Best TWAS P=1.66e-11 · Best GWAS P=1.29e-10 conditioned to 0.0598
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BCL2L13 | 0.19 | 0.09 | lasso | 13 | 0.12 | 5.9e-15 | 6.4 | -5.4 | 7.3e-08 | -0.87 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | BID | 0.28 | 0.16 | lasso | 10 | 0.15 | 5.6e-05 | 6.3 | -6.1 | 9.4e-10 | -0.88 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Brain Cortex | BID | 0.25 | 0.19 | lasso | 7 | 0.12 | 3.4e-04 | 6.3 | -6.1 | 1.2e-09 | -0.90 | 0.01 | 0.96 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | BID | 0.32 | 0.17 | enet | 10 | 0.20 | 5.7e-06 | 6.3 | -5.4 | 5.6e-08 | -0.81 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | ATP6V1E1 | 0.17 | 0.05 | lasso | 7 | 0.04 | 4.3e-04 | 4.5 | -5.1 | 2.9e-07 | -0.78 | 0.03 | 0.96 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | BID | 0.19 | 0.15 | lasso | 5 | 0.15 | 1.4e-12 | 6.4 | -5.7 | 1.0e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 7 | METSIM | Adipose | ATP6V1E1 | 0.13 | 0.10 | lasso | 7 | 0.10 | 4.1e-14 | 4.5 | -5.2 | 1.9e-07 | -0.79 | 0.04 | 0.96 | FALSE |
| 8 | YFS | Blood | BCL2L13 | 0.08 | 0.07 | bslmm | 544 | 0.10 | 1.6e-30 | 6.2 | 6.7 | 1.7e-11 | 0.78 | 0.01 | 0.99 | TRUE |