TWAS hub - ANKRD44

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1170	0.0350	9.7e-07	0.015	0.048	0.079	0.049	0.060	5.3e-03	1.5e-06	7.6e-10	1.2e-06	7.7e-08
2	GTEx	Adipose Subcutaneous	0.2700	0.0770	4.1e-10	0.061	NA	0.123	NA	0.096	9.1e-06	NA	3.1e-10	NA	3.1e-08
3	GTEx	Adrenal Gland	0.1462	0.0564	1.8e-04	0.049	NA	0.104	NA	0.153	7.7e-03	NA	1.4e-04	NA	3.9e-06
4	GTEx	Breast Mammary Tissue	0.1340	0.0550	1.5e-04	0.043	NA	0.067	NA	0.061	2.9e-03	NA	2.6e-04	NA	4.8e-04
5	GTEx	Breast Mammary Tissue (Female)	0.2424	0.0900	4.9e-04	0.094	NA	0.141	NA	0.162	9.4e-04	NA	5.6e-05	NA	1.5e-05
6	GTEx	Cells EBV-transformed lymphocytes	0.4190	0.1110	7.9e-06	0.091	NA	0.104	NA	0.086	7.0e-04	NA	3.0e-04	NA	9.4e-04
7	GTEx	Liver	0.2830	0.1250	1.8e-03	0.183	NA	0.137	NA	0.178	8.2e-06	NA	1.2e-04	NA	1.1e-05
8	GTEx	Lung	0.1581	0.0583	1.7e-05	0.014	NA	0.054	NA	0.055	2.7e-02	NA	5.8e-05	NA	4.7e-05
9	GTEx	Muscle Skeletal	0.0959	0.0376	1.2e-04	0.063	NA	0.019	NA	0.042	8.8e-07	NA	5.5e-03	NA	5.8e-05
10	GTEx	Nerve Tibial	0.5189	0.0728	8.9e-14	0.212	NA	0.156	NA	0.173	5.4e-15	NA	3.7e-11	NA	2.8e-12
11	GTEx	Pituitary	0.4230	0.1330	6.9e-04	0.080	NA	0.157	NA	0.168	4.9e-03	NA	9.6e-05	NA	5.3e-05
12	GTEx	Skin Not Sun Exposed Suprapubic	0.2730	0.0960	4.6e-06	0.085	NA	0.125	NA	0.107	2.1e-05	NA	2.5e-07	NA	1.9e-06
13	GTEx	Skin Sun Exposed Lower leg	0.2990	0.0740	1.4e-09	0.132	NA	0.162	NA	0.153	4.4e-11	NA	2.2e-13	NA	1.3e-12
14	GTEx	Small Intestine Terminal Ileum	0.2590	0.1070	5.2e-03	0.022	NA	0.020	NA	0.029	1.0e-01	NA	1.1e-01	NA	7.7e-02
15	GTEx	Testis	0.3270	0.0870	1.8e-10	0.350	NA	0.362	NA	0.341	2.4e-16	NA	6.2e-17	NA	7.1e-16
16	GTEx	Whole Blood	0.0830	0.0330	1.1e-04	0.068	NA	0.053	NA	0.056	7.3e-07	NA	1.2e-05	NA	7.0e-06
17	NTR	Blood	0.0274	0.0114	4.5e-05	0.003	0.017	0.008	0.017	0.006	2.6e-02	2.9e-06	8.7e-04	2.7e-06	3.2e-03
18	YFS	Blood	0.0222	0.0100	1.7e-04	-0.001	0.008	0.006	0.007	0.002	7.7e-01	6.3e-04	4.4e-03	1.4e-03	8.4e-02
19	TCGA	Bladder Urothelial Carcinoma	0.0730	0.0360	8.3e-03	0.005	0.021	0.001	NA	0.003	1.2e-01	6.4e-03	2.7e-01	NA	1.6e-01
20	TCGA	Prostate Adenocarcinoma	0.0841	0.0417	7.5e-04	0.024	0.014	0.012	NA	0.009	1.3e-03	1.2e-02	1.7e-02	NA	3.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Bipolar Disorder or Schizophrenia	5.6	13.7	43.2	2.4	4.8	-2.9	2.9	3.4	1.4	3.8	3.4	1.8	3.3	2.4	4.3	5.1	1.9	4.7	3.0	-6.3	-6.6	0.5	2.3
Schizophrenia (2014)	5.6	12.3	44.0	1.9	3.6	-3.1	1.9	3.0	0.9	3.6	3.1	1.3	2.4	2.1	4.3	4.6	1.8	5.4	2.5	-6.5	-6.6	1.2	2.5
Schizophrenia (2018)	5.4	11.2	38.9	2.2	3.4	-2.6	2.2	3.5	1.2	3.6	2.8	1.3	2.8	2.0	4.3	4.4	1.6	4.5	2.7	-6.0	-6.2	1.3	2.0
Allergy or Eczema	4.6	12.2	57.9	-1.0	3.1	-6.0	1.6	1.1	-0.4	3.1	0.7	-0.9	0.8	0.2	2.6	4.7	0.6	7.6	1.1	-7.0	-6.5	0.8	0.0
Hayfever, allergic rhinitis or eczema	4.1	9.0	36.7	-1.3	2.7	-4.2	1.8	0.8	0.9	2.5	1.4	0.7	1.3	1.3	2.7	4.6	1.3	6.0	1.6	-6.1	-5.5	0.1	0.7
Wheeze or whistling in the chest in last year	4.1	7.3	13.8	3.4	3.0	0.4	3.2	3.4	2.0	3.4	3.5	0.6	3.6	2.9	3.0	3.7	1.1	1.1	3.6	-2.2	-2.2	0.5	2.5
Respiratory disease	3.9	8.8	17.3	1.2	3.8	-0.6	2.3	1.9	3.4	3.2	3.9	2.8	4.1	3.1	3.5	4.2	2.2	1.0	3.2	-3.7	-4.1	-0.3	2.1
Allergy	3.5	8.0	30.4	0.2	-3.1	2.6	-2.2	-1.3	-1.3	-2.0	-2.1	-1.4	-2.1	-1.8	-3.5	-4.3	-2.1	-4.0	-2.0	5.3	5.5	-0.3	-1.6
Bipolar Disorder (2011)	3.4	3.3	8.0	-0.4	2.2	-0.4	2.0	0.6	2.2	1.5	2.2	2.0	2.3	2.0	1.6	2.8	1.4	1.0	1.6	-1.9	-2.4	-1.2	1.8
Crohns Disease (2012)	3.3	5.3	13.6	2.2	1.9	-1.1	0.9	0.3	2.4	2.5	2.8	0.5	2.1	2.3	3.4	2.4	1.0	2.6	2.5	-3.7	-3.2	2.0	2.5
Qualifications: O levels/GCSEs or equivalent	3.1	4.9	11.1	1.4	2.7	1.6	2.5	2.4	2.8	1.5	2.4	1.3	3.3	2.4	2.4	2.5	1.8	-0.7	3.1	-1.3	-1.7	1.6	2.9
Unable to work because of sickness or disability	2.9	3.7	12.5	1.3	-2.2	2.2	0.7	0.1	-0.9	-1.7	-2.0	-0.8	-1.1	-2.2	-1.7	-2.8	-1.0	-3.2	-1.4	2.7	3.5	-0.7	-1.8
Depression (self-reported)	2.8	3.4	8.4	-2.3	-1.1	-1.2	-1.2	-1.9	-2.6	-2.9	-1.8	-1.7	-2.7	-2.5	-1.0	-1.9	0.2	1.6	-2.8	0.4	-1.2	1.0	-1.6
Medication for hormone replacement therapy	2.7	3.0	6.9	-2.6	-1.5	-0.0	-1.7	-1.8	-0.3	-2.2	-1.2	-0.5	-1.5	-1.6	-2.3	-2.6	-0.1	-1.6	-1.8	2.4	1.3	-1.9	-2.5
Asthma	2.7	5.4	14.9	1.1	2.7	-1.0	1.4	1.6	2.4	2.6	2.8	2.2	3.0	2.2	2.8	2.9	1.6	1.0	2.4	-3.9	-3.6	-0.6	1.2
Heart disease (mother)	2.7	3.3	8.4	-2.7	-1.2	-1.1	-2.2	-2.9	-2.0	-2.8	-1.7	0.4	-2.2	-1.6	-1.8	-1.7	-0.7	0.2	-2.3	2.4	0.8	-0.5	-1.4
Asthma (self-reported)	2.6	5.1	14.4	1.3	2.7	-0.9	1.4	1.3	2.2	2.3	2.7	1.9	3.0	2.0	3.0	2.9	1.4	1.0	2.4	-3.8	-3.5	-0.2	1.1
Trunk fat percentage	2.5	10.0	42.1	2.9	4.2	-3.6	1.4	1.6	-0.9	3.6	3.5	-1.9	2.1	1.2	3.0	4.6	-0.1	6.5	2.2	-4.2	-4.8	1.6	0.7
Impedance of arm (right)	2.5	11.8	57.5	-3.9	1.7	-6.7	-1.0	-1.7	-1.0	-0.1	-1.2	-0.6	-1.6	-1.2	0.9	2.2	0.0	7.5	-1.6	-7.6	-6.1	1.8	0.3
Impedance of arm (left)	2.5	11.7	59.4	-3.6	1.9	-6.7	-0.7	-1.1	-1.3	0.5	-1.0	-0.7	-1.6	-1.5	0.6	2.3	0.1	7.0	-1.6	-7.7	-6.6	1.5	0.3
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	10.9	-0.3	-2.2	1.5	-2.0	-0.6	-1.3	-2.3	-1.2	0.4	-2.0	-1.2	-2.5	-3.3	-1.9	-3.2	-2.1	2.7	2.6	-1.8	-1.2
Average weekly beer plus cider intake	2.5	3.6	10.7	0.6	-3.3	0.4	-0.8	-1.1	-2.3	-2.3	-2.3	-0.5	-2.1	-1.9	-1.8	-2.8	-1.4	-0.6	-1.9	2.3	3.1	1.2	-0.7
Smoking status: Previous	2.4	3.6	9.8	2.8	1.2	1.3	0.5	0.9	1.1	2.5	2.1	1.0	2.1	3.1	3.0	2.1	0.6	0.8	3.0	-0.7	-0.5	1.3	2.5
Body fat percentage	2.3	9.2	34.5	3.4	4.0	-2.9	1.5	1.6	-0.6	3.6	3.8	-1.4	2.5	1.6	3.1	4.5	0.2	5.9	2.5	-3.4	-4.2	1.4	0.9
Medication: Seretide 50 evohaler	2.3	2.7	7.3	1.1	1.7	0.3	0.7	0.7	2.0	1.3	2.1	-0.2	1.9	2.6	2.7	2.1	-0.0	0.8	2.2	-1.2	-1.9	1.6	1.9
Neuroticism (2016)	2.2	3.1	8.0	-2.5	-1.6	-1.1	-1.8	-1.5	-2.8	-2.1	-1.4	-0.3	-2.2	-2.0	-1.4	-2.2	-0.5	0.1	-2.6	0.5	0.4	-2.3	-2.2
Primary Biliary Cirrhosis	2.2	3.2	10.8	1.3	0.8	2.6	1.3	0.5	2.7	0.4	3.3	1.1	2.5	2.2	2.0	0.3	1.3	-2.2	2.1	1.3	0.3	0.6	2.4
Arm fat percentage (right)	2.2	8.5	35.2	3.4	4.0	-2.8	1.3	1.2	-0.4	3.1	3.8	-1.2	2.5	1.5	3.4	4.3	0.3	5.9	2.4	-3.0	-3.9	1.6	0.5
