TWAS hub - RN7SKP16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.088	0.036	0.0012	0.025	NA	0.006	NA	0.009	0.0036	NA	0.096	NA	0.059
2	GTEx	Heart Atrial Appendage	0.079	0.035	0.0087	0.061	NA	0.029	NA	0.024	0.0010	NA	0.019	NA	0.030

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Age when periods started (menarche)	7.5	18.1	19.8	-4.5	-4.0
Impedance of arm (right)	6.1	28.5	36.1	4.6	6.0
Medication for cholesterol	5.9	9.0	12.2	-3.5	-2.4
Allergy or Eczema	5.7	15.0	17.8	3.5	4.2
Hayfever, allergic rhinitis or eczema	5.7	12.3	13.8	3.3	3.7
Had major operations	5.5	6.5	8.2	2.9	2.2
Bilateral oophorectomy (both ovaries removed)	5.4	6.3	9.8	1.7	3.1
Overall health rating	5.2	11.1	13.6	3.7	2.9
Medication: Blood pressure	5.2	9.9	13.0	3.6	2.6
Arm fat-free mass (right)	4.8	24.5	35.6	-3.7	-6.0
Arm predicted mass (right)	4.8	24.8	35.5	-3.8	-6.0
Allergy	4.6	10.5	11.0	-3.2	-3.3
Average weekly spirits intake	4.4	5.5	5.8	-2.3	-2.4
Impedance of arm (left)	4.4	20.2	26.4	3.7	5.1
Illness, injury, bereavement, stress in last 2 years	4.4	5.4	5.7	-2.4	-2.3
Fractured/broken bones in last 5 years	4.4	5.7	8.2	2.9	1.8
Number of incorrect matches in round	4.2	7.0	7.1	2.6	2.7
Trunk fat-free mass	4.2	24.2	36.2	-3.5	-6.0
Trunk predicted mass	4.2	24.0	36.2	-3.4	-6.0
Medication: Paracetamol	4.2	6.9	8.8	2.2	3.0
Heart disease (mother)	4.2	5.1	7.1	2.7	1.8
Impedance of whole body	4.2	21.4	29.7	3.6	5.5
Respiratory disease	4.0	8.8	9.9	3.2	2.8
Diverticular disease/diverticulitis (self-reported)	3.9	4.6	5.8	-1.9	-2.4
Medication: Ramipril	3.9	5.0	6.1	2.0	2.5
Whole body water mass	3.9	22.0	33.2	-3.3	-5.8
Number of self-reported non-cancer illnesses	3.9	6.8	8.7	3.0	2.2
Chronic bronchitis/emphysema (mother)	3.8	4.4	5.0	2.2	1.9
Health satisfaction	3.8	4.9	6.4	1.9	2.5
Whole body fat-free mass	3.8	21.9	33.1	-3.3	-5.8
Arm fat-free mass (left)	3.7	18.8	27.9	-3.1	-5.3
Ever taken oral contraceptive pill	3.6	4.0	4.4	-1.9	-2.1
Arm predicted mass (left)	3.6	18.4	27.2	-3.1	-5.2
Ovarian Cancer	3.5	4.6	5.9	-1.8	-2.4
Forced expiratory volume in 1-second (FEV1)	3.5	11.9	14.4	-3.8	-3.1
Falls in the last year	3.4	4.6	5.6	2.4	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.9	12.7	-3.6	-3.0
Basal metabolic rate	3.4	18.8	28.5	-3.0	-5.3
Blood Red Count	3.3	32.2	38.4	6.2	5.1
Serious illness, injury or assault to yourself	3.3	4.0	4.3	2.1	1.9
Length of working week for main job	3.2	3.6	4.4	-1.6	-2.1
Forced vital capacity (FVC)	3.1	12.0	13.0	-3.6	-3.3
Illnesses of father: Heart disease	3.1	4.3	7.5	2.7	1.1
Taking other prescription medications	3.0	4.6	6.0	2.4	1.8
Mouth/teeth dental problems	3.0	4.7	5.5	-2.0	-2.3
Hayfever/allergic rhinitis (self-reported)	3.0	3.9	5.1	2.3	1.6
Impedance of leg (right)	2.9	14.3	19.8	3.0	4.5
Impedance of leg (left)	2.9	13.9	18.8	3.0	4.3
Illnesses of mother	2.9	3.6	6.0	-2.4	-1.1
