6	-1.3	1.9	0.3	0.0	-1.1	-1.2	-1.6
Financial difficulties in last 2 years	1.0	1.4	5.2	1.7	-2.3	0.7	0.0	0.4	0.9	0.5
Hair/balding pattern: Pattern 4	1.0	2.4	10.8	1.3	3.3	0.2	1.1	0.9	-1.4	-0.5
Health satisfaction	1.0	1.3	3.3	1.6	0.2	0.3	0.4	1.8	1.3	0.9
Medication: Omeprazole	1.0	1.2	2.1	1.4	-0.8	1.3	0.7	1.4	0.3	1.1
Ever smoked	1.0	1.7	8.2	1.1	-2.9	-0.4	0.1	1.1	0.7	0.7
Risk taking	1.0	1.4	4.5	-1.7	-0.7	0.0	-2.1	-1.2	-0.3	-0.6
Bipolar Disorder (2011)	0.9	0.8	1.4	1.2	0.9	1.1	0.7	0.6	-0.2	1.2
Body Mass Index (BMI) (2010)	0.9	1.3	4.8	1.1	0.3	1.4	2.2	0.8	-0.1	0.7
HbA1C	0.9	1.0	5.4	-0.0	2.3	-0.4	-0.1	-0.4	-1.1	-0.4
Triglycerides	0.9	1.6	2.9	0.9	-0.5	1.1	1.7	1.4	1.4	1.4
Supplements: Glucosamine	0.9	1.2	4.6	-1.0	-0.2	-2.1	-0.8	-0.7	-0.7	-1.1
High blood pressure (mother)	0.9	1.3	3.5	0.7	-0.6	1.3	1.3	1.1	0.3	1.9
Nervous feelings	0.9	1.8	3.8	-1.2	1.3	-1.5	-1.2	-1.2	-0.3	-1.9
Had menopause	0.9	1.1	2.5	1.6	-0.1	0.6	1.5	1.4	0.5	0.7
Asthma	0.9	1.8	4.9	-1.5	-1.6	-1.1	-2.2	-1.2	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.7	0.1	-0.2	1.7	1.6	0.6	0.1	1.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.7	-0.8	1.0	-2.2	-1.1	-0.6	-0.6	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.2	-0.2	-0.4	0.6	-0.5	0.9	1.8	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.2	1.8	-0.3	0.5	0.8	1.1	1.0	1.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	-1.1	0.9	-1.5	-0.0	-0.6	-0.0	-1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	5.0	-1.3	2.2	-0.5	-0.3	-0.4	-0.6	-0.3
Asthma (self-reported)	0.9	1.8	5.2	-1.4	-1.4	-1.2	-2.3	-1.2	-0.1	-0.8
Average weekly champagne plus white wine intake	0.9	1.2	3.1	-1.2	1.2	-0.5	-0.3	-1.1	-1.8	-0.8
Leg fat percentage (left)	0.9	3.2	6.3	1.3	-1.9	0.8	2.5	1.6	2.0	1.9
Bipolar Disorder or Schizophrenia	0.8	2.0	3.9	1.7	-0.7	1.4	0.6	1.8	1.2	2.0
Intelligence (Savage-Jansen 2018)	0.8	2.6	6.9	-1.6	-0.9	-1.8	-2.6	-1.6	-0.5	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.3	0.2	-0.8	0.9	1.5	1.1	0.9	0.7
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.1	-0.5	-1.2	-0.9	-1.4	-0.4	0.6	-1.8
Medication: Levothyroxine sodium	0.8	1.4	2.6	-0.1	1.4	-1.5	-0.9	-0.6	-1.3	-1.6
Medication: Cholesterol lowering	0.8	1.3	2.0	1.4	-0.5	1.2	1.4	1.1	0.4	1.4
Illnesses of mother	0.8	1.0	2.7	-1.0	-0.8	-0.9	-1.6	-0.6	-0.0	-1.2
