Best TWAS P=1.55e-30 · Best GWAS P=1.69e-58 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BCL2L11 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.0e-04 | 5.2 | -5.6 | 2.3e-08 | 0.02 | 0.71 | 0.01 | TRUE |
| 2 | GTEx | Adrenal Gland | PSD4 | 0.16 | 0.02 | enet | 26 | 0.02 | 5.9e-02 | -2.1 | -5.3 | 1.5e-07 | -0.06 | 0.08 | 0.06 | TRUE |
| 3 | GTEx | Artery Tibial | CHCHD5 | 0.12 | 0.08 | lasso | 3 | 0.05 | 4.4e-05 | -5.1 | -5.3 | 1.4e-07 | 0.07 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Artery Tibial | ANAPC1 | 0.07 | 0.03 | lasso | 2 | 0.01 | 2.3e-02 | -4.8 | -6.5 | 8.6e-11 | 0.11 | 0.05 | 0.04 | TRUE |
| 5 | GTEx | Artery Tibial | TMEM87B | 0.12 | 0.08 | lasso | 9 | 0.07 | 5.5e-06 | -5.1 | -5.4 | 7.7e-08 | 0.03 | 0.99 | 0.00 | TRUE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | RABL2A | 0.29 | 0.10 | enet | 23 | 0.09 | 3.5e-04 | 9.4 | 11.3 | 9.0e-30 | -0.02 | 0.03 | 0.80 | TRUE |
| 7 | GTEx | Esophagus Mucosa | BCL2L11 | 0.10 | 0.00 | enet | 23 | 0.02 | 2.2e-02 | 8.4 | -9.1 | 7.4e-20 | 0.04 | 0.06 | 0.04 | FALSE |
| 8 | GTEx | Esophagus Muscularis | FBLN7 | 0.14 | 0.09 | lasso | 6 | 0.07 | 3.0e-05 | -4.4 | -5.3 | 1.4e-07 | 0.02 | 0.61 | 0.02 | TRUE |
| 9 | GTEx | Heart Atrial Appendage | ZC3H8 | 0.12 | 0.01 | lasso | 4 | 0.00 | 1.9e-01 | 5.0 | -5.7 | 1.0e-08 | 0.02 | 0.10 | 0.05 | TRUE |
| 10 | GTEx | Lung | CHCHD5 | 0.10 | 0.02 | lasso | 4 | 0.01 | 9.0e-02 | -5.1 | -5.6 | 2.8e-08 | 0.05 | 0.02 | 0.82 | FALSE |
| 11 | GTEx | Muscle Skeletal | TMEM87B | 0.04 | 0.01 | enet | 9 | 0.01 | 5.3e-02 | 4.9 | 7.4 | 1.9e-13 | -0.03 | 0.32 | 0.07 | TRUE |
| 12 | GTEx | Nerve Tibial | TMEM87B | 0.14 | 0.04 | enet | 13 | 0.07 | 1.3e-05 | 4.6 | 5.4 | 5.1e-08 | -0.02 | 0.98 | 0.00 | TRUE |
| 13 | GTEx | Nerve Tibial | AC112229.7 | 0.18 | 0.05 | enet | 14 | 0.07 | 7.1e-06 | 1.9 | -7.1 | 1.0e-12 | 0.07 | 0.22 | 0.13 | TRUE |
| 14 | GTEx | Pancreas | TMEM87B | 0.29 | 0.04 | lasso | 6 | 0.08 | 2.6e-04 | -5.3 | 6.0 | 2.3e-09 | 0.02 | 0.21 | 0.04 | TRUE |
| 15 | GTEx | Thyroid | BCL2L11 | 0.09 | 0.00 | lasso | 4 | 0.00 | 3.9e-01 | -7.9 | -7.9 | 3.2e-15 | 0.01 | 0.12 | 0.04 | TRUE |
| 16 | GTEx | Thyroid | AC016683.6 | 0.11 | 0.12 | lasso | 2 | 0.13 | 2.4e-10 | 5.8 | 6.1 | 1.2e-09 | -0.07 | 1.00 | 0.00 | FALSE |
| 17 | METSIM | Adipose | MIR4435-1HG | 0.03 | 0.00 | enet | 24 | 0.01 | 5.4e-03 | 1.8 | -9.9 | 3.0e-23 | 0.26 | 0.07 | 0.39 | TRUE |
| 18 | NTR | Blood | MERTK | 0.04 | 0.01 | bslmm | 337 | 0.03 | 1.1e-10 | -5.0 | 5.5 | 3.1e-08 | -0.08 | 0.98 | 0.00 | TRUE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | ANAPC1 | 0.05 | 0.02 | lasso | 5 | 0.01 | 9.8e-03 | 8.1 | 9.5 | 2.0e-21 | -0.06 | 0.16 | 0.05 | TRUE |
| 20 | YFS | Blood | FBLN7 | 0.03 | 0.00 | bslmm | 355 | 0.02 | 1.9e-06 | -4.8 | -5.4 | 7.3e-08 | 0.11 | 0.67 | 0.01 | FALSE |
| 21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC541471 | 0.03 | 0.00 | enet | 13 | 0.01 | 2.6e-03 | 8.1 | -8.6 | 6.6e-18 | 0.56 | 0.01 | 0.76 | TRUE |
| 22 | The Cancer Genome Atlas | Colon Adenocarcinoma | BCL2L11 | 0.07 | 0.01 | blup | 71 | 0.06 | 2.0e-04 | -8.0 | -10.4 | 2.3e-25 | 0.04 | 0.35 | 0.10 | TRUE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BCL2L11 | 0.04 | 0.02 | lasso | 3 | 0.02 | 5.7e-03 | 10.9 | -11.5 | 1.5e-30 | 0.06 | 0.07 | 0.04 | TRUE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC654433 | 0.17 | 0.15 | lasso | 6 | 0.15 | 7.4e-11 | -6.5 | -6.0 | 1.8e-09 | 0.09 | 1.00 | 0.00 | TRUE |