Forced vital capacity (FVC), Best measure	2.9	10.5	11.4	-3.4	-3.1
Leg fat-free mass (right)	2.9	15.7	24.2	-2.7	-4.9
Leg predicted mass (right)	2.9	15.5	23.8	-2.7	-4.9
Leg fat-free mass (left)	2.8	15.1	22.8	-2.7	-4.8
Leg predicted mass (left)	2.7	14.6	22.0	-2.7	-4.7
Alcohol intake frequency.	2.7	6.3	8.0	2.8	2.1
Medication: Paracetamol	2.7	4.2	6.3	1.4	2.5
Hand grip strength (left)	2.4	6.2	10.1	-1.5	-3.2
Heart disease (siblings)	2.4	2.9	3.8	1.4	1.9
Hearing difficulty/problems with background noise	2.3	3.7	5.2	2.3	1.5
Asthma	2.3	4.6	5.5	2.4	1.9
Long-standing illness, disability or infirmity	2.3	3.5	4.7	2.2	1.5
Fasting Glucose	2.2	2.6	3.5	-1.9	-1.3
Age at First Birth	2.1	3.1	4.8	-2.2	-1.2
Supplements: Zinc	2.1	2.3	2.3	1.5	1.5
Weight	2.1	10.2	14.9	-2.4	-3.9
Age at last live birth	2.1	3.1	3.4	-1.7	-1.8
Asthma (self-reported)	2.1	4.3	5.1	2.3	1.8
Blood Eosinophil Count	2.0	15.6	16.3	3.9	4.0
Maternal smoking around birth	2.0	2.9	4.3	1.2	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	6.3	-2.5	-1.4
HbA1C	1.9	2.1	2.2	-1.5	-1.5
Age at first live birth	1.9	3.3	4.0	-2.0	-1.6
Lung FVC	1.8	9.2	12.0	-3.5	-2.5
Number of treatments/medications taken	1.8	3.2	3.9	1.6	2.0
Hand grip strength (right)	1.8	4.9	8.2	-1.2	-2.9
Medication: Simvastatin	1.8	2.6	4.4	2.1	0.9
Hip circumference	1.8	7.9	10.2	-2.4	-3.2
Pack years of smoking	1.8	2.7	4.0	2.0	1.2
Relative age voice broke	1.7	2.7	3.0	-1.5	-1.7
Primary Biliary Cirrhosis	1.6	2.3	3.0	1.7	1.3
Cardiovascular Disease	1.6	5.2	7.2	2.7	1.8
Pulse wave Arterial Stiffness index	1.6	1.8	2.8	-1.7	-0.9
Breastfed as a baby	1.6	2.0	2.1	-1.4	-1.5
Cholesterol lowering medication	1.6	2.4	3.9	2.0	1.0
Townsend deprivation index at recruitment	1.5	2.1	2.9	1.7	1.1
High blood pressure	1.5	4.1	5.5	2.3	1.7
Illnesses of siblings	1.5	2.2	3.2	-1.1	-1.8
Father’s age at death	1.5	2.0	2.1	-1.4	-1.4
Number of children fathered	1.5	1.7	3.1	-1.8	-0.5
Osteoarthritis (self-reported)	1.5	1.9	3.0	1.7	0.9
Vascular/heart problems diagnosed by doctor	1.5	4.0	5.4	-2.3	-1.6
Blood Platelet Count	1.4	16.0	19.2	-3.6	-4.4
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.6	1.9	0.6
Tense / ‘highly strung’	1.4	2.3	3.1	-1.3	-1.8
Peak expiratory flow (PEF)	1.4	3.3	3.5	-1.9	-1.8
Number of full brothers	1.4	1.8	1.9	-1.3	-1.4
Average weekly red wine intake	1.4	2.1	3.0	-1.1	-1.7
Ever smoked	1.4	2.5	4.2	-0.9	-2.0
Breast Cancer	1.3	3.1	4.5	-2.1	-1.4
HDL Cholesterol	1.3	2.2	2.4	-1.4	-1.5
Pack years adult smoking proportion	1.3	1.9	3.0	1.7	0.9
Stomach or abdominal pain in last month	1.3	1.6	2.2	1.0	1.5
Gout (self-reported)	1.3	1.7	2.5	-1.0	-1.6
High blood pressure (siblings)	1.3	1.9	2.2	1.5	1.3
Family relationship satisfaction	1.3	1.6	2.6	-0.7	-1.6
Hypertension (Self-reported)	1.3	3.7	5.6	2.4	1.4
Mood swings	1.3	2.4	4.3	2.1	0.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.2	1.8	0.2
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.3	1.5	0.9
