Hub : Genes

CTD-2228K2.5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0850 0.0450 0.00510 0.044 NA 0.010 NA 0.017 0.00067 NA 0.06600 NA 0.0250
2 METSIM Adipose 0.0495 0.0209 0.00077 0.006 0.024 0.023 0.023 0.016 0.03400 0.00014 0.00017 0.00018 0.0016

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.6 0.9 1.6 -1.3 -0.4
Bipolar Disorder or Schizophrenia 0.9 2.1 4.2 -0.0 -2.1
Depressed Affect (Nagel 2018) 0.4 0.8 1.5 0.1 -1.2
Depression (Nagel 2018) 1.3 2.0 2.9 1.7 -1.0
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.9 -0.9 0.4
Neuroticism (Nagel 2018) 0.2 0.5 1.0 -0.2 -1.0
Schizophrenia (2018) 1.6 3.2 5.4 1.0 -2.3
Schizophrenia vs Biploar Disorder 1.2 1.6 3.2 1.8 -0.1
Worry (Nagel 2018) 0.5 1.0 1.9 -1.4 -0.3
Alzheimer’s Disease (in mother) 0.2 0.2 0.2 0.5 -0.4
Alzheimer’s Disease (in father) 0.2 0.2 0.3 -0.2 0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 0.3 0.4
Crohns Disease (2017) 0.1 0.2 0.3 -0.5 0.3
Irritable Bowel Disease (IBD) 4.1 9.7 15.1 -3.9 2.1
Ulcerative Colitis (UC) 8.7 16.3 24.9 -5.0 2.8
Major Depression (MDD) 1.6 1.9 2.6 1.6 -1.1
Reaction Time 0.9 1.7 3.3 -1.8 -0.1
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.1 0.8 -1.4
Breast Cancer 4.0 9.5 17.4 4.2 -1.3
Ovarian Cancer 1.2 1.6 2.3 0.9 -1.5
Prostate Cancer 0.2 0.3 0.6 -0.8 -0.2
Age at First Birth 0.7 1.0 1.8 0.6 -1.3
Bipolar Disorder (2011) 1.1 1.1 1.8 0.5 -1.4
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 -0.1 0.1
Coronary Artery Disease (CAD) 0.3 0.3 0.7 0.8 -0.1
Crohns Disease (2012) 0.1 0.2 0.5 0.0 0.7
Mean Putamen Volume 0.7 0.8 1.5 1.2 -0.2
Fasting Glucose 1.8 2.2 3.3 1.0 -1.8
HbA1C 0.7 0.8 0.9 0.9 -0.8
HDL Cholesterol 0.2 0.4 0.8 -0.1 0.9
LDL Cholesterol 0.6 1.0 1.6 1.2 -0.7
Lupus 2.4 3.6 7.0 -2.6 0.3
Neuroticism (2016) 0.3 0.4 0.9 -0.9 -0.2
Primary Biliary Cirrhosis 1.3 1.9 3.5 -1.9 0.6
Rheumatoid Arthritis 0.0 0.0 0.0 0.1 0.1
Schizophrenia (2014) 0.7 1.5 2.7 0.6 -1.6
Triglycerides 0.1 0.1 0.2 -0.4 0.0
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.6 0.0 -1.6
Ulcerative Colitis 4.6 6.6 10.5 -3.2 1.6
Blood Eosinophil Count 0.7 5.6 6.2 2.2 -2.5
Blood Platelet Count 0.5 6.2 7.3 -2.7 2.2
Blood Red Count 4.4 42.0 77.4 8.8 -2.6
Blood White Count 0.2 1.6 1.8 -1.2 1.4
Heel T-Score 0.4 3.2 3.9 2.0 -1.6
BMI 0.1 0.9 1.0 -0.8 1.0
Height 1.3 25.3 39.3 -3.3 6.3
Waist Hip Ratio (WHR) 0.2 0.9 1.8 -1.4 0.0
Systolic Blood Pressure 0.4 1.8 2.4 -1.1 1.5
Smoking Status 0.6 1.4 2.2 0.8 -1.5
Allergy or Eczema 0.4 1.0 1.3 -0.9 1.1
Cardiovascular Disease 0.8 2.6 3.0 -1.5 1.7
Hypothyroidism (self reported) 0.1 0.2 0.3 0.5 -0.2
Respiratory disease 0.1 0.1 0.1 -0.4 0.4
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.5 0.5 -0.7
Lung FEV1/FVC ratio 0.7 3.5 6.2 -2.5 0.9
Lung FVC 0.4 1.8 2.7 -1.7 1.0
Neuroticism 0.7 1.7 3.3 -0.3 -1.8
Chronotype (morning person) 0.1 0.3 0.3 0.4 -0.6
Hair Pigment 0.1 2.3 2.5 1.6 -1.4
Tanning 1.2 14.6 16.0 -4.0 3.6
