TWAS hub - SF3B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0210	2.1e-07	0.071	0.051	0.074	0.057	0.067	5.1e-09	8.2e-07	2.5e-09	1.8e-07	1.6e-08
2	GTEx	Adipose Subcutaneous	0.0760	0.0410	4.5e-03	-0.002	NA	0.004	NA	0.000	4.9e-01	NA	1.4e-01	NA	3.4e-01
3	GTEx	Breast Mammary Tissue	0.0640	0.0300	1.8e-03	0.061	NA	0.027	NA	0.035	4.3e-04	NA	1.6e-02	NA	6.6e-03
4	GTEx	Breast Mammary Tissue (Female)	0.0540	0.0435	9.5e-02	-0.008	NA	-0.010	NA	-0.009	6.9e-01	NA	9.2e-01	NA	8.1e-01
5	GTEx	Esophagus Mucosa	0.0430	0.0220	4.1e-03	0.020	NA	-0.001	NA	0.011	1.5e-02	NA	3.9e-01	NA	5.7e-02
6	GTEx	Esophagus Muscularis	0.0620	0.0360	4.3e-03	0.016	NA	0.017	NA	0.026	3.5e-02	NA	3.1e-02	NA	1.0e-02
7	GTEx	Lung	0.0608	0.0275	3.9e-04	0.037	NA	0.015	NA	0.004	7.9e-04	NA	2.2e-02	NA	1.4e-01
8	GTEx	Nerve Tibial	0.0605	0.0223	3.5e-06	0.088	NA	0.075	NA	0.079	8.2e-07	NA	5.5e-06	NA	3.3e-06
9	GTEx	Skin Not Sun Exposed Suprapubic	0.0820	0.0440	2.4e-03	-0.004	NA	0.005	NA	0.002	5.9e-01	NA	1.6e-01	NA	2.6e-01
10	GTEx	Stomach	0.1140	0.0660	8.3e-03	-0.002	NA	-0.002	NA	-0.005	4.4e-01	NA	4.0e-01	NA	6.5e-01
11	GTEx	Testis	0.0960	0.0390	4.5e-05	0.072	NA	0.077	NA	0.077	4.2e-04	NA	2.6e-04	NA	2.6e-04
12	GTEx	Thyroid	0.0430	0.0210	1.4e-03	0.018	NA	0.016	NA	0.002	1.4e-02	NA	2.0e-02	NA	2.0e-01
13	ROSMAP	Brain Pre-frontal Cortex	0.0190	0.0101	4.3e-03	0.013	0.014	0.003	0.011	0.005	6.6e-03	6.2e-03	1.3e-01	1.2e-02	6.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Allergy or Eczema	24.6	64.8	89.3	8.8	3.9	9.4	9.4	8.7	7.6	7.1	8.7	6.7	5.4	8.8	9.4	8.4
Hayfever, allergic rhinitis or eczema	20.0	43.4	63.4	7.3	3.1	7.8	8.0	7.2	6.0	6.0	7.1	5.2	4.4	7.2	7.8	6.5
Impedance of arm (right)	17.3	80.9	130.0	9.7	3.5	11.0	11.4	9.4	8.6	7.6	9.7	7.0	5.2	10.1	11.3	8.6
Impedance of arm (left)	17.2	79.4	127.7	9.5	3.6	10.8	11.2	9.2	8.8	7.4	9.6	7.2	5.4	9.8	11.3	8.6
Schizophrenia (2014)	15.5	34.3	45.4	6.6	1.3	6.7	6.7	6.5	5.3	5.8	6.2	5.7	5.1	6.3	5.7	6.0
Bipolar Disorder or Schizophrenia	12.8	31.2	40.7	6.4	0.9	6.2	5.9	6.2	4.7	5.3	6.3	6.0	5.8	5.7	5.1	5.9
Schizophrenia (2018)	12.5	26.0	36.8	5.7	1.0	6.0	6.1	5.6	4.5	4.6	5.5	4.9	4.6	5.5	5.1	5.3
Allergy	12.4	28.6	40.2	-5.8	-3.7	-6.1	-5.8	-5.5	-5.9	-3.9	-5.9	-4.8	-4.3	-5.3	-6.3	-5.4
Impedance of whole body	11.0	55.9	102.0	7.5	3.4	9.1	9.8	7.5	7.6	6.0	7.9	5.7	4.0	8.2	10.1	7.1
Unable to work because of sickness or disability	10.8	14.0	20.7	-4.3	0.1	-4.5	-3.9	-4.2	-3.2	-4.1	-4.2	-2.9	-3.2	-4.0	-4.2	-3.6
Crohns Disease (2012)	9.1	14.7	21.7	3.8	1.1	4.2	4.3	3.7	3.5	4.5	4.0	3.7	3.2	3.6	4.7	4.2
Osteoporosis (self-reported)	9.0	11.2	15.1	3.5	2.2	3.7	3.5	3.5	3.9	3.2	3.6	3.4	2.5	3.5	3.4	3.4
Hayfever/allergic rhinitis (self-reported)	7.9	10.4	21.4	3.4	0.5	4.0	4.6	3.6	2.9	2.5	3.2	2.2	0.9	4.3	4.1	2.8
Crohns Disease (2017)	7.4	16.2	25.0	4.0	2.1	4.4	4.4	4.2	3.7	5.0	4.3	2.6	3.3	3.9	5.0	4.4
Trunk fat percentage	6.8	27.2	49.1	5.7	2.1	5.2	4.9	6.0	4.6	7.0	5.4	5.4	3.5	5.6	4.3	6.2
Mouth/teeth dental problems: Dentures	6.6	11.1	16.0	3.6	-0.1	3.6	4.0	3.8	2.9	3.5	3.3	3.7	2.3	3.9	3.2	3.6
Vitamin and mineral supplements	6.2	8.4	11.8	-3.4	-1.4	-3.3	-2.7	-3.3	-2.4	-2.7	-3.4	-2.1	-2.5	-3.1	-3.3	-3.4
Chronotype (morning person)	5.7	13.1	26.1	-3.4	-0.8	-4.2	-4.8	-3.3	-3.5	-4.0	-3.9	-1.8	-2.2	-3.8	-5.1	-3.8
Arm fat-free mass (right)	5.6	28.7	50.7	-5.9	-1.3	-6.9	-6.8	-5.6	-5.0	-3.7	-5.8	-3.9	-3.7	-6.0	-7.1	-4.8
Overall health rating	5.2	11.2	20.9	-3.4	-0.8	-4.2	-4.4	-3.2	-2.6	-2.7	-3.6	-3.1	-2.6	-3.6	-4.6	-3.0
Irritability	5.2	8.8	13.6	2.9	2.2	3.0	3.4	3.4	2.9	2.9	3.0	2.2	1.8	3.7	3.3	3.3
Supplements: Calcium	5.0	5.5	7.1	2.5	1.3	2.4	2.4	2.5	2.6	2.3	2.7	2.1	2.4	2.2	2.3	2.5
Arm predicted mass (right)	4.9	25.3	45.7	-5.6	-0.8	-6.6	-6.5	-5.2	-4.6	-3.4	-5.4	-3.7	-3.4	-5.7	-6.8	-4.4
Body fat percentage	4.8	18.8	39.8	4.6	1.6	4.0	3.7	5.0	3.7	6.3	4.4	4.7	3.2	4.6	3.2	5.4
Arm fat percentage (right)	4.7	18.7	39.8	4.9	1.4	4.0	3.5	5.1	3.4	6.3	4.4	4.9	3.3	4.7	2.7	5.3
Arm fat percentage (left)	4.7	18.6	38.1	4.8	1.5	4.0	3.4	5.1	3.5	6.2	4.4	5.0	3.4	4.6	2.8	5.3
Arm predicted mass (left)	4.6	23.1	45.6	-5.2	-1.3	-6.3	-6.2	-4.9	-4.6	-3.0	-5.2	-3.3	-3.3	-5.3	-6.8	-4.1
Bipolar Disorder (2018)	4.5	7.1	12.2	3.1	0.2	2.5	1.9	3.1	1.8	3.0	3.2	3.5	3.5	2.2	1.9	2.9
Rheumatoid Arthritis	4.5	6.2	14.0	-2.1	-3.2	-2.6	-2.1	-2.2	-3.3	-1.2	-2.7	-1.8	-2.0	-1.9	-3.7	-2.5
Irritable Bowel Disease (IBD)	4.3	10.3	18.1	3.3	1.7	3.3	2.6	3.4	2.6	4.2	3.6	2.7	3.6	2.8	3.4	3.6
Average weekly spirits intake	4.3	5.4	9.1	-2.7	-0.3	-2.8	-2.7	-2.7	-1.6	-2.6	-2.4	-2.0	-1.5	-3.0	-2.2	-2.2