Medication: Paracetamol	0.8	1.3	4.2	-0.4	-1.3	2.0	0.5	0.5	1.0	1.2
Glaucoma (self-reported)	0.8	1.0	3.2	-0.9	0.3	-1.8	-0.8	-0.5	0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.6	0.5	1.9	-1.4	-0.3	-0.1	-1.6	-1.7
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.7	1.1	-1.6	1.0	0.3	0.7	0.9	0.9
Medication: Allopurinol	0.8	1.0	2.3	0.6	1.4	0.6	1.5	0.1	-1.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	7.0	-1.3	2.6	0.1	-0.3	-0.7	-1.4	-0.8
Unable to work because of sickness or disability	0.8	1.0	4.3	0.5	-2.1	0.5	-1.0	0.1	1.0	0.5
Coronary Artery Disease (CAD)	0.7	0.8	3.0	1.1	-0.7	0.9	1.7	0.3	0.3	0.3
Heel T-Score	0.7	5.5	11.6	3.4	-1.1	0.7	2.7	2.7	-0.6	3.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.5	-0.6	-1.6	-0.6	-1.2	0.0	1.1	-0.7
Trunk fat percentage	0.7	2.7	4.1	1.4	-2.0	0.9	1.8	1.2	2.0	1.8
Allergy	0.7	1.6	7.8	0.9	2.8	0.2	1.3	0.8	-0.2	-0.1
Diabetes (self-reported)	0.7	1.1	6.2	0.3	-0.3	0.7	2.5	0.5	-0.2	0.5
Fluid intelligence score	0.7	1.4	3.2	-1.2	-0.2	-1.5	-0.9	-1.8	-1.4	-0.5
Length of working week for main job	0.7	0.7	1.9	-1.4	-0.4	0.3	0.7	-1.3	-0.2	-0.8
Exposure to tobacco smoke at home	0.7	0.8	2.5	1.3	0.0	0.3	1.0	-0.1	-1.6	0.1
Tense / ‘highly strung’	0.7	1.1	2.8	-0.2	1.1	-0.9	-0.6	-0.9	-1.7	-1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.3	-0.7	1.5	0.8	0.6	-0.7	-1.8	-0.6
Birth weight	0.7	1.6	5.8	-0.3	2.4	-1.6	0.0	-0.3	-0.8	-1.3
Body fat percentage	0.7	2.9	4.8	1.5	-1.8	0.9	2.2	1.4	1.9	1.9
Medication: Ibuprofen	0.7	0.8	2.6	-0.5	-0.6	1.6	1.3	0.1	-0.4	0.8
Medication: Seretide 50 evohaler	0.7	0.8	3.2	-0.2	-0.6	1.8	1.3	-0.1	0.3	0.2
Arm fat percentage (left)	0.7	2.7	4.8	1.4	-1.7	1.0	2.2	1.2	1.9	1.7
Loneliness, isolation	0.7	1.0	2.6	0.1	-1.4	-0.1	-1.5	0.6	1.6	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.6	0.1	-0.6	-1.9	-1.9	-0.1	-0.0	0.2
Medication: Paracetamol	0.7	1.1	3.6	-0.5	-1.3	1.9	0.4	0.4	0.6	1.2
Diastolic blood pressure, automated reading	0.7	2.1	10.9	0.4	1.3	0.8	3.3	0.3	0.7	0.8
Commuting to job workplace: Cycle	0.7	0.8	2.5	0.9	-0.7	0.1	1.0	0.9	0.3	1.6
Depressed Affect (Nagel 2018)	0.6	1.4	4.2	-0.3	0.6	-1.4	-2.1	0.2	1.3	-1.0
Depression (Nagel 2018)	0.6	1.0	2.3	1.5	-0.1	-0.5	-0.3	1.4	1.4	-0.4
Major Depression (MDD)	0.6	0.8	1.4	1.1	-0.3	0.3	1.0	0.9	1.2	0.7
