Hub : Genes

RNF168

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1740	0.0650	1.9e-03	0.020	NA	0.078	NA	0.068	2.7e-02	NA	4.5e-05	NA	1.3e-04
2	GTEx	Artery Tibial	0.1128	0.0437	1.5e-03	0.055	NA	0.050	NA	0.057	4.0e-05	NA	8.7e-05	NA	3.0e-05
3	GTEx	Brain Cerebellar Hemisphere	0.3640	0.1250	2.9e-03	-0.006	NA	0.146	NA	0.054	4.9e-01	NA	1.4e-04	NA	1.7e-02
4	GTEx	Brain Cerebellum	0.2730	0.1020	5.0e-03	0.077	NA	0.029	NA	0.071	2.8e-03	NA	4.8e-02	NA	3.9e-03
5	GTEx	Cells Transformed fibroblasts	0.1090	0.0490	5.5e-03	0.018	NA	0.020	NA	0.026	1.6e-02	NA	1.2e-02	NA	4.5e-03
6	GTEx	Colon Sigmoid	0.1810	0.0790	7.6e-03	0.051	NA	0.006	NA	0.025	6.9e-03	NA	1.9e-01	NA	4.5e-02
7	GTEx	Esophagus Muscularis	0.1090	0.0410	1.0e-03	0.002	NA	0.003	NA	0.006	2.2e-01	NA	2.1e-01	NA	1.3e-01
8	GTEx	Lung	0.1386	0.0469	9.1e-04	0.081	NA	0.069	NA	0.077	8.7e-07	NA	5.4e-06	NA	1.6e-06
9	GTEx	Muscle Skeletal	0.1280	0.0404	9.8e-05	0.041	NA	0.032	NA	0.012	6.2e-05	NA	3.9e-04	NA	2.0e-02
10	METSIM	Adipose	0.1094	0.0376	1.5e-04	0.012	0.042	0.055	0.053	0.034	5.9e-03	6.6e-07	1.2e-08	2.1e-08	5.7e-06
11	NTR	Blood	0.0205	0.0096	7.0e-03	0.001	0.004	0.000	0.005	0.001	1.9e-01	2.1e-02	4.0e-01	9.7e-03	1.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.4	0.9	-0.7	0.1	0.8	-0.3	0.7	-0.3	-0.4	0.4	0.9	0.9	0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.0	-0.5	-1.0	1.4	-1.3	-0.0	-1.4	-0.0	0.9	0.2	1.4	0.1
Depressed Affect (Nagel 2018)	1.0	2.1	7.9	-0.5	1.2	-0.6	2.1	1.1	2.2	0.5	-0.7	0.7	1.3	-2.8
Depression (Nagel 2018)	2.6	4.0	9.7	1.8	1.8	1.5	2.5	1.6	2.6	2.6	0.8	-1.1	1.1	-3.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.8	-1.1	-0.7	-0.6	-0.9	-1.3	-0.3	-0.1	-1.0	0.1	-1.3	0.1
Neuroticism (Nagel 2018)	0.2	0.5	2.1	0.2	-0.1	-1.4	0.9	0.1	0.9	-0.6	-0.6	-0.1	-0.4	-1.1
Schizophrenia (2018)	0.4	0.9	2.2	-0.2	-1.3	1.0	-1.4	-0.6	-1.5	0.3	0.9	-0.5	1.0	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	-0.3	-1.0	0.1	-0.3	-0.4	-1.0	-0.1	-0.6	-0.6	0.5	0.0
Worry (Nagel 2018)	0.7	1.5	3.9	-0.2	-1.4	-2.0	-0.8	-1.3	-1.1	-1.1	-1.1	-1.1	-2.0	-0.0
Alzheimer’s Disease (in mother)	1.3	1.5	4.8	0.1	-1.4	-0.1	-1.1	-1.9	-1.5	-2.2	-1.1	-1.4	-0.2	0.3
Alzheimer’s Disease (in father)	1.3	1.4	4.1	-1.7	-0.9	-0.4	-0.9	-1.3	-0.9	0.8	-2.0	0.9	-1.4	1.1
Alzheimer’s Disease (including proxy)	1.0	1.5	3.4	-0.3	-1.4	-0.3	-1.5	-1.8	-1.5	-1.3	-1.1	-0.4	-1.6	0.9
Crohns Disease (2017)	1.3	2.9	10.9	-1.8	-1.3	1.2	-1.2	-1.8	-2.1	-1.1	-1.5	-3.3	1.3	0.5
Irritable Bowel Disease (IBD)	1.8	4.4	8.5	0.1	-2.1	2.6	-2.5	-2.5	-2.9	-1.3	-1.5	-2.7	1.6	1.4
Ulcerative Colitis (UC)	2.2	4.2	10.9	0.5	-2.6	2.1	-3.3	-2.7	-3.1	-1.1	-1.3	-0.9	0.4	1.7
Major Depression (MDD)	0.8	1.0	6.4	-0.4	-0.2	0.5	0.6	-0.5	-0.3	0.1	-0.2	-2.5	-0.2	-1.9
Reaction Time	0.2	0.4	1.3	0.7	-0.6	-0.8	-0.4	-0.6	-0.2	-1.1	1.1	-0.3	-0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.9	-0.6	-0.7	-1.4	-0.7	-1.6	-0.5	-0.4	-1.7	0.4	-0.1	1.3
Breast Cancer	0.5	1.2	5.2	0.1	-1.4	0.2	-1.3	-0.2	-1.3	-0.2	2.3	1.2	-0.5	0.8
Ovarian Cancer	0.5	0.7	2.7	-1.4	0.1	-1.0	0.6	0.3	0.1	0.4	-0.4	1.6	1.2	-0.2
Prostate Cancer	0.6	0.8	2.6	-1.6	-0.3	-1.6	-0.2	0.3	-0.4	-0.7	0.0	1.2	-1.1	0.8
Age at First Birth	0.7	1.0	2.7	0.7	1.2	-0.2	1.2	1.2	1.5	0.6	1.6	0.2	0.9	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	4.2	-2.1	-1.2	-0.3	-0.9	-0.9	-1.1	-0.5	-1.1	0.3	-1.5	-0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.8	2.8	6.2	-1.8	-1.0	-1.2	-1.8	-2.1	-2.2	-1.4	-1.0	-2.5	0.3	1.9
Mean Putamen Volume	0.9	1.0	5.0	-0.7	-0.9	-0.1	-1.3	-0.3	-1.2	-0.3	0.6	1.1	-0.6	2.2
Fasting Glucose	2.3	2.8	5.7	-2.0	-1.7	-0.1	-2.1	-1.5	-2.4	-2.1	-1.2	-0.6	-0.1	2.2
HbA1C	1.0	1.1	2.6	-1.4	1.2	0.6	1.6	0.8	1.0	0.4	0.2	-1.3	1.5	-0.1
HDL Cholesterol	0.2	0.3	0.9	0.6	-0.2	1.0	-0.2	-0.1	-0.6	0.3	0.1	-0.8	-0.7	-0.2
LDL Cholesterol	0.6	0.9	2.0	-1.4	-1.3	0.2	-1.0	-0.7	-1.4	-1.0	-0.8	-0.5	0.0	0.9
Lupus	1.2	1.8	4.1	0.0	2.0	0.1	1.9	1.4	1.8	2.0	0.0	0.3	1.4	-0.8
Neuroticism (2016)	0.4	0.6	3.1	0.1	0.2	-0.2	0.3	0.4	0.2	1.6	-0.4	0.4	-1.8	-0.3
Primary Biliary Cirrhosis	0.8	1.2	2.2	-0.1	-1.0	-0.7	-1.2	-1.5	-1.2	-1.3	-1.2	-1.2	1.3	0.2
