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chr22:21,798,199-23,032,448

Best TWAS P=7.62e-11 · Best GWAS P=1.85e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	GTEx	Ovary	LL22NC03-86G7.1	0.26	0.44	enet	21	0.35	1.4e-09	-6.4	6.5	7.6e-11	-0.97	0.00	1.00	TRUE
32	GTEx	Pancreas	LL22NC03-86G7.1	0.35	0.40	lasso	5	0.39	1.4e-17	-6.4	6.5	1.1e-10	-0.99	0.00	1.00	FALSE
44	GTEx	Vagina	LL22NC03-86G7.1	0.35	0.34	lasso	3	0.30	1.5e-07	-6.4	6.4	1.4e-10	-0.99	0.00	0.99	FALSE
13	GTEx	Brain Hypothalamus	LL22NC03-86G7.1	0.45	0.52	enet	10	0.47	1.8e-12	-6.4	6.4	1.7e-10	-0.99	0.00	1.00	FALSE
15	GTEx	Breast Mammary Tissue	LL22NC03-86G7.1	0.37	0.44	lasso	3	0.42	1.4e-23	-6.4	6.4	1.7e-10	-1.00	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	LL22NC03-86G7.1	0.37	0.54	lasso	3	0.53	3.6e-50	-6.4	6.4	1.8e-10	-1.00	0.00	1.00	FALSE
42	GTEx	Thyroid	LL22NC03-86G7.1	0.33	0.45	lasso	2	0.46	1.6e-38	-6.4	6.4	1.9e-10	-1.00	0.00	1.00	FALSE
43	GTEx	Uterus	LL22NC03-86G7.1	0.30	0.46	lasso	1	0.43	5.2e-10	-6.4	6.4	1.9e-10	-1.00	0.00	1.00	FALSE
29	GTEx	Muscle Skeletal	LL22NC03-86G7.1	0.16	0.19	lasso	2	0.20	3.0e-19	-6.4	6.3	2.2e-10	-1.00	0.00	1.00	FALSE
33	GTEx	Pituitary	LL22NC03-86G7.1	0.50	0.56	lasso	5	0.55	2.1e-16	-6.4	6.3	2.3e-10	-1.00	0.00	1.00	FALSE
10	GTEx	Brain Cortex	LL22NC03-86G7.1	0.50	0.52	lasso	3	0.58	1.2e-19	-6.4	6.3	2.4e-10	-0.98	0.00	1.00	FALSE
23	GTEx	Esophagus Mucosa	LL22NC03-86G7.1	0.21	0.26	lasso	3	0.24	3.3e-16	-6.4	6.3	3.0e-10	-0.99	0.00	1.00	FALSE
26	GTEx	Heart Atrial Appendage	LL22NC03-86G7.1	0.44	0.52	enet	8	0.51	7.3e-26	-6.3	6.3	3.1e-10	-1.00	0.00	1.00	FALSE
4	GTEx	Artery Aorta	LL22NC03-86G7.1	0.26	0.38	lasso	1	0.37	1.7e-21	-6.3	6.3	3.6e-10	-1.00	0.00	1.00	FALSE
19	GTEx	Cells Transformed fibroblasts	LL22NC03-86G7.1	0.25	0.32	lasso	3	0.33	2.3e-25	-6.4	6.3	3.6e-10	-1.00	0.00	1.00	FALSE
24	GTEx	Esophagus Muscularis	MAPK1	0.09	0.06	lasso	1	0.01	4.2e-02	-6.3	6.3	3.6e-10	-1.00	0.01	0.95	FALSE
20	GTEx	Colon Sigmoid	LL22NC03-86G7.1	0.20	0.29	lasso	2	0.18	4.7e-07	-6.4	-6.3	3.8e-10	1.00	0.00	1.00	FALSE
41	GTEx	Testis	LL22NC03-86G7.1	0.20	0.11	lasso	8	0.12	9.0e-06	-6.4	6.3	3.8e-10	-0.97	0.00	1.00	FALSE
18	GTEx	Cells Transformed fibroblasts	PPM1F	0.06	0.05	lasso	2	0.04	6.3e-04	-6.4	6.2	4.6e-10	-0.96	0.01	0.99	FALSE
37	GTEx	Small Intestine Terminal Ileum	LL22NC03-86G7.1	0.39	0.28	lasso	3	0.27	7.6e-07	-6.4	6.2	4.7e-10	-0.97	0.01	0.99	FALSE
17	GTEx	Breast Mammary Tissue (Female)	LL22NC03-86G7.1	0.37	0.40	lasso	4	0.38	3.9e-12	-6.4	6.2	4.8e-10	-1.00	0.00	1.00	FALSE
34	GTEx	Prostate	LL22NC03-86G7.1	0.32	0.34	lasso	7	0.32	6.5e-09	-6.2	6.2	5.3e-10	-0.98	0.01	0.99	FALSE
6	GTEx	Artery Tibial	LL22NC03-86G7.1	0.23	0.32	enet	24	0.33	9.7e-27	-6.4	6.2	5.4e-10	-0.96	0.00	1.00	FALSE
40	GTEx	Stomach	LL22NC03-86G7.1	0.29	0.37	enet	13	0.28	5.9e-14	-6.4	6.2	6.4e-10	-0.99	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	LL22NC03-86G7.1	0.41	0.31	lasso	4	0.31	5.0e-08	-6.4	6.2	7.0e-10	-0.97	0.00	0.99	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	LL22NC03-86G7.1	0.31	0.43	enet	22	0.43	2.0e-25	-6.4	6.1	8.3e-10	-0.98	0.00	1.00	FALSE
