Best TWAS P=5.58e-09 · Best GWAS P=1.16e-12 conditioned to 0.246
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | FAM136A | 0.11 | 0.02 | enet | 13 | 0.05 | 8.2e-05 | 3.3 | 5.5 | 3.3e-08 | -0.59 | 0.10 | 0.84 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | FAM136A | 0.31 | 0.12 | lasso | 7 | 0.16 | 5.6e-06 | 3.5 | 5.8 | 5.6e-09 | -0.48 | 0.11 | 0.86 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | NFU1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 2.0e-03 | 5.1 | -5.1 | 2.8e-07 | 0.13 | 0.04 | 0.92 | FALSE |
| 4 | GTEx | Colon Sigmoid | PCYOX1 | 0.19 | 0.00 | enet | 27 | 0.00 | 3.0e-01 | 3.2 | -5.2 | 1.9e-07 | 0.58 | 0.04 | 0.60 | FALSE |
| 5 | GTEx | Esophagus Muscularis | PCYOX1 | 0.18 | 0.16 | enet | 14 | 0.15 | 1.9e-09 | -5.1 | -5.5 | 3.6e-08 | 0.84 | 0.33 | 0.67 | FALSE |
| 6 | YFS | Blood | PCYOX1 | 0.02 | 0.01 | blup | 461 | 0.01 | 1.1e-05 | -7.1 | 5.5 | 4.3e-08 | -0.68 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | AAK1 | 0.30 | 0.16 | enet | 14 | 0.15 | 1.3e-14 | 5.8 | -5.4 | 6.2e-08 | 0.05 | 0.00 | 1.00 | TRUE |