High blood pressure (mother)	1.2	1.6	2.6	1.6	0.8
Depression (self-reported)	1.2	1.4	1.8	1.0	1.3
Prospective memory result	1.2	1.5	1.7	-1.2	-1.3
Eye problems/disorders: None of the above	1.2	1.4	2.8	1.7	0.1
Neck or shoulder pain in last month	1.2	1.7	2.6	1.6	0.9
Smoking status: Previous	1.2	1.7	3.1	-0.6	-1.8
Alcohol drinker status: Previous	1.2	1.3	2.7	1.6	0.0
Supplements: Glucosamine	1.1	1.4	1.9	-1.0	-1.4
Eye problems/disorders: Glaucoma	1.1	1.3	2.2	-1.5	-0.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.0	-1.4	-0.8
Ulcerative Colitis (UC)	1.0	2.0	3.9	-0.1	-2.0
BMI	1.0	5.7	6.9	-2.1	-2.6
Systolic Blood Pressure	1.0	4.9	6.1	1.9	2.5
Severe depression (siblings)	1.0	1.1	1.4	1.2	0.9
Sitting height	1.0	7.4	10.3	-2.1	-3.2
Past tobacco smoking	1.0	1.9	3.6	0.3	1.9
Exposure to tobacco smoke at home	1.0	1.1	1.3	-1.2	-0.9
Medication: Amlodipine	1.0	1.4	1.8	1.3	1.0
Pulse wave peak to peak time	1.0	1.2	2.0	1.4	0.6
Medication: Allopurinol	1.0	1.4	2.3	-0.7	-1.5
Osteoporosis (self-reported)	1.0	1.2	1.3	1.0	1.1
Pain type(s) experienced in last month: Hip pain	1.0	1.2	1.4	1.0	1.2
Mean Putamen Volume	0.9	1.0	1.5	-0.7	-1.2
Smoking Status	0.9	2.2	3.7	-0.8	-1.9
Medication: Metformin	0.9	1.3	2.0	-1.4	-0.7
Body mass index (BMI)	0.9	3.8	5.1	-1.6	-2.2
Alcohol usually taken with meals	0.9	1.4	2.3	-1.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.2	1.5	0.9
Happiness	0.9	1.1	1.3	1.1	0.9
Standing height	0.9	9.4	15.1	-1.9	-3.9
Supplements: Vitamin C	0.9	1.0	1.8	0.4	1.4
Medication: Bendroflumethiazide	0.9	1.3	2.2	1.5	0.7
Average weekly beer plus cider intake	0.9	1.4	1.5	-1.1	-1.2
Bipolar Disorder (2018)	0.8	1.2	1.3	1.0	1.2
Major Depression (MDD)	0.8	1.0	1.9	1.4	-0.2
Lung FEV1/FVC ratio	0.8	4.1	4.6	-1.9	-2.1
Medication for pain relief, constipation, heartburn	0.8	1.3	1.9	-0.8	-1.4
Number of operations (self-reported)	0.8	1.2	1.9	1.4	0.6
Schizophrenia vs Biploar Disorder	0.7	0.9	1.4	0.6	1.2
Schizophrenia (2014)	0.7	1.4	2.4	1.6	0.7
Relative age of first facial hair	0.7	1.4	2.1	-0.8	-1.5
Diabetes (mother)	0.7	0.9	1.5	-0.5	-1.2
Hair/balding pattern: Pattern 2	0.7	0.9	1.1	0.8	1.1
Mouth/teeth dental problems: Dentures	0.7	1.1	1.4	0.9	1.2
Migraine (self-reported)	0.7	0.9	1.3	0.7	1.2
Pulse rate, automated reading	0.7	2.2	2.3	1.4	1.5
High cholesterol (Self-reported)	0.7	1.2	2.0	1.4	0.7
Neuroticism (2016)	0.6	0.9	1.5	1.2	0.4
Rheumatoid Arthritis	0.6	0.8	1.5	1.2	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.0	0.6	1.0
Waist Hip Ratio (WHR)	0.6	2.8	2.8	1.6	1.7
Waist circumference	0.6	2.2	3.4	-1.0	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	1.2	0.2
Qualifications: None of the above	0.6	1.2	1.2	1.1	1.1
Alcohol intake versus 10 years previously	0.6	0.9	0.9	0.9	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	0.4	-1.1
Leg pain on walking	0.6	0.8	1.2	-1.1	-0.6
