TWAS hub - LIN54

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0180	5.5e-06	0.081	0.052	0.061	0.063	0.068	4.8e-10	5.3e-07	6.8e-08	4.3e-08	1.1e-08
2	GTEx	Thyroid	0.0750	0.0360	5.0e-03	0.041	NA	0.005	NA	-0.001	4.0e-04	NA	1.2e-01	NA	3.8e-01
3	YFS	Blood	0.0349	0.0098	1.5e-10	0.043	0.037	0.044	0.040	0.042	7.0e-14	2.7e-12	2.5e-14	3.5e-13	1.1e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Laxatives (e.g. Dulcolax, Senokot)	7.4	8.6	13.0	0.7	3.6	3.5
Tense / ‘highly strung’	6.7	11.1	16.4	0.8	4.0	4.0
Medication for hormone replacement therapy	5.3	5.9	6.9	2.6	2.3	2.3
Loneliness, isolation	5.3	7.3	10.1	1.5	3.2	3.1
Medication: Ibuprofen	5.1	6.1	6.5	2.4	2.5	2.5
Cardiovascular Disease	4.6	15.1	22.7	0.4	4.8	4.7
Ovarian Cancer	4.5	5.9	8.4	-1.1	-2.9	-2.9
Current tobacco smoking	4.3	7.0	9.1	1.8	3.0	2.9
Neuroticism score	4.1	8.5	12.8	0.6	3.6	3.5
Breast Cancer	4.0	9.7	14.1	2.0	3.8	3.3
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.0	6.3	1.7	2.5	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	6.0	9.0	0.9	2.9	3.0
Heart attack	3.8	4.8	5.3	2.3	2.1	2.1
Blood Red Count	3.7	36.2	65.3	8.1	4.5	4.8
Vascular/heart problems diagnosed by doctor	3.7	10.0	15.4	0.2	-3.8	-3.9
Medication: Lisinopril	3.6	4.6	6.9	0.6	2.6	2.6
Worry (Nagel 2018)	3.4	7.1	11.2	-0.0	3.3	3.2
Gout (self-reported)	3.4	4.6	6.2	-1.5	-2.5	-2.3
Smoking status: Current	3.4	5.3	7.5	1.3	2.7	2.6
Heart attack/myocardial infarction (self-reported)	3.4	4.4	6.1	2.5	1.9	1.9
Major Depression (MDD)	3.3	4.0	5.7	1.1	2.4	2.2
Loud music exposure frequency	3.2	3.5	5.0	0.8	2.2	2.2
Medication for pain relief, constipation, heartburn	3.1	5.3	7.4	-1.3	-2.6	-2.7
Heart disease (siblings)	3.1	3.8	5.0	-1.3	-2.2	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	9.5	-0.8	-3.1	-2.9
High blood pressure	2.9	8.0	12.0	-1.0	3.3	3.5
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	6.9	0.4	2.6	2.6
Worrier / anxious feelings	2.9	5.5	8.6	0.4	2.9	2.8
Blood clot in the leg (DVT)	2.9	3.7	7.5	2.7	1.3	1.4
Illnesses of father: Heart disease	2.9	4.0	4.9	2.2	1.9	1.9
High cholesterol (Self-reported)	2.9	5.1	7.4	0.9	2.7	2.7
Smoking Status	2.8	6.7	9.2	1.3	3.0	3.0
Neuroticism	2.8	6.8	9.8	1.1	3.1	3.1
Breast cancer (self-reported)	2.8	3.4	4.2	-1.4	-2.0	-2.0
Alcohol intake versus 10 years previously	2.6	3.9	4.6	-1.6	-2.1	-2.1
Lung FEV1/FVC ratio	2.5	12.8	19.9	-0.6	-4.5	-4.2
Peak expiratory flow (PEF)	2.5	5.7	9.0	-0.6	-3.0	-2.8
Medication: Seretide 50 evohaler	2.5	2.9	4.5	2.1	1.4	1.5
Hypertension (Self-reported)	2.5	6.9	9.8	-1.3	3.1	3.1
Deep venous thrombosis (DVT) (self-reported)	2.5	3.3	7.0	2.7	1.1	1.2
Age at First Birth	2.4	3.4	3.8	-1.9	-1.9	-1.8
Wears glasses or contact lenses	2.4	2.8	3.9	-1.0	-1.9	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	3.6	1.9	1.4	1.4