Hand grip strength (left) 0.4 1.0 1.6 -0.7 1.3
Number of treatments/medications taken 0.1 0.2 0.3 -0.5 0.1
Average weekly spirits intake 3.6 4.5 8.2 0.9 -2.9
Sensitivity / hurt feelings 0.1 0.1 0.2 -0.5 -0.2
Frequency of depressed mood in last 2 weeks 3.3 4.7 6.2 2.5 -1.8
Hearing difficulty/problems: Yes 0.3 0.5 0.9 -0.2 1.0
Relative age of first facial hair 0.4 0.8 1.6 -0.4 1.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.6 0.8 0.7
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.6 0.5 -1.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 -0.0 0.4
Systolic blood pressure, automated reading 0.4 1.3 1.8 -0.9 1.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.9 -1.0 -0.1
Angina 0.2 0.3 0.6 -0.7 0.1
Medication for hormone replacement therapy 1.4 1.6 1.6 1.3 -1.2
Vitamin and mineral supplements 1.4 1.8 2.0 1.4 -1.3
Supplements: Zinc 0.0 0.0 0.0 0.1 0.1
Medication: Co-codamol 0.3 0.3 0.7 -0.1 -0.8
Medication: Metformin 0.2 0.2 0.4 0.7 0.1
Diabetes (father) 3.5 4.4 6.0 1.7 -2.4
Diabetes (mother) 1.2 1.5 1.8 1.3 1.1
Severe depression (siblings) 0.4 0.5 0.9 -0.9 -0.3
Pack years adult smoking proportion 0.1 0.2 0.4 -0.3 0.6
Impedance of leg (right) 0.0 0.0 0.1 0.3 -0.1
Leg fat-free mass (left) 1.0 5.6 7.1 -2.0 2.7
Trunk fat percentage 2.1 8.5 8.7 -3.0 2.9
Hand grip strength (right) 0.4 1.0 1.4 -0.8 1.2
Townsend deprivation index at recruitment 2.3 3.2 5.1 1.1 -2.2
Current tobacco smoking 1.5 2.5 4.7 0.5 -2.2
Average weekly fortified wine intake 0.3 0.4 0.6 -0.4 0.8
Maternal smoking around birth 0.2 0.3 0.3 -0.5 0.6
Fed-up feelings 0.5 0.9 1.7 -1.3 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.9 0.9 -0.4
Relative age voice broke 0.2 0.3 0.6 -0.8 0.2
Taking other prescription medications 0.0 0.1 0.1 -0.3 -0.1
Age when periods started (menarche) 0.8 2.0 3.6 1.9 -0.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.1 -0.8 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.9 0.1 -0.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.9 -0.0 1.0
Qualifications: CSEs or equivalent 1.9 2.5 4.4 2.1 -0.8
Serious illness, injury or assault to yourself 1.3 1.5 3.1 -0.0 1.8
High blood pressure 0.3 0.9 1.0 -1.0 0.9
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.2 -0.1
Multivitamins +/- minerals 0.3 0.3 0.4 -0.5 0.7
Stomach or abdominal pain in last month 1.9 2.4 2.9 1.4 -1.7
Supplements: Glucosamine 0.1 0.2 0.3 -0.3 -0.5
Diverticular disease/diverticulitis (self-reported) 3.0 3.5 5.9 2.4 -1.1
Medication: Atenolol 2.0 2.5 3.6 1.9 -1.2
Medication: Levothyroxine sodium 0.1 0.1 0.1 0.4 0.2
Sitting height 0.7 4.8 9.2 -0.6 3.0
Chronic bronchitis/emphysema (father) 0.1 0.2 0.2 0.3 0.5
High blood pressure (mother) 0.9 1.3 1.5 1.0 -1.2
Body mass index (BMI) 0.1 0.4 0.7 -0.4 0.9
Impedance of leg (left) 0.1 0.4 0.7 0.8 -0.3
Leg predicted mass (left) 1.0 5.5 7.0 -2.0 2.6
Trunk fat mass 1.9 8.2 8.7 -2.8 3.0
Waist circumference 1.0 3.7 4.2 -2.0 1.8