Rheumatoid Arthritis	0.8	1.1	4.4	-0.3	1.4	0.9	1.4	0.1	1.6	-0.0	-0.1	-0.2	0.2	-2.1
Schizophrenia (2014)	0.7	1.6	5.2	-0.5	-1.7	1.1	-2.1	-0.7	-2.3	-0.6	0.7	-0.8	1.3	0.6
Triglycerides	1.5	2.4	6.6	-0.5	1.4	2.6	1.5	1.6	1.8	2.0	1.0	-0.6	1.1	-1.8
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.6	-0.1	1.6	0.5	1.5	1.4	1.5	0.8	-0.0	1.5	0.9	-0.4
Ulcerative Colitis	0.6	0.9	2.7	0.2	-0.8	-0.3	-1.6	-1.3	-1.4	0.0	-0.5	0.2	0.2	1.6
Blood Eosinophil Count	0.3	2.0	5.3	-1.7	1.2	-0.0	1.4	2.2	1.4	0.9	0.5	2.3	1.3	-0.9
Blood Platelet Count	0.3	3.6	11.8	0.7	-0.4	-3.2	-1.3	0.6	-0.6	-0.4	2.2	1.0	-2.9	3.4
Blood Red Count	1.0	9.4	30.8	0.9	-3.8	3.7	-2.0	-2.7	-2.8	-1.9	-0.7	-0.8	4.5	5.5
Blood White Count	0.5	3.4	17.2	2.9	0.1	0.2	0.5	1.4	0.8	0.8	4.2	-1.4	-1.9	1.6
Heel T-Score	0.1	0.6	2.2	1.5	-0.1	-0.7	0.1	0.3	0.3	0.1	1.2	1.2	-0.9	0.3
BMI	3.3	19.0	42.9	0.8	5.5	2.8	6.5	5.7	6.3	4.3	-0.2	3.8	3.6	-2.9
Height	0.1	2.2	9.2	-1.0	0.3	-0.6	1.8	1.1	1.8	0.1	-1.5	3.0	1.0	-1.8
Waist Hip Ratio (WHR)	0.5	2.2	11.4	1.3	0.2	2.0	0.7	-0.1	0.4	0.9	1.3	-2.1	0.3	-3.4
Systolic Blood Pressure	4.7	23.4	39.9	-4.6	-6.3	-3.0	-6.1	-5.4	-5.7	-6.3	0.4	-4.7	-4.7	2.1
Smoking Status	1.6	3.9	15.7	-0.9	1.3	2.6	2.6	1.4	1.9	1.9	-1.1	0.0	1.2	-4.0
Allergy or Eczema	0.7	1.8	6.7	-0.3	-1.4	1.0	-0.9	-0.4	-1.5	-1.6	0.4	-1.4	2.6	-1.2
Cardiovascular Disease	0.5	1.6	4.5	-1.9	-2.1	-0.0	-1.4	-1.0	-1.7	0.0	-0.1	-1.3	-1.3	0.5
Hypothyroidism (self reported)	1.3	3.0	14.0	2.4	0.9	-1.9	0.5	1.9	1.2	0.3	0.8	3.7	0.3	1.6
Respiratory disease	0.2	0.4	0.9	-1.0	-0.9	-0.5	-0.7	-0.5	-1.0	0.1	-0.1	0.6	-0.5	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	5.4	-1.0	-0.2	0.3	0.5	-0.6	0.3	-0.3	-0.6	-2.3	0.9	-1.6
Lung FEV1/FVC ratio	1.5	7.6	16.3	2.5	3.2	4.0	3.0	3.1	4.0	2.0	2.5	0.7	1.9	-1.4
Lung FVC	1.7	8.6	20.1	-0.5	-3.5	-1.0	-4.0	-3.4	-4.5	-1.7	-0.4	-1.7	-4.2	3.1
Neuroticism	0.8	2.0	5.1	0.0	1.5	-0.8	2.0	1.1	2.2	1.3	-0.2	0.2	-1.5	-2.3
Chronotype (morning person)	1.7	3.9	8.8	-0.4	-2.2	-1.6	-3.0	-1.9	-2.7	-2.8	-0.0	-0.3	-1.6	2.4
Hair Pigment	0.0	0.7	2.8	-1.1	-0.6	-1.0	-1.7	-0.9	-1.3	0.0	-0.0	0.0	-0.1	-0.3
Tanning	0.1	0.6	3.7	-0.6	0.4	-0.4	0.7	0.5	0.8	0.8	-0.3	-0.3	-1.9	0.7
Hand grip strength (left)	0.4	1.0	5.2	-2.3	-0.7	0.9	-0.3	-0.1	-0.6	-0.1	-1.9	0.8	-0.5	0.4
Number of treatments/medications taken	0.7	1.2	7.0	-0.0	0.3	-0.0	1.1	0.6	0.8	0.3	1.0	-1.7	0.0	-2.6
Average weekly spirits intake	1.8	2.2	5.6	0.4	1.6	0.7	1.8	1.3	1.8	1.9	-0.4	0.3	1.8	-2.4
Sensitivity / hurt feelings	0.4	0.6	3.6	-0.5	-0.5	-0.5	0.1	-0.4	0.2	-1.4	-0.4	0.3	-1.9	0.6
Frequency of depressed mood in last 2 weeks	1.7	2.3	6.9	1.3	0.9	1.3	1.7	1.7	1.6	1.9	1.1	-1.2	0.0	-2.6
Hearing difficulty/problems: Yes	0.3	0.5	3.8	0.2	-0.4	-1.9	-0.2	0.1	0.5	0.0	0.2	0.9	0.8	-0.0
Relative age of first facial hair	0.6	1.3	4.4	-0.7	0.1	2.1	0.2	-0.4	0.2	-0.4	0.2	-1.4	1.8	-2.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	-0.2	0.0	-0.8	-0.2	-0.4	0.5	-0.7	0.6	1.3	-0.7	1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.2	0.7	1.6	0.5	1.5	1.1	1.8	-0.1	0.4	-0.2	0.0	-1.4
Ever had hysterectomy (womb removed)	1.3	1.5	4.0	1.4	1.5	0.6	1.3	1.6	1.3	0.8	0.7	0.8	2.0	-0.3
Systolic blood pressure, automated reading	1.4	3.9	12.1	-3.5	-2.2	-1.7	-2.1	-1.8	-1.5	-2.7	0.2	-1.7	-1.7	0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	3.3	-1.2	0.9	0.7	0.8	0.5	0.9	-0.6	0.1	-0.5	0.9	-1.8
Angina	1.1	1.4	6.9	0.1	0.8	0.2	1.7	0.6	1.6	-0.5	0.9	-0.5	1.0	-2.6
Medication for hormone replacement therapy	1.8	2.0	5.2	-1.6	-1.9	0.1	-1.7	-2.3	-1.7	-1.3	-1.5	-1.1	-0.2	0.0
Vitamin and mineral supplements	0.4	0.5	1.2	-0.2	0.9	0.7	0.7	1.0	0.5	1.1	0.4	-0.1	-1.0	0.4
Supplements: Zinc	1.2	1.3	4.4	0.8	-1.3	-0.5	-1.6	-0.7	-1.5	-2.1	0.4	1.2	0.1	0.9
Medication: Co-codamol	0.6	0.7	3.7	-0.3	0.4	0.8	0.8	0.5	0.1	1.0	-0.3	0.2	1.9	-1.3
Medication: Metformin	0.9	1.2	4.2	-0.9	-0.0	1.0	0.4	-0.5	0.2	-0.5	-0.3	-1.8	2.0	-1.9
Diabetes (father)	0.5	0.7	2.1	-1.4	-0.5	-0.2	-1.0	-1.2	-0.2	-1.0	-0.4	0.7	0.7	0.5
Diabetes (mother)	0.6	0.7	3.3	-1.0	-0.7	0.2	-0.1	0.0	-0.4	0.2	0.3	-1.8	-1.1	-1.2