Mean Putamen Volume	0.6	0.7	1.9	-0.6	0.9	-0.6	-0.1	-1.1	-1.4	-0.7
Primary Biliary Cirrhosis	0.6	0.9	3.6	1.0	1.0	-0.3	0.2	0.2	-1.9	-0.6
Rheumatoid Arthritis	0.6	0.8	2.6	0.2	0.6	0.4	1.2	-0.2	-1.6	1.0
Blood Eosinophil Count	0.6	4.8	8.6	2.8	-0.9	2.3	2.9	1.8	0.3	2.8
Hearing difficulty/problems: Yes	0.6	0.9	2.4	1.6	0.1	-1.3	-0.3	1.3	0.3	0.3
Relative age of first facial hair	0.6	1.3	4.4	0.4	1.4	-2.1	0.7	-0.2	-1.2	-0.7
Medication: Co-codamol	0.6	0.7	1.9	0.8	0.6	1.0	0.7	0.3	-1.4	0.5
Hand grip strength (right)	0.6	1.6	5.2	-2.3	1.1	-0.8	0.3	-1.1	-0.2	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.8	0.7	-0.6	-0.5	-0.3	1.1	1.7	-0.2
Serious illness, injury or assault to yourself	0.6	0.7	2.0	1.1	-0.5	1.4	0.5	0.9	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	5.6	0.9	-2.4	-0.3	-0.2	1.0	0.3	1.1
Pain all over the body in last month	0.6	0.7	1.6	1.0	0.2	0.5	0.3	1.3	0.3	1.2
Pulse rate	0.6	1.1	2.6	-0.0	1.6	1.3	1.0	0.4	0.5	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.0	-1.0	-0.1	-1.4	-1.2	-0.5	0.3	-1.4
Pulse wave reflection index	0.6	0.7	1.3	-1.0	-0.5	0.2	-0.8	-1.1	-0.9	-1.1
Leg fat percentage (right)	0.6	2.3	5.7	1.2	-1.5	0.5	2.4	1.2	1.6	1.6
Eye problems/disorders: None of the above	0.6	0.6	1.2	-0.2	-1.1	0.7	-0.9	-0.9	-1.1	0.1
Breast cancer (self-reported)	0.6	0.8	2.0	1.4	0.8	0.3	0.8	1.0	0.4	0.9
Commuting to job workplace: Public transport	0.6	0.7	1.8	-0.4	0.6	-0.3	-0.9	-0.9	-1.3	-1.1
Medication: Bendroflumethiazide	0.6	0.9	1.5	0.9	-0.6	1.0	0.7	1.0	0.9	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	-0.1	-0.8	-0.9	-1.4	-0.6	-1.0	-0.3
Pain experienced in last month	0.6	0.9	4.3	-0.7	2.1	-0.8	0.3	-0.2	-0.5	-0.8
Leg fat mass (left)	0.6	2.2	5.1	0.5	-2.3	0.3	1.9	0.8	2.1	1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.1	0.8	-1.1	0.9	1.8	0.2	0.0	0.9
Hand grip strength (left)	0.5	1.4	4.8	-2.2	0.9	-1.2	0.0	-1.1	0.3	-1.4
Average weekly fortified wine intake	0.5	0.5	1.6	-0.9	0.5	-0.3	0.2	-0.8	-0.4	-1.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	1.0	0.4	0.4	1.2	1.0	-0.0	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.6	-1.4	-1.9	-0.2	-0.8	-1.1	-0.5	-0.5
Mouth/teeth dental problems	0.5	0.8	2.3	-1.5	0.9	0.5	-0.3	-0.9	-0.5	-0.9
Arm fat percentage (right)	0.5	2.0	3.8	1.3	-1.6	0.5	1.9	1.1	1.7	1.4