Number of incorrect matches in round 1.0 1.7 2.8 -1.7 0.8
Past tobacco smoking 0.0 0.1 0.1 0.2 0.3
Alcohol usually taken with meals 1.0 1.7 2.4 -1.0 1.5
Nervous feelings 0.1 0.1 0.2 -0.4 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 0.7 -0.4
Hearing difficulty/problems with background noise 0.3 0.4 0.9 0.9 0.1
Hair/balding pattern: Pattern 2 5.4 6.9 12.4 3.5 -1.2
Had menopause 0.5 0.7 1.3 0.2 1.1
Had other major operations 0.2 0.2 0.5 0.0 0.7
Forced vital capacity (FVC) 0.8 3.0 4.1 -1.4 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 1.5 0.9 -1.2
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 1.3 1.1 -1.2
Qualifications: None of the above 0.9 2.0 4.0 -2.0 -0.3
Financial difficulties in last 2 years 0.6 0.8 1.1 1.0 0.7
Mouth/teeth dental problems 3.8 5.9 7.5 -2.7 2.0
Heart attack 2.0 2.6 3.7 -1.9 1.2
Allergy 0.0 0.0 0.0 -0.2 0.0
Pain all over the body in last month 0.1 0.2 0.2 -0.5 0.3
Diabetes (self-reported) 0.5 0.8 1.0 0.7 -1.0
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.7 -1.9 -0.7
Medication: Ramipril 0.8 1.0 2.0 1.4 -0.2
Medication: Simvastatin 0.4 0.6 0.8 0.9 0.6
Fluid intelligence score 0.0 0.0 0.1 0.2 -0.1
Illnesses of siblings 0.1 0.2 0.3 -0.6 -0.0
Neuroticism score 0.1 0.3 0.4 -0.6 -0.4
Weight 1.0 5.0 6.5 -1.9 2.5
Impedance of arm (right) 1.4 6.6 11.2 -3.4 1.4
Arm fat percentage (right) 1.1 4.3 6.3 -2.5 1.5
Trunk fat-free mass 0.3 1.6 2.9 -0.5 1.7
Hip circumference 1.1 4.9 6.6 -1.8 2.6
Time employed in main current job 1.3 1.5 2.4 1.6 -0.7
Alcohol intake versus 10 years previously 2.6 3.9 4.1 1.9 -2.0
Father’s age at death 2.3 3.1 4.5 -2.1 1.4
Worrier / anxious feelings 0.6 1.1 1.7 -1.3 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.1 1.4 -0.5
Falls in the last year 1.2 1.6 2.8 -1.7 0.7
Hair/balding pattern: Pattern 3 0.3 0.5 0.9 -0.3 -0.9
Number of live births 1.2 1.7 2.5 -0.9 1.6
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 6.1 -1.6 2.5
Pulse rate 3.8 6.4 7.6 2.3 -2.8
Happiness 0.4 0.5 0.8 0.9 -0.5
Noisy workplace 1.5 1.9 2.9 0.9 -1.7
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.1 1.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 -0.1 0.8
Mouth/teeth dental problems: Dentures 1.3 2.3 3.6 1.9 -1.0
Asthma 0.0 0.0 0.0 -0.1 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 -0.5 0.0
Medication: Cholesterol lowering 0.0 0.1 0.1 -0.2 0.3
Depression (self-reported) 0.4 0.5 0.6 0.7 -0.7
Medication: Lansoprazole 3.7 4.2 6.7 2.6 -1.3
Prospective memory result 3.1 3.8 4.7 1.7 -2.2
Lung cancer (father) 1.2 1.5 1.5 1.2 -1.2
Illnesses of mother 1.3 1.6 1.7 -1.3 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.1 6.8 -1.9 2.6
Pulse wave Arterial Stiffness index 0.3 0.4 0.6 0.4 -0.8
Impedance of arm (left) 1.1 4.9 8.5 -2.9 1.1
Arm fat mass (right) 1.0 4.3 4.7 -2.2 2.0
Trunk predicted mass 0.3 1.5 2.7 -0.5 1.6
Standing height 1.3 13.2 15.4 -3.3 3.9