High blood pressure (siblings)	2.2	3.1	8.5	0.9	1.8	-1.1	2.9	2.6	0.9	2.9	1.4	0.4	2.2	1.2	1.8	2.9	-0.8	1.8	2.4	-0.4	-1.4	-0.1	1.3
Hearing aid user	2.2	2.5	6.0	0.4	1.7	1.3	1.8	1.0	1.6	0.1	2.3	2.1	2.3	2.5	1.7	1.0	1.2	-0.8	1.9	-0.6	-1.7	-0.1	2.0
Eye problems/disorders: Glaucoma	2.2	2.6	6.1	1.0	0.8	1.5	2.5	1.3	2.0	1.2	2.5	1.4	2.4	1.6	1.0	1.4	1.7	-2.0	1.6	0.8	-0.3	-1.4	1.8
Alcohol drinker status: Never	2.2	2.6	10.0	1.0	0.0	3.2	1.0	1.0	1.8	0.9	2.3	2.1	1.4	2.4	1.1	0.5	1.1	-1.8	2.1	0.9	0.1	0.5	2.6
Bipolar Disorder (2018)	2.1	3.3	11.8	0.9	3.4	-1.3	2.0	1.2	0.7	1.6	1.9	1.2	1.8	1.4	1.6	2.7	1.0	1.9	1.5	-2.6	-2.8	-0.8	1.2
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	15.4	-3.3	-0.0	-2.2	-1.1	-1.1	-0.1	-0.6	-0.5	-0.6	-0.8	0.2	0.6	0.9	0.9	3.9	-0.9	-3.3	-2.3	1.1	-0.3
Arm fat percentage (left)	2.1	8.5	33.3	3.5	4.0	-2.8	1.3	1.3	-0.6	3.3	3.7	-1.3	2.4	1.3	3.1	4.4	0.3	5.8	2.3	-3.0	-4.1	1.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	10.9	-0.5	0.4	1.0	0.7	0.7	2.1	0.5	1.9	3.3	1.6	2.3	1.3	0.6	2.2	-0.6	1.3	-0.8	-1.4	-0.9	1.6
Alcohol intake frequency.	1.9	4.4	9.2	2.1	1.3	1.4	1.9	1.8	2.7	3.0	2.7	2.9	2.5	2.8	2.0	3.0	1.0	0.2	3.0	-0.4	-0.5	-0.5	2.1
Heel T-Score	1.8	14.0	44.2	-2.2	-2.3	-3.2	-4.0	-3.6	-5.1	-3.6	-6.7	-4.4	-4.3	-4.3	-2.4	-2.1	-4.3	2.9	-4.1	1.7	3.9	0.8	-4.0
Mouth/teeth dental problems: Dentures	1.8	3.0	13.9	0.2	1.6	-1.7	-0.8	-1.6	0.2	0.7	1.8	0.7	0.6	1.3	2.0	2.1	0.3	3.7	0.5	-3.7	-2.6	0.9	1.0
Trunk fat mass	1.7	7.1	23.6	3.2	3.5	-2.5	1.7	1.9	-0.5	3.5	3.4	-2.0	2.3	1.2	2.6	3.9	-0.2	4.9	2.4	-2.8	-3.3	1.2	0.3
Pulse wave Arterial Stiffness index	1.7	2.0	7.4	2.7	1.8	-0.9	0.5	0.5	-0.5	1.6	1.7	1.1	0.4	1.2	0.6	1.9	0.4	2.0	0.9	-1.8	-2.0	0.7	1.8
Birth weight of first child	1.7	3.0	6.9	2.6	1.3	1.6	2.1	2.4	1.3	1.2	1.4	1.2	1.8	1.3	2.5	2.1	1.2	0.1	2.0	-0.8	-1.4	1.8	2.4
Osteoporosis (self-reported)	1.7	2.1	10.4	0.4	1.5	-2.5	-1.4	-1.5	-0.9	1.4	0.6	-0.4	-0.2	0.6	0.8	2.1	0.7	3.2	0.4	-2.4	-1.8	-0.2	0.2
Supplements: Calcium	1.7	1.9	5.5	1.0	1.5	-1.1	-0.1	-0.4	1.2	1.5	2.1	0.4	1.2	1.6	1.8	1.9	0.5	1.5	1.4	-1.5	-2.4	0.6	1.4
Impedance of whole body	1.7	8.9	53.0	-3.5	1.2	-5.7	-0.5	-0.6	-1.1	0.5	-1.2	-1.0	-1.3	-1.4	0.4	1.7	-0.1	5.8	-1.4	-7.3	-5.5	1.3	0.4
Schizophrenia vs Biploar Disorder	1.6	2.1	11.0	0.6	-0.4	-0.7	1.2	2.7	0.2	2.2	0.3	-0.1	0.4	0.4	1.1	1.6	-0.7	2.0	0.9	-3.3	-2.3	0.6	0.8
Crohns Disease (2017)	1.6	3.5	10.4	1.7	2.1	-1.9	0.4	0.1	1.1	2.1	1.6	0.4	1.0	1.7	2.3	1.9	0.9	3.2	1.8	-2.5	-2.9	2.0	1.9
Hand grip strength (left)	1.6	4.1	12.0	-0.9	-1.9	0.6	-0.9	-0.3	-1.3	-1.5	-2.6	-0.5	-2.2	-1.8	-3.0	-3.2	0.6	-3.2	-2.0	3.5	2.7	-1.4	-1.7
Past tobacco smoking	1.6	2.9	7.4	-2.5	-0.9	-0.8	0.1	-0.7	-0.5	-2.2	-1.8	-1.0	-1.6	-2.7	-2.6	-2.1	-0.1	-1.6	-2.4	1.0	0.9	-1.4	-2.5
Leg fat percentage (right)	1.6	5.9	15.4	3.5	3.0	-1.0	1.5	1.4	0.1	3.2	3.9	-0.7	2.7	2.0	2.9	3.6	0.8	3.7	2.6	-1.7	-2.5	0.9	1.2
Exposure to tobacco smoke outside home	1.6	2.1	5.5	1.8	1.8	1.3	1.6	2.1	1.1	0.1	2.3	2.4	2.2	0.8	2.0	1.1	0.6	-0.8	1.4	0.6	-0.9	-0.1	0.1
Pulse wave peak to peak time	1.6	1.9	7.0	-2.6	-1.8	0.7	-0.4	-0.3	0.6	-1.3	-1.6	-1.4	-0.4	-1.1	-0.6	-1.8	-0.4	-2.0	-0.8	1.6	1.9	-0.7	-1.8
Whole body fat mass	1.6	6.8	16.6	3.8	3.5	-1.5	2.0	2.1	-0.1	3.5	3.8	-1.5	2.8	1.7	2.8	3.9	0.1	4.1	2.8	-1.9	-2.8	1.2	0.6
Ever smoked	1.6	2.7	7.2	1.9	0.8	0.5	-0.3	0.5	1.1	1.9	1.9	1.6	1.6	2.7	2.6	2.0	0.5	1.6	2.2	-0.9	-1.1	1.1	2.5
Glaucoma (self-reported)	1.5	1.7	5.1	0.3	0.1	1.5	2.2	1.4	1.9	0.7	1.3	1.4	1.8	1.3	0.5	1.4	0.9	-1.3	1.3	1.1	0.1	-0.2	2.0
Arm fat mass (left)	1.5	6.0	15.6	4.0	3.5	-1.2	1.9	2.0	-0.3	3.1	3.8	-1.5	2.7	1.4	2.7	3.6	0.1	3.6	2.6	-1.2	-2.4	0.9	0.2
Leg fat percentage (left)	1.5	5.5	12.8	3.6	3.0	-0.9	1.6	1.7	-0.0	3.2	3.5	-1.1	2.6	1.8	2.7	3.4	0.5	3.5	2.6	-1.5	-2.1	1.1	0.9
Coronary Artery Disease (CAD)	1.4	1.6	6.0	-1.7	-1.2	-1.9	-1.0	-1.2	-1.6	-0.8	-1.3	-1.3	-1.2	-1.0	-1.1	-0.3	-1.8	2.4	-1.4	-0.7	0.1	0.2	-0.6
Medication: Lansoprazole	1.4	1.6	7.4	1.1	-0.5	-0.3	-2.7	-2.0	-1.4	-0.9	-1.2	-1.3	-1.3	-0.7	-0.6	-1.1	-1.6	0.5	-0.8	0.7	1.8	1.5	-0.6
Tense / ‘highly strung’	1.4	2.4	6.6	-1.0	-2.4	-1.0	-2.1	-2.2	-2.6	-2.0	-1.3	0.4	-1.9	-0.7	-0.4	-1.7	-0.5	1.2	-2.0	0.2	1.0	-1.2	-1.5
Number of children fathered	1.4	1.6	4.2	2.1	1.7	-1.3	0.4	1.6	-0.6	1.8	0.4	-1.0	0.6	0.0	0.9	1.7	-0.6	1.5	0.9	-1.7	-1.4	1.6	1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.2	0.9	0.1	-0.6	-0.7	-0.7	-1.0	-1.2	-1.9	-1.5	-1.0	-1.9	-1.3	-1.1	-1.3	-0.3	-1.1	1.4	2.0	-0.6	-2.3
Medication: Gliclazide	1.4	1.6	4.5	-0.4	-1.4	0.0	-1.0	-2.1	-0.7	-2.1	-1.7	-0.7	-1.3	-1.4	-1.2	-1.6	-1.4	-0.5	-1.6	1.1	1.6	0.3	-0.5
Medication: Bendroflumethiazide	1.4	2.1	7.0	2.6	0.9	1.2	1.3	2.0	0.9	2.3	1.5	0.2	2.1	0.5	0.7	0.7	-1.1	-1.8	2.1	1.4	0.3	0.7	0.9
Arm fat mass (right)	1.3	5.4	14.9	3.9	3.3	-1.1	1.7	1.6	-0.2	2.7	3.6	-1.4	2.5	1.5	2.8	3.4	0.2	3.7	2.4	-0.9	-2.1	1.2	0.2
Illnesses of father: High blood pressure	1.3	1.6	7.1	-0.2	1.0	-1.9	1.0	1.1	-0.3	1.1	0.1	-0.9	0.9	-0.6	1.2	1.7	-0.4	2.1	0.4	-2.7	-1.9	-1.0	-0.3
Age at First Birth	1.2	1.8	5.5	-0.5	-1.9	0.7	-2.2	-1.2	-1.1	-1.0	-1.5	0.2	-2.3	-0.4	-1.7	-1.8	-0.7	-1.1	-1.4	1.4	1.9	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.9	-1.1	-1.3	1.0	-0.2	-0.4	-0.9	-1.6	-1.5	0.8	-1.2	-0.8	-1.5	-1.0	-0.3	-1.1	-1.3	1.4	2.0	-0.8	-0.1
Vitamin and mineral supplements	1.2	1.6	7.8	-0.8	-1.6	2.0	1.2	-0.6	0.1	-1.3	-1.0	-0.4	-0.1	-0.8	-1.0	-1.2	-0.6	-2.3	-0.4	1.9	2.8	0.3	0.5
Severe depression (siblings)	1.2	1.4	3.9	0.3	-1.5	-0.5	-0.9	-0.3	-1.4	-0.4	-1.7	0.2	-1.6	-1.1	-1.7	-1.1	-1.5	-0.1	-1.3	2.0	1.6	0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	8.7	-1.3	-0.2	-1.8	-2.1	-1.1	-1.9	-0.8	-2.5	-3.0	-1.5	-1.8	-0.9	-0.4	-2.5	1.3	-1.5	0.5	1.6	0.3	-1.8
Multivitamins +/- minerals	1.2	1.6	5.2	0.9	1.3	-0.6	0.0	1.1	0.8	1.7	1.9	0.1	1.6	1.3	2.3	1.5	0.3	0.6	1.7	-1.3	-1.7	-0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	6.2	0.0	-1.8	0.3	0.1	-0.0	-1.9	-1.5	-1.9	-0.3	-1.3	-1.6	-1.0	-1.8	-0.7	-1.5	-1.2	2.0	2.5	-0.9	-0.7