Impedance of leg (right)	4.3	20.7	47.7	3.8	2.6	5.4	6.2	4.0	5.5	3.4	4.5	3.2	1.8	4.8	6.9	4.2
Illnesses of father: High blood pressure	4.3	5.3	8.6	2.6	2.1	2.7	2.3	2.4	2.6	1.9	2.2	2.9	0.7	2.6	2.0	2.2
Mouth/teeth dental problems: Mouth ulcers	4.2	6.7	10.0	-2.7	-0.4	-2.8	-2.8	-2.8	-2.3	-2.7	-2.5	-2.6	-3.2	-3.0	-2.3	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	4.1	6.2	9.3	3.0	2.2	2.4	1.3	2.9	2.2	2.5	2.9	3.1	2.4	2.1	1.9	3.0
Arm fat-free mass (left)	4.1	20.9	40.5	-5.0	-1.0	-6.0	-5.9	-4.7	-4.3	-2.8	-5.0	-3.2	-3.1	-5.1	-6.4	-3.9
Blood Platelet Count	4.0	46.7	65.4	-7.6	-2.5	-7.5	-6.2	-7.7	-6.4	-5.5	-8.1	-6.2	-6.9	-6.9	-7.4	-8.0
Trunk fat-free mass	3.9	22.1	38.4	-5.1	-1.4	-5.9	-5.8	-5.0	-4.7	-3.2	-5.1	-3.5	-3.2	-5.2	-6.2	-4.3
Trunk predicted mass	3.9	22.5	39.2	-5.2	-1.5	-6.0	-5.8	-5.0	-4.8	-3.2	-5.2	-3.6	-3.2	-5.2	-6.3	-4.4
Asthma (self-reported)	3.7	7.4	12.0	3.0	0.2	3.3	3.4	2.7	1.7	2.3	3.0	2.5	2.5	2.7	3.5	3.1
Impedance of leg (left)	3.6	17.4	41.9	3.5	2.5	5.0	5.8	3.7	4.9	3.0	4.1	2.7	1.6	4.5	6.5	3.9
Asthma	3.6	7.1	12.7	2.8	-0.1	3.2	3.5	2.6	1.6	2.1	2.9	2.3	2.4	2.7	3.6	2.9
Mother’s age at death	3.6	4.5	13.0	1.7	3.0	2.1	1.8	1.7	3.6	0.9	2.1	2.1	0.2	2.0	2.3	2.0
Medication: Atenolol	3.1	3.8	9.4	1.8	0.4	1.9	1.9	1.9	2.3	3.1	1.9	1.3	1.1	2.2	1.9	2.5
Alcohol usually taken with meals	3.1	5.0	8.4	2.4	2.5	2.6	1.8	1.9	2.3	1.9	2.7	2.1	1.8	1.8	2.9	2.0
Whole body fat-free mass	3.1	17.7	35.3	-4.4	-1.1	-5.4	-5.4	-4.3	-4.3	-2.6	-4.5	-3.0	-2.9	-4.6	-5.9	-3.7
Whole body water mass	3.1	17.5	34.6	-4.4	-1.2	-5.4	-5.3	-4.2	-4.3	-2.6	-4.5	-3.0	-2.9	-4.6	-5.9	-3.7
Back pain experienced in last month	3.0	4.4	9.7	-2.5	1.4	-2.7	-3.1	-2.2	-0.4	-1.8	-2.2	-1.0	-1.9	-2.4	-2.5	-1.5
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.6	7.3	-2.3	1.0	-2.5	-2.7	-2.1	-1.1	-2.5	-2.4	-1.4	-1.4	-2.4	-2.7	-2.2
Number of self-reported non-cancer illnesses	2.9	5.1	8.6	2.5	-0.5	2.4	2.3	2.4	1.7	2.9	2.3	2.4	2.1	2.3	2.1	2.5
Trunk fat mass	2.8	12.0	30.2	3.7	1.2	3.1	3.0	4.0	2.6	5.5	3.5	3.8	2.2	3.7	2.2	4.4
Happiness	2.8	3.4	8.4	-1.5	1.1	-2.0	-2.1	-1.4	-1.1	-2.5	-1.9	-1.4	-1.0	-1.8	-2.9	-2.1
Verbal and Numeric Reasoning (VNR)	2.7	6.6	13.3	2.6	1.7	3.1	2.7	2.4	2.7	1.9	3.0	1.5	1.9	2.4	3.6	2.6
Pulse wave Arterial Stiffness index	2.7	3.1	4.3	2.1	-1.0	1.7	1.6	2.1	1.6	1.7	2.0	1.5	2.1	1.9	1.3	2.1
Bipolar Disorder (2011)	2.6	2.5	3.8	1.9	0.1	1.9	1.9	1.9	1.2	1.7	1.8	1.5	1.8	1.6	1.2	1.1
Medication: Seretide 50 evohaler	2.6	3.0	5.1	1.5	2.1	1.5	1.7	1.4	2.3	2.0	1.7	1.6	1.5	1.6	1.6	1.7
Osteoarthritis (self-reported)	2.5	3.2	6.0	-1.8	0.6	-2.2	-2.4	-2.0	-1.2	-1.3	-1.9	-1.7	-1.2	-2.5	-2.0	-1.5
Average weekly beer plus cider intake	2.5	3.6	5.2	-1.9	-2.1	-2.1	-1.4	-1.7	-1.9	-1.8	-2.2	-1.7	-2.2	-1.4	-2.3	-1.7
Had other major operations	2.4	2.9	8.2	1.4	2.9	1.5	1.4	1.0	2.5	0.6	1.8	1.2	1.8	1.2	2.0	1.6
Alcohol drinker status: Never	2.4	2.9	4.8	-1.7	-1.6	-1.8	-1.7	-1.8	-1.1	-1.5	-1.8	-1.7	-0.5	-2.1	-2.2	-2.0
Primary Biliary Cirrhosis	2.3	3.3	7.4	-1.7	-0.9	-2.2	-2.2	-2.0	-1.4	-1.0	-2.0	-0.7	-0.8	-2.4	-2.7	-1.9
Waist Hip Ratio (WHR)	2.3	10.2	19.1	3.7	1.3	4.1	3.7	3.3	3.0	2.6	3.7	2.0	1.6	3.4	4.4	3.1
Pulse wave peak to peak time	2.3	2.7	4.6	-1.9	1.1	-1.5	-1.3	-2.0	-1.5	-1.5	-1.8	-1.4	-2.1	-1.7	-1.1	-1.9
Eye problems/disorders: Diabetes related eye disease	2.2	2.5	4.6	-1.4	0.1	-1.6	-1.6	-1.5	-1.2	-2.1	-1.7	-1.9	-1.2	-1.5	-1.7	-1.9
Prospective memory result	2.2	2.7	4.5	-1.6	-1.8	-1.8	-1.7	-1.6	-2.1	-1.8	-1.6	-1.5	-0.1	-1.7	-1.7	-1.7
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.3	1.4	1.2	1.7	1.1	1.2	1.7	1.9	1.7	1.5	1.3	1.5	2.1	1.7
Diastolic blood pressure, automated reading	2.2	6.9	16.7	-2.3	-4.1	-2.2	-1.4	-2.3	-3.6	-2.1	-2.6	-3.0	-2.6	-1.9	-2.1	-2.9
Alcohol drinker status: Previous	2.2	2.5	5.1	-1.8	-1.2	-1.6	-1.3	-1.6	-1.8	-0.8	-1.8	-2.3	-0.9	-1.4	-1.8	-1.8
Schizophrenia vs Biploar Disorder	2.1	2.7	10.0	1.4	-1.1	2.1	3.2	1.4	1.2	1.3	1.0	0.9	-0.3	2.3	2.2	1.1
Triglycerides	2.1	3.4	4.9	1.9	1.6	1.9	1.5	1.8	1.9	1.7	2.2	2.1	1.9	1.6	1.6	2.1
Respiratory disease	2.1	4.8	10.1	2.0	-0.7	2.5	2.8	2.0	1.4	1.8	2.3	1.9	2.4	2.3	3.2	2.3
Sensitivity / hurt feelings	2.1	3.7	5.8	2.2	1.2	2.1	2.2	2.3	1.9	1.8	1.7	2.4	1.0	2.4	1.1	1.9
Medication for hormone replacement therapy	2.1	2.4	6.2	-1.4	-1.4	-1.3	-1.2	-1.7	-2.5	-2.1	-1.2	-2.1	-0.8	-0.9	-0.6	-1.6
Birth weight	2.1	4.5	8.6	-2.0	-0.3	-2.5	-2.7	-2.1	-2.0	-0.9	-2.2	-2.4	-0.6	-2.6	-2.9	-2.3
Comparative body size at age 10	2.1	5.8	11.8	-2.1	-1.4	-2.9	-3.4	-2.1	-2.4	-2.0	-2.2	-2.6	-0.5	-2.5	-3.4	-2.3