Length of working week for main job 0.6 0.6 1.0 0.5 -1.0
Exposure to tobacco smoke at home 0.0 0.0 0.0 0.2 -0.1
Breastfed as a baby 0.4 0.5 0.7 0.8 0.5
Tense / ‘highly strung’ 0.4 0.6 1.1 -1.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.2 0.8 -1.5
Hair/balding pattern: Pattern 4 1.1 2.7 4.8 -0.8 -2.2
Birth weight of first child 0.4 0.7 1.0 0.6 1.0
Peak expiratory flow (PEF) 0.8 1.9 3.5 -0.5 1.9
Pulse wave reflection index 0.0 0.0 0.0 -0.2 -0.2
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.0 0.8 -1.4
Loud music exposure frequency 1.4 1.6 1.6 1.3 -1.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.5 1.2 0.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 0.8 0.9 -0.8
Blood clot in the leg (DVT) 0.3 0.3 0.6 -0.2 0.8
Medication: Paracetamol 0.1 0.1 0.2 -0.2 -0.5
Headache pain in last month 1.4 2.3 2.9 -1.7 1.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 0.9 0.9 -0.9
Glaucoma (self-reported) 0.7 0.9 1.0 -1.0 0.9
Gout (self-reported) 1.5 2.1 2.4 -1.3 1.6
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 -0.1 0.1
Medication: Amlodipine 0.8 1.1 1.8 -1.4 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.1 -1.1 1.0
Birth weight 0.4 0.9 1.1 -0.8 1.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 0.5 0.4
High blood pressure (siblings) 0.1 0.1 0.2 0.1 0.5
Forced vital capacity (FVC), Best measure 1.8 6.7 8.0 -2.3 2.8
Body fat percentage 1.3 5.2 5.9 -2.4 2.1
Leg fat percentage (right) 0.2 0.7 1.1 -1.1 0.6
Arm fat-free mass (right) 0.3 1.7 3.5 -0.1 1.9
Exposure to tobacco smoke outside home 2.9 3.8 6.9 0.9 -2.6
Comparative body size at age 10 0.7 2.0 4.0 -0.2 2.0
Number of full brothers 0.0 0.1 0.1 -0.2 0.3
Worry too long after embarrassment 0.7 1.2 2.3 -1.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 2.4 1.6 -1.0
Wheeze or whistling in the chest in last year 0.2 0.4 0.7 0.8 -0.4
Number of children fathered 0.3 0.3 0.7 0.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.1 -1.0 0.3
Age at first live birth 0.4 0.7 1.0 -0.6 1.0
Pulse wave peak to peak time 0.7 0.8 1.2 -0.7 1.1
Health satisfaction 0.8 1.1 1.7 1.3 -0.7
Shortness of breath walking on level ground 0.4 0.5 0.5 -0.7 -0.6
Qualifications: College or University degree 0.9 2.9 4.6 2.1 -1.1
Eye problems/disorders: None of the above 0.6 0.7 1.4 0.0 1.2
Mouth/teeth dental problems: Loose teeth 1.1 1.3 1.5 1.0 -1.2
Emphysema/chronic bronchitis 0.3 0.3 0.6 0.7 0.2
Medication for pain relief, constipation, heartburn 0.7 1.3 1.6 -1.0 1.3
Neck or shoulder pain in last month 0.2 0.3 0.4 -0.6 -0.5
Medication: Blood pressure 0.7 1.3 1.7 -0.9 1.3
Angina (self-reported) 0.2 0.2 0.4 -0.6 0.1
Migraine (self-reported) 0.4 0.4 0.5 -0.7 0.7
Medication: Ibuprofen 0.3 0.3 0.6 -0.8 0.1
Medication: Allopurinol 1.2 1.6 2.1 -1.1 1.5
Medication: Omeprazole 2.2 2.7 4.7 2.2 -0.8
Medication: Seretide 50 evohaler 0.9 1.0 1.1 1.0 -1.0
Mean time to correctly identify matches 1.2 2.3 4.6 -2.1 0.0
