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chr2:110,852,875-115,095,488

Best TWAS P=1.55e-30 · Best GWAS P=1.69e-58 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	BCL2L11	0.04	0.02	lasso	3	0.02	5.7e-03	10.9	-11.5	1.5e-30	0.06	0.07	0.04	TRUE
6	GTEx	Esophagus Gastroesophageal Junction	RABL2A	0.29	0.10	enet	23	0.09	3.5e-04	9.4	11.3	9.0e-30	-0.02	0.03	0.80	TRUE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	BCL2L11	0.07	0.01	blup	71	0.06	2.0e-04	-8.0	-10.4	2.3e-25	0.04	0.35	0.10	TRUE
17	METSIM	Adipose	MIR4435-1HG	0.03	0.00	enet	24	0.01	5.4e-03	1.8	-9.9	3.0e-23	0.26	0.07	0.39	TRUE
19	ROSMAP	Brain Pre-frontal Cortex	ANAPC1	0.05	0.02	lasso	5	0.01	9.8e-03	8.1	9.5	2.0e-21	-0.06	0.16	0.05	TRUE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC541471	0.03	0.00	enet	13	0.01	2.6e-03	8.1	-8.6	6.6e-18	0.56	0.01	0.76	TRUE
15	GTEx	Thyroid	BCL2L11	0.09	0.00	lasso	4	0.00	3.9e-01	-7.9	-7.9	3.2e-15	0.01	0.12	0.04	TRUE
11	GTEx	Muscle Skeletal	TMEM87B	0.04	0.01	enet	9	0.01	5.3e-02	4.9	7.4	1.9e-13	-0.03	0.32	0.07	TRUE
13	GTEx	Nerve Tibial	AC112229.7	0.18	0.05	enet	14	0.07	7.1e-06	1.9	-7.1	1.0e-12	0.07	0.22	0.13	TRUE
4	GTEx	Artery Tibial	ANAPC1	0.07	0.03	lasso	2	0.01	2.3e-02	-4.8	-6.5	8.6e-11	0.11	0.05	0.04	TRUE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC654433	0.17	0.15	lasso	6	0.15	7.4e-11	-6.5	-6.0	1.8e-09	0.09	1.00	0.00	TRUE
14	GTEx	Pancreas	TMEM87B	0.29	0.04	lasso	6	0.08	2.6e-04	-5.3	6.0	2.3e-09	0.02	0.21	0.04	TRUE
9	GTEx	Heart Atrial Appendage	ZC3H8	0.12	0.01	lasso	4	0.00	1.9e-01	5.0	-5.7	1.0e-08	0.02	0.10	0.05	TRUE
1	CommonMind	Brain Pre-frontal Cortex	BCL2L11	0.04	0.04	lasso	2	0.03	2.0e-04	5.2	-5.6	2.3e-08	0.02	0.71	0.01	TRUE
18	NTR	Blood	MERTK	0.04	0.01	bslmm	337	0.03	1.1e-10	-5.0	5.5	3.1e-08	-0.08	0.98	0.00	TRUE
12	GTEx	Nerve Tibial	TMEM87B	0.14	0.04	enet	13	0.07	1.3e-05	4.6	5.4	5.1e-08	-0.02	0.98	0.00	TRUE
5	GTEx	Artery Tibial	TMEM87B	0.12	0.08	lasso	9	0.07	5.5e-06	-5.1	-5.4	7.7e-08	0.03	0.99	0.00	TRUE
3	GTEx	Artery Tibial	CHCHD5	0.12	0.08	lasso	3	0.05	4.4e-05	-5.1	-5.3	1.4e-07	0.07	0.01	0.99	TRUE
8	GTEx	Esophagus Muscularis	FBLN7	0.14	0.09	lasso	6	0.07	3.0e-05	-4.4	-5.3	1.4e-07	0.02	0.61	0.02	TRUE
2	GTEx	Adrenal Gland	PSD4	0.16	0.02	enet	26	0.02	5.9e-02	-2.1	-5.3	1.5e-07	-0.06	0.08	0.06	TRUE
7	GTEx	Esophagus Mucosa	BCL2L11	0.10	0.00	enet	23	0.02	2.2e-02	8.4	-9.1	7.4e-20	0.04	0.06	0.04	FALSE
16	GTEx	Thyroid	AC016683.6	0.11	0.12	lasso	2	0.13	2.4e-10	5.8	6.1	1.2e-09	-0.07	1.00	0.00	FALSE
10	GTEx	Lung	CHCHD5	0.10	0.02	lasso	4	0.01	9.0e-02	-5.1	-5.6	2.8e-08	0.05	0.02	0.82	FALSE
20	YFS	Blood	FBLN7	0.03	0.00	bslmm	355	0.02	1.9e-06	-4.8	-5.4	7.3e-08	0.11	0.67	0.01	FALSE