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chr4:86,819,377-89,008,506

Best TWAS P=3.08e-32 · Best GWAS P=4.94e-30 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RP11-529H2.2	0.07	0.03	lasso	6	0.05	1.3e-04	-7.1	-5.7	1.3e-08	0.27	0.27	0.05	TRUE
2	GTEx	Adipose Visceral Omentum	HSD17B13	0.17	0.02	enet	18	0.05	2.1e-03	-7.1	-8.6	7.6e-18	0.42	0.88	0.03	FALSE
3	GTEx	Artery Tibial	AFF1	0.10	0.06	lasso	5	0.06	2.4e-05	9.6	9.4	4.6e-21	-0.48	0.75	0.14	FALSE
4	GTEx	Brain Caudate basal ganglia	C4orf36	0.25	0.01	enet	25	0.09	1.6e-03	2.3	-5.5	3.5e-08	0.52	0.06	0.22	FALSE
5	GTEx	Brain Cerebellar Hemisphere	AFF1	0.52	0.14	enet	47	0.27	1.4e-07	9.6	7.2	4.7e-13	-0.26	0.55	0.08	FALSE
6	GTEx	Brain Cerebellum	AFF1	0.30	0.09	enet	15	0.26	2.5e-08	4.6	11.1	1.1e-28	-0.61	0.07	0.88	FALSE
7	GTEx	Breast Mammary Tissue	HSD17B11	0.27	0.01	enet	40	0.03	8.1e-03	-7.9	-6.3	2.2e-10	0.37	0.12	0.06	FALSE
8	GTEx	Breast Mammary Tissue	RP11-529H2.2	0.22	0.07	enet	9	0.06	6.3e-04	-7.9	-6.9	4.1e-12	0.26	0.38	0.03	TRUE
9	GTEx	Breast Mammary Tissue (Female)	HSD17B11	0.14	-0.01	lasso	2	0.01	2.1e-01	-9.0	-9.4	6.8e-21	0.64	0.04	0.14	FALSE
10	GTEx	Breast Mammary Tissue (Female)	RP11-529H2.2	0.07	0.03	lasso	1	-0.01	8.0e-01	-5.6	-5.6	1.9e-08	0.21	0.04	0.06	FALSE
11	GTEx	Cells Transformed fibroblasts	KLHL8	0.07	0.01	lasso	5	0.02	2.1e-02	5.8	7.7	1.6e-14	-0.23	0.68	0.01	FALSE
12	GTEx	Colon Sigmoid	PTPN13	0.21	0.03	lasso	7	0.06	4.6e-03	-7.8	7.0	1.9e-12	-0.51	0.07	0.18	FALSE
13	GTEx	Esophagus Mucosa	HSD17B11	0.09	0.04	lasso	6	0.07	2.3e-05	-7.9	-7.8	7.1e-15	0.26	0.60	0.04	FALSE
14	GTEx	Esophagus Mucosa	RP11-529H2.2	0.12	0.00	lasso	7	0.00	1.6e-01	-7.9	-9.2	4.5e-20	0.41	0.04	0.57	TRUE
15	GTEx	Esophagus Muscularis	PTPN13	0.12	0.00	enet	21	0.01	1.2e-01	-7.8	5.8	5.0e-09	-0.41	0.10	0.13	FALSE
16	GTEx	Esophagus Muscularis	AFF1	0.11	0.09	lasso	2	0.10	1.3e-06	-10.3	11.8	3.1e-32	-0.84	0.02	0.97	TRUE
17	GTEx	Lung	HSD17B13	0.07	0.01	lasso	4	0.00	1.8e-01	-4.4	5.4	6.8e-08	-0.19	0.25	0.03	FALSE
18	GTEx	Skin Sun Exposed Lower leg	HSD17B13	0.11	0.09	lasso	5	0.08	2.2e-07	-5.9	6.0	2.1e-09	-0.21	0.98	0.00	FALSE
19	GTEx	Spleen	HSD17B13	0.26	0.13	lasso	7	0.22	2.2e-06	-5.7	5.1	3.1e-07	-0.20	0.29	0.05	FALSE
20	GTEx	Thyroid	HSD17B11	0.15	0.04	enet	16	0.05	1.6e-04	-7.9	-6.9	6.3e-12	0.21	0.30	0.03	FALSE
21	GTEx	Thyroid	RP11-529H2.2	0.10	0.06	lasso	5	0.04	4.4e-04	-7.9	-7.9	2.4e-15	0.28	0.74	0.02	TRUE
22	GTEx	Whole Blood	HSD17B13	0.25	0.12	enet	33	0.14	5.3e-13	-5.8	6.9	4.0e-12	-0.31	1.00	0.00	FALSE
23	METSIM	Adipose	AFF1	0.06	0.05	lasso	11	0.06	8.1e-09	-6.2	6.2	5.8e-10	-0.43	1.00	0.00	FALSE
24	NTR	Blood	HSD17B11	0.02	0.01	lasso	6	0.01	3.1e-05	4.4	-6.5	6.5e-11	0.25	0.60	0.04	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf36	0.02	0.01	blup	36	0.01	3.7e-02	6.4	-7.5	4.5e-14	0.39	0.02	0.10	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	C4orf36	0.05	0.03	lasso	4	0.02	9.1e-04	6.4	-6.0	2.5e-09	0.23	0.58	0.02	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD17B11	0.06	0.02	blup	51	0.05	2.2e-04	-4.4	-6.1	1.2e-09	0.18	0.04	0.19	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	HSD17B11	0.04	0.03	blup	50	0.00	3.3e-01	4.2	-6.6	3.1e-11	0.20	0.06	0.25	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	C4orf36	0.03	0.01	blup	36	0.02	4.1e-03	6.4	-7.4	1.0e-13	0.37	0.03	0.08	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B11	0.14	0.11	blup	51	0.16	7.0e-15	-5.6	-7.0	3.5e-12	0.25	0.72	0.28	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B13	0.04	0.01	blup	43	0.02	3.2e-03	-6.5	6.8	1.1e-11	-0.27	0.02	0.59	TRUE