Heart disease (mother) 0.5 0.7 1.1 -0.4 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.3 1.1 -0.4
Whole body fat mass 1.2 4.9 5.3 -2.3 2.1
Leg fat mass (right) 0.4 1.5 1.8 -1.3 1.1
Arm predicted mass (right) 0.3 1.4 2.8 0.2 1.7
Pulse rate, automated reading 1.4 4.5 5.3 1.9 -2.3
Alcohol intake frequency. 1.5 3.4 3.9 2.0 -1.7
Comparative height size at age 10 2.7 14.7 15.0 -3.9 3.8
Number of full sisters 1.3 1.6 1.9 1.2 -1.4
Suffer from ‘nerves’ 0.5 0.7 0.8 0.8 -0.9
Overall health rating 0.4 0.8 1.4 0.4 -1.2
Chest pain or discomfort 2.3 3.3 5.2 2.3 -1.2
Had major operations 1.2 1.4 1.5 1.1 -1.2
Age at last live birth 0.1 0.2 0.3 -0.5 0.4
Family relationship satisfaction 0.4 0.4 0.8 -0.3 0.9
Leg pain on walking 0.4 0.4 0.8 0.3 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 4.6 2.1 0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.7 0.8 0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 0.7 -0.4 -0.9
Medication: Aspirin 0.2 0.2 0.4 -0.1 -0.7
Supplements: Vitamin C 2.6 3.1 3.2 -1.8 1.7
Knee pain experienced in last month 0.6 0.9 1.8 -1.3 0.1
Hypertension (Self-reported) 0.1 0.2 0.3 -0.6 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 5.6 6.5 9.1 3.0 -2.0
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.4 -0.2
Illnesses of siblings: Diabetes 0.0 0.0 0.1 -0.3 -0.1
Smoking status: Previous 0.2 0.3 0.3 -0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.2 6.1 -1.5 2.5
Whole body fat-free mass 0.5 3.0 4.9 -1.1 2.2
Leg fat-free mass (right) 0.9 4.7 6.6 -1.7 2.6
Arm fat percentage (left) 0.9 3.6 5.6 -2.4 1.3
Average weekly red wine intake 0.0 0.0 0.0 0.2 0.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.0 -0.5 1.4
Mood swings 0.6 1.1 1.5 0.9 -1.2
Loneliness, isolation 0.5 0.7 1.2 1.1 0.5
Long-standing illness, disability or infirmity 0.5 0.8 1.4 1.2 -0.4
Ever had bowel cancer screening 0.3 0.3 0.6 -0.2 -0.8
Diabetes diagnosed by doctor 0.3 0.5 0.5 0.7 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.1 -1.0 -0.2
Friendships satisfaction 0.7 0.8 1.1 -0.7 1.1
Qualifications: nursing, teaching 0.1 0.1 0.2 -0.1 -0.4
Commuting to job workplace: Walk 0.8 0.9 1.6 1.3 -0.4
Eye problems/disorders: Cataract 1.3 1.5 3.0 -0.1 -1.7
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 4.5 1.0 -2.1
Medication for cholesterol 1.8 2.7 3.3 -1.8 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.2 -1.8 -0.1
Back pain experienced in last month 3.0 4.3 4.5 -2.1 2.0
Mineral and other dietary supplements 0.2 0.3 0.5 0.7 0.2
Breast cancer (self-reported) 3.4 4.1 6.4 -2.5 1.3
Asthma (self-reported) 0.0 0.0 0.0 0.1 -0.0
Osteoporosis (self-reported) 0.1 0.1 0.1 -0.3 -0.2
Osteoarthritis (self-reported) 0.8 1.0 1.3 -0.9 -1.1
Medication: Aspirin 0.2 0.2 0.3 -0.6 -0.4
Medication: Gliclazide 1.3 1.5 2.3 1.5 -0.8
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.6 -0.1
Smoking status: Current 1.8 2.8 5.4 0.5 -2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.0 -1.4 0.9