Severe depression (siblings)	0.1	0.1	0.4	0.5	-0.1	0.3	-0.6	0.1	0.1	0.2	0.0	0.3	0.4	0.1
Pack years adult smoking proportion	2.1	3.1	8.2	0.1	2.2	0.4	2.9	2.2	2.5	1.6	-0.9	1.4	1.7	-1.3
Impedance of leg (right)	1.0	4.8	13.5	0.2	-2.6	-1.1	-2.7	-3.4	-2.6	-1.9	0.3	-3.7	-1.4	-0.1
Leg fat-free mass (left)	1.6	8.3	17.7	-0.1	3.2	2.8	4.2	4.0	3.7	2.1	-1.3	3.5	1.8	-2.2
Trunk fat percentage	1.7	6.6	14.8	0.7	2.8	1.5	3.8	3.0	3.8	2.3	-0.2	2.3	2.4	-2.9
Hand grip strength (right)	0.3	0.9	3.4	-1.5	-0.4	-0.0	-0.6	-0.3	-0.6	-0.1	-1.8	1.7	-0.1	0.4
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.9	-1.0	-0.6	-0.8	0.0	-0.7	-0.2	0.8	-0.5	-1.2	0.8
Current tobacco smoking	0.4	0.7	5.2	-0.2	0.0	0.5	0.7	0.2	0.1	1.1	-0.3	-0.1	0.2	-2.3
Average weekly fortified wine intake	1.0	1.1	3.5	-1.9	0.1	0.8	0.7	0.2	0.4	0.6	-1.1	-1.3	-1.7	1.1
Maternal smoking around birth	0.6	0.9	4.9	-0.0	0.3	0.5	0.9	0.3	0.9	1.4	-0.1	0.6	0.2	-2.2
Fed-up feelings	0.8	1.5	3.6	1.3	1.3	-0.5	1.6	1.4	1.7	0.9	0.1	1.9	0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	6.1	1.0	1.1	-0.0	1.2	1.2	1.4	2.5	1.2	-0.5	-1.1	-1.9
Relative age voice broke	0.1	0.2	0.8	-0.9	0.0	0.0	-0.2	-0.7	0.1	0.4	-0.2	-0.2	0.1	-0.3
Taking other prescription medications	1.2	1.9	5.2	0.1	1.5	-0.0	2.3	1.6	1.9	0.4	0.9	-0.1	1.0	-2.3
Age when periods started (menarche)	0.4	0.9	4.5	1.1	-0.2	-0.3	0.2	-0.8	0.1	-1.0	-0.3	-2.1	-1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.9	0.4	-0.7	1.1	0.5	-0.5	0.0	-1.1	-0.3	-1.7	1.6	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	-0.4	1.0	0.9	1.2	1.1	1.0	1.4	0.4	0.5	-0.7	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.0	1.4	-0.7	-0.5	-0.7	0.0	-0.3	-0.5	0.4	0.5	-0.5	0.6
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.7	-0.1	0.1	0.2	0.2	-0.3	-0.1	-0.9	0.4	0.8	-0.8
Serious illness, injury or assault to yourself	0.9	1.1	3.2	-1.5	-1.0	-1.8	-0.9	-1.1	-1.1	-0.0	-1.3	-0.7	-0.6	-0.2
High blood pressure	0.6	1.6	5.9	-1.6	-2.4	-0.2	-0.7	-0.1	-1.3	-0.5	0.1	-2.4	-0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	5.2	0.2	-0.7	0.7	-0.2	-0.5	-0.7	-1.3	0.1	-1.2	2.3	-1.4
Multivitamins +/- minerals	0.6	0.8	2.7	0.2	-0.9	-0.8	-0.5	-0.8	-0.4	-1.6	0.1	-0.9	1.5	-0.8
Stomach or abdominal pain in last month	0.3	0.3	1.9	-0.6	0.2	-0.2	0.2	0.3	-0.4	0.4	-0.5	1.4	0.7	-0.1
Supplements: Glucosamine	0.9	1.2	2.9	0.6	1.2	0.5	1.0	1.3	1.2	1.7	0.9	0.3	0.8	-1.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	0.0	-1.0	-0.2	-1.1	-0.9	-1.5	-0.2	0.1	-0.1	-0.3	1.4
Medication: Atenolol	0.3	0.3	1.1	0.3	-0.5	-0.7	0.2	0.7	0.2	-0.4	0.5	-0.2	-0.9	1.1
Medication: Levothyroxine sodium	0.7	1.2	5.2	1.0	-0.0	-1.7	-0.4	0.9	0.2	-0.5	0.4	2.3	0.5	1.5
Sitting height	0.3	1.8	5.4	-1.4	-1.6	0.8	-0.7	-0.7	-1.4	-2.3	-2.3	0.6	-1.0	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.3	0.7	-0.8	0.9	0.6	1.1	0.1	0.3	0.5	0.5	0.9
High blood pressure (mother)	0.9	1.2	4.4	-0.6	-1.0	0.6	-0.5	-0.7	-0.5	-1.9	-0.2	-2.1	-1.6	0.5
Body mass index (BMI)	2.6	11.1	23.1	0.5	3.9	2.6	4.8	4.5	4.6	3.4	0.2	2.8	2.7	-2.9
Impedance of leg (left)	1.1	5.2	13.2	0.4	-2.9	-1.6	-2.7	-3.6	-2.8	-2.1	0.0	-3.4	-1.3	0.3
Leg predicted mass (left)	1.6	8.6	18.2	-0.0	3.2	3.0	4.3	4.0	3.8	2.1	-1.2	3.4	1.8	-2.2
Trunk fat mass	2.0	8.8	20.2	0.4	3.1	2.3	4.5	3.6	4.2	2.5	-0.7	2.6	2.7	-3.2
Waist circumference	2.5	9.1	19.8	0.4	3.2	3.1	4.4	3.6	4.1	2.8	0.1	2.0	2.6	-3.5
Number of incorrect matches in round	1.0	1.7	3.3	0.7	-1.8	-0.8	-1.4	-0.9	-1.3	-1.2	1.7	-1.6	-1.5	-0.8
Past tobacco smoking	1.9	3.5	8.3	0.8	-2.1	-1.4	-2.5	-1.3	-2.3	-1.4	0.8	-0.8	-2.9	2.6
Alcohol usually taken with meals	0.5	0.9	2.2	1.1	1.5	-0.3	0.9	0.5	1.5	0.5	1.3	-0.4	-0.9	0.3
Nervous feelings	1.1	2.1	4.4	-0.7	-1.5	-1.4	-1.8	-1.9	-2.1	-0.3	-1.6	-0.4	-1.5	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.7	1.5	0.6	0.5	0.8	1.1	0.8	1.2	1.6	-0.3	-0.2	-1.6
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.5	0.0	-0.5	-0.5	-0.0	-0.1	-0.1	0.1	0.0	0.1	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.8	-0.4	-0.3	-0.1	-0.1	0.2	-0.6	-0.9	0.2	0.6	-1.4	0.9
