Best TWAS P=7.62e-11 · Best GWAS P=1.85e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LL22NC03-86G7.1 | 0.37 | 0.54 | lasso | 3 | 0.53 | 3.6e-50 | -6.4 | 6.4 | 1.8e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | LL22NC03-86G7.1 | 0.33 | 0.41 | enet | 22 | 0.37 | 2.9e-20 | -6.4 | 5.9 | 3.1e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adrenal Gland | LL22NC03-86G7.1 | 0.32 | 0.34 | lasso | 3 | 0.36 | 1.1e-13 | -6.2 | 5.7 | 1.6e-08 | -0.93 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Artery Aorta | LL22NC03-86G7.1 | 0.26 | 0.38 | lasso | 1 | 0.37 | 1.7e-21 | -6.3 | 6.3 | 3.6e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Coronary | LL22NC03-86G7.1 | 0.31 | 0.34 | enet | 14 | 0.26 | 3.0e-09 | -6.4 | 5.9 | 3.2e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Artery Tibial | LL22NC03-86G7.1 | 0.23 | 0.32 | enet | 24 | 0.33 | 9.7e-27 | -6.4 | 6.2 | 5.4e-10 | -0.96 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Caudate basal ganglia | LL22NC03-86G7.1 | 0.47 | 0.50 | enet | 12 | 0.49 | 6.3e-16 | -6.4 | 6.1 | 9.0e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | LL22NC03-86G7.1 | 0.48 | 0.40 | enet | 32 | 0.41 | 1.3e-11 | -6.2 | 6.0 | 1.6e-09 | -0.93 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Brain Cerebellum | LL22NC03-86G7.1 | 0.50 | 0.50 | enet | 18 | 0.54 | 9.6e-19 | -6.3 | 6.0 | 1.6e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Brain Cortex | LL22NC03-86G7.1 | 0.50 | 0.52 | lasso | 3 | 0.58 | 1.2e-19 | -6.4 | 6.3 | 2.4e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Brain Hippocampus | LL22NC03-86G7.1 | 0.40 | 0.40 | enet | 22 | 0.29 | 1.4e-07 | -6.4 | 5.8 | 6.5e-09 | -0.91 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Brain Hypothalamus | TOP3B | 0.20 | 0.17 | lasso | 2 | 0.11 | 1.3e-03 | -5.4 | 5.4 | 6.6e-08 | -0.86 | 0.02 | 0.91 | FALSE |
| 13 | GTEx | Brain Hypothalamus | LL22NC03-86G7.1 | 0.45 | 0.52 | enet | 10 | 0.47 | 1.8e-12 | -6.4 | 6.4 | 1.7e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Brain Nucleus accumbens basal ganglia | LL22NC03-86G7.1 | 0.61 | 0.50 | enet | 32 | 0.56 | 7.3e-18 | -6.4 | 6.0 | 1.6e-09 | -0.94 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Breast Mammary Tissue | LL22NC03-86G7.1 | 0.37 | 0.44 | lasso | 3 | 0.42 | 1.4e-23 | -6.4 | 6.4 | 1.7e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Breast Mammary Tissue (Male) | LL22NC03-86G7.1 | 0.41 | 0.31 | lasso | 4 | 0.31 | 5.0e-08 | -6.4 | 6.2 | 7.0e-10 | -0.97 | 0.00 | 0.99 | FALSE |
| 17 | GTEx | Breast Mammary Tissue (Female) | LL22NC03-86G7.1 | 0.37 | 0.40 | lasso | 4 | 0.38 | 3.9e-12 | -6.4 | 6.2 | 4.8e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Cells Transformed fibroblasts | PPM1F | 0.06 | 0.05 | lasso | 2 | 0.04 | 6.3e-04 | -6.4 | 6.2 | 4.6e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 19 | GTEx | Cells Transformed fibroblasts | LL22NC03-86G7.1 | 0.25 | 0.32 | lasso | 3 | 0.33 | 2.3e-25 | -6.4 | 6.3 | 3.6e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Colon Sigmoid | LL22NC03-86G7.1 | 0.20 | 0.29 | lasso | 2 | 0.18 | 4.7e-07 | -6.4 | -6.3 | 3.8e-10 | 1.00 | 0.00 | 1.00 | FALSE |
| 21 | GTEx | Colon Transverse | LL22NC03-86G7.1 | 0.46 | 0.49 | enet | 39 | 0.44 | 5.6e-23 | -6.4 | 6.1 | 9.1e-10 | -0.94 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Esophagus Gastroesophageal Junction | LL22NC03-86G7.1 | 0.36 | 0.40 | enet | 18 | 0.24 | 4.3e-09 | -6.4 | 5.9 | 2.9e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 23 | GTEx | Esophagus Mucosa | LL22NC03-86G7.1 | 0.21 | 0.26 | lasso | 3 | 0.24 | 3.3e-16 | -6.4 | 6.3 | 3.0e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 24 | GTEx | Esophagus Muscularis | MAPK1 | 0.09 | 0.06 | lasso | 1 | 0.01 | 4.2e-02 | -6.3 | 6.3 | 3.6e-10 | -1.00 | 0.01 | 0.95 | FALSE |