Whole body water mass 0.6 3.3 5.4 -1.1 2.3
Leg predicted mass (right) 0.8 4.5 6.7 -1.6 2.6
Arm fat mass (left) 0.9 3.6 3.7 -1.9 1.9
Number of self-reported non-cancer illnesses 0.7 1.3 2.2 -1.5 0.6
Average weekly champagne plus white wine intake 0.2 0.3 0.6 0.2 -0.8
Miserableness 0.4 0.7 0.8 0.9 -0.8
Guilty feelings 1.2 1.8 2.1 1.3 -1.4
Wears glasses or contact lenses 0.4 0.5 0.9 -0.2 -1.0
Ever taken oral contraceptive pill 0.3 0.3 0.6 -0.8 -0.1
Hearing aid user 0.6 0.6 0.9 0.6 -1.0
Mother’s age at death 2.6 3.3 6.4 -2.5 0.4
Financial situation satisfaction 1.0 1.3 2.6 1.6 0.1
Tinnitus: Yes, now most or all of the time 1.6 1.9 2.0 1.4 -1.3
Commuting to job workplace: Public transport 0.7 0.9 1.1 -0.8 -1.0
Eye problems/disorders: Glaucoma 0.3 0.4 0.5 -0.6 0.7
Medication: Blood pressure 1.5 2.9 3.0 1.7 -1.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.2 -1.5 0.8
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.1 -0.6 1.1
High cholesterol (Self-reported) 0.8 1.4 2.0 1.4 -0.9
Medication: Bendroflumethiazide 0.5 0.7 1.4 0.3 1.2
Medication: Paracetamol 0.0 0.1 0.1 -0.1 -0.3
Medication: Lisinopril 0.4 0.5 1.0 1.0 0.1
Medication: Atorvastatin 0.1 0.1 0.2 -0.3 0.4
Illnesses of father: High blood pressure 0.3 0.4 0.5 -0.7 0.5
Alcohol drinker status: Never 1.1 1.3 2.5 1.6 -0.4
Ever smoked 0.1 0.2 0.5 -0.2 -0.7
Basal metabolic rate 0.7 3.8 6.0 -1.2 2.5
Leg fat percentage (left) 0.1 0.4 0.6 -0.8 0.4
Arm fat-free mass (left) 0.4 2.1 4.1 -0.0 2.0
Number of operations (self-reported) 0.9 1.3 1.6 1.0 -1.3
Average weekly beer plus cider intake 0.5 0.8 1.5 -1.2 0.1
Irritability 0.4 0.7 1.3 0.1 1.1
Risk taking 0.8 1.1 2.1 1.5 -0.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.5 0.2
Fractured/broken bones in last 5 years 1.7 2.2 2.8 1.7 -1.3
Age started oral contraceptive pill 0.9 1.1 2.0 0.4 1.4
Diastolic blood pressure, automated reading 0.6 1.8 3.2 -0.6 1.8
Ever depressed for a whole week 4.2 5.2 10.0 0.6 -3.2
Unable to work because of sickness or disability 1.4 1.8 2.8 0.9 -1.7
Commuting to job workplace: Cycle 0.0 0.0 0.0 -0.2 -0.2
Myopia 1.7 2.4 3.9 -2.0 1.0
Vascular/heart problems diagnosed by doctor 0.4 1.0 1.1 1.0 -1.1
Cholesterol lowering medication 0.3 0.4 0.5 0.7 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 3.2 1.8 -0.8
Pain experienced in last month 1.2 2.1 4.1 2.0 -0.1
Supplements: Calcium 0.2 0.2 0.3 -0.6 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.2 -0.2 1.1
Heart attack/myocardial infarction (self-reported) 1.7 2.1 3.1 -1.8 1.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 -0.2 0.8
Heart disease (siblings) 1.3 1.5 2.8 -0.5 -1.7
Alcohol drinker status: Previous 0.1 0.2 0.3 0.5 0.1
Pack years of smoking 0.3 0.4 0.7 -0.4 0.8
Impedance of whole body 0.3 1.6 2.7 -1.6 0.8
Leg fat mass (left) 0.4 1.5 1.5 -1.2 1.2
Arm predicted mass (left) 0.4 1.8 3.6 0.0 1.9