Had menopause	1.1	1.4	5.6	0.9	1.0	-1.6	0.4	1.0	1.1	1.3	0.4	2.4	1.0	-0.2
Had other major operations	0.3	0.3	1.7	0.2	0.3	-1.3	0.3	-0.1	0.5	0.4	-0.5	0.9	-0.4	0.1
Forced vital capacity (FVC)	1.2	4.5	10.6	-2.5	-2.3	-0.7	-2.2	-1.8	-2.8	-2.3	-1.5	-0.3	-3.3	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.8	0.4	1.6	1.9	1.8	1.5	1.8	1.7	0.8	0.6	-0.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.8	0.9	-1.7	1.3	-1.1	-0.4	-0.9	-0.1	0.8	0.1	-0.5	-0.8
Qualifications: None of the above	0.8	1.7	4.3	0.3	1.1	0.2	2.1	1.4	1.8	0.5	1.1	-1.7	0.2	-1.9
Financial difficulties in last 2 years	0.7	1.0	4.5	0.2	-0.2	-2.1	0.1	0.8	-0.0	0.3	1.4	0.0	0.2	-1.8
Mouth/teeth dental problems	0.3	0.4	2.0	-1.4	0.5	-0.6	0.1	0.2	-0.1	-0.2	-0.2	0.8	1.1	0.4
Heart attack	0.6	0.8	3.9	0.7	-0.9	-0.5	-1.1	-1.0	-0.7	-2.0	0.9	-0.2	0.2	0.4
Allergy	0.2	0.5	2.5	-0.5	0.5	-0.4	0.1	0.0	0.7	1.0	0.1	0.0	-1.6	0.8
Pain all over the body in last month	0.4	0.4	2.5	-0.3	0.2	-1.0	-0.3	-0.7	0.1	0.1	0.2	0.1	-1.6	-0.1
Diabetes (self-reported)	0.7	1.0	3.0	-1.7	-0.1	0.8	0.4	-0.4	0.5	-0.2	-1.1	-1.1	1.6	-1.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.9	-0.2	-0.4	-0.3	-0.6	0.1	-0.5	-0.2	1.0	0.3	0.4	-0.1
Medication: Ramipril	1.6	2.0	4.1	0.6	1.3	2.0	1.5	1.9	1.6	1.7	0.7	1.1	1.8	-0.2
Medication: Simvastatin	0.3	0.4	2.9	-0.0	-0.1	0.9	0.7	-0.0	0.2	0.3	-0.1	-1.7	-0.0	-0.7
Fluid intelligence score	0.3	0.5	2.0	0.3	0.1	0.1	0.0	-0.6	0.5	0.4	-1.2	1.4	1.0	0.7
Illnesses of siblings	0.8	1.1	2.1	-0.8	-0.6	1.4	-1.5	-1.2	-1.0	-1.2	-0.7	0.8	-0.6	1.3
Neuroticism score	0.3	0.5	1.7	-0.1	0.2	-1.0	0.9	0.3	0.8	0.2	-0.5	-0.3	-1.3	-1.2
Weight	2.2	10.7	24.1	0.2	3.5	2.8	4.9	4.3	4.5	2.8	-0.8	3.3	2.3	-3.1
Impedance of arm (right)	1.2	5.7	10.8	-0.2	-3.0	-1.8	-3.3	-3.2	-2.9	-3.2	0.3	-2.3	-1.6	1.4
Arm fat percentage (right)	1.6	6.1	13.3	0.1	2.8	2.0	3.6	3.3	3.7	2.0	0.1	2.4	1.9	-2.3
Trunk fat-free mass	1.0	5.8	13.1	-0.5	2.5	2.7	3.6	3.4	2.9	1.7	-1.6	2.8	1.0	-1.7
Hip circumference	1.8	7.6	15.9	0.7	2.9	2.7	4.0	3.5	3.8	2.5	-0.7	3.3	1.9	-1.8
Time employed in main current job	1.1	1.3	5.9	0.8	-0.5	1.3	-0.2	-1.0	-0.0	-0.6	-0.6	-1.5	2.4	-1.3
Alcohol intake versus 10 years previously	0.3	0.5	2.5	-0.2	-0.6	0.3	0.6	0.4	0.3	-1.1	0.4	-1.6	0.1	-0.8
Father’s age at death	0.3	0.4	1.8	-0.3	0.4	-0.6	-0.4	0.5	0.1	-0.2	0.8	1.3	-0.6	0.5
Worrier / anxious feelings	0.2	0.4	1.0	0.6	-0.4	-1.0	0.4	0.1	-0.2	-0.8	-0.9	-0.6	-0.8	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	4.1	0.5	0.4	-0.3	0.8	0.2	0.3	0.4	1.2	-1.0	-1.4	-2.0
Falls in the last year	1.1	1.6	2.8	0.3	1.3	0.5	1.6	1.7	1.6	1.4	0.4	1.2	1.4	-1.1
Hair/balding pattern: Pattern 3	0.9	1.3	5.8	-1.1	0.4	-2.2	-0.1	-0.1	0.4	1.3	0.2	0.2	-2.4	-0.2
Number of live births	0.6	0.8	3.7	-0.2	0.1	-1.7	-0.4	0.4	0.6	0.5	0.4	1.9	1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.8	-0.9	-1.3	0.8	-1.3	-0.8	-1.6	-1.9	-0.5	-0.6	-2.4	1.0
Pulse rate	0.7	1.2	4.0	0.1	-1.6	0.7	-1.2	-1.1	-2.0	-1.0	-0.9	-0.9	0.8	0.2
Happiness	0.8	1.0	2.4	1.2	-1.6	0.6	-1.3	-0.5	-1.1	-0.5	1.4	-0.9	-0.7	-0.2
Noisy workplace	0.5	0.6	2.2	1.5	0.4	0.2	0.7	0.6	0.6	0.1	1.4	-0.1	-0.6	-0.9
Qualifications: A levels/AS levels or equivalent	2.1	4.8	12.3	0.5	-2.5	0.1	-3.5	-2.5	-3.2	-1.7	-0.6	0.2	-1.5	3.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.0	1.2	1.3	-1.9	0.2	1.2	1.1	0.6	1.8	2.0	-0.1	0.7
Mouth/teeth dental problems: Dentures	0.6	1.1	4.4	2.1	0.6	0.4	0.9	0.7	1.1	-0.3	1.6	-0.0	0.2	-1.3
Asthma	0.6	1.2	3.6	-0.6	-1.9	-0.5	-1.6	-0.7	-1.9	-1.1	0.7	0.6	-0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.6	0.3	0.7	1.0	1.0	0.9	0.0	0.4	-0.2	0.1	-0.8
Medication: Cholesterol lowering	0.3	0.5	1.8	0.5	0.3	0.6	1.2	0.4	0.8	0.4	0.3	-1.3	0.4	-0.9
Depression (self-reported)	0.3	0.4	2.2	1.5	-0.7	0.3	0.2	0.7	-0.1	-0.0	0.0	-1.0	-0.2	-0.2
Medication: Lansoprazole	0.4	0.5	1.6	-0.0	0.9	0.5	0.5	0.5	0.8	0.3	0.6	0.9	0.5	-1.2
Prospective memory result	0.6	0.8	3.4	-0.1	0.3	1.8	-0.1	-0.6	-0.5	-0.6	-1.1	0.3	1.5	0.6
Lung cancer (father)	2.1	2.5	4.6	1.4	2.1	-0.5	1.5	2.1	1.9	1.8	1.5	1.5	0.3	-1.5