Trunk fat-free mass	0.5	2.7	5.7	-2.4	-0.1	-2.1	-0.6	-2.1	-0.9	-1.8
Alcohol intake versus 10 years previously	0.5	0.7	1.8	0.4	0.3	1.4	1.3	0.5	0.1	1.0
Trunk predicted mass	0.5	2.7	5.9	-2.4	-0.1	-2.0	-0.6	-2.1	-0.9	-1.8
Loud music exposure frequency	0.5	0.6	1.1	-0.9	0.3	1.0	0.0	-1.0	-0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	1.0	-0.5	-1.2	-1.0	0.0	-0.7	-0.3
Gout (self-reported)	0.5	0.7	1.8	-0.6	1.0	0.8	0.5	-0.5	-1.4	-0.6
Osteoporosis (self-reported)	0.5	0.6	1.1	-1.0	0.4	0.3	-0.4	-1.0	-1.0	-0.7
Number of operations (self-reported)	0.5	0.7	1.9	-0.9	0.7	0.3	0.4	-1.1	-1.4	-0.6
Fractured/broken bones in last 5 years	0.5	0.6	1.4	0.7	-0.7	0.7	0.5	0.3	-1.1	1.2
Neuroticism (2016)	0.4	0.6	2.7	-0.3	-0.9	-0.7	-1.6	-0.1	0.2	-0.4
Average weekly spirits intake	0.4	0.5	1.9	-1.4	-0.4	-0.2	-0.4	-0.9	0.2	-0.4
Medication for hormone replacement therapy	0.4	0.4	1.1	0.2	-0.7	1.1	-0.7	0.6	0.7	0.4
Vitamin and mineral supplements	0.4	0.6	1.2	-0.3	0.9	0.2	-0.1	-0.9	-1.0	-1.1
Supplements: Zinc	0.4	0.5	2.0	-0.0	1.4	-0.6	0.5	0.5	-0.4	-0.5
Townsend deprivation index at recruitment	0.4	0.5	1.1	1.0	0.7	-0.9	-0.3	1.0	0.0	-0.5
Maternal smoking around birth	0.4	0.6	2.0	-0.4	-1.4	-0.5	-0.9	-0.6	0.5	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	1.0	1.1	-0.1	0.6	0.4	-1.0	0.1
Trunk fat mass	0.4	1.7	3.6	0.7	-1.9	0.4	1.6	0.6	1.8	1.3
Waist circumference	0.4	1.6	3.7	0.6	-1.3	0.3	1.9	1.0	1.8	1.2
Alcohol usually taken with meals	0.4	0.7	3.6	-0.7	-0.6	1.9	0.3	-0.1	-0.3	0.4
Hearing difficulty/problems with background noise	0.4	0.7	1.2	0.6	0.9	-1.1	-0.9	-0.1	-0.7	-1.0
Had other major operations	0.4	0.5	2.0	-0.5	-0.9	-0.4	-1.4	0.0	0.4	0.5
Qualifications: None of the above	0.4	0.9	1.7	0.8	-0.6	-0.6	1.0	0.9	1.3	1.2
Time employed in main current job	0.4	0.5	1.3	1.2	-0.4	-1.0	0.6	0.6	-0.4	-0.2
Falls in the last year	0.4	0.5	1.3	-0.1	0.2	-1.1	-0.7	-0.6	-1.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.9	-1.3	0.3	0.5	-0.1	-1.2	-1.7	-0.8
Impedance of arm (left)	0.4	1.9	4.9	1.6	0.8	2.2	1.4	1.0	-0.0	1.4
Whole body fat mass	0.4	1.8	3.9	0.5	-2.0	0.4	1.8	0.6	1.8	1.2
Leg fat mass (right)	0.4	1.6	3.7	0.3	-1.9	0.1	1.8	0.4	1.7	1.0