Intelligence (Savage-Jansen 2018)	2.2	6.6	6.9	-2.6	-2.6	-2.5
Verbal and Numeric Reasoning (VNR)	2.2	5.2	7.8	-0.9	-2.8	-2.6
Neuroticism (2016)	2.2	3.1	4.2	1.2	2.1	1.9
Blood Platelet Count	2.2	25.4	53.6	-7.3	-3.3	-3.4
Chronic bronchitis/emphysema (father)	2.2	2.6	3.9	0.2	2.0	1.9
Fluid intelligence score	2.2	4.5	4.9	-2.2	-2.2	-2.0
Pulse rate	2.2	3.7	4.8	1.5	2.1	2.2
Number of children fathered	2.2	2.4	3.3	-1.8	-1.4	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.9	-2.2	1.3	1.3
Risk taking	2.1	3.1	4.0	1.0	2.0	2.0
Average weekly spirits intake	2.0	2.5	3.5	0.8	-1.8	-1.9
Happiness	2.0	2.4	3.2	1.0	1.8	1.7
Age started oral contraceptive pill	2.0	2.5	2.7	-1.7	-1.4	-1.6
Supplements: Glucosamine	1.9	2.5	7.3	-2.7	-0.3	-0.1
Lung cancer (father)	1.9	2.2	4.2	2.1	1.1	1.1
Medication for cholesterol	1.9	2.8	3.5	-1.2	-1.9	-1.8
Bipolar Disorder or Schizophrenia	1.8	4.3	6.4	0.6	2.5	2.5
HDL Cholesterol	1.8	3.0	4.4	-1.2	1.8	2.1
Noisy workplace	1.8	2.3	3.9	2.0	1.2	1.3
Worry too long after embarrassment	1.8	3.0	4.5	0.3	2.1	2.1
Alzheimer’s Disease (in father)	1.7	1.8	3.5	-1.9	-0.9	-1.1
Suffer from ‘nerves’	1.7	2.7	3.9	-0.8	2.0	1.9
Handedness (chirality/laterality): Left-handed	1.7	2.0	3.0	-0.7	1.7	1.6
Number of treatments/medications taken	1.6	2.9	3.9	1.0	2.0	1.9
High blood pressure (siblings)	1.6	2.2	6.1	-2.5	-0.5	-0.6
Medication: Aspirin	1.6	2.1	3.2	0.5	1.6	1.8
Ever taken oral contraceptive pill	1.6	1.8	2.1	1.2	1.4	1.5
Blood Eosinophil Count	1.5	11.6	33.3	5.8	-0.9	-0.8
Nervous feelings	1.5	2.7	4.5	0.1	2.1	1.9
Prostate Cancer	1.4	2.0	5.2	-2.3	-0.7	-0.7
Blood White Count	1.4	10.1	28.2	5.3	-1.1	-0.9
Diabetes (self-reported)	1.4	2.2	2.8	-1.0	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	7.6	-0.5	-2.8	-2.4
Emphysema/chronic bronchitis	1.4	1.6	2.7	1.6	0.9	1.2
Neck or shoulder pain in last month	1.4	2.0	3.0	0.6	1.7	1.6
Number of self-reported non-cancer illnesses	1.4	2.4	3.3	1.0	1.7	1.8
Financial situation satisfaction	1.4	1.8	2.3	1.1	1.5	1.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.6	0.6	1.4	1.6
Fractured/broken bones in last 5 years	1.4	1.9	3.0	0.4	-1.7	-1.6
Pain experienced in last month	1.4	2.3	2.9	1.1	1.7	1.7
Bipolar Disorder (2018)	1.3	2.0	2.5	1.2	1.6	1.5
Neuroticism (Nagel 2018)	1.3	2.9	4.5	0.0	2.1	2.1
Schizophrenia (2018)	1.3	2.6	4.0	-0.1	2.0	2.0
Alzheimer’s Disease (in mother)	1.3	1.5	4.3	2.1	0.3	0.3
Fed-up feelings	1.3	2.3	3.2	1.8	1.4	1.4
Stomach or abdominal pain in last month	1.3	1.6	2.6	1.6	1.1	1.0
Medication: Ramipril	1.3	1.7	2.6	-1.6	-1.1	-1.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	3.0	-0.7	-1.7	-1.7
Medication: Allopurinol	1.3	1.7	3.1	-0.0	-1.8	-1.4