Blood Eosinophil Count	2.0	15.6	23.8	3.8	2.2	4.0	4.5	4.0	3.6	4.7	3.5	4.9	2.2	4.7	3.5	4.5
Blood Red Count	2.0	19.3	35.1	-4.5	-0.5	-5.2	-5.2	-4.4	-4.8	-4.0	-4.8	-2.8	-3.6	-4.6	-5.9	-4.2
Hand grip strength (left)	2.0	5.3	6.8	-2.3	0.3	-2.6	-2.4	-2.6	-2.4	-2.5	-2.4	-2.5	-1.7	-2.5	-2.4	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.3	1.7	1.0	1.8	1.8	1.4	1.6	1.7	1.5	0.8	1.4	1.6	1.8	1.2
Glaucoma (self-reported)	2.0	2.3	4.3	-1.7	-0.7	-1.8	-1.4	-1.6	-1.0	-0.7	-1.9	-1.6	-0.9	-1.3	-2.0	-2.1
Health satisfaction	2.0	2.6	7.8	-1.6	1.1	-2.2	-2.2	-1.4	-0.8	-0.5	-1.9	-0.5	-0.9	-1.9	-2.8	-1.1
Financial situation satisfaction	2.0	2.5	6.2	-1.7	-1.5	-1.8	-1.5	-1.4	-2.5	-1.7	-1.4	-1.5	0.4	-1.8	-1.4	-1.2
Eye problems/disorders: Glaucoma	2.0	2.4	4.3	-1.9	-0.5	-2.0	-1.6	-1.8	-0.8	-0.9	-2.0	-1.1	-0.8	-1.4	-2.1	-2.0
Basal metabolic rate	2.0	10.9	25.5	-3.4	-0.7	-4.4	-4.5	-3.2	-3.4	-1.6	-3.5	-2.0	-2.2	-3.5	-5.0	-2.6
Father’s age at death	1.9	2.6	4.7	1.8	1.2	1.8	1.7	1.9	2.2	1.0	1.8	1.5	0.1	1.6	1.8	1.5
Pulse rate	1.9	3.2	4.9	1.8	-0.2	1.9	2.2	1.9	1.2	2.2	1.8	2.2	1.2	2.0	1.8	1.8
Length of working week for main job	1.9	2.1	3.3	-1.5	0.7	-1.6	-1.8	-1.7	-0.9	-1.6	-1.6	-1.5	-1.3	-1.5	-1.5	-1.4
Medication: Paracetamol	1.9	2.9	5.2	1.8	-0.5	1.8	1.5	1.9	0.4	2.3	1.9	1.4	1.9	1.2	1.9	2.3
Fractured/broken bones in last 5 years	1.9	2.5	4.1	2.0	-0.7	1.8	1.9	1.7	0.5	1.7	1.6	1.0	2.0	1.6	1.5	1.6
Intelligence (Savage-Jansen 2018)	1.8	5.5	14.3	2.3	1.5	2.7	2.1	2.2	2.6	1.6	3.0	1.2	1.7	2.0	3.8	2.6
Coronary Artery Disease (CAD)	1.8	2.2	4.0	1.8	-0.8	1.8	2.0	1.9	0.5	1.9	1.2	1.4	-0.1	1.8	1.0	1.3
Neuroticism	1.8	4.4	6.6	2.5	2.0	2.3	2.4	2.5	1.9	2.6	2.1	1.7	0.6	2.4	1.4	2.1
Fluid intelligence score	1.8	3.6	10.6	1.8	0.2	2.3	2.2	1.6	1.5	1.9	2.4	1.2	1.2	1.6	3.3	2.0
Illnesses of father: None of the above (group 1)	1.8	2.2	3.4	-1.7	-1.8	-1.6	-1.8	-1.3	-1.6	-1.4	-1.4	-1.1	0.8	-1.9	-1.0	-1.3
Ulcerative Colitis	1.7	2.5	5.8	1.7	1.6	1.2	0.4	1.6	1.0	1.2	1.9	2.4	2.4	1.2	0.9	1.8
Taking other prescription medications	1.7	2.6	6.9	1.7	-0.1	1.8	2.0	1.7	1.5	2.6	1.4	1.4	0.7	1.6	1.4	1.7
Medication: Ramipril	1.7	2.1	3.4	-1.2	-1.0	-1.5	-1.4	-1.4	-1.9	-1.0	-1.4	-1.6	-1.8	-1.4	-1.6	-1.6
Exposure to tobacco smoke outside home	1.7	2.3	5.3	-1.1	-0.6	-2.0	-2.3	-1.0	-1.9	-1.6	-1.3	-0.9	0.3	-1.6	-2.3	-1.0
Number of children fathered	1.7	1.9	3.8	1.1	1.2	1.2	1.6	1.1	1.9	1.3	1.1	1.6	1.1	1.6	1.0	1.6
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.0	1.5	0.5	1.3	1.0	1.5	1.4	0.4	1.8	0.6	2.0	1.8	1.7	1.6
Major Depression (MDD)	1.6	1.9	5.8	1.3	-0.6	1.3	1.1	1.3	1.3	1.0	1.8	0.8	1.7	1.0	2.4	1.5
Hand grip strength (right)	1.6	4.3	6.2	-2.2	1.3	-2.5	-2.3	-2.4	-1.3	-2.1	-2.2	-1.5	-1.9	-2.1	-2.3	-2.2
Whole body fat mass	1.6	6.6	21.6	2.6	0.9	1.9	1.7	3.0	1.8	4.7	2.4	3.1	1.7	2.5	1.0	3.5
High blood pressure (mother)	1.5	2.1	3.6	1.9	1.5	1.5	1.2	1.6	1.9	1.1	1.5	1.8	0.9	1.3	0.9	1.2
Neuroticism score	1.5	3.2	6.6	1.9	2.6	1.7	1.9	2.1	1.9	1.5	1.6	1.8	0.6	1.9	1.2	1.7
Depression (self-reported)	1.5	1.8	5.5	1.4	2.3	1.4	1.1	1.6	1.7	0.7	1.3	0.9	1.1	1.0	1.2	1.0
Blood clot in the leg (DVT)	1.5	1.9	6.2	-1.3	0.2	-1.6	-1.9	-1.5	-0.3	-2.5	-0.9	-1.4	-0.4	-1.8	-0.8	-1.4
Leg fat-free mass (right)	1.5	8.0	21.4	-2.5	-0.7	-3.7	-3.9	-2.5	-3.3	-1.4	-2.8	-1.7	-1.9	-2.9	-4.6	-2.2
Leg predicted mass (right)	1.5	7.8	21.2	-2.5	-0.7	-3.7	-3.8	-2.4	-3.3	-1.3	-2.8	-1.7	-1.8	-2.9	-4.6	-2.2
Mouth/teeth dental problems	1.4	2.2	4.0	-1.8	-0.2	-1.5	-1.9	-1.9	-1.3	-1.5	-1.5	-1.4	-0.5	-2.0	-0.9	-1.6
Gout (self-reported)	1.4	2.0	4.7	-1.6	-1.0	-1.8	-2.2	-1.8	-1.3	-0.6	-1.4	-1.1	-0.0	-1.7	-1.3	-0.8
Long-standing illness, disability or infirmity	1.4	2.2	3.7	-1.5	-1.6	-1.8	-1.5	-1.5	-1.9	-0.2	-1.6	-1.1	-1.7	-1.3	-1.6	-1.1
Ever had bowel cancer screening	1.4	1.7	3.2	1.1	1.3	1.0	0.7	1.0	1.8	0.9	1.8	1.4	1.0	0.6	1.6	1.8
Miserableness	1.4	2.5	6.4	1.7	1.2	1.5	2.1	2.0	1.1	2.5	1.2	1.4	0.5	2.0	0.6	1.3
HbA1C	1.3	1.4	2.3	-1.5	0.3	-1.4	-1.5	-1.5	-0.5	-0.6	-1.5	0.1	-0.8	-1.5	-1.5	-1.1
Ever had hysterectomy (womb removed)	1.3	1.5	3.4	-1.0	-1.0	-1.4	-1.5	-1.0	-1.6	-1.0	-1.2	-0.3	-0.4	-1.6	-1.8	-0.9
Supplements: Zinc	1.3	1.4	2.0	1.4	1.3	1.2	1.1	1.2	1.3	1.1	1.4	1.0	1.1	1.0	1.0	1.4
Supplements: Glucosamine	1.3	1.7	3.3	1.2	0.0	1.5	1.5	1.4	1.1	1.2	1.4	1.3	0.7	1.5	1.8	1.5
Leg fat percentage (right)	1.3	4.6	15.1	1.9	0.7	1.4	1.2	2.4	1.9	3.9	1.8	2.7	1.6	2.1	0.9	3.0
Medication: Allopurinol	1.3	1.8	3.6	-1.5	-0.2	-1.6	-1.9	-1.8	-1.2	-0.8	-1.4	-1.2	-0.5	-1.7	-1.3	-1.1