Fluid intelligence score	1.2	2.4	7.5	-0.9	2.1	-0.8	0.7	0.8	2.3	1.5	1.7	-0.6	1.8	1.6	1.3	1.9	0.7	0.6	1.8	-2.3	-2.7	1.0	1.3
Birth weight	1.2	2.5	8.7	2.8	0.6	2.8	1.3	1.6	0.7	1.4	1.4	1.8	1.0	1.0	0.2	0.3	1.3	-2.4	1.6	3.0	0.8	0.1	1.2
Number of operations (self-reported)	1.2	1.7	4.3	2.1	1.0	-0.1	1.5	1.9	0.8	1.6	1.3	0.6	1.6	0.8	2.0	1.9	-0.3	0.4	1.6	-0.9	-1.1	0.9	1.0
Fractured/broken bones in last 5 years	1.2	1.6	3.5	1.3	1.9	0.4	1.2	0.9	1.4	1.1	0.9	1.8	1.5	1.2	1.2	1.7	0.6	1.0	1.4	-1.5	-1.0	0.7	1.0
Commuting to job workplace: Cycle	1.2	1.4	5.4	0.3	0.1	1.3	0.0	0.3	2.3	0.9	1.5	0.5	1.6	1.8	1.6	0.6	0.7	-0.6	1.7	-0.9	-0.7	0.8	1.9
Verbal and Numeric Reasoning (VNR)	1.1	2.6	8.8	-0.2	2.5	-1.6	1.3	1.5	1.1	1.7	0.6	-0.1	1.5	0.8	1.3	2.5	-0.2	1.3	1.7	-2.5	-3.0	1.5	1.6
Average weekly spirits intake	1.1	1.3	5.2	1.5	-0.8	1.6	-0.9	-0.2	0.1	0.0	-0.7	0.6	-0.4	0.1	-0.8	-1.4	-0.6	-2.3	-0.2	2.3	2.3	-0.2	0.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	6.6	-0.8	-0.3	-2.6	-0.7	-0.3	-1.5	0.3	-1.2	-1.3	-0.7	-2.0	-0.6	-0.0	-1.3	1.1	-1.0	-0.0	-0.1	-1.2	-1.6
Falls in the last year	1.1	1.5	4.0	1.5	1.0	1.7	1.3	0.6	1.5	-0.7	0.8	0.9	1.6	1.1	1.8	0.4	1.2	-0.9	1.2	-0.6	0.7	2.0	1.1
Lung cancer (father)	1.1	1.3	7.0	0.7	1.8	1.3	0.9	1.0	1.0	0.9	0.8	2.6	1.1	1.3	1.0	1.1	0.8	-1.0	1.2	-0.3	-0.3	-0.5	0.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.5	-2.1	-0.3	-0.7	-0.6	-0.3	-2.0	-1.3	-1.0	0.2	-1.1	-1.7	-0.8	-1.2	-0.2	0.9	-1.4	-0.4	-0.3	-1.3	-2.0
Headache pain in last month	1.1	1.8	8.9	3.0	0.8	0.9	1.6	1.2	1.5	1.8	1.4	1.1	1.9	1.6	1.0	1.3	-0.0	-1.2	1.5	-0.2	-0.0	-0.8	1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.8	0.6	0.6	0.5	0.4	-0.9	1.7	-0.3	1.9	0.5	1.5	1.8	1.8	0.6	1.7	0.1	1.0	-1.6	-1.3	1.0	1.4
Shortness of breath walking on level ground	1.1	1.3	4.3	2.1	1.6	0.4	1.3	1.5	0.2	1.4	1.1	1.3	1.7	0.7	1.3	1.6	0.5	-0.1	1.4	-0.1	-0.2	0.3	0.4
Leg fat mass (right)	1.1	4.4	14.1	3.8	2.6	-0.2	1.7	1.6	-0.0	2.7	3.6	-1.1	2.6	1.8	2.4	2.9	0.2	2.6	2.5	-0.4	-1.3	0.8	0.6
Commuting to job workplace: Public transport	1.1	1.3	3.9	-1.7	0.1	1.2	0.7	0.4	1.3	0.1	1.8	1.1	0.8	2.0	1.3	0.4	1.7	-1.0	0.9	-1.0	-1.2	-0.8	0.7
Irritability	1.1	1.9	11.5	-0.6	0.9	-2.6	-1.8	-1.6	-1.6	-0.0	0.1	-0.6	-0.4	-0.8	0.9	0.7	0.2	3.4	-0.8	-1.4	-2.0	-0.1	-0.5
Leg fat mass (left)	1.1	4.3	14.0	3.7	2.6	-0.1	1.8	1.7	-0.1	2.7	3.4	-1.3	2.6	1.7	2.3	2.9	0.1	2.5	2.5	-0.4	-1.1	0.8	0.4
Waist circumference	1.0	3.5	10.8	3.0	2.6	-1.5	0.8	0.9	-0.6	2.6	2.7	-1.3	1.8	1.2	2.0	2.9	0.0	3.3	1.8	-0.9	-1.5	0.4	-0.1
Number of incorrect matches in round	1.0	1.7	7.6	2.8	1.2	0.5	0.3	0.5	0.4	1.1	2.6	0.6	1.2	1.7	1.6	0.6	0.7	0.6	1.2	-1.0	-1.6	0.5	1.4
Hair/balding pattern: Pattern 2	1.0	1.3	7.2	-0.2	0.3	-1.6	0.2	0.9	-1.7	0.1	-0.9	0.4	-0.5	-1.8	-0.5	0.5	-0.5	2.7	-0.9	-2.0	-0.8	0.4	-1.2
Pain all over the body in last month	1.0	1.0	5.7	0.1	-0.3	0.1	-0.4	-0.5	-0.2	-1.2	-1.9	-1.0	-0.5	-1.4	-0.9	-0.6	-1.6	-0.5	-0.5	0.3	2.4	1.2	-0.2
Medication: Ramipril	1.0	1.3	5.7	-0.8	-1.4	0.7	-0.9	-1.3	0.1	-1.6	0.4	1.3	-0.7	-0.1	-0.5	-1.4	-0.5	-1.0	-0.7	2.4	1.7	-1.6	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.8	0.7	1.0	-0.3	0.3	0.1	1.5	1.7	1.4	1.1	1.2	1.2	1.2	1.4	0.3	0.4	1.5	-1.1	-1.4	0.1	1.5
Loud music exposure frequency	1.0	1.1	7.7	0.0	0.6	1.0	0.9	0.8	1.6	0.8	0.6	2.8	0.9	1.0	0.2	0.6	-0.0	-1.0	1.0	-0.3	-0.3	-0.5	1.6
Arm fat-free mass (right)	1.0	5.1	18.1	3.7	-0.0	4.0	2.2	2.5	0.8	1.5	1.8	-0.6	1.9	1.0	0.3	-0.1	-0.0	-4.0	2.1	4.3	3.5	-0.8	-0.3
Overall health rating	1.0	2.1	11.1	1.9	-0.6	3.0	-0.2	0.3	-0.5	-0.7	0.7	1.6	0.7	0.6	0.4	-0.8	0.2	-1.8	0.7	3.3	2.8	-0.2	0.2
Myopia	1.0	1.5	9.2	-1.4	-1.4	0.1	-0.7	-2.0	-0.7	-3.0	-0.6	-1.0	-0.8	-0.9	0.2	-1.8	0.1	-1.0	-1.2	0.9	1.1	0.0	-1.1
Heart attack/myocardial infarction (self-reported)	1.0	1.2	6.1	2.5	0.5	-0.4	0.3	1.3	-1.9	0.6	-0.7	-0.5	0.4	-0.8	0.3	0.8	-2.0	1.5	0.6	0.2	0.9	1.7	0.5
Intelligence (Savage-Jansen 2018)	0.9	2.7	8.2	-1.2	2.9	-1.0	1.4	1.6	1.3	1.4	0.6	0.5	1.9	1.3	1.0	2.6	-0.3	1.0	2.0	-2.6	-2.7	0.5	1.6
Prostate Cancer	0.9	1.2	3.5	1.1	0.4	1.6	0.7	0.6	1.8	0.8	1.2	1.2	0.9	1.3	1.2	0.5	1.0	-1.0	1.4	-0.6	-0.6	0.7	1.9
Lupus	0.9	1.4	3.7	0.6	0.7	0.9	1.9	1.1	1.9	0.9	0.8	0.6	1.8	1.8	0.6	1.2	0.6	-1.4	1.5	-0.6	1.2	-1.2	0.8
Blood Eosinophil Count	0.9	7.2	20.2	1.7	3.7	-3.7	2.1	1.7	0.3	2.0	1.3	-4.1	2.2	0.8	2.8	3.5	-0.7	4.5	1.2	-4.5	-3.3	2.1	-0.3
Blood White Count	0.9	6.4	16.2	3.8	3.7	0.8	2.6	2.4	0.9	0.8	1.9	0.6	2.6	2.2	4.0	3.4	1.6	3.1	2.4	-2.3	-2.4	3.1	1.9
BMI	0.9	5.1	23.3	4.8	3.2	1.1	2.0	2.2	-0.0	2.0	3.7	-0.8	3.0	1.9	2.4	2.5	1.0	1.5	2.9	1.3	-0.7	1.3	0.6
Smoking Status	0.9	2.3	5.9	1.5	0.7	0.5	0.3	1.0	0.1	0.6	1.6	0.9	1.2	2.0	2.4	2.0	0.9	2.4	1.6	-1.4	-1.5	2.1	2.3
Sensitivity / hurt feelings	0.9	1.5	6.9	-0.5	-0.4	-2.6	-1.9	-1.3	-1.7	-0.1	-1.0	-1.4	-1.0	-1.4	-0.1	-0.0	0.0	2.3	-1.0	-0.5	-0.5	0.7	-0.9
Hand grip strength (right)	0.9	2.4	7.8	-0.8	-1.6	1.1	-0.4	-0.3	-1.1	-1.6	-0.8	-1.1	-1.6	-0.8	-1.6	-2.5	1.0	-2.8	-1.6	2.4	1.8	-1.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	5.2	2.3	1.0	0.9	1.5	1.7	0.4	1.1	0.9	0.2	1.3	0.5	2.0	0.5	0.9	-0.4	1.4	-0.1	-0.0	0.8	0.6
Relative age voice broke	0.9	1.3	6.7	-2.6	-1.4	1.2	-0.9	-1.3	-0.7	-2.1	-0.6	1.3	-1.5	-0.2	-0.4	-1.3	0.6	0.0	-1.3	0.2	0.4	-0.3	0.1
Medication: Atenolol	0.9	1.1	5.9	1.6	0.3	-1.1	0.3	0.3	-1.1	0.5	0.2	-0.4	0.1	0.4	0.5	1.1	-1.8	2.4	0.2	-1.3	-0.8	1.5	1.0
Body mass index (BMI)	0.9	3.8	18.9	4.3	2.5	0.7	1.6	1.6	-0.3	2.1	3.2	-0.8	2.4	1.4	2.1	2.4	0.3	1.7	2.4	1.1	-0.4	0.7	0.2
Hip circumference	0.9	3.8	11.5	3.2	2.5	-1.2	1.5	1.2	-0.5	2.8	3.4	-1.3	2.0	1.2	1.8	2.9	-0.3	2.9	1.6	-0.6	-2.1	-0.4	-0.1
Prospective memory result	0.9	1.1	4.8	-0.3	-0.3	1.4	-0.3	-0.6	0.6	-1.3	-0.9	1.5	-0.3	0.1	-0.4	-1.7	1.1	-2.2	-0.5	1.2	1.6	-0.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	8.5	0.6	1.2	-1.2	-0.4	-0.7	-1.0	-1.2	1.7	-0.7	0.2	-0.2	1.4	0.1	1.1	1.6	-0.3	-1.1	-2.9	0.9	-0.4
Gout (self-reported)	0.9	1.3	4.0	2.0	0.4	1.2	1.5	1.0	1.2	0.7	0.5	-1.0	1.6	0.6	0.2	0.0	0.4	-2.0	1.6	0.6	0.9	1.1	1.3