Pack years adult smoking proportion	1.2	1.9	2.2	1.1	1.5	1.5
High blood pressure (mother)	1.2	1.6	4.9	-2.2	-0.1	-0.1
Had menopause	1.2	1.5	1.9	-1.4	-1.1	-1.2
Medication: Amlodipine	1.2	1.6	1.8	-1.2	1.3	1.3
Eye problems/disorders: None of the above	1.2	1.3	2.1	0.8	1.2	1.4
Myopia	1.2	1.8	1.9	-1.3	-1.4	-1.3
Schizophrenia (2014)	1.1	2.4	4.0	0.2	2.0	1.8
Systolic Blood Pressure	1.1	5.7	8.0	-2.8	2.2	2.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.0	0.7	1.4	1.3
Medication: Co-codamol	1.1	1.3	2.1	-1.4	-0.9	-1.1
Diabetes (father)	1.1	1.3	3.3	1.8	0.5	0.6
Heart disease (mother)	1.1	1.3	2.2	0.1	-1.3	-1.5
Pulse rate, automated reading	1.1	3.7	4.6	1.4	2.1	2.1
Chest pain or discomfort	1.1	1.5	2.4	-0.1	1.5	1.5
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.2	-2.0	0.2	0.1
Supplements: Calcium	1.1	1.2	1.9	-0.2	1.3	1.4
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.3	-1.1	-1.1	-1.0
Sensitivity / hurt feelings	1.0	1.7	2.2	0.9	1.5	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.8	0.9	1.2	1.3
Number of live births	1.0	1.4	2.5	-0.5	1.6	1.3
Medication: Lansoprazole	1.0	1.1	1.5	-0.9	-1.1	-1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.3	-0.8	-1.5	-1.3
Exposure to tobacco smoke outside home	1.0	1.3	1.3	1.1	1.2	1.1
Knee pain experienced in last month	1.0	1.6	2.6	-1.6	-1.1	-1.0
Ever had bowel cancer screening	1.0	1.2	1.7	-0.2	1.3	1.3
Diabetes diagnosed by doctor	1.0	1.6	1.9	-1.0	-1.3	-1.4
Commuting to job workplace: Walk	1.0	1.1	1.5	-0.4	-1.2	-1.2
Osteoporosis (self-reported)	1.0	1.2	3.2	-1.8	-0.4	-0.6
Hearing aid user	1.0	1.1	1.8	0.3	-1.3	-1.2
Medication: Atenolol	0.9	1.1	1.8	0.3	1.1	1.4
Father’s age at death	0.9	1.2	3.3	-1.8	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	4.9	-0.3	-2.2	-1.9
Age at first live birth	0.9	1.6	1.6	-1.2	-1.3	-1.2
Medication: Blood pressure	0.9	1.6	2.4	-0.6	1.5	1.6
Illnesses of siblings: Diabetes	0.9	1.1	1.5	0.5	1.2	1.2
Mood swings	0.9	1.7	2.6	-0.0	1.6	1.6
Medication: Aspirin	0.9	1.2	1.9	0.0	1.3	1.4
Schizophrenia vs Biploar Disorder	0.8	1.1	1.9	0.5	1.4	1.1
Irritable Bowel Disease (IBD)	0.8	2.0	4.6	-2.1	0.7	0.8
Triglycerides	0.8	1.2	1.9	1.0	1.4	0.9
Ulcerative Colitis	0.8	1.2	2.3	-1.5	0.8	0.7
Systolic blood pressure, automated reading	0.8	2.3	6.7	-2.6	0.5	0.3
Qualifications: None of the above	0.8	1.7	2.2	1.0	1.5	1.4
Time employed in main current job	0.8	0.9	1.4	0.8	1.2	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.2	-1.1	-1.4	-1.5
Prospective memory result	0.8	1.0	1.0	-0.9	-1.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.4	0.9	0.9	1.2
Shortness of breath walking on level ground	0.8	1.0	1.0	-1.0	-1.0	-1.0
Angina (self-reported)	0.8	1.1	2.0	1.4	0.8	0.9
Comparative height size at age 10	0.8	4.6	10.6	3.3	1.3	1.3