Had major operations	0.4	0.4	1.5	-0.4	-1.2	-0.1	-0.4	-0.7	-0.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.3	-0.3	-1.1	0.9	0.6	-0.2	-0.3	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.3	1.1	-0.1	0.0	1.1	0.7	-0.7	0.5
Ever had bowel cancer screening	0.4	0.5	1.3	-0.2	-0.1	-0.9	-1.1	-0.3	-1.1	0.0
Commuting to job workplace: Walk	0.4	0.5	1.4	-0.2	-0.1	-1.2	-1.2	-0.0	-0.3	-0.5
Back pain experienced in last month	0.4	0.6	2.5	-0.9	-0.4	0.5	-1.6	-0.2	0.9	-0.3
Whole body water mass	0.4	2.1	5.0	-2.2	-0.9	-1.7	-0.7	-1.9	-0.1	-1.4
Arm fat mass (left)	0.4	1.7	4.1	0.4	-2.0	0.3	1.6	0.5	1.8	1.1
Miserableness	0.4	0.7	2.7	0.2	-0.4	-1.0	-1.6	-0.2	0.2	-1.1
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	-0.9	0.3	-0.9	-0.4	-0.4	0.6	-0.8
Alcohol drinker status: Never	0.4	0.5	2.7	0.1	0.5	1.6	0.1	0.4	0.5	0.2
Arm fat-free mass (left)	0.4	2.1	5.4	-2.3	-0.9	-1.6	-0.6	-1.9	-0.2	-1.4
Age started oral contraceptive pill	0.4	0.6	3.0	-0.5	1.7	-0.1	0.1	-0.2	-0.6	-0.5
Arm predicted mass (left)	0.4	2.0	5.0	-2.2	-0.9	-1.8	-0.4	-1.8	0.0	-1.4
Allergy or Eczema	0.3	0.7	2.7	-0.5	-1.6	-0.6	-1.1	-0.4	-0.2	-0.5
Hypothyroidism (self reported)	0.3	0.8	2.4	0.2	0.7	-1.2	-0.9	0.2	-0.5	-1.5
Lung FEV1/FVC ratio	0.3	1.5	4.7	0.9	0.9	1.3	2.2	0.1	-1.5	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.9	0.1	-0.4	0.7	0.6	0.6	0.5
Pack years adult smoking proportion	0.3	0.5	1.4	0.3	-1.1	1.2	0.3	-0.6	-0.2	0.4
Fed-up feelings	0.3	0.6	2.7	0.2	0.1	0.2	-0.2	1.2	1.6	0.0
Multivitamins +/- minerals	0.3	0.4	0.9	0.4	0.5	-1.0	0.5	0.9	0.4	0.6
Sitting height	0.3	2.3	4.2	-2.0	-1.4	-1.4	-1.2	-1.9	0.5	-1.6
Body mass index (BMI)	0.3	1.2	3.0	0.2	-1.7	0.1	1.2	0.5	1.7	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.3	0.9	-0.0	-0.6	-0.3	0.4	-0.1	-1.1
Forced vital capacity (FVC)	0.3	1.2	2.8	-1.7	-0.4	-1.0	-1.2	-0.9	-0.8	-1.2
Impedance of arm (right)	0.3	1.2	2.5	1.6	1.3	1.1	1.3	0.7	-0.6	0.8
Hip circumference	0.3	1.4	4.2	-1.6	-0.2	-2.0	-0.0	-1.2	0.3	-1.2
Number of live births	0.3	0.4	1.8	-0.4	-0.7	-0.2	-0.4	0.4	1.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.0	-1.3	0.5	-0.6	-0.4	-0.9	-1.2	-1.4
Pulse wave Arterial Stiffness index	0.3	0.3	1.3	-0.7	-0.5	1.1	0.1	0.1	0.2	0.2
Arm fat mass (right)	0.3	1.3	3.2	0.4	-1.8	0.0	1.5	0.5	1.6	0.9
Arm fat-free mass (right)	0.3	1.5	4.6	-2.1	-1.0	-1.1	-0.4	-1.5	0.3	-1.0
Exposure to tobacco smoke outside home	0.3	0.5	1.5	-0.1	-1.2	-1.0	-0.7	0.2	0.2	0.2