Medication: Omeprazole	0.9	1.0	4.8	0.3	-0.1	0.3	-0.4	-0.7	1.3	1.1	2.2	1.2	1.0	1.6	1.0	0.7	1.5	-0.2	1.2	0.9	-0.2	-0.5	0.8
Arm predicted mass (right)	0.9	4.8	18.0	3.7	0.3	3.6	1.9	2.5	0.7	1.7	1.8	-0.7	1.9	0.9	0.4	-0.0	-0.2	-3.7	2.1	4.2	3.2	-0.9	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.1	-0.0	-0.3	-0.7	-0.7	-0.5	-1.4	-1.3	-1.8	-1.5	-2.0	-1.4	-2.3	-1.6	1.4	-1.4	-1.9	0.8	1.3	-0.2	-1.4
Number of self-reported non-cancer illnesses	0.9	1.5	5.5	0.6	1.9	-1.8	-0.5	-0.8	0.0	1.2	1.8	-0.6	1.2	1.1	1.2	1.7	-0.4	2.3	1.1	-1.0	-1.6	0.6	0.3
Medication: Paracetamol	0.9	1.4	6.7	2.0	1.8	-0.9	0.1	1.0	0.2	1.3	0.7	0.4	1.1	-0.3	0.7	1.0	-1.3	1.1	0.8	-2.6	-1.5	0.8	0.2
Arm fat-free mass (left)	0.9	4.8	14.0	3.7	0.8	3.5	2.2	2.7	1.2	1.9	2.4	-0.8	2.5	1.3	1.1	0.6	0.2	-3.1	2.6	3.7	2.6	-0.5	-0.2
Alcohol drinker status: Previous	0.9	1.0	4.5	1.1	-0.0	2.1	0.5	0.8	1.5	0.4	1.3	1.7	0.9	1.2	-0.1	0.1	0.6	-1.1	0.9	0.9	0.8	-0.7	0.5
Arm predicted mass (left)	0.9	4.7	14.9	3.8	0.5	3.6	2.2	2.3	1.0	1.5	2.4	-0.7	2.3	1.2	1.0	0.3	0.2	-3.2	2.3	3.9	2.9	-0.6	-0.3
Depression (Nagel 2018)	0.8	1.2	3.2	1.0	1.0	1.0	1.6	1.4	0.6	1.1	1.8	1.0	1.6	1.3	1.5	0.6	0.3	-0.7	1.5	-0.4	-0.6	0.2	1.1
Irritable Bowel Disease (IBD)	0.8	1.9	7.1	1.2	2.2	-1.7	0.4	-0.4	0.5	0.6	1.7	0.2	0.6	1.1	1.6	1.2	0.7	2.5	0.7	-1.5	-2.7	1.0	1.1
Major Depression (MDD)	0.8	1.0	5.9	-0.0	1.5	0.5	0.5	1.0	0.8	0.4	0.4	1.2	0.3	0.3	0.3	0.5	1.5	0.5	0.6	-1.4	-2.4	0.9	1.0
Fasting Glucose	0.8	1.0	4.9	0.7	0.6	0.6	1.1	0.6	-0.1	0.2	1.1	0.6	1.0	0.5	2.2	1.1	0.9	0.4	1.1	-0.6	-1.2	1.3	1.3
HbA1C	0.8	0.9	3.3	1.3	-0.5	1.5	1.8	1.6	0.8	1.1	0.1	-1.6	0.7	-0.2	0.9	0.3	-0.2	-0.8	1.0	0.2	0.6	0.5	-0.5
Rheumatoid Arthritis	0.8	1.0	5.3	1.6	0.1	2.3	1.2	1.2	0.7	0.5	0.2	0.4	0.9	1.1	-0.7	0.5	-0.5	-0.9	1.0	0.6	1.9	0.1	0.4
Ulcerative Colitis	0.8	1.2	3.4	0.2	0.7	-1.4	-0.8	-1.3	-1.6	-1.5	0.9	-0.8	-0.9	-0.6	-0.3	-0.4	0.7	1.3	-1.6	-0.3	-1.8	-1.2	-1.2
Heart attack	0.8	1.1	5.0	2.2	0.6	-0.4	0.2	1.0	-1.7	0.4	-0.5	-0.3	0.3	-0.6	0.4	0.8	-1.8	1.4	0.6	0.1	0.8	1.7	0.7
Neuroticism score	0.8	1.6	5.5	-0.7	-0.9	-2.3	-1.8	-1.5	-2.4	-0.5	-0.7	-0.9	-1.2	-1.5	0.6	-0.4	-0.7	2.0	-1.4	0.1	-0.2	-0.9	-1.4
Father’s age at death	0.8	1.0	3.8	-2.0	-1.2	-1.2	-1.6	-1.6	-1.0	-0.9	-0.5	-0.8	-1.3	-0.4	-0.2	-0.6	0.1	1.1	-1.0	-0.4	-0.7	0.8	-0.1
Worrier / anxious feelings	0.8	1.5	4.4	-0.8	-1.1	-2.0	-1.5	-1.4	-1.8	-0.4	-1.5	-0.9	-1.3	-2.1	-0.9	-1.0	-0.7	0.7	-1.4	0.5	0.1	-1.0	-1.0
Illnesses of mother	0.8	1.0	3.6	0.4	1.0	0.7	1.6	1.9	1.3	1.6	0.6	-0.3	1.1	0.5	0.3	0.8	0.8	-0.5	0.8	-1.6	-0.3	-0.5	-0.5
Blood clot in the leg (DVT)	0.8	1.1	3.7	-1.2	-1.1	1.7	-0.8	-0.7	-0.0	-1.8	-0.6	1.1	-0.9	0.4	-0.5	-1.1	0.6	-1.5	-0.5	1.9	0.3	0.1	0.5
Mood swings	0.8	1.4	7.4	-0.1	-0.5	-1.3	-1.9	-1.5	-2.1	-0.6	-0.0	-1.6	-1.0	-0.8	0.8	-0.3	-0.7	2.7	-1.0	-0.0	0.2	0.1	-1.0
Commuting to job workplace: Walk	0.8	0.9	3.2	-0.7	-0.3	1.1	0.4	-0.2	1.3	-0.4	1.8	1.1	0.9	1.5	0.3	0.1	1.1	-0.9	0.5	0.6	-0.5	0.2	1.6
Average weekly champagne plus white wine intake	0.8	1.1	4.8	-2.0	-1.0	0.1	-1.6	-2.2	0.0	-1.9	-0.8	0.7	-0.8	-0.6	-0.5	-1.1	0.3	0.0	-1.2	0.2	0.1	-0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	6.4	-0.3	1.1	-0.4	0.3	-0.5	-0.1	-1.0	0.1	2.5	-0.2	0.8	0.5	1.2	1.4	1.8	0.2	-0.7	-0.7	0.2	0.7
Blood Platelet Count	0.7	8.5	46.5	-1.1	-3.4	3.7	0.8	-0.0	1.9	-1.3	0.1	-1.9	-0.2	-0.6	-2.3	-3.9	0.8	-6.8	-0.9	5.5	5.2	-2.2	-1.6
Blood Red Count	0.7	7.0	27.2	-0.4	-2.4	1.8	-1.8	-2.1	-1.4	-3.5	-2.0	-1.7	-1.9	-1.6	-2.6	-3.7	-1.8	-3.1	-2.3	4.5	5.2	-1.5	-2.4
Chronotype (morning person)	0.7	1.6	8.6	-0.5	0.5	1.5	0.9	-0.3	-0.3	-2.2	0.4	-0.7	0.7	-0.5	0.1	-1.3	1.8	-2.9	-0.1	2.2	1.1	-1.0	-1.4
Systolic blood pressure, automated reading	0.7	2.0	6.2	0.4	0.8	0.6	0.7	-0.0	1.1	2.0	2.1	2.2	1.6	2.5	0.9	1.6	-0.3	0.8	1.8	-1.1	-0.7	-0.5	2.2
Impedance of leg (right)	0.7	3.4	23.4	-2.4	0.2	-3.2	-0.1	-0.4	-0.3	0.6	-0.4	-0.8	-0.6	-0.3	0.6	0.9	0.3	3.4	-0.7	-4.8	-3.5	0.6	0.9
Impedance of leg (left)	0.7	3.2	21.9	-2.5	0.2	-3.1	-0.4	-0.3	-0.7	0.4	-1.2	-1.5	-0.9	-0.8	0.2	0.5	-0.2	3.1	-0.9	-4.7	-3.0	0.8	0.4
Had menopause	0.7	0.8	5.5	0.0	-0.4	-0.9	-1.5	-2.3	-0.7	-0.8	0.5	-0.0	-0.9	-0.3	-0.7	-0.3	-1.4	1.0	-1.0	0.9	0.2	-0.3	0.1
Qualifications: None of the above	0.7	1.4	13.0	3.6	-0.0	0.8	-0.5	-0.1	0.1	2.2	1.5	0.6	1.1	0.7	0.8	0.5	-0.6	-0.3	1.1	1.3	0.4	-0.7	0.4
Weight	0.7	3.5	12.8	3.6	2.5	0.2	2.0	2.2	0.0	2.6	3.0	-1.5	2.3	1.2	1.8	2.4	0.3	1.3	2.3	0.5	-0.6	0.4	-0.2
Trunk fat-free mass	0.7	4.1	15.8	2.8	-0.0	3.4	1.8	2.0	1.3	1.4	1.6	-0.7	1.7	0.9	0.3	-0.2	0.4	-3.9	1.9	4.0	3.2	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.9	-2.4	-0.9	-0.3	-1.9	-1.6	-1.2	-2.0	-1.0	0.5	-2.4	-0.5	-1.9	-2.1	0.6	-0.3	-2.0	-0.1	0.6	-2.3	-1.3
Trunk predicted mass	0.7	4.1	16.0	2.7	-0.1	3.3	1.8	2.0	1.3	1.3	1.5	-0.8	1.7	0.8	0.3	-0.3	0.4	-3.8	1.8	4.0	3.2	-0.7	-0.7
Length of working week for main job	0.7	0.7	3.3	1.4	0.4	1.5	-0.1	-0.3	1.1	-0.4	0.3	-0.3	0.5	1.1	0.2	-0.2	0.5	-1.8	0.7	1.1	1.1	0.3	0.7
Forced vital capacity (FVC), Best measure	0.7	2.4	7.1	-2.7	-1.3	0.4	-1.1	-0.8	-0.7	-1.9	-0.9	-0.3	-2.2	-0.7	-2.2	-2.6	0.9	-2.0	-1.9	-0.0	1.0	-2.2	-1.1
Qualifications: College or University degree	0.7	2.1	8.3	-2.9	-1.1	0.3	-0.8	-1.2	0.1	-2.2	-2.7	0.1	-0.9	-0.7	-1.7	-2.0	0.2	-2.0	-0.9	1.6	1.9	0.5	-0.1
Eye problems/disorders: None of the above	0.7	0.8	3.0	-1.2	-0.6	-1.0	0.6	0.5	-1.1	0.1	-1.2	-1.2	-0.6	-1.7	0.1	-0.3	-1.4	0.7	-0.5	-0.6	-0.2	0.2	-1.1
Angina (self-reported)	0.7	0.9	4.4	2.1	1.2	-0.1	-0.3	-0.4	-1.6	-0.0	0.9	0.9	0.3	1.2	0.8	1.0	-0.3	1.6	0.5	-0.4	-0.1	0.5	1.3
Medication: Ibuprofen	0.7	0.8	3.3	-1.4	1.8	-0.7	0.5	0.7	-0.1	-0.1	0.6	-0.9	1.0	-0.2	0.5	0.8	-0.8	0.5	0.1	-1.3	-0.9	-0.9	-1.4
Number of full sisters	0.7	0.9	5.8	-0.6	-0.4	1.5	-0.5	-0.5	-0.6	-2.4	-0.0	0.8	-0.6	-0.6	-0.4	-1.7	-0.5	-1.2	-1.3	0.6	0.0	-0.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	5.8	0.2	-0.8	0.3	-2.4	-2.0	0.5	0.2	0.4	-0.4	-0.3	1.0	0.3	-0.3	-0.5	0.6	0.5	0.8	1.6	0.7	0.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	3.3	0.3	0.6	-1.7	-0.5	-0.8	-0.8	-0.9	-1.4	0.1	-0.6	-1.8	0.1	-0.6	0.2	0.6	-0.9	0.0	0.0	0.1	-1.7