Smoking status: Previous	0.8	1.2	1.8	-0.1	1.3	1.3
Mineral and other dietary supplements	0.8	1.1	1.3	1.1	-1.0	-1.1
Guilty feelings	0.8	1.2	1.8	-0.6	1.2	1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.5	0.6	1.0	1.2
Illnesses of father: High blood pressure	0.8	1.0	2.8	-1.7	0.2	0.4
Unable to work because of sickness or disability	0.8	1.0	1.5	0.3	1.2	1.2
Pack years of smoking	0.8	1.2	1.4	0.9	1.2	1.2
Ulcerative Colitis (UC)	0.7	1.3	3.6	-1.9	0.3	0.4
Mean Putamen Volume	0.7	0.8	1.4	-0.2	1.2	0.9
Lupus	0.7	1.1	2.2	0.0	1.0	1.5
Lung FVC	0.7	3.4	5.6	-2.4	-1.6	-1.4
Angina	0.7	1.0	2.0	1.4	0.6	0.7
Waist circumference	0.7	2.6	3.1	1.5	-1.6	-1.8
Medication: Cholesterol lowering	0.7	1.0	1.4	0.7	1.1	1.2
Forced vital capacity (FVC), Best measure	0.7	2.5	4.0	-0.6	-2.0	-1.7
Qualifications: College or University degree	0.7	2.2	4.4	-2.1	-1.1	-1.0
Age at last live birth	0.7	1.0	1.2	-0.8	-1.0	-1.1
Medication: Gliclazide	0.7	0.7	0.9	0.8	-0.9	-0.8
Number of operations (self-reported)	0.7	1.1	1.4	0.8	1.2	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.1	0.8	0.9	1.1
Crohns Disease (2017)	0.6	1.3	1.9	-1.4	0.9	1.1
Past tobacco smoking	0.6	1.2	1.7	0.5	-1.3	-1.3
Financial difficulties in last 2 years	0.6	0.8	2.5	1.6	-0.1	-0.1
Medication: Simvastatin	0.6	1.0	1.4	-0.2	1.2	1.2
Medication: Paracetamol	0.6	0.9	1.4	0.2	1.2	1.2
Number of full brothers	0.6	0.7	0.8	-0.9	-0.8	-0.9
Health satisfaction	0.6	0.7	1.3	1.1	0.7	0.7
Medication: Atorvastatin	0.6	0.7	1.3	1.1	0.7	0.6
Bipolar Disorder (2011)	0.5	0.5	1.0	-1.0	0.6	0.5
Body Mass Index (BMI) (2010)	0.5	0.6	1.1	-1.0	-0.6	-0.7
Fasting Glucose	0.5	0.6	1.5	-1.2	0.4	0.4
Primary Biliary Cirrhosis	0.5	0.7	1.2	0.3	1.1	0.9
Chronotype (morning person)	0.5	1.2	2.3	1.5	-0.8	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.8	1.3	-0.1	0.1
Supplements: Zinc	0.5	0.6	0.9	-0.5	0.9	0.8
Medication: Metformin	0.5	0.8	0.9	-0.9	-0.8	-0.9
Diabetes (mother)	0.5	0.7	1.9	1.4	0.2	0.2
Trunk fat percentage	0.5	1.8	3.5	1.9	-0.9	-1.1
Trunk fat mass	0.5	2.1	3.7	1.9	-1.1	-1.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	-1.3	-0.3	-0.2
Pain all over the body in last month	0.5	0.5	0.5	-0.7	-0.6	-0.7
Hip circumference	0.5	2.1	2.4	1.6	-1.4	-1.5
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	0.3	1.1	1.0
Pulse wave Arterial Stiffness index	0.5	0.5	0.8	0.4	0.8	0.9
Exposure to tobacco smoke at home	0.5	0.6	1.5	1.2	0.3	0.2
Breastfed as a baby	0.5	0.6	0.7	-0.7	-0.8	-0.8
Birth weight of first child	0.5	0.9	2.3	-1.5	-0.6	-0.5
Leg pain on walking	0.5	0.6	1.8	-1.4	0.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.8	-0.5	-0.9	-0.8
Long-standing illness, disability or infirmity	0.5	0.8	1.1	1.0	0.8	0.9
