Best TWAS P=4.54e-21 · Best GWAS P=2.88e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1109 | 0.09 | 0.08 | bslmm | 390 | 0.08 | 8.9e-10 | 8.3 | -5.6 | 1.6e-08 | -0.91 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | 8.5 | -7.8 | 5.6e-15 | -0.88 | 0.01 | 0.94 | FALSE |
| 3 | GTEx | Artery Tibial | KIAA1109 | 0.16 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 8.3 | -8.0 | 1.1e-15 | -0.97 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1109 | 0.22 | 0.07 | lasso | 7 | 0.03 | 5.9e-02 | 8.3 | -8.2 | 1.8e-16 | -0.97 | 0.01 | 0.88 | FALSE |
| 5 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | 7.1 | -7.9 | 2.5e-15 | -0.86 | 0.02 | 0.75 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | 8.3 | -7.7 | 1.5e-14 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | SPATA5 | 0.05 | 0.01 | bslmm | 485 | 0.01 | 1.2e-02 | 2.9 | -5.9 | 3.3e-09 | -0.13 | 0.17 | 0.02 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | 8.3 | -8.3 | 7.2e-17 | -0.99 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | 7.1 | -9.4 | 4.5e-21 | -0.66 | 0.00 | 0.86 | TRUE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1109 | 0.05 | 0.05 | enet | 8 | 0.04 | 1.3e-05 | 8.3 | -5.7 | 9.7e-09 | -0.93 | 0.00 | 1.00 | TRUE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | 8.3 | -8.7 | 3.6e-18 | -0.99 | 0.00 | 1.00 | TRUE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 7.1 | -8.1 | 4.5e-16 | -0.95 | 0.00 | 1.00 | FALSE |