Ever smoked	1.3	2.3	4.2	1.6	1.3	1.3	1.3	1.6	2.0	2.0	1.5	0.8	1.3	1.3	1.3	1.8
Depressed Affect (Nagel 2018)	1.2	2.6	8.0	1.7	0.6	1.5	2.1	1.9	1.0	2.8	1.3	1.6	0.5	1.9	0.8	1.6
Mean Putamen Volume	1.2	1.4	2.7	1.4	0.9	1.6	1.6	1.3	1.0	0.8	1.2	0.5	0.5	1.4	1.3	0.9
HDL Cholesterol	1.2	2.0	3.4	-1.5	-0.6	-1.2	-1.1	-1.5	-1.4	-1.6	-1.5	-1.3	-1.6	-1.6	-1.1	-1.8
Lupus	1.2	1.9	5.4	-1.2	-0.3	-1.4	-1.1	-1.3	-0.9	-1.9	-1.7	-0.2	-1.1	-1.2	-2.3	-1.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.3	-1.2	-1.7	-1.3	-1.2	-1.2	-1.8	-0.1	-1.4	0.3	-0.2	-1.2	-1.6	-1.1
Diabetes (father)	1.2	1.4	3.1	-0.9	-0.6	-1.1	-1.8	-1.1	-1.6	-1.2	-1.0	0.0	-1.7	-1.5	-1.3	-0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.9	1.3	0.6	1.3	1.0	1.3	1.1	1.4	1.2	2.0	0.1	1.1	1.1	1.1
Past tobacco smoking	1.2	2.1	4.6	-1.5	-1.3	-1.1	-0.9	-1.5	-2.0	-2.1	-1.3	-1.0	-1.4	-1.2	-1.1	-1.9
Hair/balding pattern: Pattern 2	1.2	1.5	2.9	1.4	-0.4	1.5	1.7	1.6	0.5	0.8	1.1	1.1	0.1	1.7	1.1	1.5
Number of full sisters	1.2	1.5	2.8	-1.2	-0.4	-1.6	-1.7	-1.2	-0.9	-1.3	-1.3	-0.6	-1.2	-1.4	-1.6	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.2	-1.0	1.8	-1.2	-1.3	-1.3	-0.1	-1.3	-1.1	-1.0	-1.5	-1.4	-1.0	-1.1
Medication: Bendroflumethiazide	1.2	1.8	4.2	-1.1	-2.0	-1.5	-1.8	-1.4	-1.7	0.5	-1.0	-0.6	-0.1	-2.1	-1.4	-0.7
Myopia	1.2	1.8	3.7	-1.0	1.4	-1.2	-1.5	-1.1	-0.5	-1.9	-1.3	0.3	-1.1	-1.7	-1.9	-1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.1	-1.1	-1.2	-1.6	-1.8	-1.2	-1.2	-1.0	-0.9	-0.1	0.1	-1.7	-1.4	-0.9
Multivitamins +/- minerals	1.1	1.4	3.6	1.3	1.9	1.2	1.0	1.3	1.4	0.7	1.2	1.2	0.6	1.1	1.0	1.2
Leg predicted mass (left)	1.1	5.8	17.1	-2.1	-0.5	-3.2	-3.4	-2.0	-2.8	-0.8	-2.4	-1.3	-1.6	-2.4	-4.1	-1.7
Waist circumference	1.1	3.9	12.8	2.2	0.6	1.4	0.9	2.4	1.2	3.6	1.9	2.4	1.4	1.9	0.4	2.7
Falls in the last year	1.1	1.5	2.8	-1.4	-0.6	-1.6	-1.6	-1.3	-1.0	-1.0	-1.4	-0.7	-0.5	-1.7	-1.4	-0.8
Breastfed as a baby	1.1	1.3	1.9	1.2	1.4	1.1	1.0	1.3	1.4	1.2	1.2	0.9	0.8	1.3	1.0	1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.2	1.2	-0.1	1.6	1.8	0.9	1.0	1.1	1.0	1.3	0.8	1.1	1.5	1.0
Arm fat mass (left)	1.1	4.6	16.3	2.2	1.0	1.2	0.7	2.5	1.3	4.0	1.9	3.0	1.6	2.0	0.1	3.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.8	-1.2	0.1	-1.5	-1.9	-1.2	-0.7	-0.8	-1.1	-1.6	-0.5	-1.4	-1.4	-0.6
Leg fat-free mass (left)	1.0	5.6	16.6	-2.1	-0.6	-3.2	-3.3	-2.0	-2.8	-0.8	-2.3	-1.2	-1.5	-2.4	-4.1	-1.7
Qualifications: CSEs or equivalent	1.0	1.4	2.3	-1.5	-0.1	-1.5	-1.4	-1.1	-0.5	-1.5	-1.3	-0.4	-0.5	-1.3	-1.4	-1.4
Financial difficulties in last 2 years	1.0	1.3	5.7	1.1	2.4	0.9	1.0	1.1	1.5	0.3	0.9	1.5	0.0	0.5	0.5	0.9
Arm fat mass (right)	1.0	4.1	15.4	2.0	0.9	1.0	0.6	2.4	1.2	3.9	1.8	2.7	1.5	1.9	-0.1	2.9
Pulse wave reflection index	1.0	1.3	3.2	-1.2	0.8	-1.4	-1.8	-0.9	-0.1	-1.8	-0.9	-0.8	-0.6	-1.3	-1.2	-0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.7	-1.0	0.3	-1.3	-1.4	-0.8	-1.9	-0.4	-1.0	-0.4	-0.9	-1.0	-1.5	-0.6
Knee pain experienced in last month	1.0	1.6	4.7	-1.5	1.8	-1.8	-2.2	-1.1	0.7	-1.3	-0.8	-0.2	0.0	-1.5	-0.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.2	-0.8	0.3	-0.9	-0.9	-1.4	-0.9	-1.4	-1.1	-1.5	-1.0	-1.2	-1.0	-1.3
Body Mass Index (BMI) (2010)	0.9	1.3	2.5	1.3	0.6	0.8	0.7	1.5	1.0	0.9	1.1	1.4	1.2	1.6	0.2	1.4
Stomach or abdominal pain in last month	0.9	1.1	1.9	-1.1	0.3	-1.1	-1.3	-1.1	-0.2	-1.1	-1.2	-0.7	-1.4	-1.3	-1.0	-1.1
Number of incorrect matches in round	0.9	1.4	5.9	0.8	-0.3	0.8	0.5	1.0	0.9	1.9	0.8	0.8	2.4	0.8	1.2	1.5
Had menopause	0.9	1.1	2.2	1.2	1.4	1.0	0.8	1.3	1.5	1.2	1.2	0.7	-0.4	0.8	0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.6	-1.1	1.9	-1.5	-1.9	-0.9	0.3	-1.1	-1.0	0.6	-0.1	-1.4	-1.6	-0.4
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.2	1.5	0.9	1.2	1.0	1.2	0.2	0.0	1.1	1.2	0.7	0.9	1.0	1.3
High cholesterol (Self-reported)	0.9	1.5	4.8	-1.1	-2.2	-1.3	-1.2	-1.3	-1.5	0.2	-1.4	-0.3	0.1	-0.9	-1.5	-1.2
Leg fat percentage (left)	0.9	3.3	13.2	1.6	0.5	1.0	0.9	2.1	1.4	3.6	1.4	2.3	1.4	1.8	0.4	2.7
Ever depressed for a whole week	0.9	1.1	1.7	1.2	1.3	1.1	0.7	0.9	0.9	0.8	1.2	0.5	1.3	0.8	1.3	1.1
Ovarian Cancer	0.8	1.0	2.7	-1.1	-1.6	-1.2	-1.1	-0.8	-1.4	-0.0	-1.1	-0.5	-0.0	-0.7	-1.2	-0.8
Angina	0.8	1.1	5.1	0.8	1.0	0.3	-0.5	1.0	2.3	0.7	0.9	1.4	0.7	0.5	0.3	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	7.1	0.9	2.7	1.0	1.1	1.1	2.2	1.1	1.0	1.2	-0.4	1.4	0.9	1.2
Medication: Simvastatin	0.8	1.2	5.7	0.9	-2.0	0.6	0.6	0.7	-0.4	2.4	0.8	0.7	0.9	0.9	0.5	0.9