Migraine (self-reported)	0.3	0.4	0.8	-0.6	-0.1	0.7	0.9	0.7	-0.0	0.7
Arm predicted mass (right)	0.3	1.7	4.9	-2.2	-0.9	-1.2	-0.4	-1.8	-0.1	-1.2
Pulse rate, automated reading	0.3	0.9	3.2	-0.2	1.8	0.7	1.4	-0.1	0.2	0.8
Supplements: Vitamin C	0.3	0.4	1.2	0.4	-1.1	0.0	-0.1	0.2	1.0	0.4
Whole body fat-free mass	0.3	1.9	4.7	-2.2	-0.8	-1.7	-0.6	-1.8	-0.2	-1.4
Leg fat-free mass (right)	0.3	1.4	2.8	-1.7	-1.6	-1.1	-0.6	-1.2	0.9	-0.8
Average weekly red wine intake	0.3	0.5	2.4	0.5	0.4	-0.2	0.6	-0.2	-1.6	-0.3
Qualifications: nursing, teaching	0.3	0.5	1.3	-1.1	0.5	1.1	0.5	-0.2	-0.7	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.9	-1.1	0.3	-0.6	0.4	0.1	0.4
Mineral and other dietary supplements	0.3	0.5	1.5	-0.4	-0.4	0.8	0.2	-1.2	-0.8	-0.4
Osteoarthritis (self-reported)	0.3	0.4	1.6	1.3	-0.3	0.7	0.1	0.1	-0.0	0.5
Leg predicted mass (right)	0.3	1.4	2.9	-1.7	-1.6	-1.1	-0.6	-1.2	0.9	-0.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.6	-0.1	-1.3	-0.2	-0.4	-0.5	-0.6	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	-0.6	-1.1	0.3	-0.5	-0.2	0.9	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	0.3	1.0	-1.0	0.3	0.9	0.4	0.2
Basal metabolic rate	0.3	1.6	4.0	-2.0	-1.1	-1.5	-0.4	-1.6	0.2	-1.1
Irritability	0.3	0.6	1.4	0.3	-0.8	-1.0	-1.2	-0.6	0.0	-0.8
Supplements: Calcium	0.3	0.3	1.0	0.4	0.4	1.0	0.6	0.2	-0.2	0.4
Impedance of whole body	0.3	1.5	3.4	1.3	0.7	1.9	1.3	1.1	0.0	1.3
Schizophrenia (2014)	0.2	0.4	0.9	0.7	0.0	0.2	-0.2	0.7	0.9	0.8
BMI	0.2	1.1	3.6	-0.6	-1.9	-0.5	1.3	-0.1	1.3	0.2
Respiratory disease	0.2	0.5	1.1	-0.5	-1.0	-0.7	-1.0	-0.6	0.3	-0.3
Lung FVC	0.2	0.8	2.4	-0.5	0.2	-0.7	-1.2	-0.5	-1.5	-0.8
Chronotype (morning person)	0.2	0.5	3.5	-0.4	1.9	-0.2	0.2	0.1	-0.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	2.0	-0.1	-1.4	-0.1	0.2	0.0	-0.2	-0.3
Diabetes (mother)	0.2	0.2	0.8	0.9	-0.0	0.0	0.6	-0.1	0.3	0.5
Impedance of leg (right)	0.2	1.0	2.1	0.9	1.4	0.8	1.2	0.5	-1.1	0.5
Leg fat-free mass (left)	0.2	1.3	2.6	-1.6	-1.4	-1.1	-0.4	-1.4	0.5	-0.9
Taking other prescription medications	0.2	0.3	0.7	-0.3	-0.7	0.9	-0.3	-0.2	-0.7	-0.1
Age when periods started (menarche)	0.2	0.5	1.5	0.6	-1.2	0.1	0.3	0.4	0.5	1.0
Impedance of leg (left)	0.2	1.0	1.6	1.0	0.7	1.1	1.3	1.1	-0.3	1.1