| 25 | GTEx | Esophagus Muscularis | LL22NC03-86G7.1 | 0.22 | 0.24 | enet | 16 | 0.18 | 6.1e-11 | -6.4 | 6.0 | 2.5e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 26 | GTEx | Heart Atrial Appendage | LL22NC03-86G7.1 | 0.44 | 0.52 | enet | 8 | 0.51 | 7.3e-26 | -6.3 | 6.3 | 3.1e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 27 | GTEx | Heart Left Ventricle | LL22NC03-86G7.1 | 0.27 | 0.36 | enet | 8 | 0.36 | 4.0e-20 | -6.4 | 6.0 | 1.9e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 28 | GTEx | Lung | LL22NC03-86G7.1 | 0.19 | 0.26 | enet | 14 | 0.26 | 5.9e-20 | -6.4 | 6.0 | 2.7e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 29 | GTEx | Muscle Skeletal | LL22NC03-86G7.1 | 0.16 | 0.19 | lasso | 2 | 0.20 | 3.0e-19 | -6.4 | 6.3 | 2.2e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 30 | GTEx | Nerve Tibial | LL22NC03-86G7.1 | 0.34 | 0.48 | enet | 27 | 0.52 | 2.0e-42 | -6.4 | 6.0 | 1.5e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 31 | GTEx | Ovary | LL22NC03-86G7.1 | 0.26 | 0.44 | enet | 21 | 0.35 | 1.4e-09 | -6.4 | 6.5 | 7.6e-11 | -0.97 | 0.00 | 1.00 | TRUE |
| 32 | GTEx | Pancreas | LL22NC03-86G7.1 | 0.35 | 0.40 | lasso | 5 | 0.39 | 1.4e-17 | -6.4 | 6.5 | 1.1e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 33 | GTEx | Pituitary | LL22NC03-86G7.1 | 0.50 | 0.56 | lasso | 5 | 0.55 | 2.1e-16 | -6.4 | 6.3 | 2.3e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 34 | GTEx | Prostate | LL22NC03-86G7.1 | 0.32 | 0.34 | lasso | 7 | 0.32 | 6.5e-09 | -6.2 | 6.2 | 5.3e-10 | -0.98 | 0.01 | 0.99 | FALSE |
| 35 | GTEx | Skin Not Sun Exposed Suprapubic | LL22NC03-86G7.1 | 0.31 | 0.43 | enet | 22 | 0.43 | 2.0e-25 | -6.4 | 6.1 | 8.3e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 36 | GTEx | Skin Sun Exposed Lower leg | LL22NC03-86G7.1 | 0.30 | 0.43 | enet | 9 | 0.43 | 7.8e-39 | -6.4 | 6.1 | 1.1e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 37 | GTEx | Small Intestine Terminal Ileum | LL22NC03-86G7.1 | 0.39 | 0.28 | lasso | 3 | 0.27 | 7.6e-07 | -6.4 | 6.2 | 4.7e-10 | -0.97 | 0.01 | 0.99 | FALSE |
| 38 | GTEx | Spleen | TOP3B | 0.20 | 0.03 | lasso | 5 | 0.06 | 1.5e-02 | -5.7 | 5.8 | 6.4e-09 | -0.91 | 0.04 | 0.81 | FALSE |
| 39 | GTEx | Spleen | LL22NC03-86G7.1 | 0.44 | 0.27 | lasso | 8 | 0.31 | 9.9e-09 | 5.4 | 5.5 | 3.1e-08 | -0.90 | 0.01 | 0.99 | FALSE |
| 40 | GTEx | Stomach | LL22NC03-86G7.1 | 0.29 | 0.37 | enet | 13 | 0.28 | 5.9e-14 | -6.4 | 6.2 | 6.4e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 41 | GTEx | Testis | LL22NC03-86G7.1 | 0.20 | 0.11 | lasso | 8 | 0.12 | 9.0e-06 | -6.4 | 6.3 | 3.8e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 42 | GTEx | Thyroid | LL22NC03-86G7.1 | 0.33 | 0.45 | lasso | 2 | 0.46 | 1.6e-38 | -6.4 | 6.4 | 1.9e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 43 | GTEx | Uterus | LL22NC03-86G7.1 | 0.30 | 0.46 | lasso | 1 | 0.43 | 5.2e-10 | -6.4 | 6.4 | 1.9e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 44 | GTEx | Vagina | LL22NC03-86G7.1 | 0.35 | 0.34 | lasso | 3 | 0.30 | 1.5e-07 | -6.4 | 6.4 | 1.4e-10 | -0.99 | 0.00 | 0.99 | FALSE |
| 45 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PPM1F | 0.06 | 0.04 | blup | 57 | 0.04 | 4.8e-03 | -6.4 | 5.4 | 5.9e-08 | -0.89 | 0.01 | 0.94 | FALSE |
| 46 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TOP3B | 0.08 | 0.00 | blup | 67 | 0.03 | 1.3e-02 | -4.9 | 5.1 | 2.7e-07 | -0.88 | 0.01 | 0.88 | FALSE |
| 47 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TOP3B | 0.04 | 0.01 | enet | 6 | 0.03 | 1.0e-04 | -4.1 | 5.4 | 5.3e-08 | -0.77 | 0.01 | 0.91 | FALSE |
| 48 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPM1F | 0.03 | 0.02 | blup | 57 | 0.02 | 2.7e-03 | -5.7 | 5.3 | 1.0e-07 | -0.92 | 0.01 | 0.96 | FALSE |
| 49 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PPM1F | 0.14 | 0.09 | lasso | 3 | 0.10 | 7.7e-05 | -5.7 | 5.8 | 7.5e-09 | -0.81 | 0.04 | 0.76 | FALSE |
| 50 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPM1F | 0.03 | 0.03 | lasso | 2 | 0.02 | 3.8e-03 | -4.9 | 5.2 | 2.6e-07 | -0.92 | 0.02 | 0.88 | FALSE |