Noisy workplace	0.8	1.0	2.0	-0.9	-1.4	-0.9	-0.9	-0.7	-1.2	-0.3	-0.9	-1.4	-0.9	-1.1	-0.9	-0.8
Medication: Paracetamol	0.8	1.4	3.1	1.2	0.0	1.2	1.1	1.4	0.3	1.4	1.4	0.9	0.8	0.9	1.5	1.7
High blood pressure (siblings)	0.8	1.2	4.6	1.1	-0.5	0.8	0.8	1.2	0.9	2.1	1.0	1.2	0.8	1.0	0.5	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.7	1.4	1.6	0.8	0.4	1.2	0.6	1.2	1.0	0.6	1.4	0.8	0.2	1.0
Emphysema/chronic bronchitis	0.8	0.9	7.2	0.1	2.7	-0.1	-0.4	0.1	1.8	-0.6	0.2	0.5	0.4	0.4	0.1	0.5
Angina (self-reported)	0.8	1.1	4.6	0.8	0.7	0.3	-0.6	1.0	2.1	0.8	0.9	1.4	0.9	0.5	0.3	1.6
Migraine (self-reported)	0.8	1.0	2.3	-1.2	0.5	-1.2	-1.0	-1.3	-0.5	-1.2	-1.0	-0.8	-0.8	-1.5	-0.5	-0.8
Suffer from ‘nerves’	0.8	1.2	2.8	1.0	1.1	0.9	0.6	1.3	1.7	0.5	1.2	1.6	1.0	0.9	0.8	1.1
Supplements: Vitamin C	0.8	0.9	2.0	1.2	0.7	0.9	0.3	1.1	0.0	0.6	1.4	-0.3	1.4	0.8	1.1	1.4
Mood swings	0.8	1.5	3.4	1.2	1.8	0.8	1.0	1.6	1.4	1.4	0.6	1.7	0.3	1.5	-0.0	1.2
Pain experienced in last month	0.8	1.3	5.8	0.9	-2.4	1.3	1.7	0.8	-1.3	0.0	0.6	-0.6	1.0	1.2	1.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	4.3	-0.9	0.4	-1.1	-1.5	-1.1	-0.0	-2.1	-0.4	-1.0	-0.4	-1.4	-0.4	-1.0
Age at First Birth	0.7	1.1	2.0	-1.2	0.6	-1.1	-1.0	-1.0	0.1	-1.3	-1.1	-1.4	-1.2	-1.0	-0.7	-1.1
Smoking Status	0.7	1.8	3.5	1.6	1.3	0.9	0.7	1.7	1.9	1.5	1.0	1.6	1.1	1.4	0.2	1.5
Tanning	0.7	8.7	12.9	-3.0	-2.0	-3.2	-3.0	-3.0	-3.0	-2.8	-3.3	-2.5	-2.4	-3.0	-3.6	-3.2
Diabetes (mother)	0.7	0.9	2.3	-0.3	0.1	-0.7	-1.4	-0.8	-1.5	-1.4	-0.5	-0.7	0.1	-1.2	-1.4	-0.8
Average weekly fortified wine intake	0.7	0.8	4.9	0.4	2.2	0.5	0.3	0.5	1.4	0.9	0.4	0.5	0.4	0.3	0.8	0.5
Worrier / anxious feelings	0.7	1.2	2.3	1.1	0.5	1.3	1.5	1.2	1.2	0.6	1.2	1.5	0.4	1.0	1.3	1.0
Peak expiratory flow (PEF)	0.7	1.6	3.2	1.3	0.8	1.3	1.3	1.4	1.0	0.8	1.6	0.1	0.4	1.8	1.8	1.6
Shortness of breath walking on level ground	0.7	0.8	2.8	-0.5	-1.0	-0.9	-1.4	-0.5	-0.9	-0.5	-0.7	0.3	1.1	-0.9	-1.7	-0.4
Qualifications: College or University degree	0.7	2.1	6.7	-1.3	-1.6	-1.0	-1.0	-1.5	-1.7	-1.9	-0.8	-2.6	-0.8	-1.5	-0.1	-1.5
Comparative height size at age 10	0.7	3.6	6.1	-2.0	0.9	-2.2	-2.2	-2.0	-1.8	-1.6	-1.7	-1.6	-2.4	-2.5	-1.9	-1.4
Illnesses of siblings: Diabetes	0.7	0.9	1.9	1.0	-0.7	0.8	0.8	1.2	0.1	1.4	0.9	1.2	-0.1	1.0	0.3	1.3
Smoking status: Previous	0.7	1.0	3.7	0.7	0.7	0.4	0.3	0.7	1.4	1.9	0.8	0.7	1.5	0.3	0.6	1.3
Average weekly red wine intake	0.7	1.1	5.5	0.9	2.3	1.0	0.4	0.7	1.4	0.3	0.9	1.4	0.1	0.5	0.7	0.6
Loneliness, isolation	0.7	1.0	3.2	1.3	1.8	1.0	0.9	1.2	1.6	0.5	0.9	0.8	0.1	0.8	0.3	0.4
Friendships satisfaction	0.7	0.9	6.7	0.9	2.6	0.1	-0.6	0.9	1.1	-0.5	0.6	0.7	0.7	0.3	-0.5	0.4
Ulcerative Colitis (UC)	0.6	1.0	5.6	0.8	0.6	0.3	-0.7	0.8	0.2	1.5	0.9	1.2	2.4	0.0	-0.1	1.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	-0.8	-0.2	-0.7	-0.4	-1.0	-0.4	-0.3	-0.6	-1.3	-1.3	-0.8	-0.6	-1.0
Cardiovascular Disease	0.6	1.9	8.5	-0.8	-2.9	-1.4	-1.5	-0.9	-1.8	-0.4	-1.0	-0.7	-0.2	-1.2	-1.8	-1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.3	-0.8	0.7	-1.1	-1.2	-0.8	-1.0	-0.8	-0.9	-0.6	0.2	-1.1	-0.9	-0.7
Hip circumference	0.6	2.8	10.3	1.6	0.7	0.9	0.5	1.9	1.1	3.2	1.4	2.4	1.0	1.6	0.1	2.3
Tense / ‘highly strung’	0.6	1.0	2.3	1.3	0.8	1.1	1.2	1.5	1.0	0.4	0.9	0.6	-0.5	1.4	0.7	0.9
Forced vital capacity (FVC), Best measure	0.6	2.1	6.7	-1.6	-0.3	-1.2	-0.7	-1.9	-1.1	-2.6	-1.4	-0.8	-1.7	-1.3	-0.7	-1.7
Wheeze or whistling in the chest in last year	0.6	1.1	3.7	0.8	0.4	0.7	0.8	0.8	1.5	1.9	0.5	1.4	1.0	0.7	0.1	1.2
Age at first live birth	0.6	1.0	2.8	1.0	-0.0	1.3	1.7	0.9	0.5	1.3	1.0	0.1	0.8	1.2	1.3	0.7
Medication: Blood pressure	0.6	1.0	4.9	1.1	-1.3	0.7	0.5	1.0	-0.2	2.2	0.8	0.3	0.3	0.9	0.1	1.2
Family relationship satisfaction	0.6	0.8	6.0	-0.1	2.4	-0.5	-0.9	-0.2	0.6	-1.2	-0.1	-0.6	-0.1	-0.4	-0.5	-0.3
Medication: Lisinopril	0.6	0.7	2.3	-0.8	-1.5	-1.0	-1.1	-0.6	-0.9	0.1	-0.7	-0.4	0.8	-0.9	-0.8	-0.6
Neuroticism (Nagel 2018)	0.5	1.2	1.8	1.1	1.3	0.9	1.4	1.3	1.3	1.3	1.1	1.1	0.6	1.1	0.6	1.2
Worry (Nagel 2018)	0.5	1.0	1.8	1.3	0.4	1.2	1.0	1.3	0.8	0.7	1.3	0.9	0.5	1.1	0.7	1.1
LDL Cholesterol	0.5	0.9	1.3	1.0	0.6	1.0	0.7	1.0	1.0	0.6	0.9	1.1	1.1	1.1	0.7	0.9
Neuroticism (2016)	0.5	0.8	6.2	-0.0	2.5	0.1	-0.3	0.1	0.9	-1.2	0.4	-0.2	-1.1	0.2	0.4	0.4
Blood White Count	0.5	4.0	13.8	1.8	1.7	0.9	0.1	2.3	2.2	1.7	1.6	2.7	3.7	1.4	0.0	2.5
Lung FEV1/FVC ratio	0.5	2.7	6.3	2.2	0.9	1.4	0.4	2.5	1.6	1.6	2.3	1.0	1.3	1.6	0.9	2.1
Number of treatments/medications taken	0.5	0.8	3.8	0.6	-2.0	0.4	0.4	0.5	-0.4	1.8	0.6	0.3	0.8	0.6	0.5	1.0