Loneliness, isolation	0.7	1.0	3.8	-0.8	0.5	-0.2	-0.0	-0.1	0.2	0.1	1.9	1.6	1.0	1.7	1.7	1.3	0.7	0.7	0.9	-0.1	-1.1	-1.0	0.8
Eye problems/disorders: Cataract	0.7	0.8	3.3	1.8	1.1	0.4	-0.3	-0.9	1.1	-0.2	1.3	0.5	0.7	1.7	0.5	0.6	1.1	0.3	0.6	-0.4	-0.4	0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	-0.6	-0.9	1.5	-0.5	-0.2	-0.1	-1.0	-1.2	0.2	-1.1	0.0	-1.0	-1.3	0.8	-1.3	-0.5	0.9	0.6	1.2	0.3
Back pain experienced in last month	0.7	1.0	4.5	1.7	-0.8	1.4	0.4	0.2	-0.8	-0.3	1.2	0.0	0.7	-0.3	0.6	-0.6	-0.4	-1.2	0.1	2.1	1.5	-1.1	-0.5
Osteoarthritis (self-reported)	0.7	1.0	5.0	0.9	-0.0	1.4	0.4	0.4	-0.1	-0.7	-0.6	-0.9	-0.0	-0.9	-0.3	-1.3	0.5	-2.1	-0.4	2.2	1.3	0.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	3.6	-1.2	-1.2	1.1	-1.1	-1.0	-0.2	-1.7	-0.7	0.8	-1.1	0.1	-0.6	-1.2	0.3	-1.2	-0.7	1.9	0.2	0.0	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	4.2	0.4	-0.8	-0.6	-1.1	0.0	-2.0	0.2	-0.7	-1.0	-1.4	-1.3	-1.0	-0.9	-1.5	0.4	-1.0	0.5	0.9	-0.1	-0.7
HDL Cholesterol	0.6	1.0	3.7	-1.9	-1.3	0.9	0.4	-0.4	0.1	-1.3	-0.7	-0.8	-0.4	-1.1	-0.7	-1.3	-0.8	-1.9	-0.6	0.4	0.7	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.2	-0.6	-0.4	1.4	-0.1	-0.6	1.2	0.0	-0.1	0.7	0.4	1.8	-0.1	0.4	-0.2	-0.8	0.9	1.2	1.5	0.2	1.2
Angina	0.6	0.8	3.3	1.8	1.1	-0.2	-0.2	-0.5	-1.6	-0.2	0.8	1.0	0.3	1.1	0.8	1.0	-0.3	1.5	0.4	-0.4	0.1	0.5	1.4
Medication: Metformin	0.6	0.9	5.4	-0.4	-0.4	0.4	-0.9	-1.6	0.0	-1.0	-0.8	0.7	-0.4	-0.4	-0.4	-0.4	-0.9	-0.0	-0.4	2.3	2.0	-0.7	-0.7
Taking other prescription medications	0.6	0.9	3.0	0.1	0.4	-1.3	-0.8	-1.5	-0.2	0.1	1.7	0.0	0.3	0.8	1.1	0.5	0.9	1.7	0.4	-0.9	-1.4	0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.9	-0.1	0.6	0.0	-0.2	-0.8	0.7	0.1	1.3	0.5	1.0	1.0	2.0	0.7	0.3	0.7	1.0	-1.0	-0.8	0.3	0.0
Stomach or abdominal pain in last month	0.6	0.7	4.2	0.7	-1.0	0.2	-0.5	-0.2	-0.2	-0.0	-0.8	0.6	-0.6	-0.6	-0.8	-0.9	-0.7	-0.9	-0.5	1.8	2.0	-0.4	0.2
Supplements: Glucosamine	0.6	0.8	2.2	-0.0	0.0	-1.1	-0.8	-0.1	0.1	1.4	1.2	-0.8	0.2	0.6	0.8	0.7	-0.2	1.4	0.2	-1.5	-1.5	-0.9	-0.6
Alcohol usually taken with meals	0.6	0.9	3.6	-1.5	0.6	-1.8	-1.2	-1.9	0.4	0.0	0.8	-0.5	-0.1	0.3	0.3	0.5	-0.7	0.9	-0.3	-0.1	-1.6	-1.3	-0.5
Hearing difficulty/problems with background noise	0.6	1.0	3.8	-0.9	0.3	-1.0	-0.5	-1.3	-1.4	-1.3	-0.4	-1.9	-0.7	-1.1	0.1	-0.6	-1.2	0.7	-0.8	-0.0	0.3	-0.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	5.1	0.1	-0.4	-1.0	-1.3	0.2	-2.1	0.0	-1.9	-2.2	-1.1	-0.8	0.1	0.3	-2.2	1.7	-0.4	-0.9	0.5	1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.5	0.5	-0.1	0.3	0.0	-0.1	-0.8	-0.8	-0.0	0.1	-0.4	-1.3	-0.8	-1.2	0.2	-1.5	-0.8	0.8	0.3	-1.6	-1.5
Mouth/teeth dental problems	0.6	0.9	4.6	-0.4	0.4	0.6	1.5	1.7	0.7	1.2	-0.0	-0.7	0.9	0.1	-0.3	0.1	1.4	-2.1	0.8	0.5	0.3	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	8.2	-1.9	-1.0	-0.2	-1.4	-0.9	-0.9	-1.6	-0.9	1.2	-2.3	-0.7	-2.0	-1.8	0.4	-0.6	-2.0	-0.0	0.1	-2.9	-1.3
Pulse rate	0.6	1.1	4.2	-0.8	0.3	-2.1	-1.1	-1.4	-1.2	0.4	-0.7	-0.7	-1.1	-0.1	-0.9	0.4	-1.0	1.6	-1.1	-0.8	-0.7	-1.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.3	-1.8	1.2	-0.6	0.3	0.3	-0.6	-0.2	0.3	-1.1	0.3	-0.3	0.4	0.5	-1.0	0.7	-0.2	-1.3	-1.0	-1.2	-1.7
Peak expiratory flow (PEF)	0.6	1.3	4.6	0.0	-0.2	-1.2	-2.0	-1.2	-1.6	-0.7	-0.7	1.2	-2.2	-0.4	-1.3	-0.7	-0.4	1.7	-1.5	-0.4	-0.1	-1.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.1	-1.3	-0.9	0.0	-0.3	-1.4	-0.1	-0.2	1.1	-0.2	-0.4	0.2	-0.5	-0.9	1.2	-1.5	-0.5	0.8	-0.1	-1.1	0.6
Age at first live birth	0.6	1.0	3.0	0.0	0.5	-0.9	1.6	1.6	1.0	1.5	-0.7	-0.2	0.7	1.0	0.2	1.7	0.2	0.7	1.0	-1.3	-0.5	0.9	1.1
Health satisfaction	0.6	0.7	3.4	1.8	0.5	0.9	0.4	0.8	-0.6	0.3	1.1	0.0	0.9	0.4	1.4	0.1	0.5	-0.9	1.0	1.1	1.2	0.1	-0.1
Migraine (self-reported)	0.6	0.7	3.0	0.6	-0.2	1.3	0.2	0.4	1.3	-0.0	1.2	0.3	0.8	1.2	1.2	-0.5	0.0	-1.7	1.1	0.4	-0.2	0.5	1.0
Medication: Allopurinol	0.6	0.8	4.1	0.7	-0.2	0.4	1.1	1.0	0.4	0.4	-0.6	-2.0	0.3	-0.3	-1.0	-0.7	-0.0	-1.9	0.4	1.2	0.8	0.8	0.4
Leg pain on walking	0.6	0.7	2.3	0.4	1.0	1.2	-1.0	-0.2	0.6	-0.4	1.0	1.5	0.8	1.1	1.3	0.5	0.8	0.3	0.7	1.0	-0.2	0.7	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.2	-1.5	-1.1	0.8	-0.4	0.0	-0.8	-0.6	-0.3	-0.2	-1.3	-0.6	-0.8	-1.3	0.0	-1.1	-0.7	0.8	1.0	-1.0	-0.5
Illnesses of siblings: Diabetes	0.6	0.8	2.4	1.4	1.5	-0.6	-0.1	0.7	-0.6	0.5	1.1	-0.4	0.7	0.1	0.9	0.9	0.5	1.6	0.5	-0.8	-1.2	1.3	-0.3
Whole body fat-free mass	0.6	3.5	12.8	3.1	0.3	3.1	1.8	2.1	0.9	1.3	1.6	-0.7	1.6	0.7	0.5	0.0	0.2	-3.1	1.8	3.6	2.8	-0.5	-0.7
Friendships satisfaction	0.6	0.8	3.3	-1.4	0.6	-1.1	-1.0	-0.5	-1.8	-1.4	-0.7	-0.3	-1.2	-0.4	0.0	-0.1	1.4	0.9	-0.7	0.4	-0.3	0.0	-0.4
Breast cancer (self-reported)	0.6	0.7	3.2	-1.1	-1.2	0.6	-0.6	-1.0	0.5	-1.0	-0.6	0.8	-0.3	-0.5	-0.7	-0.6	0.6	-0.0	-0.3	1.8	0.6	1.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.4	-1.6	-0.4	-0.2	-1.5	-1.0	-1.1	-1.4	-1.2	1.4	-1.5	-0.6	-1.4	-1.1	-0.4	-0.7	-1.3	-0.4	0.3	-1.8	-0.7
Whole body water mass	0.6	3.5	12.7	3.1	0.3	3.0	1.8	2.1	1.0	1.4	1.7	-0.5	1.7	0.8	0.5	0.1	0.1	-3.1	1.9	3.6	2.7	-0.6	-0.6
Mother’s age at death	0.6	0.8	2.6	-0.2	-0.4	-1.5	-1.4	-1.2	-0.8	0.6	-0.0	-1.6	-0.6	-0.0	0.6	0.6	-0.3	1.4	-0.4	-1.3	-1.1	0.0	0.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.5	-0.7	-0.2	-0.1	-1.7	-1.9	0.7	0.3	1.4	0.6	0.1	1.0	0.1	0.1	1.0	-0.1	0.4	1.2	0.3	-0.3	0.2
Pain experienced in last month	0.6	1.0	8.5	-2.9	-0.7	-0.7	0.3	-0.1	0.6	-0.4	-2.0	-0.2	-0.8	-0.4	-1.3	-0.2	0.9	0.6	-0.3	-0.8	-0.6	0.9	-0.6
Pack years of smoking	0.6	0.9	2.7	-0.4	-0.3	-0.6	-1.3	-1.4	-1.5	-1.6	0.2	1.2	-1.2	-0.5	0.6	-0.3	-0.2	1.5	-1.3	-0.1	0.0	-0.6	-0.7
Depressed Affect (Nagel 2018)	0.5	1.0	5.7	0.7	0.4	-0.6	-0.5	-1.1	-0.2	1.0	1.6	0.3	0.6	1.2	1.7	1.2	-0.8	2.4	0.5	-0.6	-0.4	0.1	0.3
Mean Putamen Volume	0.5	0.6	1.8	-1.4	-0.4	-1.3	-0.4	-0.7	-0.9	-0.7	-1.2	-0.5	-0.9	-0.7	-0.5	-0.0	-0.5	1.3	-0.9	-0.4	-0.6	0.2	-0.2
Triglycerides	0.5	0.8	3.4	1.0	1.7	-1.8	-0.2	0.2	-1.0	1.0	0.1	-0.0	-0.3	-0.4	0.2	0.7	-0.7	1.0	-0.4	-0.4	-1.5	-1.4	-0.5