Illnesses of mother	0.5	0.6	2.4	-0.5	1.0	-0.2	-0.4	-0.4	-0.0	0.7	-0.9	1.3	1.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	6.0	-0.8	-0.9	1.4	-0.8	-0.0	-1.1	-1.4	0.1	-0.4	-2.5	0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	0.3	-0.5	1.2	-0.1	-0.0	-0.0	-1.1	0.1	-0.6	1.3	0.4
Impedance of arm (left)	0.9	4.1	9.9	0.1	-2.6	-1.9	-3.0	-3.1	-2.6	-1.9	0.3	-1.6	-1.4	1.0
Arm fat mass (right)	2.2	9.0	19.3	0.2	3.3	2.5	4.4	4.0	4.2	2.6	-0.4	3.0	2.4	-2.8
Trunk predicted mass	1.0	5.9	13.2	-0.5	2.5	2.6	3.6	3.5	3.0	1.7	-1.5	2.9	1.0	-1.6
Standing height	0.1	1.1	5.4	-0.5	-0.4	0.7	0.9	0.2	0.5	-0.9	-2.3	1.7	-0.4	-1.1
Length of working week for main job	0.7	0.8	1.9	-0.3	-1.4	-1.3	-0.6	-1.2	-0.5	-0.7	-1.0	-0.8	-0.8	0.5
Exposure to tobacco smoke at home	0.6	0.7	4.5	-0.7	-0.5	-0.1	0.1	0.2	-0.5	0.1	-1.3	0.0	-0.4	2.1
Breastfed as a baby	0.4	0.5	1.7	0.4	-0.3	-0.1	0.4	-0.4	-0.0	1.2	-1.3	-0.0	-0.8	-1.0
Tense / ‘highly strung’	2.1	3.5	7.2	-1.4	-2.5	-2.0	-2.1	-1.7	-2.3	-2.7	-1.0	-1.2	-1.8	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.6	1.2	0.8	0.3	1.1	1.7	0.9	0.8	1.4	0.5	-0.2	-1.9
Hair/balding pattern: Pattern 4	0.2	0.6	4.5	2.1	0.3	0.3	-0.1	0.1	0.5	0.4	0.8	0.6	0.3	-0.2
Birth weight of first child	0.7	1.3	3.0	0.6	1.5	0.8	1.1	0.6	1.3	1.3	-1.2	1.7	1.2	-0.0
Peak expiratory flow (PEF)	0.3	0.7	3.1	0.1	0.3	1.8	0.7	1.2	0.6	-1.2	0.2	0.5	0.6	0.1
Pulse wave reflection index	0.6	0.7	1.9	1.2	1.1	0.1	0.9	0.8	1.4	0.4	0.5	0.1	0.9	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.6	0.6	-0.1	0.6	0.2	0.2	0.3	0.7	0.9	0.3	1.4	-1.6
Loud music exposure frequency	0.6	0.7	2.6	-0.3	-0.8	-0.3	-0.4	-0.7	-1.1	-1.0	0.1	-1.6	-1.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	0.8	0.0	0.1	-1.3	-1.4	-0.9	0.1	-1.2	0.0	0.3	0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	-0.4	-0.3	1.4	0.0	-0.1	-0.2	1.1	-0.6	-1.2	-0.2	-0.6
Blood clot in the leg (DVT)	1.0	1.3	2.7	1.1	1.2	0.7	1.4	1.4	1.6	0.9	0.4	0.7	1.6	-0.9
Medication: Paracetamol	0.4	0.6	3.9	-0.5	0.1	0.9	0.2	0.1	0.5	0.1	0.5	-1.2	0.1	-2.0
Headache pain in last month	0.6	1.1	2.1	1.2	0.8	0.3	1.4	1.1	1.4	0.1	1.4	0.9	0.3	-1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	4.6	-0.5	0.3	-0.4	-0.9	-0.1	-0.4	-0.2	-0.2	2.1	-0.1	1.6
Glaucoma (self-reported)	0.3	0.4	1.5	0.7	0.7	0.2	0.8	-0.5	0.7	1.2	-0.2	-0.0	0.5	-0.6
Gout (self-reported)	0.2	0.3	0.8	0.9	0.0	0.0	0.6	0.5	0.6	-0.2	0.5	0.8	0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	7.0	0.6	-0.3	-1.4	-1.0	0.2	-0.5	-0.6	-0.5	2.6	-0.1	1.7
Medication: Amlodipine	0.8	1.1	2.3	0.1	-1.5	0.3	-0.9	-0.9	-1.5	-0.5	0.1	-1.5	-1.4	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.0	-0.1	-0.3	0.7	0.0	-0.6	-0.4	0.8	-0.4	-0.8	0.3	-1.4
Birth weight	0.4	0.8	2.0	-0.8	-0.2	-0.9	0.1	-0.3	-0.3	-1.2	-0.3	-1.4	1.4	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	0.4	0.9	-0.0	1.2	0.8	0.8	0.7	0.5	-0.1	-0.4	-0.4
High blood pressure (siblings)	0.5	0.7	4.7	0.9	-0.4	-2.2	0.1	0.8	0.2	0.3	0.9	-0.2	-0.7	0.7
Forced vital capacity (FVC), Best measure	1.0	3.8	12.1	-2.1	-2.3	0.3	-1.9	-1.4	-2.6	-2.1	-1.1	-0.6	-3.5	1.4
Body fat percentage	1.6	6.5	14.2	0.8	2.6	1.8	3.8	2.9	3.7	2.3	-0.2	1.9	2.6	-3.1
Leg fat percentage (right)	1.7	6.2	12.7	0.8	2.6	1.7	3.6	3.0	3.5	2.5	0.7	0.9	2.1	-3.5
Arm fat-free mass (right)	1.7	8.8	20.0	-0.2	3.3	2.8	4.5	3.7	3.8	2.9	-1.8	3.1	2.0	-2.3
Exposure to tobacco smoke outside home	0.8	1.1	3.0	-0.1	1.7	0.2	1.6	1.2	1.4	1.2	-0.5	0.6	0.9	-0.5
Comparative body size at age 10	0.4	1.2	4.3	0.8	0.7	-0.1	1.0	1.2	1.5	1.5	0.7	2.1	0.8	-0.3
Number of full brothers	0.9	1.2	5.7	-0.1	-0.1	0.4	1.0	0.5	0.2	0.2	1.4	-2.4	0.1	-2.0
Worry too long after embarrassment	0.4	0.6	3.5	1.9	0.3	0.0	0.4	0.6	0.8	0.7	1.1	-0.0	-0.8	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.2	-1.0	-0.7	-0.6	-0.2	-0.9	0.7	-0.3	0.3	-1.0	0.2
Wheeze or whistling in the chest in last year	1.1	2.0	3.5	1.2	0.9	-0.5	1.9	1.8	1.8	0.4	1.1	1.7	1.8	-1.6
Number of children fathered	0.9	1.0	2.5	1.3	1.2	0.8	1.2	0.6	1.6	0.6	-1.0	-0.7	1.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.1	-0.0	0.7	0.0	0.1	0.4	0.6	0.5	-0.4	-0.2	-0.4