7	GTEx	Brain Caudate basal ganglia	LL22NC03-86G7.1	0.47	0.50	enet	12	0.49	6.3e-16	-6.4	6.1	9.0e-10	-0.97	0.00	1.00	FALSE
21	GTEx	Colon Transverse	LL22NC03-86G7.1	0.46	0.49	enet	39	0.44	5.6e-23	-6.4	6.1	9.1e-10	-0.94	0.00	1.00	FALSE
36	GTEx	Skin Sun Exposed Lower leg	LL22NC03-86G7.1	0.30	0.43	enet	9	0.43	7.8e-39	-6.4	6.1	1.1e-09	-0.99	0.00	1.00	FALSE
30	GTEx	Nerve Tibial	LL22NC03-86G7.1	0.34	0.48	enet	27	0.52	2.0e-42	-6.4	6.0	1.5e-09	-0.98	0.00	1.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	LL22NC03-86G7.1	0.48	0.40	enet	32	0.41	1.3e-11	-6.2	6.0	1.6e-09	-0.93	0.01	0.99	FALSE
9	GTEx	Brain Cerebellum	LL22NC03-86G7.1	0.50	0.50	enet	18	0.54	9.6e-19	-6.3	6.0	1.6e-09	-0.98	0.00	1.00	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	LL22NC03-86G7.1	0.61	0.50	enet	32	0.56	7.3e-18	-6.4	6.0	1.6e-09	-0.94	0.01	0.99	FALSE
27	GTEx	Heart Left Ventricle	LL22NC03-86G7.1	0.27	0.36	enet	8	0.36	4.0e-20	-6.4	6.0	1.9e-09	-0.99	0.00	1.00	FALSE
25	GTEx	Esophagus Muscularis	LL22NC03-86G7.1	0.22	0.24	enet	16	0.18	6.1e-11	-6.4	6.0	2.5e-09	-0.99	0.00	1.00	FALSE
28	GTEx	Lung	LL22NC03-86G7.1	0.19	0.26	enet	14	0.26	5.9e-20	-6.4	6.0	2.7e-09	-0.97	0.00	1.00	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	LL22NC03-86G7.1	0.36	0.40	enet	18	0.24	4.3e-09	-6.4	5.9	2.9e-09	-0.98	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	LL22NC03-86G7.1	0.33	0.41	enet	22	0.37	2.9e-20	-6.4	5.9	3.1e-09	-0.98	0.00	1.00	FALSE
5	GTEx	Artery Coronary	LL22NC03-86G7.1	0.31	0.34	enet	14	0.26	3.0e-09	-6.4	5.9	3.2e-09	-0.99	0.00	1.00	FALSE
38	GTEx	Spleen	TOP3B	0.20	0.03	lasso	5	0.06	1.5e-02	-5.7	5.8	6.4e-09	-0.91	0.04	0.81	FALSE
11	GTEx	Brain Hippocampus	LL22NC03-86G7.1	0.40	0.40	enet	22	0.29	1.4e-07	-6.4	5.8	6.5e-09	-0.91	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PPM1F	0.14	0.09	lasso	3	0.10	7.7e-05	-5.7	5.8	7.5e-09	-0.81	0.04	0.76	FALSE
3	GTEx	Adrenal Gland	LL22NC03-86G7.1	0.32	0.34	lasso	3	0.36	1.1e-13	-6.2	5.7	1.6e-08	-0.93	0.01	0.99	FALSE
39	GTEx	Spleen	LL22NC03-86G7.1	0.44	0.27	lasso	8	0.31	9.9e-09	5.4	5.5	3.1e-08	-0.90	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TOP3B	0.04	0.01	enet	6	0.03	1.0e-04	-4.1	5.4	5.3e-08	-0.77	0.01	0.91	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PPM1F	0.06	0.04	blup	57	0.04	4.8e-03	-6.4	5.4	5.9e-08	-0.89	0.01	0.94	FALSE
12	GTEx	Brain Hypothalamus	TOP3B	0.20	0.17	lasso	2	0.11	1.3e-03	-5.4	5.4	6.6e-08	-0.86	0.02	0.91	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPM1F	0.03	0.02	blup	57	0.02	2.7e-03	-5.7	5.3	1.0e-07	-0.92	0.01	0.96	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1F	0.03	0.03	lasso	2	0.02	3.8e-03	-4.9	5.2	2.6e-07	-0.92	0.02	0.88	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TOP3B	0.08	0.00	blup	67	0.03	1.3e-02	-4.9	5.1	2.7e-07	-0.88	0.01	0.88	FALSE