Number of treatments/medications taken	0.5	0.8	4.7	1.5	1.3	-0.5	-0.9	-1.3	0.2	0.3	2.2	0.1	1.2	0.9	0.8	0.5	-0.3	0.7	0.7	0.2	-0.8	-0.0	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	0.9	-1.1	0.3	-0.7	-0.7	-1.0	-0.7	-0.7	0.3	-1.1	-1.0	-0.3	-1.2	-0.5	-0.5	-0.8	1.4	1.1	0.4	-0.4
Supplements: Zinc	0.5	0.5	1.8	1.4	0.1	-0.8	-0.7	0.1	-1.2	0.4	-1.3	-0.4	-1.1	-0.3	-0.5	0.3	-1.3	0.9	-0.3	-0.2	-0.1	-0.1	-0.2
Diabetes (father)	0.5	0.6	2.6	0.5	0.5	0.1	0.6	0.8	-0.7	-0.7	-0.5	-1.1	0.4	-1.6	-0.8	-0.7	0.7	-0.8	-0.3	0.5	0.5	0.0	-1.6
Diabetes (mother)	0.5	0.6	2.9	0.3	0.1	0.2	-0.3	0.3	-0.1	-1.7	-1.6	0.4	-0.3	-0.4	-0.6	-0.9	0.1	-1.2	-0.5	1.2	1.4	0.6	-0.5
Pack years adult smoking proportion	0.5	0.8	2.7	-0.5	-0.1	-0.7	-1.0	-1.0	-1.4	-1.6	0.2	1.0	-1.1	-0.7	0.7	-0.3	-0.2	1.4	-1.2	-0.3	-0.0	-0.6	-1.0
Average weekly fortified wine intake	0.5	0.6	2.2	1.4	0.5	-0.0	-0.3	-0.9	0.9	0.8	1.3	0.6	0.5	0.7	1.5	0.9	-0.2	0.3	0.7	-0.2	-0.1	-0.4	0.2
Age when periods started (menarche)	0.5	1.1	4.1	2.0	-0.2	0.8	0.9	1.3	0.3	1.0	1.1	-0.8	0.6	0.8	1.6	0.4	0.2	0.6	1.0	-1.2	-0.4	1.8	1.5
High blood pressure (mother)	0.5	0.6	3.2	0.3	-0.6	-1.2	-0.6	-1.8	-0.7	-0.1	1.1	0.2	-0.1	0.4	1.1	0.3	-0.5	0.9	-0.3	0.0	-1.1	-1.2	0.4
Forced vital capacity (FVC)	0.5	2.0	8.2	-2.2	-1.1	-0.0	-0.9	-0.2	-0.7	-1.2	-0.9	0.5	-2.1	-1.0	-2.1	-2.0	0.8	-1.6	-1.9	-0.3	0.1	-2.9	-1.4
Medication: Simvastatin	0.5	0.8	3.5	0.6	1.4	-1.1	0.2	-0.6	0.6	1.0	1.9	-0.1	1.2	1.2	-0.0	1.2	-0.7	0.6	0.7	0.4	-0.5	-0.9	0.3
Alcohol intake versus 10 years previously	0.5	0.7	3.7	0.4	-0.3	0.2	0.8	0.9	0.3	1.9	0.6	0.9	0.4	0.6	1.1	1.3	0.4	1.0	1.2	-0.7	-0.1	-0.3	0.8
Happiness	0.5	0.6	2.7	-0.9	-0.6	0.8	0.1	0.4	-0.9	-0.8	0.2	1.6	-0.3	0.0	0.4	-0.2	0.8	-0.6	-0.2	1.5	0.8	-1.1	-0.1
Noisy workplace	0.5	0.6	1.9	-0.9	-0.0	1.2	-1.2	-0.9	0.1	-0.9	-0.3	1.0	-0.0	1.0	-0.1	-0.8	0.4	-0.4	0.1	0.8	1.4	1.1	0.3
Neck or shoulder pain in last month	0.5	0.7	4.6	2.1	0.8	1.0	-0.5	-0.2	0.1	0.2	1.0	0.6	0.7	0.7	1.5	-0.1	-0.3	-0.7	0.7	0.7	0.6	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.3	-0.9	-0.3	-0.2	-1.3	-1.1	0.0	-1.0	-0.5	0.5	-0.7	-1.0	-0.4	-1.0	-0.1	-0.7	-0.7	0.4	0.7	-1.5	-0.9
Suffer from ‘nerves’	0.5	0.8	2.4	-1.2	-0.2	-0.9	-0.5	-1.0	-1.5	-1.4	-0.7	-0.2	-0.8	-0.6	0.3	0.3	-0.2	1.5	-1.1	-0.5	-0.9	-0.8	-0.5
Medication: Aspirin	0.5	0.6	2.4	1.0	0.2	0.3	-1.6	-1.3	-0.6	-1.1	0.9	-0.8	0.0	0.0	-0.0	-1.1	-0.8	-0.3	-0.3	1.1	0.7	-0.2	-0.8
Knee pain experienced in last month	0.5	0.7	3.1	0.8	1.0	1.7	0.4	0.2	-0.0	0.1	1.5	0.3	1.0	1.0	1.8	0.4	0.3	-0.5	1.0	0.3	-0.4	-0.2	0.6
Average weekly red wine intake	0.5	0.7	3.8	-0.5	0.8	-1.3	-0.4	0.4	-0.9	-0.4	-1.1	-1.9	-0.8	-1.3	-0.5	-0.3	-0.9	0.5	-0.7	-0.3	-0.4	0.9	-0.6
Long-standing illness, disability or infirmity	0.5	0.8	1.9	1.0	0.8	1.4	-0.2	-1.0	0.7	-0.7	1.4	0.6	1.3	1.1	0.3	0.0	0.4	-1.3	0.7	0.9	1.0	-0.5	0.4
Financial situation satisfaction	0.5	0.6	3.9	0.4	0.7	1.4	-0.3	-0.1	0.5	-0.5	0.6	2.0	0.4	0.9	0.4	-0.6	1.2	-0.9	0.1	0.4	0.7	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.7	1.3	-0.2	0.0	-0.5	-0.1	0.4	1.4	0.7	-0.5	0.3	0.9	-0.7	-0.0	-1.4	-1.4	0.1	0.5	0.1	-1.7	0.1
High cholesterol (Self-reported)	0.5	0.8	3.4	0.7	0.9	0.6	0.8	-0.0	1.4	0.3	1.9	-0.7	1.2	1.4	0.3	0.4	1.4	-1.0	0.7	1.0	0.2	-0.5	0.2
Basal metabolic rate	0.5	2.9	10.7	3.3	1.0	2.4	1.9	2.2	0.7	1.6	2.1	-0.8	1.9	0.9	0.9	0.7	0.3	-1.9	2.0	2.8	1.8	-0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	5.2	-0.0	0.2	-1.2	-1.2	-0.9	-0.4	0.1	0.1	-2.3	-0.5	-0.1	-0.4	-0.2	-1.1	0.6	-0.3	-0.7	-0.9	0.2	-0.3
Diastolic blood pressure, automated reading	0.5	1.5	6.7	-0.7	-0.8	1.1	0.2	-0.6	0.4	0.9	0.9	1.9	0.4	0.7	-1.8	-0.6	0.1	-2.1	0.2	1.6	1.7	-2.6	0.6
Alzheimer’s Disease (in father)	0.4	0.4	2.6	0.2	-0.6	-0.7	-0.3	0.0	-1.4	0.3	-0.3	0.1	-0.4	-0.6	-0.4	0.2	-1.6	0.1	-0.3	1.0	0.6	-1.0	-0.1
Body Mass Index (BMI) (2010)	0.4	0.5	3.8	0.5	0.4	-1.4	-0.1	-0.8	-1.1	-0.6	-0.2	0.0	-0.2	-0.5	-0.2	0.7	-0.2	1.9	-0.7	-0.6	-0.2	-0.2	-0.2
Waist Hip Ratio (WHR)	0.4	2.0	13.2	-2.1	0.1	-3.6	-2.1	-1.3	-0.6	0.3	-1.6	-0.1	-1.1	-0.9	0.1	0.6	-0.4	2.6	-0.8	-1.8	-0.3	-0.0	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.9	-1.5	0.3	0.9	-0.5	-1.1	0.2	-1.3	0.0	1.1	0.2	0.7	-0.1	-0.3	0.1	-0.6	0.1	1.7	1.4	-1.3	-0.5
Medication: Co-codamol	0.4	0.5	2.3	1.2	0.9	-0.1	0.8	0.5	0.1	-0.2	0.5	-0.2	0.8	0.6	1.5	0.8	0.6	1.0	0.4	-1.0	-0.3	0.1	-0.4
Maternal smoking around birth	0.4	0.6	3.2	-0.3	0.3	-0.1	0.7	0.9	-1.1	-0.2	0.1	1.5	-0.3	-0.5	0.2	0.4	0.2	0.8	-0.3	-1.8	-0.1	-1.6	-0.8
Medication: Levothyroxine sodium	0.4	0.7	1.9	1.2	0.5	0.8	-0.2	-0.7	1.1	-0.1	1.0	0.1	1.0	1.2	1.0	0.5	-0.5	0.3	0.7	1.4	0.7	0.8	1.2
Breastfed as a baby	0.4	0.5	2.1	-0.1	0.6	-1.4	-0.2	-0.5	-0.3	0.3	1.0	-0.2	0.1	0.2	0.7	0.8	0.5	1.4	0.1	0.1	-1.4	-0.6	0.2
Comparative body size at age 10	0.4	1.2	7.1	0.9	0.4	2.0	-0.4	0.8	0.3	0.1	0.6	1.9	0.5	0.6	-0.1	-0.1	0.5	-1.4	1.0	2.7	1.6	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	4.4	2.1	0.3	-0.8	0.6	0.5	-0.1	0.5	0.6	-0.2	0.4	-0.3	0.6	0.9	0.5	0.6	0.3	0.5	-0.7	-0.0	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	3.5	-0.6	-0.7	0.3	1.9	1.2	0.9	0.8	-0.6	1.0	0.1	0.0	-0.4	0.5	1.1	-1.3	0.2	0.4	0.1	-1.0	0.9
Supplements: Vitamin C	0.4	0.5	2.5	0.6	0.4	-0.5	-1.0	-0.1	-0.5	-0.7	-1.6	0.6	-0.9	-0.8	-1.3	-0.7	-0.4	0.0	-0.7	0.3	-0.3	-0.0	-0.3
Illnesses of father: Heart disease	0.4	0.5	2.7	-0.7	-0.8	-0.3	-1.6	-1.6	0.3	-0.3	0.7	0.3	-0.1	0.7	0.5	-0.0	-0.7	0.6	0.2	0.1	0.8	-0.8	-0.1
Medication: Aspirin	0.4	0.5	3.5	1.9	0.5	0.3	-0.7	-0.6	-0.2	-0.5	1.2	-0.7	0.6	0.5	0.6	-0.5	-0.5	0.2	0.3	0.7	0.5	0.4	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	1.1	-0.1	0.7	0.6	-0.4	0.2	-0.6	-0.6	0.8	-0.2	-0.1	-0.4	-0.5	1.0	-1.0	-0.3	1.1	0.5	1.0	0.6
Miserableness	0.4	0.7	5.3	-0.4	0.4	-1.6	-0.1	-0.8	-0.6	0.2	1.3	0.1	0.2	-0.0	1.0	0.8	0.5	2.3	-0.3	-0.2	-1.0	-0.2	0.2
Guilty feelings	0.4	0.7	3.3	-0.7	-0.9	-0.3	-0.9	-0.1	-0.6	0.1	-0.6	-0.9	-0.4	-1.1	-0.4	-0.9	-1.0	-1.2	-0.3	1.8	0.5	-0.6	-0.7