Age at first live birth	0.5	0.8	4.3	0.5	1.0	0.8	0.0	0.4	0.3	-0.4	-0.7	0.5	1.3	2.1
Pulse wave peak to peak time	0.4	0.5	2.1	-0.3	0.4	-1.2	0.0	-0.0	-0.0	1.1	-0.2	0.7	-1.4	-0.5
Health satisfaction	0.3	0.4	2.0	0.4	-0.1	1.1	0.2	0.4	-0.1	0.7	0.7	-0.4	-1.4	-0.3
Shortness of breath walking on level ground	1.1	1.3	4.2	-0.1	0.6	1.7	1.0	-0.0	0.6	2.0	-1.5	-0.8	0.9	-1.5
Qualifications: College or University degree	1.7	5.5	15.5	-0.3	-3.1	-1.1	-3.9	-2.5	-3.3	-1.8	-0.3	-0.7	-2.1	3.0
Eye problems/disorders: None of the above	1.3	1.5	3.6	-0.1	-1.8	-0.0	-1.9	-0.4	-1.8	-1.3	-0.0	-0.1	-1.4	1.6
Mouth/teeth dental problems: Loose teeth	0.4	0.4	2.0	0.3	0.0	0.5	0.4	-0.5	0.0	1.2	-1.4	-0.8	-0.3	0.2
Emphysema/chronic bronchitis	0.8	0.9	4.0	2.0	0.5	-0.6	0.7	0.4	0.8	0.8	-0.4	0.4	1.4	-0.8
Medication for pain relief, constipation, heartburn	1.2	2.1	9.3	-1.3	-0.5	-1.0	-1.0	-0.8	-1.4	-0.3	-2.2	1.3	-0.9	3.1
Neck or shoulder pain in last month	3.4	4.8	8.1	1.7	2.7	2.0	2.7	2.8	2.8	2.7	0.6	1.4	1.8	-1.5
Medication: Blood pressure	0.7	1.2	7.4	0.1	-1.2	-0.3	0.4	-0.2	-0.1	-1.0	0.3	-2.7	-0.0	-1.6
Angina (self-reported)	1.2	1.6	6.7	0.1	1.0	0.4	1.9	0.9	1.6	-0.4	1.1	-0.5	0.9	-2.6
Migraine (self-reported)	0.3	0.4	3.2	0.6	-0.1	0.1	-0.4	-0.1	-0.0	-0.3	0.1	0.9	1.8	0.2
Medication: Ibuprofen	0.6	0.7	2.4	-0.1	0.2	1.5	0.8	1.1	0.7	0.0	1.2	-0.2	0.4	-1.1
Medication: Allopurinol	0.4	0.5	1.5	0.0	0.8	-0.1	1.2	1.1	1.1	0.7	0.2	0.8	0.2	-0.0
Medication: Omeprazole	3.3	4.0	9.0	1.2	2.7	0.6	2.5	3.0	3.0	1.3	2.4	0.5	0.8	-1.5
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.1	-0.0	-0.9	0.4	0.6	-0.0	0.6	-0.0	0.7	0.7	-0.8
Mean time to correctly identify matches	0.3	0.6	2.2	0.9	0.5	-1.5	0.6	0.2	0.9	-0.3	1.3	-0.0	0.3	-0.5
Heart disease (mother)	2.0	2.5	6.6	1.4	0.9	2.6	1.8	1.4	1.9	1.1	0.6	-0.5	2.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	2.3	0.1	-0.8	0.5	-0.4	-0.4	-0.5	-1.5	0.2	0.1	0.6	-0.9
Whole body fat mass	2.2	9.2	20.4	0.6	3.1	2.5	4.5	3.7	4.2	2.6	-0.6	2.5	2.8	-3.4
Leg fat mass (right)	2.5	9.6	21.2	0.3	3.4	2.6	4.6	4.0	4.3	2.6	-0.1	2.0	2.6	-3.7
Arm predicted mass (right)	1.5	7.9	18.1	0.0	2.9	2.7	4.2	3.6	3.5	2.6	-1.8	2.8	2.0	-2.5
Pulse rate, automated reading	0.4	1.4	3.2	0.4	-1.1	1.7	-0.7	-1.2	-1.4	-0.6	-0.8	-1.8	1.8	-0.6
Alcohol intake frequency.	0.6	1.4	3.3	1.2	0.4	1.6	1.7	1.2	1.4	0.1	0.6	-0.2	1.8	-1.1
Comparative height size at age 10	0.3	1.8	8.4	1.0	1.2	-0.6	1.3	1.6	1.6	0.8	0.0	2.9	-0.8	0.6
Number of full sisters	0.2	0.3	1.0	0.5	0.1	0.5	-0.1	0.5	0.3	1.0	0.6	-0.3	-0.6	0.4
Suffer from ‘nerves’	0.4	0.7	3.3	0.2	-0.2	-1.8	0.4	0.2	0.0	0.1	-0.4	-0.8	-1.8	0.1
Overall health rating	1.0	2.1	4.3	1.9	1.0	0.2	1.8	2.1	1.5	1.6	1.6	1.1	0.3	-1.8
Chest pain or discomfort	0.3	0.4	1.5	1.2	-0.8	-0.5	-0.2	-0.6	-0.7	-0.5	0.0	-0.5	0.3	-0.5
Had major operations	1.1	1.3	8.9	-0.0	1.1	1.2	0.6	0.8	0.7	-0.3	-0.6	0.7	3.0	0.5
Age at last live birth	0.3	0.4	1.8	-0.4	0.8	0.7	0.1	0.1	0.1	0.1	-1.3	-0.1	1.0	0.2
Family relationship satisfaction	0.5	0.6	1.7	0.4	-1.1	-0.1	-1.3	-0.7	-1.1	-0.1	0.5	-0.5	-1.2	0.5
Leg pain on walking	3.5	4.3	10.3	0.4	2.7	2.6	2.2	1.8	2.3	3.2	0.5	0.3	2.1	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	-0.6	0.2	-1.0	0.0	-0.0	0.3	0.2	0.2	-0.7	0.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.6	-0.1	1.5	0.0	1.5	1.2	1.4	0.4	-0.2	2.4	1.7	-0.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.2	0.1	-0.7	2.0	-1.1	-1.2	-1.2	-0.4	-1.2	-1.1	-0.2	2.0
Medication: Aspirin	0.8	1.1	3.5	1.9	-1.0	-0.8	-1.0	-0.9	-0.2	-1.4	1.6	-0.8	-0.0	-0.5
Supplements: Vitamin C	0.2	0.3	1.3	-0.3	-0.5	-0.1	-0.6	-0.1	-0.5	-0.1	-1.0	1.1	0.0	0.3
Knee pain experienced in last month	1.4	2.2	8.6	-0.7	1.5	2.9	1.7	1.8	1.4	0.9	-0.6	-1.3	0.3	-1.4
Hypertension (Self-reported)	0.6	1.6	5.5	-1.8	-2.4	-0.6	-0.7	-0.2	-1.2	-0.4	0.1	-2.3	-1.0	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.4	0.4	0.7	0.2	0.5	0.7	0.6	-0.4	0.1	0.9	0.8	-1.2
Illnesses of father: Heart disease	0.9	1.3	5.4	-0.7	-2.3	-0.3	-1.1	-1.5	-0.9	-1.2	-0.6	-0.9	-0.1	-1.2
Illnesses of siblings: Diabetes	1.4	1.8	4.5	0.9	1.6	-0.1	1.2	1.1	1.6	2.1	0.8	1.1	1.5	-1.4
