Best TWAS P=1.2e-09 · Best GWAS P=3.66e-10 conditioned to 0.109
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Breast Mammary Tissue | SF3B1 | 0.06 | 0.06 | lasso | 4 | 0.03 | 6.6e-03 | -4.4 | -5.2 | 1.9e-07 | 0.70 | 0.17 | 0.68 | FALSE |
2 | GTEx | Breast Mammary Tissue (Female) | SF3B1 | 0.05 | -0.01 | lasso | 3 | -0.01 | 8.1e-01 | -4.5 | -5.2 | 2.4e-07 | 0.75 | 0.05 | 0.10 | FALSE |
3 | GTEx | Lung | RFTN2 | 0.06 | 0.08 | lasso | 8 | 0.06 | 2.7e-05 | -6.1 | -6.1 | 1.4e-09 | 0.99 | 0.03 | 0.97 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | MARS2 | 0.04 | 0.05 | enet | 8 | 0.03 | 1.2e-03 | -6.1 | 6.0 | 1.6e-09 | -0.98 | 0.04 | 0.96 | FALSE |
5 | GTEx | Spleen | RFTN2 | 0.11 | 0.03 | enet | 26 | 0.05 | 2.4e-02 | -6.2 | -6.1 | 1.2e-09 | 0.96 | 0.04 | 0.70 | FALSE |
6 | GTEx | Spleen | MARS2 | 0.12 | 0.04 | lasso | 5 | 0.00 | 3.4e-01 | -6.2 | 6.1 | 1.2e-09 | -0.94 | 0.04 | 0.57 | TRUE |
7 | GTEx | Thyroid | SF3B1 | 0.04 | 0.02 | enet | 14 | 0.02 | 2.0e-02 | -5.0 | -5.9 | 3.1e-09 | 0.83 | 0.08 | 0.84 | FALSE |
8 | GTEx | Thyroid | PLCL1 | 0.04 | 0.01 | lasso | 4 | 0.00 | 2.6e-01 | -6.0 | -5.8 | 6.5e-09 | 0.89 | 0.11 | 0.73 | FALSE |
9 | GTEx | Whole Blood | PLCL1 | 0.08 | 0.08 | enet | 15 | 0.05 | 4.1e-05 | -5.3 | -5.2 | 1.8e-07 | 0.89 | 0.35 | 0.65 | FALSE |
10 | YFS | Blood | ANKRD44 | 0.02 | 0.00 | blup | 416 | 0.01 | 6.3e-04 | -2.2 | 5.2 | 1.8e-07 | -0.46 | 0.14 | 0.48 | FALSE |
11 | YFS | Blood | PLCL1 | 0.10 | 0.10 | lasso | 9 | 0.14 | 1.5e-43 | -5.6 | -5.8 | 7.4e-09 | 0.84 | 0.45 | 0.55 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFTN2 | 0.05 | 0.01 | blup | 61 | 0.02 | 3.1e-02 | -4.4 | -5.9 | 3.3e-09 | 0.81 | 0.04 | 0.41 | FALSE |