Medication: Atorvastatin	0.6	0.8	1.0	-0.8	-1.0
Ever depressed for a whole week	0.6	0.7	1.1	-0.6	-1.1
Supplements: Calcium	0.6	0.6	0.8	0.9	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	0.8	-0.9	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	1.8	1.3	0.7
Prostate Cancer	0.5	0.7	1.1	-0.5	-1.1
Systolic blood pressure, automated reading	0.5	1.5	1.9	1.4	1.1
Fed-up feelings	0.5	0.9	1.7	1.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.1	-1.0	-0.8
Worry too long after embarrassment	0.5	0.8	1.5	1.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	0.5	-1.0
Shortness of breath walking on level ground	0.5	0.6	1.1	-0.4	-1.1
Emphysema/chronic bronchitis	0.5	0.6	0.7	-0.7	-0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	-1.0	-0.5
Knee pain experienced in last month	0.5	0.8	1.4	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.4	-1.2	-0.9
Loneliness, isolation	0.5	0.6	0.9	-0.6	-1.0
Leg fat mass (left)	0.5	2.1	3.2	-1.0	-1.8
Reaction Time	0.4	0.8	1.3	-1.2	0.4
Ulcerative Colitis	0.4	0.6	0.8	0.6	-0.9
Neuroticism	0.4	1.0	1.8	1.3	0.4
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	-0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	0.9	0.7	-1.0
Pain all over the body in last month	0.4	0.5	0.9	0.9	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.8	-0.9	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.1	1.1	0.1
Whole body fat mass	0.4	1.7	2.4	-1.0	-1.6
Leg fat mass (right)	0.4	1.7	2.7	-0.9	-1.6
Chest pain or discomfort	0.4	0.5	1.0	1.0	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.9	0.4
Friendships satisfaction	0.4	0.5	0.9	1.0	-0.0
Commuting to job workplace: Walk	0.4	0.5	0.8	-0.9	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	-0.9	-0.2
Arm fat mass (left)	0.4	1.8	2.8	-0.9	-1.7
Miserableness	0.4	0.7	1.5	1.2	-0.1
Guilty feelings	0.4	0.5	1.1	-0.1	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	1.0	0.3
Medication: Lisinopril	0.4	0.5	0.8	-0.5	-0.9
Irritability	0.4	0.7	1.3	-0.3	-1.1
Risk taking	0.4	0.5	1.1	0.0	-1.0
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	1.2	0.1
Neuroticism (Nagel 2018)	0.3	0.8	1.5	1.2	0.4
Hypothyroidism (self reported)	0.3	0.8	0.9	-0.8	-1.0
Chronotype (morning person)	0.3	0.7	1.4	-1.2	-0.3
Tanning	0.3	3.2	4.2	-1.5	-2.1
Hearing difficulty/problems: Yes	0.3	0.5	1.0	1.0	-0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	-0.3	0.7
Trunk fat mass	0.3	1.2	1.7	-0.8	-1.3
Had menopause	0.3	0.3	0.6	0.8	0.3
Medication: Cholesterol lowering	0.3	0.5	0.8	0.9	0.5
Arm fat mass (right)	0.3	1.3	2.0	-0.7	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.2	-1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.7	0.1	1.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.3	-0.8
Headache pain in last month	0.3	0.5	0.9	1.0	0.1
Glaucoma (self-reported)	0.3	0.4	0.7	-0.8	-0.3
Number of full sisters	0.3	0.4	0.5	-0.7	-0.5