Wears glasses or contact lenses	0.4	0.4	2.1	-0.5	0.1	-0.2	-0.0	-0.7	1.1	-0.1	1.1	0.2	0.4	1.4	0.2	0.1	0.3	-0.7	0.3	0.5	-0.4	-1.0	0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.5	1.6	-0.1	1.4	-0.0	0.8	-0.8	0.4	-0.3	0.2	0.0	-0.1	0.2	-0.6	0.1	-0.8	0.5	1.3	0.8	0.6	-0.0
Medication: Atorvastatin	0.4	0.4	2.1	0.8	0.1	-0.6	-0.2	-0.5	-0.5	-0.4	-0.4	-1.4	-0.4	-0.7	-0.1	-0.6	0.2	-0.0	-0.5	1.3	0.8	0.1	-1.1
Age started oral contraceptive pill	0.4	0.4	2.2	1.0	0.5	0.6	0.0	-0.2	0.4	0.0	1.1	-0.2	0.4	1.0	0.6	0.3	0.4	-0.2	0.6	-0.4	-0.8	0.7	1.5
Ever depressed for a whole week	0.4	0.6	4.2	0.1	0.4	0.1	0.4	0.3	-0.7	-0.3	1.2	1.0	-0.1	-0.1	-0.0	-0.1	1.0	-0.2	-0.4	-0.5	-2.0	-1.3	-0.3
Heart disease (siblings)	0.4	0.4	1.7	-0.4	-0.5	0.0	-1.3	-1.2	0.2	-0.4	0.2	-0.9	-0.2	0.2	-0.3	-0.3	-1.0	-0.4	-0.0	1.3	1.1	-0.2	-0.1
Worry (Nagel 2018)	0.3	0.6	2.4	0.2	-0.7	-1.3	-0.9	-1.3	-1.4	-0.1	-0.7	0.5	-0.4	-0.5	-0.2	0.2	-0.3	0.8	-0.8	0.6	0.2	-1.5	-0.7
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	1.2	0.1	-0.2	-0.6	0.5	-0.8	0.4	0.2	-0.8	-0.5	-0.4	-0.2	-0.1	-0.7	1.0	-0.3	-0.8	0.3	0.9	-0.1
Reaction Time	0.3	0.6	6.1	-2.5	-0.7	-0.5	-0.8	-0.9	-0.5	-0.4	-0.1	-0.4	-0.4	-0.3	-0.2	-0.7	0.6	-0.3	-0.5	-0.3	-0.6	-0.8	-0.1
Breast Cancer	0.3	0.7	2.5	-0.8	-0.6	0.4	0.7	1.2	1.1	1.6	0.3	-1.1	1.0	0.3	0.2	0.2	-0.8	-1.2	1.0	-1.1	-0.0	-0.2	0.2
Ovarian Cancer	0.3	0.4	1.4	0.2	0.5	1.0	1.2	0.2	0.8	0.0	0.1	0.1	1.2	0.7	0.3	0.5	0.2	0.3	0.8	0.4	0.3	0.3	0.3
Hypothyroidism (self reported)	0.3	0.6	3.1	1.8	0.0	0.1	-0.7	-0.5	0.3	0.7	0.3	-1.2	0.4	0.1	0.5	0.5	-0.7	1.0	0.5	1.1	1.0	1.2	0.3
Lung FVC	0.3	1.7	7.8	-1.7	-0.8	0.4	-1.6	-1.6	-1.0	-1.5	0.4	1.6	-1.9	0.1	-1.4	-1.2	1.2	-0.1	-1.7	0.1	-0.4	-2.8	-0.7
Neuroticism	0.3	0.8	4.5	0.1	-0.1	-2.1	-1.1	-1.0	-1.1	0.6	0.3	-0.3	-0.0	-0.5	1.0	0.9	-0.7	2.1	-0.2	-0.3	-0.6	-0.3	-0.2
Relative age of first facial hair	0.3	0.6	1.8	-0.7	0.9	0.2	1.1	0.2	-0.8	-1.3	-0.7	-0.1	-0.5	-1.0	0.5	0.1	1.0	0.8	-0.8	-0.9	-1.1	1.3	0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.5	1.4	0.4	0.6	0.2	0.0	-0.7	1.2	-0.4	1.2	-0.4	1.0	0.7	0.4	0.1	0.1	-0.6	0.4	1.2	1.0	0.5	-0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.5	0.2	0.4	0.9	-0.5	-0.6	0.2	-0.2	0.5	-0.0	0.4	0.8	0.3	-0.3	0.1	-1.3	0.3	1.6	0.5	-1.0	-0.1
Leg fat-free mass (left)	0.3	1.7	7.5	2.7	1.0	1.7	1.5	1.6	0.4	1.1	1.8	-0.5	1.4	0.7	0.8	0.7	0.3	-1.1	1.5	2.2	1.3	-0.1	-0.7
Townsend deprivation index at recruitment	0.3	0.5	1.7	-0.3	-0.6	-0.5	-0.4	-0.7	-0.5	-0.5	-0.6	-0.0	-0.5	-1.1	-0.8	-0.5	-0.6	0.1	-0.7	0.8	1.3	-0.9	-0.6
Current tobacco smoking	0.3	0.4	2.3	0.9	-0.4	0.7	0.8	1.5	-0.8	-0.5	-0.3	1.1	-0.0	-0.3	-0.1	0.1	0.4	0.4	-0.3	-0.0	-0.2	0.9	0.8
Fed-up feelings	0.3	0.5	2.2	1.1	-0.2	0.0	-0.5	-0.6	-0.2	0.5	0.4	0.3	0.0	0.5	1.2	0.6	-0.6	1.5	0.2	-0.3	0.5	1.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	2.0	0.2	0.5	0.2	0.5	1.4	-0.1	0.6	-0.5	-0.2	0.8	-0.4	0.4	0.7	-1.1	-0.2	0.5	-0.5	0.1	0.9	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.6	-0.2	-0.4	1.2	0.9	0.4	-0.6	-0.5	1.0	1.1	0.1	0.0	0.0	-0.2	0.3	-0.6	-0.1	0.3	0.1	-1.3	-0.0
Leg predicted mass (left)	0.3	1.8	8.1	2.8	0.9	1.7	1.5	1.6	0.3	1.1	1.8	-0.5	1.4	0.6	0.8	0.7	0.2	-1.1	1.4	2.3	1.3	-0.1	-0.7
Nervous feelings	0.3	0.6	2.0	-1.3	-0.6	-0.9	0.5	-0.4	-1.1	-1.2	-0.8	1.4	-0.4	-0.6	0.2	0.4	0.2	0.7	-0.7	-0.1	-0.7	-0.9	-0.1
Had other major operations	0.3	0.4	1.4	0.7	0.6	-0.7	-0.4	-1.1	0.1	0.0	0.5	0.2	0.0	-0.0	1.1	0.7	0.4	1.0	0.3	-0.3	-1.2	0.8	0.8
Financial difficulties in last 2 years	0.3	0.5	2.3	-0.1	0.4	-1.1	0.4	0.6	-1.5	0.4	-0.8	-0.4	-1.0	-0.9	-0.0	0.2	-0.3	1.1	-0.3	-0.8	-0.1	0.5	-0.3
Illnesses of siblings	0.3	0.4	1.7	0.5	-0.0	1.1	-0.0	0.0	0.9	-0.4	0.3	1.2	0.4	0.8	0.4	-0.1	1.3	-1.0	0.2	-1.0	0.1	-0.1	0.4
Time employed in main current job	0.3	0.4	2.2	1.5	0.7	-0.2	-0.2	-0.1	-0.4	-0.9	-0.5	-1.0	-0.2	-0.8	-0.1	0.1	-0.5	0.5	-0.5	0.3	0.4	0.8	-0.8
Hair/balding pattern: Pattern 3	0.3	0.5	2.6	-1.2	-0.9	0.5	-0.4	-1.2	-0.1	-1.3	0.3	-0.2	-0.5	0.2	0.3	-0.5	-0.4	0.1	-0.3	1.6	0.3	-0.3	-0.2
Number of live births	0.3	0.5	2.4	-0.4	-1.4	-0.2	-0.9	-0.7	-1.1	0.2	-0.4	0.7	-0.7	-0.8	0.1	-0.4	-1.6	0.4	-0.3	0.2	0.5	0.3	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	0.2	0.9	1.1	1.2	0.9	1.4	-0.7	-0.8	0.3	0.8	-0.1	0.5	-0.0	0.5	-1.1	0.6	0.2	-0.1	1.2	0.3
Medication: Cholesterol lowering	0.3	0.5	2.4	0.7	0.1	-0.0	-0.8	-1.6	0.6	-0.3	1.1	-0.1	-0.0	1.0	-1.0	-0.4	0.1	-0.3	-0.1	1.6	0.5	-0.4	0.1
Exposure to tobacco smoke at home	0.3	0.3	1.4	-0.7	-0.2	-0.4	0.8	-0.1	0.2	-0.9	-0.3	0.5	-0.4	-0.3	-0.7	0.0	-0.4	-0.6	-0.5	1.2	0.7	-0.5	0.2
Medication: Paracetamol	0.3	0.5	3.4	1.1	0.3	-0.5	-0.8	-0.2	-0.5	0.2	0.0	0.0	0.0	-0.6	0.1	-0.0	-1.4	1.0	-0.1	-1.8	-0.5	0.3	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	2.4	-1.1	-0.2	0.4	0.2	1.2	-0.3	-0.1	-1.5	0.8	-0.5	-0.9	0.1	-0.0	-0.0	-0.3	-0.5	-1.0	-0.1	-0.2	-0.2
Medication: Amlodipine	0.3	0.4	2.2	1.5	0.8	0.3	0.8	0.7	0.2	0.0	0.6	-0.9	0.8	0.6	0.3	0.6	-0.3	-0.4	0.8	-0.2	-0.0	0.6	0.5
Number of full brothers	0.3	0.4	1.8	0.5	0.1	0.2	-0.5	-1.3	1.0	0.1	0.6	-0.0	0.2	0.6	-0.0	0.4	-0.8	0.4	0.2	0.9	1.3	-0.5	-0.2
Worry too long after embarrassment	0.3	0.6	2.0	-0.4	-0.6	-0.7	-1.4	-1.0	-0.5	-0.7	-0.2	-0.1	-0.8	-0.7	0.1	-1.0	1.2	-0.6	-1.0	0.6	-0.1	-0.8	-0.7
Emphysema/chronic bronchitis	0.3	0.4	1.4	0.3	1.2	-0.1	0.1	0.1	-0.4	-0.2	0.6	0.5	0.2	0.1	1.1	0.8	0.4	1.1	0.3	-0.7	-0.4	0.4	0.9
Mean time to correctly identify matches	0.3	0.6	6.0	-2.4	-0.9	-0.5	-0.6	-0.8	-0.4	0.2	0.6	-0.4	-0.3	0.0	0.0	-0.3	-0.2	0.1	-0.4	-0.3	-0.9	-1.3	-0.2
Chest pain or discomfort	0.3	0.4	2.3	0.7	0.8	0.8	0.2	0.8	-0.4	0.0	0.9	0.0	0.5	1.5	0.5	0.4	0.9	0.2	0.5	0.2	0.1	0.3	1.2
Age at last live birth	0.3	0.4	1.2	0.2	-1.1	-0.6	0.4	0.5	-0.1	1.0	-0.8	-0.6	-0.6	0.2	-0.7	0.3	-0.8	0.4	0.2	0.1	0.2	1.1	1.0
Family relationship satisfaction	0.3	0.4	2.5	-1.0	0.8	0.2	0.5	0.7	-0.4	-0.3	0.1	0.9	0.2	0.3	0.7	0.5	1.6	-0.2	0.4	0.2	-0.1	-0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	2.4	-0.1	0.1	-0.8	-0.7	-0.4	-0.5	-0.0	-0.5	-1.6	-0.4	-0.2	-0.7	-0.4	0.1	0.1	-0.4	-0.3	-0.0	0.9	-0.6