Hearing difficulty/problems: Yes	0.5	0.7	3.1	-0.3	1.8	-0.6	-1.6	-0.3	0.6	-0.4	-0.2	0.2	-0.7	-1.1	-0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.8	-0.5	1.1	-1.0	-0.9	-0.3	0.1	-0.5	-0.8	0.5	0.6	-1.0	-1.7	-0.3
Medication: Levothyroxine sodium	0.5	0.8	2.5	-1.1	-0.6	-1.3	-1.6	-0.9	-0.5	-0.0	-0.9	0.1	1.0	-0.8	-1.1	-0.5
Hearing difficulty/problems with background noise	0.5	0.9	6.7	0.7	2.6	0.3	-0.2	0.6	0.7	-0.1	0.7	1.0	-0.8	0.3	-0.1	0.9
Hair/balding pattern: Pattern 4	0.5	1.3	2.1	1.2	-0.6	1.4	1.4	1.0	0.6	1.0	1.4	0.0	1.4	1.3	1.4	0.9
Eye problems/disorders: None of the above	0.5	0.6	1.8	0.6	0.6	0.9	0.7	0.5	0.8	0.4	1.0	0.7	0.1	0.5	1.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	-0.9	1.1	-0.8	-0.3	-0.7	-0.3	-1.0	-0.7	-1.4	-0.9	-0.2	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.0	-1.2	0.5	-1.1	-1.1	-1.3	-0.9	-1.4	-1.1	-0.1	-0.4	-1.1	-1.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.8	0.1	-1.7	0.3	0.3	-0.1	-0.8	-1.0	-0.1	-1.0	0.8	-0.1	0.3	-0.4
Commuting to job workplace: Walk	0.5	0.5	1.8	-0.6	-1.3	-0.6	-0.7	-0.5	-0.6	-0.3	-0.7	-0.7	-0.2	-0.8	-0.6	-1.1
Average weekly champagne plus white wine intake	0.5	0.7	1.5	1.1	1.1	1.1	0.6	0.7	1.0	-0.1	1.2	0.8	0.2	0.6	1.2	0.6
Guilty feelings	0.5	0.7	6.4	-0.5	2.5	-0.5	-0.4	-0.3	0.6	-0.4	-0.1	-0.5	-0.5	-0.9	0.1	-0.3
Alzheimer’s Disease (in father)	0.4	0.4	2.8	0.5	1.7	0.1	0.2	0.2	0.9	0.4	0.0	0.7	-0.7	-0.0	-0.8	-0.2
Fasting Glucose	0.4	0.5	2.4	0.2	1.6	-0.2	0.5	0.3	1.3	-0.1	0.0	1.1	0.8	0.1	-0.7	0.1
BMI	0.4	2.1	10.3	-0.4	0.0	-1.9	-2.6	0.1	-0.9	1.5	-0.8	1.2	0.6	-0.9	-3.2	0.5
Relative age of first facial hair	0.4	0.7	2.7	0.6	1.3	0.6	0.5	0.8	1.6	-0.4	0.8	0.8	0.5	0.8	0.9	0.7
Systolic blood pressure, automated reading	0.4	1.3	8.8	0.8	-3.0	0.9	1.1	0.8	-0.5	1.5	0.5	-0.4	0.3	0.9	0.7	0.4
Medication: Metformin	0.4	0.5	1.8	-0.2	-0.4	-0.9	-0.8	-0.3	-1.1	0.5	-0.4	-1.1	-0.4	-0.4	-1.3	-0.6
Sitting height	0.4	3.0	4.7	1.5	1.8	1.7	2.0	1.5	1.1	1.7	2.0	1.6	0.6	2.1	1.9	2.2
Body mass index (BMI)	0.4	1.7	8.6	-0.3	-0.2	-1.6	-2.3	0.1	-1.1	1.5	-0.7	0.8	0.5	-0.7	-2.9	0.5
Medication: Cholesterol lowering	0.4	0.7	3.3	0.5	-1.7	0.2	-0.0	0.0	-1.2	1.8	0.1	-0.6	0.3	0.1	-0.3	0.1
Lung cancer (father)	0.4	0.4	2.9	0.2	0.2	-0.3	-0.8	-0.1	-0.5	-0.7	0.1	-0.8	1.7	-0.3	-0.6	0.1
Exposure to tobacco smoke at home	0.4	0.5	2.5	-0.2	1.6	-0.4	-0.2	-0.4	-0.4	-0.5	-0.3	-0.8	-1.1	-0.4	-0.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.8	-0.7	1.7	-0.3	-0.1	-0.3	0.9	-2.0	-0.2	0.1	-0.0	-0.3	0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	-0.7	-0.7	-0.4	-0.5	-0.9	-0.1	-0.7	-0.8	-0.1	-1.1	-0.6	-0.3	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.9	-0.9	0.8	-0.3	-0.2	-0.9	0.3	-1.2	-0.9	-0.8	-0.5	-0.7	-0.3	-1.4
Neck or shoulder pain in last month	0.4	0.6	2.8	-0.4	1.7	-0.9	-1.3	-0.5	0.7	-0.4	-0.2	0.1	0.2	-1.1	-0.8	0.1
Medication for cholesterol	0.4	0.5	1.6	0.7	1.3	1.1	1.2	0.7	0.6	0.2	0.5	0.1	-0.3	0.5	0.7	0.2
Number of operations (self-reported)	0.4	0.6	1.5	0.9	1.2	0.7	0.9	0.6	0.8	0.6	0.6	1.2	0.8	0.4	0.4	0.8
Age started oral contraceptive pill	0.4	0.5	1.6	0.8	1.1	0.6	0.3	0.6	1.0	1.2	0.6	0.8	0.3	0.2	0.2	0.6
Heart disease (siblings)	0.4	0.5	3.1	-0.2	1.8	-0.4	-0.1	-0.4	0.2	0.2	-0.3	-0.3	-1.7	0.1	-0.5	-0.2
Breast Cancer	0.3	0.7	2.3	-0.9	-1.5	-0.4	0.1	-1.0	-0.9	-0.4	-0.6	-0.7	-1.4	-0.5	0.3	-0.6
Systolic Blood Pressure	0.3	1.4	11.6	-0.1	-3.4	0.2	0.9	-0.1	-1.3	0.1	-0.3	-1.2	-1.2	0.3	0.5	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	-0.5	-0.0	-0.9	-1.2	-0.5	-1.0	0.0	-0.6	-1.0	-0.3	-0.7	-1.2	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.3	0.9	-0.6	-0.8	-0.4	-0.2	-0.9	-0.6	-0.4	-0.4	-0.9	-1.0	-0.6
Fed-up feelings	0.3	0.5	1.3	0.2	1.0	0.2	1.2	0.6	1.0	0.9	0.1	0.3	0.1	1.0	0.2	0.5
Relative age voice broke	0.3	0.4	1.4	-0.4	0.9	-0.1	0.2	-0.1	0.8	-1.1	-0.1	-1.0	-1.2	0.1	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.4	0.2	1.9	0.4	0.5	0.5	0.8	0.5	0.3	0.6	-0.9	1.0	0.3	0.5
Nervous feelings	0.3	0.5	1.2	1.0	0.7	0.8	0.5	1.1	0.8	-0.3	0.8	0.2	0.9	0.9	0.4	0.4
Qualifications: None of the above	0.3	0.6	1.9	-0.4	-1.4	-0.9	-1.0	-0.3	-0.7	0.4	-0.7	-0.2	1.1	-0.5	-1.3	-0.3
Heart attack	0.3	0.4	1.0	0.4	0.8	-0.1	-0.4	0.5	1.0	0.8	0.1	0.7	0.0	0.3	-0.6	0.9
Pain all over the body in last month	0.3	0.3	1.1	-0.5	0.6	-0.8	-0.1	-0.6	-0.3	0.1	-0.6	-0.3	-1.1	-0.5	-0.7	-0.1
Time employed in main current job	0.3	0.3	1.1	-0.2	0.3	-0.6	-1.0	-0.1	-0.6	0.4	-0.2	0.4	0.7	-0.3	-1.0	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	-0.4	1.1	-0.8	-1.1	-0.2	0.0	0.1	-0.5	-0.4	-0.8	-0.8	-0.8	-0.8