Eye problems/disorders: Cataract	0.5	0.6	0.6	0.8	-0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.0	-0.5	-1.0	-1.0
Medication: Bendroflumethiazide	0.5	0.7	1.0	-0.8	1.0	0.8
HbA1C	0.4	0.5	0.8	0.1	-0.9	-0.8
Average weekly fortified wine intake	0.4	0.5	1.4	1.2	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	1.5	-0.4	-0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.2	1.1	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.6	0.8	0.6	0.8
Alcohol usually taken with meals	0.4	0.7	1.0	0.6	0.8	1.0
Hearing difficulty/problems with background noise	0.4	0.7	1.1	0.3	1.0	1.0
Arm fat percentage (right)	0.4	1.6	2.5	1.6	-1.0	-1.2
Illnesses of mother	0.4	0.5	0.8	-0.1	0.9	0.9
Arm fat mass (right)	0.4	1.7	2.8	1.7	-1.0	-1.1
Length of working week for main job	0.4	0.4	1.1	1.1	-0.2	-0.3
Body fat percentage	0.4	1.6	2.1	1.5	-1.1	-1.3
Comparative body size at age 10	0.4	1.1	1.6	0.5	1.2	1.2
Migraine (self-reported)	0.4	0.5	0.8	-0.9	-0.5	-0.5
Medication: Omeprazole	0.4	0.4	0.9	1.0	0.5	0.4
Whole body fat mass	0.4	1.7	3.2	1.8	-0.9	-1.1
Number of full sisters	0.4	0.5	0.9	-0.3	-0.9	-0.7
Arm fat percentage (left)	0.4	1.8	2.0	1.4	-1.2	-1.4
Friendships satisfaction	0.4	0.5	1.5	1.2	-0.0	-0.1
Asthma (self-reported)	0.4	0.7	1.5	-1.2	-0.6	-0.5
Arm fat mass (left)	0.4	1.6	2.3	1.5	-1.0	-1.2
Average weekly champagne plus white wine intake	0.4	0.6	1.8	-1.4	-0.0	-0.0
Alcohol drinker status: Previous	0.4	0.5	1.1	1.1	-0.4	-0.4
Depression (Nagel 2018)	0.3	0.4	0.6	0.5	0.7	0.8
BMI	0.3	1.7	2.4	0.7	-1.5	-1.5
Hearing difficulty/problems: Yes	0.3	0.5	1.0	1.0	-0.6	-0.3
Relative age of first facial hair	0.3	0.7	0.7	-0.8	0.9	0.8
Severe depression (siblings)	0.3	0.3	0.5	-0.7	0.4	0.5
Maternal smoking around birth	0.3	0.4	0.8	0.9	-0.3	-0.5
Relative age voice broke	0.3	0.5	0.9	1.0	0.6	0.5
Body mass index (BMI)	0.3	1.4	2.1	0.6	-1.3	-1.5
Forced vital capacity (FVC)	0.3	1.1	1.8	-0.4	-1.4	-1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.3	0.8	0.6
Weight	0.3	1.3	1.8	1.4	-1.0	-1.1
Asthma	0.3	0.6	1.1	-1.0	-0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.6	-0.2	-0.6	-0.8
Leg fat percentage (right)	0.3	1.0	1.2	0.9	-1.0	-1.1
Wheeze or whistling in the chest in last year	0.3	0.6	0.8	-0.9	-0.7	-0.8
Pulse wave peak to peak time	0.3	0.4	0.6	-0.1	-0.7	-0.8
Leg fat mass (right)	0.3	1.3	2.5	1.6	-0.8	-0.8
Had major operations	0.3	0.3	0.7	0.8	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	-0.4	-0.7	-0.6
Supplements: Vitamin C	0.3	0.4	0.7	-0.9	0.5	0.4
Qualifications: nursing, teaching	0.3	0.4	0.7	-0.4	-0.9	-0.6
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.8	0.4	0.3
Medication: Blood pressure	0.3	0.7	0.8	-0.9	0.7	0.8
Ever smoked	0.3	0.6	1.0	-1.0	0.6	0.6
Irritability	0.3	0.6	0.8	-0.6	0.9	0.7