Smoking status: Previous	2.0	3.0	5.6	-0.8	2.2	1.5	2.4	1.8	2.3	1.1	-0.6	1.0	2.3	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.3	-0.6	-1.1	0.7	-0.3	-0.9	-0.9	-0.9	-1.0	0.3	-1.1	0.7
Whole body fat-free mass	1.2	6.9	15.4	-0.4	2.7	2.7	3.9	3.6	3.3	1.8	-1.7	3.2	1.4	-1.8
Leg fat-free mass (right)	1.4	7.7	16.8	-0.0	3.0	2.4	4.1	3.9	3.6	1.9	-1.3	3.7	1.7	-1.8
Arm fat percentage (left)	1.7	6.9	14.3	0.4	2.9	2.0	3.8	3.4	3.8	2.5	0.1	2.5	2.3	-2.4
Average weekly red wine intake	0.7	1.1	4.8	0.4	-0.2	0.7	-0.6	-1.2	-0.5	0.0	-0.1	-2.2	-1.9	0.7
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.8	1.0	-1.7	-0.7	-2.0	-1.6	-1.6	-0.4	-0.1	-1.1	-1.7	1.0
Mood swings	1.3	2.3	9.0	-1.1	1.2	0.4	2.4	1.4	2.0	0.8	-0.2	-0.4	0.7	-3.0
Loneliness, isolation	0.3	0.4	1.9	0.1	-0.9	-1.4	-0.3	0.0	-0.3	-0.1	0.6	-0.9	-0.9	-0.1
Long-standing illness, disability or infirmity	0.9	1.4	3.3	0.6	1.8	-0.1	1.7	1.1	1.7	1.3	0.1	0.8	0.7	-1.3
Ever had bowel cancer screening	0.3	0.3	1.6	0.4	-0.1	-0.1	0.0	0.1	-0.2	0.4	0.9	-1.3	0.9	-0.3
Diabetes diagnosed by doctor	0.6	1.1	3.1	-0.9	0.3	1.0	0.9	0.1	0.9	-0.1	-0.5	-1.4	1.8	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	-0.1	-0.6	-0.2	-1.2	-0.6	-1.0	-0.0	0.1	0.6	1.4	-0.9
Friendships satisfaction	1.6	2.0	5.5	-0.3	-1.5	-0.3	-2.1	-1.1	-1.8	-1.6	0.2	-0.4	-1.5	2.4
Qualifications: nursing, teaching	0.5	0.7	2.4	1.6	-0.6	0.1	-0.9	0.1	-0.7	-1.1	1.3	0.2	-1.0	0.5
Commuting to job workplace: Walk	1.9	2.0	4.9	-0.7	-1.9	-0.9	-2.2	-1.8	-1.9	-1.5	-1.1	-0.5	0.1	1.5
Eye problems/disorders: Cataract	1.3	1.5	3.8	0.2	1.4	-0.4	1.6	0.3	1.6	1.9	-0.7	0.2	1.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	4.9	-0.2	-1.1	-0.9	-1.1	-0.7	-1.0	-0.3	-0.1	0.6	-2.2	0.5
Medication for cholesterol	0.9	1.4	5.5	2.4	1.2	0.2	1.3	1.1	1.3	0.7	0.9	0.6	1.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	1.2	0.0	-0.8	0.2	0.6	-0.0	-0.0	0.9	1.3	0.5	-1.0
Back pain experienced in last month	0.2	0.2	1.2	-1.1	-0.2	0.6	-0.0	0.5	-0.0	-0.0	-0.1	0.7	-0.2	-0.3
Mineral and other dietary supplements	0.5	0.6	2.8	-0.1	0.4	1.7	0.6	0.2	0.0	1.6	-1.0	-0.1	-0.4	-0.1
Breast cancer (self-reported)	0.5	0.6	2.3	-0.1	0.3	-0.5	1.5	0.6	0.9	-0.0	-1.0	-0.3	1.0	-0.9
Asthma (self-reported)	0.4	0.9	2.7	-0.9	-1.5	-0.4	-1.3	-0.5	-1.6	-0.9	0.6	0.8	-0.1	0.2
Osteoporosis (self-reported)	0.7	0.9	3.2	0.3	1.2	-0.0	0.9	0.8	1.2	1.0	0.1	1.8	0.4	1.1
Osteoarthritis (self-reported)	0.9	1.2	4.3	-0.1	1.1	0.4	1.5	2.1	1.4	0.7	1.1	1.1	0.7	0.3
Medication: Aspirin	0.7	0.9	3.9	1.8	-0.5	-0.5	-0.8	-0.3	0.0	-1.1	2.0	-0.3	-0.1	-0.3
Medication: Gliclazide	0.6	0.7	2.4	-0.5	-0.6	0.7	-0.6	-1.2	-0.2	-1.1	-1.6	-0.2	0.7	-0.0
Illnesses of father: None of the above (group 1)	2.2	2.7	5.7	2.4	1.8	2.4	1.8	1.6	1.3	1.8	1.1	-0.1	1.1	-1.4
Smoking status: Current	0.4	0.7	5.0	-0.5	-0.3	0.1	0.4	-0.1	-0.1	1.1	-0.5	-0.3	-0.5	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.6	-0.5	0.8	0.7	0.3	1.0	0.2	0.6	1.7	-0.6	-1.9	-0.3
Whole body water mass	1.2	6.8	15.1	-0.5	2.7	2.7	3.9	3.6	3.2	1.8	-1.5	3.2	1.4	-1.8
Leg predicted mass (right)	1.5	8.0	17.2	-0.0	3.1	2.4	4.2	4.0	3.6	2.0	-1.3	3.8	1.7	-1.9
Arm fat mass (left)	2.3	9.5	20.5	0.1	3.5	2.4	4.5	4.0	4.3	2.9	-0.4	3.1	2.4	-2.7
Number of self-reported non-cancer illnesses	0.2	0.4	1.7	0.5	-0.9	-0.7	-0.3	0.3	-0.4	0.3	1.3	0.2	0.0	-0.3
Average weekly champagne plus white wine intake	1.1	1.5	3.6	-0.6	-1.6	0.0	-1.4	-1.1	-1.5	-1.9	0.1	-0.9	-1.1	1.5
Miserableness	2.0	3.4	7.8	0.1	1.9	-0.4	2.6	2.3	2.8	1.6	0.1	1.9	0.9	-2.6
Guilty feelings	0.5	0.8	2.1	0.7	0.1	-0.5	0.8	0.6	0.9	1.0	0.5	-1.0	-1.4	-1.4
Wears glasses or contact lenses	3.0	3.5	12.5	0.3	1.6	-2.0	1.2	1.8	1.9	2.5	1.0	3.5	1.6	1.0
Ever taken oral contraceptive pill	2.0	2.2	7.2	-0.2	-1.6	0.4	-1.2	-2.3	-1.7	-1.3	-1.5	-2.7	0.8	0.0
Hearing aid user	0.4	0.4	1.4	0.3	0.6	0.1	0.8	0.2	0.9	-0.1	1.2	0.4	0.5	-0.9
Mother’s age at death	1.7	2.1	4.2	0.4	1.9	-1.2	1.0	1.7	2.0	1.1	1.9	2.0	1.1	0.6
Financial situation satisfaction	1.7	2.1	8.1	-0.3	-1.3	-2.8	-1.2	-1.1	-1.2	-0.8	1.3	-0.4	-2.6	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.3	0.7	0.4	0.5	0.7	0.7	0.9	0.3	0.4	1.4	-0.2
