Best TWAS P=6.24e-16 · Best GWAS P=2.88e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIN54 | 0.06 | 0.08 | lasso | 2 | 0.07 | 1.1e-08 | -8.2 | 8.1 | 6.2e-16 | -1.00 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | THAP9-AS1 | 0.16 | 0.12 | lasso | 6 | 0.11 | 2.7e-06 | -8.1 | -8.0 | 9.9e-16 | 0.92 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | THAP9-AS1 | 0.07 | 0.07 | lasso | 1 | 0.02 | 8.4e-02 | -8.1 | -8.1 | 7.7e-16 | 0.91 | 0.02 | 0.79 | FALSE |
| 4 | GTEx | Muscle Skeletal | TMEM150C | 0.16 | 0.02 | lasso | 4 | 0.06 | 2.2e-06 | 4.4 | -5.5 | 3.7e-08 | 0.13 | 0.97 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | THAP9-AS1 | 0.08 | 0.00 | enet | 7 | 0.01 | 5.3e-02 | 2.3 | -5.6 | 1.9e-08 | 0.68 | 0.06 | 0.68 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM150C | 0.10 | 0.07 | enet | 13 | 0.09 | 9.4e-11 | 4.9 | -5.3 | 1.3e-07 | 0.05 | 0.04 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM150C | 0.12 | 0.07 | lasso | 4 | 0.08 | 3.8e-08 | 4.5 | -5.5 | 3.1e-08 | 0.06 | 0.01 | 0.98 | TRUE |