Leg fat mass (left)	0.3	1.2	2.1	1.5	-0.8	-0.9
Depressed Affect (Nagel 2018)	0.2	0.5	0.6	0.8	0.6	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.8	-0.3	-0.4
Crohns Disease (2012)	0.2	0.4	0.6	-0.7	0.4	0.6
Hypothyroidism (self reported)	0.2	0.6	1.3	1.2	0.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.8	-0.2	-0.2
Vitamin and mineral supplements	0.2	0.2	0.7	0.8	-0.2	-0.0
Age when periods started (menarche)	0.2	0.5	0.7	0.8	0.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.8	0.1	0.1
Multivitamins +/- minerals	0.2	0.3	0.4	-0.4	0.6	0.5
Sitting height	0.2	1.1	1.6	0.8	1.1	1.3
Number of incorrect matches in round	0.2	0.3	0.5	-0.1	0.7	0.6
Had other major operations	0.2	0.2	0.3	-0.3	0.5	0.5
Allergy	0.2	0.4	0.6	-0.8	-0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.8	0.2	0.1
Illnesses of siblings	0.2	0.2	0.7	0.8	-0.1	-0.1
Falls in the last year	0.2	0.3	0.5	0.3	-0.7	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.8	-0.2	-0.2
Pulse wave reflection index	0.2	0.2	0.5	-0.7	-0.3	-0.3
Headache pain in last month	0.2	0.3	0.4	0.6	0.4	0.5
Glaucoma (self-reported)	0.2	0.2	0.3	-0.4	-0.3	-0.5
Overall health rating	0.2	0.3	1.0	1.0	0.0	-0.0
Family relationship satisfaction	0.2	0.3	0.5	-0.3	0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.3	-0.4	-0.5
Average weekly red wine intake	0.2	0.3	0.7	0.9	0.1	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.3	0.5	0.6
Mother’s age at death	0.2	0.2	0.4	-0.6	-0.4	-0.2
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	0.4	0.2
Leg fat percentage (left)	0.2	0.9	1.3	0.7	-0.9	-1.1
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.9	0.2	0.2
Ever depressed for a whole week	0.2	0.3	0.4	-0.3	0.6	0.6
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.8	0.0	0.1
Cholesterol lowering medication	0.2	0.3	0.6	0.0	0.8	0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	-0.6	0.3	0.6
Reaction Time	0.1	0.2	0.4	-0.1	0.6	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.4	0.1	0.3
LDL Cholesterol	0.1	0.1	0.4	0.6	-0.1	0.0
Rheumatoid Arthritis	0.1	0.2	0.3	0.6	-0.3	-0.3
Height	0.1	2.8	7.0	2.6	-0.9	-0.8
Waist Hip Ratio (WHR)	0.1	0.6	1.6	1.3	-0.4	-0.4
Respiratory disease	0.1	0.1	0.3	0.6	-0.1	0.0
Hair Pigment	0.1	2.3	3.1	1.1	1.5	1.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.2	0.3	0.4
Impedance of leg (right)	0.1	0.4	0.6	0.8	0.4	0.6
Leg fat-free mass (left)	0.1	0.5	1.2	1.1	-0.3	-0.3
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.0	0.3	0.5
Taking other prescription medications	0.1	0.1	0.1	0.3	0.2	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	-0.1	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.3	-0.4	-0.3
Leg predicted mass (left)	0.1	0.4	0.9	1.0	-0.3	-0.3