Illnesses of mother	0.3	0.3	1.6	-0.8	-1.3	-0.4	0.3	-0.5	-0.9	0.2	-0.5	0.1	-0.2	-0.3	0.2	-0.1
Birth weight of first child	0.3	0.5	2.3	0.4	1.4	-0.0	-0.3	0.2	1.0	0.4	-0.0	0.5	1.5	0.2	-1.0	0.0
Loud music exposure frequency	0.3	0.3	2.1	-0.3	-1.0	-0.1	0.0	-0.6	-0.3	-0.4	0.0	-1.4	-0.1	-0.3	0.6	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.5	0.2	1.6	-0.2	-0.1	0.2	0.3	0.1	-0.1	0.9	-0.6	0.4	-0.9	0.1
Heart disease (mother)	0.3	0.4	3.1	0.4	1.8	0.1	-0.5	0.1	0.3	-0.7	0.4	-0.9	-0.2	0.4	0.2	-0.0
Leg fat mass (right)	0.3	1.3	8.4	0.6	0.2	-0.2	-0.4	1.1	0.3	2.9	0.4	1.5	0.4	0.7	-0.9	1.7
Chest pain or discomfort	0.3	0.5	1.8	-0.5	1.4	-0.6	-0.7	-0.3	1.2	0.1	-0.5	-0.1	-0.9	-0.4	-0.5	-0.1
Leg pain on walking	0.3	0.4	1.4	-0.4	-0.2	-1.0	-1.2	-0.1	-0.3	0.2	-0.2	-0.5	0.9	-0.4	-0.9	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.5	0.3	-1.6	0.4	0.5	0.2	-0.6	0.5	0.4	0.5	0.7	0.6	0.4	0.6
Illnesses of father: Heart disease	0.3	0.4	1.0	0.5	0.9	0.4	0.9	0.3	0.6	0.0	0.3	-0.6	-0.9	1.0	0.1	0.1
Qualifications: nursing, teaching	0.3	0.4	0.7	0.7	0.4	0.8	0.8	0.5	0.7	0.7	0.7	0.8	-0.4	0.4	0.7	0.5
Breast cancer (self-reported)	0.3	0.3	1.9	-0.2	-0.9	-0.2	-0.1	-0.2	-0.8	-0.1	-0.1	-1.4	0.5	-0.3	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	4.2	-0.4	-1.0	-0.2	-0.7	-0.6	-0.8	-2.1	-0.2	-0.8	-0.4	-0.3	0.2	-0.6
Ever taken oral contraceptive pill	0.3	0.3	1.2	0.2	-1.0	0.3	0.8	0.1	-1.1	0.1	-0.1	-0.6	0.1	0.5	-0.1	-0.3
Hearing aid user	0.3	0.3	1.9	-0.1	-1.4	-0.3	-0.6	-0.1	-0.2	-0.4	0.1	-0.0	0.9	-0.7	0.3	-0.1
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.7	-0.9	-0.4	0.1	-0.7	-0.2	-0.9	-0.3	-0.8	-0.3	-0.4	0.1	-0.8
Cholesterol lowering medication	0.3	0.5	2.0	-0.5	-1.4	-0.9	-1.1	-0.3	-0.4	0.6	-0.4	0.7	0.4	-0.4	-0.9	0.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	-0.8	-1.0	-0.2	0.2	-0.8	-0.5	-0.1	-0.4	-0.5	-1.1	-0.6	0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.5	0.7	-0.1	-0.4	0.6	0.9	1.0	0.2	0.7	0.2	0.3	-0.6	1.0
Leg fat mass (left)	0.3	1.1	7.3	0.4	-0.0	-0.5	-0.6	0.9	-0.1	2.7	0.2	1.3	0.2	0.5	-1.2	1.5
Alzheimer’s Disease (in mother)	0.2	0.2	1.4	0.1	-0.1	0.1	0.5	0.4	0.2	0.6	-0.2	1.2	0.3	-0.2	-0.1	0.3
Alzheimer’s Disease (including proxy)	0.2	0.2	1.0	-0.1	1.0	-0.2	0.0	-0.2	0.2	-0.2	-0.5	0.6	-0.5	-0.5	-0.6	-0.3
Prostate Cancer	0.2	0.3	2.0	-0.0	0.5	0.1	-0.4	-0.4	0.5	-0.3	0.3	-0.2	1.4	-0.6	0.6	-0.1
Heel T-Score	0.2	1.6	9.5	0.8	3.1	0.5	0.5	1.4	0.6	0.8	0.8	1.6	-0.1	1.5	0.2	1.2
Medication: Co-codamol	0.2	0.2	0.7	-0.3	0.9	-0.4	0.1	-0.0	0.4	-0.2	-0.1	0.8	-0.3	0.4	-0.0	0.7
Pack years adult smoking proportion	0.2	0.3	1.6	0.3	1.3	-0.1	-0.2	0.3	0.3	-0.8	0.2	1.0	0.2	0.5	-0.4	0.3
Townsend deprivation index at recruitment	0.2	0.3	1.3	-0.1	-1.2	-0.3	-0.1	-0.1	-1.1	-0.1	-0.6	-0.4	-0.4	-0.1	-0.6	-0.7
Current tobacco smoking	0.2	0.4	1.1	-0.5	-0.3	-0.7	-0.6	-0.3	-0.2	-1.0	-0.7	-0.6	-0.3	-0.4	-0.9	-0.5
Maternal smoking around birth	0.2	0.2	1.3	0.3	0.7	0.0	0.2	0.1	0.4	-1.1	-0.0	0.6	-0.4	0.4	-0.4	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	0.5	-0.2	0.2	0.1	0.5	0.2	0.1	0.2	1.0	0.2	0.3	-0.1	0.7
High blood pressure	0.2	0.5	4.8	0.3	-2.2	-0.1	-0.4	0.1	-0.8	0.7	-0.0	0.2	0.1	-0.1	-0.7	0.2
Forced vital capacity (FVC)	0.2	0.7	3.8	-0.8	0.3	-0.3	0.1	-1.1	-0.7	-1.9	-0.5	-0.9	-0.9	-0.3	0.2	-1.1
Diabetes (self-reported)	0.2	0.3	0.9	0.0	0.3	-0.4	-0.1	-0.2	-0.9	0.5	-0.3	-0.8	-0.5	-0.2	-0.8	-0.6
Illnesses of siblings	0.2	0.3	0.8	-0.5	-0.8	-0.3	-0.3	-0.5	-0.7	-0.9	-0.4	-0.1	0.8	-0.7	-0.3	-0.6
Weight	0.2	1.1	5.1	-0.4	0.1	-1.4	-1.6	-0.1	-0.9	1.6	-0.6	0.7	-0.3	-0.5	-2.3	0.5
Number of live births	0.2	0.3	1.7	0.5	0.9	0.5	0.5	0.6	1.3	-0.1	0.3	-0.2	-0.4	0.2	0.4	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	0.4	0.2	0.2	0.2	0.6	-0.1	-0.2	0.8	0.7	-0.1	0.1	0.9	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	-0.9	-0.4	-1.0	-1.2	-0.6	-0.2	0.2	-0.7	0.1	0.4	-0.5	-0.9	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.0	0.1	0.6	0.0	-0.3	0.3	1.0	-0.7	0.4	0.3	0.4	0.2	0.3	0.1
Number of full brothers	0.2	0.2	0.6	-0.5	-0.6	-0.5	-0.1	-0.4	-0.8	0.8	-0.4	-0.5	-0.5	-0.0	-0.2	-0.2
Worry too long after embarrassment	0.2	0.3	2.2	0.1	1.5	0.0	-0.1	0.0	0.2	-0.7	0.0	0.4	0.7	-0.0	-0.2	-0.0
Mean time to correctly identify matches	0.2	0.3	1.0	0.3	0.4	0.6	0.9	0.2	1.0	0.2	0.2	0.9	-0.8	0.1	0.7	-0.1
Alcohol intake frequency.	0.2	0.5	1.9	-0.1	-1.4	-0.3	0.1	-0.0	-0.6	0.5	-0.6	-0.7	0.4	-0.1	-1.4	-0.7
Age at last live birth	0.2	0.4	1.0	0.6	0.2	0.7	1.0	0.6	0.9	0.8	0.5	-0.1	0.2	0.5	0.6	0.3