Suffer from ‘nerves’	0.3	0.5	1.0	1.0	0.0
Eye problems/disorders: Cataract	0.3	0.3	0.6	-0.8	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.6	0.6	0.8
Breast cancer (self-reported)	0.3	0.3	0.4	-0.5	-0.6
Financial situation satisfaction	0.3	0.3	0.6	-0.8	-0.3
Unable to work because of sickness or disability	0.3	0.4	0.7	0.2	0.8
Pain experienced in last month	0.3	0.5	0.8	-0.9	-0.4
Schizophrenia (2018)	0.2	0.4	0.8	0.9	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	-0.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.3	-0.5	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	0.2	-1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.8	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.3	0.5	0.5
Crohns Disease (2012)	0.2	0.2	0.4	0.2	-0.7
LDL Cholesterol	0.2	0.3	0.3	0.5	0.5
Blood White Count	0.2	1.2	1.4	1.2	1.0
Height	0.2	4.7	9.3	-0.3	-3.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.4	-0.5	-0.6
Medication for hormone replacement therapy	0.2	0.3	0.4	0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.7	-0.6	-0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.0	0.7
Heart attack	0.2	0.3	0.4	0.7	0.3
Diabetes (self-reported)	0.2	0.4	0.5	-0.5	-0.7
Fluid intelligence score	0.2	0.5	0.5	-0.6	-0.7
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	0.1	0.7
Medication: Lansoprazole	0.2	0.2	0.4	0.0	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.7	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.5	0.7	0.6
Qualifications: College or University degree	0.2	0.6	1.1	1.1	0.2
Medication: Blood pressure	0.2	0.4	0.5	0.6	0.7
Angina (self-reported)	0.2	0.2	0.2	-0.5	-0.4
Mean time to correctly identify matches	0.2	0.4	0.8	-0.3	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.1	0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.3	0.7
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.2	-0.7
Alcohol drinker status: Never	0.2	0.3	0.5	0.7	0.2
Diastolic blood pressure, automated reading	0.2	0.6	0.9	-0.5	-0.9
Depression (Nagel 2018)	0.1	0.2	0.3	0.5	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.4	-0.6	-0.6
Bipolar Disorder (2011)	0.1	0.0	0.1	0.2	0.3
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.3	-0.5
Lupus	0.1	0.2	0.3	0.2	0.6
Triglycerides	0.1	0.1	0.3	0.0	0.5
Heel T-Score	0.1	1.1	1.3	0.9	1.1
Vitamin and mineral supplements	0.1	0.1	0.3	-0.1	-0.5
Medication: Co-codamol	0.1	0.1	0.2	-0.0	-0.5
Current tobacco smoking	0.1	0.1	0.1	-0.3	-0.4
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	0.2	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	0.2	0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.2	-0.4	-0.3
Had other major operations	0.1	0.1	0.1	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.2	-0.7
Financial difficulties in last 2 years	0.1	0.1	0.1	0.4	0.4
Neuroticism score	0.1	0.3	0.5	0.7	-0.4
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.2