Mouth/teeth dental problems	0.1	0.1	0.2	0.4	0.2	0.4
Impedance of arm (right)	0.1	0.6	1.5	1.2	0.3	0.4
Trunk fat-free mass	0.1	0.4	0.6	0.7	-0.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	0.5	0.3	0.4
Trunk predicted mass	0.1	0.4	0.6	0.8	-0.6	-0.5
Standing height	0.1	1.1	3.1	1.8	0.3	0.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.6	0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.5	0.2	0.3
Birth weight	0.1	0.2	0.6	-0.8	0.2	0.1
Arm fat-free mass (right)	0.1	0.3	0.3	0.5	-0.5	-0.5
Mean time to correctly identify matches	0.1	0.2	0.6	-0.8	0.3	0.1
Arm predicted mass (right)	0.1	0.3	0.6	0.8	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	0.7	0.4	0.5
Whole body fat-free mass	0.1	0.4	0.6	0.8	-0.5	-0.5
Back pain experienced in last month	0.1	0.1	0.2	0.5	0.3	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.5	0.0	-0.4
Whole body water mass	0.1	0.4	0.7	0.8	-0.5	-0.5
Miserableness	0.1	0.2	0.3	0.0	0.6	0.5
Medication: Paracetamol	0.1	0.1	0.4	0.6	0.0	0.1
Basal metabolic rate	0.1	0.6	1.1	1.1	-0.6	-0.6
Diastolic blood pressure, automated reading	0.1	0.2	0.2	-0.4	-0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.5	0.7	-0.1	-0.2
Heel T-Score	0.0	0.3	0.8	0.9	-0.1	0.0
Allergy or Eczema	0.0	0.1	0.1	0.3	0.3	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	-0.1	0.0
Tanning	0.0	0.1	0.1	-0.4	-0.2	-0.2
Hand grip strength (left)	0.0	0.0	0.1	-0.2	0.1	0.2
Ever had hysterectomy (womb removed)	0.0	0.1	0.2	0.4	0.0	-0.0
Hand grip strength (right)	0.0	0.0	0.1	0.2	-0.2	-0.0
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.2	0.1	-0.0
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.0	0.3	0.1
Impedance of leg (left)	0.0	0.2	0.2	0.3	0.4	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.3	-0.2	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.2	0.2	-0.0
Depression (self-reported)	0.0	0.0	0.0	0.1	0.1	0.2
Impedance of arm (left)	0.0	0.2	0.6	0.7	-0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.2	0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.3	0.3	0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.2	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.1	-0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.1	-0.2	-0.2
Alcohol intake frequency.	0.0	0.1	0.1	0.2	-0.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.3	0.2	0.1
Leg fat-free mass (right)	0.0	0.2	0.4	0.7	-0.3	-0.3
Leg predicted mass (right)	0.0	0.2	0.4	0.7	-0.3	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.0	-0.1	-0.4
Arm fat-free mass (left)	0.0	0.2	0.3	0.6	-0.4	-0.4
Impedance of whole body	0.0	0.1	0.2	0.5	0.1	0.2
Arm predicted mass (left)	0.0	0.2	0.3	0.5	-0.5	-0.4

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