Medication: Aspirin	0.2	0.2	1.0	-0.3	-0.3	-0.6	-1.0	-0.4	-0.6	0.2	-0.1	-0.0	-0.4	-0.4	-0.5	0.4
Hypertension (Self-reported)	0.2	0.5	4.0	0.1	-2.0	-0.4	-0.9	-0.1	-0.8	0.6	-0.1	0.0	0.3	-0.4	-0.9	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.1	-0.3	-0.6	-0.4	0.3	-0.2	0.0	0.0	-0.5	-0.0	-1.1	0.1	-0.6	-0.4
Eye problems/disorders: Cataract	0.2	0.3	1.0	0.7	-0.2	0.4	0.2	0.7	0.0	0.8	0.4	1.0	0.3	0.3	-0.3	0.5
Mineral and other dietary supplements	0.2	0.3	1.1	-0.3	0.8	-0.6	-0.8	-0.2	0.1	-0.5	-0.4	-0.5	-0.2	-0.3	-1.1	-0.3
Medication: Aspirin	0.2	0.2	0.7	-0.2	-0.3	-0.5	-0.9	-0.2	-0.5	0.6	0.1	0.2	-0.1	-0.2	-0.4	0.7
Medication: Gliclazide	0.2	0.3	1.1	-0.1	0.5	-0.4	-0.2	-0.2	-0.2	0.1	-0.5	0.0	-1.1	-0.5	-1.0	-0.5
Smoking status: Current	0.2	0.3	1.1	-0.3	-0.2	-0.6	-0.5	-0.2	-0.2	-1.1	-0.6	-0.7	-0.4	-0.3	-0.8	-0.4
Wears glasses or contact lenses	0.2	0.3	1.3	0.5	0.4	0.5	0.4	0.3	0.8	1.2	0.5	-0.3	0.0	0.4	0.5	0.2
Medication: Blood pressure	0.2	0.3	1.1	0.7	-0.1	0.1	0.0	0.5	0.8	1.0	0.5	0.8	0.4	0.1	-0.0	0.8
Medication: Atorvastatin	0.2	0.2	0.6	-0.4	-0.1	-0.4	-0.8	-0.6	-0.6	-0.0	-0.4	-0.3	0.2	-0.7	-0.5	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.8	-0.1	-0.7	0.4	0.1	-0.4	0.4	-0.0	-0.1	-0.5	0.6	-0.1	0.9	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	5.2	-0.2	2.3	0.3	0.7	-0.1	0.6	-0.7	0.2	-0.1	0.2	0.2	0.9	-0.1
Pack years of smoking	0.2	0.4	2.3	0.3	1.5	0.0	-0.1	0.3	0.6	-0.7	0.3	0.9	0.2	0.5	-0.3	0.4
Depression (Nagel 2018)	0.1	0.2	0.7	-0.1	-0.2	-0.4	-0.2	-0.2	-0.3	0.2	-0.3	0.4	-0.1	-0.9	-0.9	-0.3
Reaction Time	0.1	0.2	1.1	0.2	0.1	0.3	0.6	0.2	0.5	-0.2	-0.2	1.0	-0.9	-0.2	0.1	-0.5
Height	0.1	1.1	6.2	-1.1	0.4	-0.2	1.3	-1.3	-0.4	-0.1	-0.7	-1.2	-2.5	-0.6	0.7	-0.7
Hypothyroidism (self reported)	0.1	0.3	1.4	-0.5	-0.4	-0.7	-0.7	-0.3	-0.2	0.6	-0.6	0.5	0.1	0.1	-1.2	-0.2
Lung FVC	0.1	0.3	3.7	-0.1	-0.4	-0.0	-0.2	-0.3	-0.0	-1.9	0.1	-0.1	-0.1	0.0	-0.1	-0.5
Hair Pigment	0.1	1.5	3.2	-1.4	-1.0	-1.0	-0.6	-1.4	-1.4	-1.2	-1.5	-1.8	-0.8	-0.9	-1.2	-1.4
Severe depression (siblings)	0.1	0.1	0.4	0.0	-0.4	-0.0	0.5	-0.1	-0.4	0.1	-0.2	-0.7	-0.0	0.3	-0.3	-0.4
Age when periods started (menarche)	0.1	0.3	0.9	-0.0	0.5	0.1	0.8	0.2	1.0	0.9	-0.2	0.8	0.1	0.2	-0.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.1	0.5	-0.0	-0.3	-0.0	0.6	0.1	0.2	0.7	0.1	-0.1	-0.2	0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.8	-0.0	-0.0	-0.0	-0.1	0.1	-0.1	0.9	0.2	0.7	-0.5	0.0	0.1	0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.3	-0.2	0.1	0.1	0.2	0.1	0.1	0.0	0.4	0.7	0.4	-0.3	0.4
Alcohol intake versus 10 years previously	0.1	0.2	1.6	-0.2	-1.3	-0.2	0.5	-0.1	0.2	-0.0	-0.6	0.4	0.1	0.0	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.5	-0.1	0.4	0.0	0.1	-0.2	-0.4	-1.2	0.2	-0.8	-0.5	0.3	0.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.1	0.7	-0.0	-0.4	-0.3	-0.1	-0.5	0.3	-0.6	0.8	-0.5	-0.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.7	0.3	-0.2	0.1	0.0	0.5	0.0	0.3	0.5	0.8	-0.4	0.5	0.4	0.6
Medication: Lansoprazole	0.1	0.2	1.1	0.1	0.0	-0.2	-0.4	0.2	-0.0	1.1	0.1	0.6	-0.2	0.0	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	2.1	-0.4	-0.0	-0.3	-0.1	-0.4	-0.3	-1.4	-0.1	-0.2	-0.6	-0.1	0.2	-0.4
Standing height	0.1	0.6	2.5	-0.3	1.2	0.4	1.4	-0.4	0.4	0.4	0.1	-0.1	-1.6	0.4	1.1	0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.0	0.1	0.0	-0.3	-0.1	0.6	-0.1	0.2	0.7	0.6	-0.7	-0.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.5	-0.0	0.3	0.3	0.4	0.6	0.5	0.2	0.4	0.6	0.2	-0.3	0.1
Headache pain in last month	0.1	0.2	1.0	-0.3	0.2	-0.5	-1.0	-0.2	0.0	0.2	-0.5	0.3	-0.2	-0.8	-0.8	-0.3
Medication: Amlodipine	0.1	0.1	1.0	0.0	0.1	-0.4	-1.0	-0.1	-0.1	0.1	-0.2	0.1	-0.4	-0.4	-0.6	0.1
Medication: Ibuprofen	0.1	0.1	0.7	0.2	-0.7	0.0	-0.2	0.3	-0.4	0.4	0.3	0.8	0.1	0.1	0.0	0.4
Medication: Omeprazole	0.1	0.2	1.0	0.0	0.4	-0.1	0.4	-0.1	0.5	0.1	-0.1	-0.3	-1.0	0.0	-0.4	-0.3
Pulse rate, automated reading	0.1	0.4	2.0	-0.1	-1.3	-0.3	0.2	-0.2	-1.4	-0.5	-0.4	-0.1	0.2	0.3	-0.7	-0.6
Had major operations	0.1	0.1	0.7	0.2	-0.1	0.1	-0.2	-0.1	-0.6	0.8	-0.1	-0.5	0.0	-0.4	0.0	-0.0
Diabetes diagnosed by doctor	0.1	0.2	0.9	-0.1	0.3	-0.5	-0.4	-0.3	-1.0	0.4	-0.0	-0.7	-0.4	-0.2	-0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.6	-0.1	-0.5	0.1	-0.0	-0.3	-0.3	0.3	-0.2	0.2	-0.7	-0.3	0.1	-0.3
Risk taking	0.1	0.1	0.3	-0.1	0.3	0.0	-0.3	-0.1	-0.0	0.4	0.1	-0.3	-0.6	-0.2	0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	1.0	0.2	0.4	0.0	0.2	0.2	0.5	0.3	0.1	-0.4	-1.0	0.2	-0.3	-0.2

Hub : Genes

SF3B1

Models

Trait associations