Leg predicted mass (left)	0.2	1.2	2.5	-1.6	-1.4	-1.1	-0.3	-1.3	0.6	-0.8
Weight	0.2	0.9	2.8	-1.1	-1.7	-0.5	0.6	-0.6	1.1	-0.1
Standing height	0.2	2.5	6.7	-2.6	-0.1	-1.1	-0.9	-2.1	-0.9	-1.8
Peak expiratory flow (PEF)	0.2	0.4	1.2	-1.1	-0.4	-0.3	-0.1	-0.8	-0.4	-0.7
Blood clot in the leg (DVT)	0.2	0.3	1.1	-0.3	1.0	-0.3	-0.2	-0.1	-0.8	0.2
Headache pain in last month	0.2	0.3	1.4	0.2	-1.2	0.5	0.3	0.2	-0.1	0.1
Medication: Amlodipine	0.2	0.3	0.8	0.4	0.6	0.6	-0.3	0.9	0.2	0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.1	-1.1	-0.5	-0.7	-1.5	-0.9	-0.6	-0.7
Pulse wave peak to peak time	0.2	0.3	1.5	0.4	0.4	-1.2	-0.2	-0.3	-0.2	-0.3
Qualifications: College or University degree	0.2	0.7	3.5	-1.1	0.3	1.9	0.5	-0.1	-0.2	0.0
Heart disease (mother)	0.2	0.3	1.3	-0.6	0.4	0.3	1.1	0.1	0.4	0.2
Comparative height size at age 10	0.2	0.8	2.6	-1.4	-1.6	0.9	0.1	-0.5	0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.7	-0.0	0.4	0.3	0.3	0.9	0.6
Mother’s age at death	0.2	0.2	0.8	0.3	-0.3	0.0	0.7	-0.9	-0.4	-0.2
Myopia	0.2	0.3	0.5	-0.6	-0.5	-0.5	-0.6	-0.7	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.4	1.0	-0.5	-0.5	-0.2	-0.8	-0.0
Pack years of smoking	0.2	0.3	0.6	0.6	-0.7	0.8	0.6	-0.3	-0.1	0.4
Height	0.1	2.5	8.1	-2.8	1.0	-1.4	0.2	-1.8	-1.0	-1.7
Hair Pigment	0.1	3.7	7.6	-1.5	2.8	-1.9	-1.6	-1.9	-1.9	-1.6
Tanning	0.1	1.3	2.7	0.3	-1.4	-0.9	-1.6	1.3	1.3	0.4
Severe depression (siblings)	0.1	0.1	0.4	0.3	-0.3	0.1	-0.6	-0.0	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.3	-0.0	-1.2	-0.6	-0.5	0.4	-0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.9	0.1	0.5	0.1	0.1	-0.6	-0.3	-1.0
Depression (self-reported)	0.1	0.2	0.5	0.3	0.2	-0.7	-0.6	0.2	0.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	-0.6	0.4	0.1	-0.3	-0.7	-1.0	-0.6
Comparative body size at age 10	0.1	0.3	1.0	-0.7	0.1	-0.4	-0.3	-0.4	-0.2	-1.0
Knee pain experienced in last month	0.1	0.2	0.5	0.5	-0.4	-0.1	0.4	0.3	-0.7	0.2
Illnesses of father: Heart disease	0.1	0.2	0.6	0.0	-0.8	-0.1	0.5	-0.1	-0.7	-0.2
Wears glasses or contact lenses	0.1	0.1	0.2	-0.1	-0.0	-0.2	-0.1	0.2	-0.5	0.3
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.4	-0.6	0.2	-0.5	-0.2	0.6	-0.1
Schizophrenia (2018)	0.0	0.1	0.6	0.1	0.0	0.1	-0.8	0.2	0.1	-0.0

Hub : Genes

TRAF3IP3

Models

Trait associations