Best TWAS P=6.15e-20 · Best GWAS P=7.1e-26 conditioned to 1.54e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AFF3 | 0.31 | 0.24 | enet | 32 | 0.25 | 9.2e-31 | -5.8 | -7.3 | 2.3e-13 | 0.65 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | CHST10 | 0.18 | 0.04 | lasso | 4 | 0.05 | 5.6e-03 | -2.4 | 6.0 | 1.5e-09 | -0.45 | 0.34 | 0.10 | FALSE |
| 3 | GTEx | Artery Tibial | AFF3 | 0.06 | 0.04 | enet | 6 | 0.04 | 4.3e-04 | 8.3 | -9.1 | 6.1e-20 | 0.83 | 0.57 | 0.23 | TRUE |
| 4 | NTR | Blood | AFF3 | 0.03 | 0.01 | blup | 626 | 0.01 | 4.0e-03 | 5.2 | 5.6 | 2.6e-08 | -0.46 | 0.32 | 0.11 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | AFF3 | 0.31 | 0.24 | enet | 38 | 0.25 | 3.5e-32 | -5.9 | -5.1 | 2.7e-07 | 0.55 | 1.00 | 0.00 | FALSE |
| 6 | YFS | Blood | AFF3 | 0.06 | 0.04 | enet | 11 | 0.06 | 6.2e-18 | -3.2 | 7.2 | 4.8e-13 | -0.52 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AFF3 | 0.03 | 0.01 | blup | 240 | 0.02 | 6.6e-03 | -10.4 | -9.0 | 2.3e-19 | 0.83 | 0.02 | 0.90 | FALSE |