Commuting to job workplace: Public transport	1.0	1.2	3.4	-1.0	0.7	-0.4	0.8	0.2	0.6	1.2	0.3	-1.8	-1.5	-1.7
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	0.6	0.4	-0.5	1.0	-1.0	0.6	0.6	-1.0	-0.6	0.2	-0.9
Medication: Blood pressure	0.3	0.6	2.0	-1.2	0.4	0.0	0.6	1.4	0.8	0.3	0.6	0.6	-1.0	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	3.6	-0.8	-0.1	-0.2	0.3	-0.5	-0.0	-0.2	-1.9	-0.0	0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.9	0.6	-0.5	-2.0	-0.6	-0.4	-0.2	-1.5	0.6	-0.9	0.2	-0.9
High cholesterol (Self-reported)	0.2	0.4	2.1	0.1	-0.4	1.1	-0.2	-0.1	-0.5	0.3	-0.1	-1.5	-0.4	-0.8
Medication: Bendroflumethiazide	0.6	0.9	3.5	-0.9	-0.5	-1.9	0.9	1.2	0.6	-0.6	1.0	-0.9	-0.2	0.0
Medication: Paracetamol	0.6	0.9	2.4	-1.2	-0.8	1.5	-0.7	-0.6	-0.6	-0.2	0.4	-1.3	-0.4	-1.5
Medication: Lisinopril	0.8	1.0	3.1	-0.1	-1.1	-1.8	-1.1	-0.9	-0.9	-1.0	1.2	-0.9	-0.6	-0.5
Medication: Atorvastatin	0.4	0.6	1.7	-0.0	-1.0	-0.2	-0.9	-0.4	-0.5	-0.9	1.3	-0.6	-0.8	0.6
Illnesses of father: High blood pressure	4.5	5.6	11.0	-1.5	-2.7	-2.5	-2.7	-1.9	-2.9	-3.0	0.3	-1.5	-3.3	2.1
Alcohol drinker status: Never	0.2	0.2	0.9	-0.7	-0.3	-0.6	-0.1	-0.3	-0.1	-0.8	-0.9	0.1	0.1	0.4
Ever smoked	1.4	2.4	7.0	-0.8	1.4	1.7	1.9	0.7	1.4	1.3	-1.1	0.2	2.6	-2.2
Basal metabolic rate	1.4	7.8	17.7	-0.3	3.0	2.8	4.2	3.9	3.6	2.0	-1.4	3.3	1.5	-2.1
Leg fat percentage (left)	1.6	5.8	12.4	1.0	2.4	1.5	3.5	2.9	3.3	2.3	0.4	1.2	2.4	-3.2
Arm fat-free mass (left)	1.6	8.2	17.7	-0.3	3.2	2.8	4.2	4.0	3.6	2.4	-1.4	3.3	1.9	-1.9
Number of operations (self-reported)	0.9	1.4	6.4	0.8	1.3	-0.6	1.2	0.8	1.2	0.3	-0.2	1.5	2.5	0.5
Average weekly beer plus cider intake	0.8	1.2	3.6	-1.9	0.9	1.8	0.7	0.5	0.3	1.2	-0.8	-0.4	1.1	-1.2
Irritability	0.4	0.6	2.0	-0.7	-0.5	-0.2	-0.1	-0.9	-0.2	-1.0	-1.2	-0.8	0.6	-1.4
Risk taking	0.5	0.7	2.4	-1.2	-0.5	-1.2	-0.2	-0.2	-0.2	1.4	0.2	0.1	-0.0	-1.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	-1.0	-0.4	-0.4	0.1	-1.2	-0.6	0.6	-0.9	-0.9	-0.2	-0.4
Fractured/broken bones in last 5 years	0.7	0.9	1.5	-0.2	1.2	0.8	1.0	1.0	1.2	1.2	-0.6	1.2	1.2	-0.6
Age started oral contraceptive pill	0.9	1.1	2.2	1.2	0.9	-0.8	1.1	1.1	1.4	1.4	0.1	1.5	0.9	-0.1
Diastolic blood pressure, automated reading	1.5	4.5	9.5	-3.0	-2.8	-1.2	-2.5	-2.0	-2.0	-3.1	-0.1	-1.7	-1.6	1.5
Ever depressed for a whole week	1.4	1.7	6.0	2.4	-1.9	0.4	-1.6	-1.0	-1.1	-1.3	1.0	0.6	-1.2	-0.2
Unable to work because of sickness or disability	0.5	0.6	2.5	0.9	0.5	1.1	0.6	0.8	0.5	0.6	-0.4	-0.2	0.6	-1.6
Commuting to job workplace: Cycle	2.1	2.5	6.9	0.9	-2.5	-0.8	-2.6	-1.5	-2.4	-0.7	0.5	-1.6	-0.3	1.5
Myopia	0.5	0.7	2.2	-0.2	0.6	-1.5	0.5	0.5	0.9	-0.4	-0.1	1.0	0.9	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.1	1.0	1.7	0.4	0.4	-0.2	0.7	0.3	-0.8	1.8	-0.1	0.8
Cholesterol lowering medication	0.1	0.1	0.5	-0.4	-0.2	0.2	-0.3	-0.2	-0.1	0.3	0.3	0.0	-0.7	0.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	5.1	0.7	2.1	0.4	1.9	2.2	2.3	0.6	2.1	0.4	0.9	-1.4
Pain experienced in last month	1.0	1.7	3.9	-0.4	-1.6	-1.4	-1.7	-1.5	-2.0	-1.0	0.2	-1.7	-0.1	1.1
Supplements: Calcium	0.4	0.5	1.8	-0.9	-0.4	-0.0	0.2	0.4	-0.1	-1.4	-0.7	1.0	-0.1	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	2.1	-0.7	0.0	0.9	0.1	-0.3	-0.0	-0.2	0.7	-1.4	-0.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.7	0.7	-0.9	-0.6	-1.0	-1.0	-0.6	-1.9	1.0	-0.2	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.1	1.4	1.0	0.9	1.2	1.2	1.5	0.9	0.4	0.7	1.8	-0.8
Heart disease (siblings)	0.6	0.8	2.1	-0.4	0.6	0.9	1.4	1.0	0.6	0.4	0.4	-1.0	1.2	-1.1
Alcohol drinker status: Previous	0.2	0.2	0.7	0.9	-0.7	0.5	-0.0	-0.2	-0.5	-0.1	-0.1	-0.5	-0.2	-0.4
Pack years of smoking	2.2	3.2	8.5	0.1	2.3	0.3	2.9	2.1	2.6	1.4	-0.8	1.4	1.9	-1.5
Impedance of whole body	1.1	5.5	15.1	0.2	-3.0	-1.9	-3.2	-3.9	-2.9	-2.2	-0.1	-2.7	-1.2	0.7
Leg fat mass (left)	2.4	9.4	21.3	0.5	3.3	2.5	4.6	3.9	4.3	2.6	-0.2	2.3	2.7	-3.5
Arm predicted mass (left)	1.6	8.3	18.9	-0.1	3.2	2.9	4.3	3.9	3.7	2.3	-1.6	3.0	1.8	-2.1