Leg fat-free mass (right)	0.3	1.7	6.9	2.6	0.8	1.8	1.3	1.7	0.0	0.8	1.1	-0.8	1.0	0.1	0.3	0.2	-0.1	-1.6	1.2	2.6	1.8	-0.2	-1.1
Diabetes diagnosed by doctor	0.3	0.5	2.4	-1.1	0.7	0.1	-0.5	-0.9	0.3	-0.8	-0.3	0.5	-0.1	0.2	-0.4	-0.1	0.0	-0.3	-0.2	1.2	0.8	-1.5	-0.8
Mineral and other dietary supplements	0.3	0.4	1.1	-0.2	-0.2	0.4	0.8	0.1	-0.9	-1.0	-1.0	0.8	-0.4	-0.7	-0.1	0.0	0.7	0.7	-0.1	0.5	1.1	0.9	0.4
Smoking status: Current	0.3	0.4	1.9	0.6	-0.6	0.7	0.2	0.8	-0.9	-1.0	-0.4	1.4	-0.4	-0.5	-0.5	-0.3	0.3	0.3	-0.7	0.2	-0.1	0.8	0.6
Leg predicted mass (right)	0.3	1.7	6.7	2.6	0.8	1.8	1.2	1.6	0.1	0.8	1.1	-0.8	1.0	0.2	0.3	0.3	-0.2	-1.6	1.2	2.6	1.8	-0.1	-1.1
Medication: Lisinopril	0.3	0.4	1.4	0.4	-0.1	0.7	-0.7	-1.2	0.6	-0.2	1.1	0.3	0.4	0.9	0.8	-0.3	0.8	-0.3	0.7	0.6	0.5	0.6	0.7
Risk taking	0.3	0.5	4.9	-2.2	-0.0	-0.1	-0.4	-0.4	0.0	-1.1	-0.3	-0.5	-0.6	-0.4	-0.6	-0.8	-0.1	0.3	-0.7	0.5	0.1	0.1	-0.5
Cholesterol lowering medication	0.3	0.5	2.2	0.1	1.2	-0.4	0.4	0.1	-0.5	0.5	1.2	-0.4	0.7	0.8	0.3	1.2	-0.2	0.8	0.4	0.3	0.0	-1.5	-0.5
Basal cell carcinoma (self-reported)	0.3	0.3	2.0	-1.4	-1.4	0.1	0.4	-0.2	0.4	-0.3	-0.3	0.4	-0.3	0.2	0.0	-0.6	0.5	-0.6	-0.1	-0.6	0.6	-0.5	0.0
Neuroticism (Nagel 2018)	0.2	0.5	2.7	0.0	-0.2	-0.8	-1.5	-1.6	-0.9	0.1	0.3	0.5	-0.3	0.1	0.5	0.2	-0.3	1.3	-0.5	0.7	0.1	-0.6	-0.2
Ulcerative Colitis (UC)	0.2	0.4	1.5	0.7	1.1	-0.1	0.3	-0.8	-0.3	-1.2	1.1	-0.4	0.0	0.2	0.3	-0.3	0.8	0.3	-0.5	0.4	-1.0	0.3	0.1
LDL Cholesterol	0.2	0.4	1.6	0.1	0.3	-1.1	-0.1	0.6	-0.6	0.7	0.1	-0.5	-0.2	-0.7	0.2	0.4	-0.6	1.3	-0.3	-0.4	-0.8	-0.5	-0.8
Systolic Blood Pressure	0.2	0.8	4.4	-2.1	-1.2	0.1	-0.2	-1.0	0.2	-0.1	0.0	1.8	-0.3	0.7	-0.8	-0.7	-0.6	-0.1	-0.4	-0.6	0.6	-1.5	0.4
Cardiovascular Disease	0.2	0.6	1.9	0.3	0.7	1.2	0.2	0.6	0.7	0.3	1.4	0.8	1.4	0.9	0.6	0.2	-0.3	-0.7	1.1	1.1	0.9	-0.6	-0.1
Lung FEV1/FVC ratio	0.2	1.1	5.9	0.9	0.5	-0.1	-1.9	-1.7	-1.1	-0.9	0.3	1.7	-0.9	1.3	0.3	0.4	-0.4	2.4	-0.0	0.3	-0.4	0.6	0.4
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.2	0.0	0.2	0.3	0.6	-1.1	-0.2	-0.2	-1.0	0.5	0.2	0.5	0.0	-0.8	-0.2	0.5	0.9	0.6	0.2	-0.3
Ever had hysterectomy (womb removed)	0.2	0.3	1.4	0.6	0.3	0.9	-0.3	0.3	0.0	-0.1	0.6	0.2	0.3	0.2	0.3	-0.8	-0.9	-1.2	0.0	0.6	0.2	-0.1	-0.4
Serious illness, injury or assault to yourself	0.2	0.3	1.4	0.2	-0.1	0.1	0.3	-0.4	0.4	-1.2	1.0	-0.4	0.3	-0.7	0.0	-0.5	-0.6	0.4	-0.6	-0.1	-0.4	0.1	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	1.6	0.2	-0.0	0.8	0.1	0.2	-0.2	0.1	0.1	-0.7	-0.0	0.3	0.8	0.0	0.4	0.1	0.2	-1.0	-0.2	1.2	-0.6
Diabetes (self-reported)	0.2	0.4	2.0	-1.3	0.2	0.6	-0.4	-0.6	0.2	-0.5	0.1	0.7	0.1	0.5	0.5	0.0	0.3	-0.1	0.3	0.7	0.8	-1.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.8	0.9	0.9	0.7	0.1	0.2	-0.5	-0.5	0.6	-0.5	0.5	-0.3	1.3	-0.6	0.1	-0.7	0.3	0.8	0.3	0.4	-0.3
Pulse wave reflection index	0.2	0.3	2.0	1.2	0.3	0.2	0.3	0.6	-1.4	-0.1	0.5	0.3	-0.2	-0.7	-0.2	-0.0	-0.1	-0.0	-0.2	0.5	0.1	-0.8	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	2.4	0.6	-0.3	0.5	0.2	-0.3	0.0	-0.6	0.1	1.0	-0.2	0.3	0.5	0.0	0.2	0.4	0.0	0.2	-0.2	1.0	1.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.9	1.3	0.1	0.1	-0.6	-0.7	0.1	0.3	0.0	-1.0	0.3	-0.0	0.2	0.1	-0.7	0.6	0.2	1.4	1.1	1.1	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.1	-0.8	0.4	-0.3	-0.5	-0.4	-0.4	0.1	-0.3	0.5	-0.1	0.6	0.3	0.5	1.1	0.7	0.3	-0.0	-0.4	-0.0	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.0	0.8	-0.0	-0.5	0.4	0.2	-0.4	-0.2	-0.6	-1.0	-0.1	-0.7	0.1	0.3	-0.2	0.8	-0.2	0.5	0.5	-0.0	-0.3
Medication: Blood pressure	0.2	0.4	2.2	1.5	0.2	-0.7	0.2	-0.3	-0.7	-0.0	1.0	-0.4	0.3	0.2	0.3	0.0	-0.5	1.3	0.3	0.1	-0.4	0.6	-0.1
Comparative height size at age 10	0.2	1.3	5.3	-0.3	-0.5	0.9	0.2	0.1	-1.0	-1.2	-0.8	-1.5	-0.6	-1.0	-1.2	-1.9	-0.6	-2.3	-0.7	1.5	1.6	-0.2	-1.4
Had major operations	0.2	0.3	2.1	0.3	0.2	0.3	-0.3	-0.3	-0.2	-0.6	-0.5	-1.0	-0.2	0.4	-0.7	0.0	-1.4	-0.4	-0.1	0.2	0.4	0.8	0.1
Hypertension (Self-reported)	0.2	0.6	2.4	1.2	0.7	0.4	0.1	0.5	-0.1	0.3	1.5	-0.3	1.2	0.9	1.2	0.4	-0.6	0.5	1.2	0.1	-0.2	0.7	0.6
Ever had bowel cancer screening	0.2	0.3	1.5	-0.1	1.0	0.1	0.4	0.1	-0.3	-0.4	0.3	0.2	-0.0	0.2	0.3	0.1	0.9	0.5	-0.1	-0.8	-1.2	0.7	0.3
Qualifications: nursing, teaching	0.2	0.3	3.7	-1.9	-0.1	-0.3	0.4	-0.1	0.2	-0.5	-0.4	-0.7	0.2	0.4	-0.2	-0.0	-0.0	-0.1	0.1	-0.6	-0.3	-0.1	0.2
Medication for cholesterol	0.2	0.3	2.1	-0.3	-0.6	-0.1	-0.2	0.1	0.2	-0.2	-0.8	0.2	-0.6	-0.3	-0.5	-0.4	0.3	-0.2	-0.5	-0.7	-0.4	1.4	0.7
Ever taken oral contraceptive pill	0.2	0.2	1.2	-0.6	-0.6	-0.1	0.1	-0.2	0.3	-0.2	-0.5	-0.5	-0.1	-0.0	-0.0	0.0	0.2	0.7	0.2	0.4	-0.0	1.1	-0.7
Medication: Blood pressure	0.2	0.3	1.1	1.0	0.4	-0.1	-0.2	0.2	-0.5	0.8	0.5	-0.4	0.3	0.3	0.6	0.6	-0.9	0.6	0.9	0.1	0.1	0.4	0.8
Vascular/heart problems diagnosed by doctor	0.2	0.5	3.3	-0.7	-0.6	-0.3	0.3	-0.2	0.4	-0.3	-1.8	-0.3	-1.1	-1.2	-1.0	-0.5	0.5	-0.6	-1.1	0.0	0.0	-0.2	-0.7
Height	0.1	1.8	9.1	-0.8	-1.0	-1.1	0.5	1.4	0.7	1.5	-2.1	-3.0	-0.4	-1.4	-1.4	-1.0	-1.4	-2.0	-0.1	0.3	1.7	0.5	-1.0
Tanning	0.1	1.2	7.8	-0.8	-1.5	1.5	-0.3	0.5	0.0	-0.6	-0.5	0.3	-0.5	-0.3	-1.3	-1.2	0.4	-1.9	-0.4	1.4	2.8	-0.5	-0.3
High blood pressure	0.1	0.4	2.0	0.6	0.6	-0.1	-0.1	0.4	-0.2	0.4	1.4	-0.3	1.0	0.7	0.8	0.4	-0.5	0.7	0.9	0.0	-0.2	0.5	0.4
Sitting height	0.1	1.1	5.9	0.3	1.2	-2.4	-0.1	0.5	-0.6	0.6	-0.8	-1.7	-0.8	-0.9	-0.3	0.5	-1.0	1.5	-0.5	-1.3	-0.4	-0.4	-1.5
Standing height	0.1	0.8	4.2	-1.1	0.3	-1.0	1.4	1.8	0.6	1.2	-0.1	-2.1	0.1	-0.5	-0.3	0.1	0.1	-0.8	0.1	-1.1	-0.4	-0.5	-0.8
Hair/balding pattern: Pattern 4	0.1	0.2	1.8	-0.2	0.0	-0.5	0.1	0.0	0.4	0.9	0.4	0.0	-0.2	0.5	-0.1	0.5	0.6	0.4	0.1	-0.5	-1.3	-0.2	0.4
Pulse rate, automated reading	0.1	0.5	4.1	0.6	0.5	-0.5	0.4	0.0	-0.2	0.5	-0.6	0.7	-0.4	-0.2	-1.0	0.3	0.6	-0.3	-0.4	0.1	0.4	-2.0	-1.1
Hair Pigment	0.0	0.4	2.5	0.0	-1.6	0.6	0.3	0.6	0.0	-0.1	-0.8	0.9	-0.1	0.7	0.1	-0.6	0.3	-0.6	-0.0	0.6	0.8	-0.2	-0.2

Hub : Genes

ANKRD44

Models

Trait associations