Pulse rate	0.1	0.1	0.2	-0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.3	-0.6
Birth weight of first child	0.1	0.1	0.2	0.4	-0.2
Pulse wave reflection index	0.1	0.2	0.2	-0.4	-0.4
Loud music exposure frequency	0.1	0.1	0.1	0.3	0.4
Birth weight	0.1	0.3	0.4	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.0	-0.5
Medication: Ibuprofen	0.1	0.2	0.4	-0.6	-0.1
Medication: Omeprazole	0.1	0.2	0.3	-0.6	-0.0
Comparative height size at age 10	0.1	0.4	0.6	0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.3	-0.0
Medication: Aspirin	0.1	0.1	0.2	0.5	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	-0.4	0.4
Back pain experienced in last month	0.1	0.2	0.3	0.6	-0.1
Medication: Aspirin	0.1	0.2	0.3	0.5	0.3
Smoking status: Current	0.1	0.1	0.2	-0.2	-0.4
Wears glasses or contact lenses	0.1	0.2	0.3	-0.1	-0.5
Hearing aid user	0.1	0.1	0.1	-0.2	-0.3
Mother’s age at death	0.1	0.1	0.2	-0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.2	0.3
Myopia	0.1	0.2	0.2	-0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	0.3	0.3
Worry (Nagel 2018)	0.0	0.0	0.1	0.3	-0.0
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	-0.1
Crohns Disease (2017)	0.0	0.0	0.0	0.1	0.1
Hair Pigment	0.0	0.6	0.9	-1.0	-0.6
Sensitivity / hurt feelings	0.0	0.0	0.0	-0.1	0.2
Angina	0.0	0.0	0.0	-0.1	-0.2
Diabetes (father)	0.0	0.0	0.0	0.1	0.2
Trunk fat percentage	0.0	0.0	0.1	0.1	0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.1
Medication: Atenolol	0.0	0.0	0.0	0.0	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.2	0.1
Nervous feelings	0.0	0.0	0.0	0.2	-0.1
Arm fat percentage (right)	0.0	0.1	0.1	0.3	0.3
Time employed in main current job	0.0	0.0	0.0	-0.2	-0.2
Number of live births	0.0	0.0	0.0	0.2	0.2
Noisy workplace	0.0	0.0	0.1	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	-0.1	0.1
Lung cancer (father)	0.0	0.0	0.0	-0.2	0.1
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.2	-0.0
Body fat percentage	0.0	0.0	0.0	-0.1	0.1
Leg fat percentage (right)	0.0	0.1	0.1	-0.3	-0.3
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.0	-0.2
Comparative body size at age 10	0.0	0.1	0.1	-0.3	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	-0.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.3	0.1
Arm fat percentage (left)	0.0	0.0	0.0	-0.1	-0.1
Ever had bowel cancer screening	0.0	0.0	0.0	0.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.1	-0.2
Qualifications: nursing, teaching	0.0	0.1	0.1	0.2	-0.3
Mineral and other dietary supplements	0.0	0.0	0.0	-0.1	0.1
Medication: Gliclazide	0.0	0.0	0.0	-0.0	-0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	0.1	-0.2
Leg fat percentage (left)	0.0	0.1	0.1	-0.2	-0.3
Age started oral contraceptive pill	0.0	0.0	0.0	0.1	0.1
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.0	-0.3

Hub : Genes

RN7SKP16

Models

Trait associations