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chr4:38,097,478-39,643,536

Best TWAS P=2.31e-16 · Best GWAS P=2.76e-17 conditioned to 0.00306

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TLR1	0.08	0.07	lasso	2	0.07	1.3e-08	-7.7	-8.1	8.2e-16	0.83	0.24	0.76	FALSE
2	GTEx	Breast Mammary Tissue	FAM114A1	0.11	0.04	lasso	3	0.05	1.0e-03	-7.7	-5.5	3.2e-08	0.59	0.15	0.59	FALSE
3	GTEx	Cells Transformed fibroblasts	TLR6	0.28	0.19	lasso	5	0.17	1.7e-12	-7.3	7.3	2.9e-13	-0.71	0.90	0.10	FALSE
4	GTEx	Esophagus Mucosa	TLR1	0.20	0.02	lasso	6	0.04	9.8e-04	-7.3	7.5	5.1e-14	-0.78	0.07	0.92	FALSE
5	GTEx	Esophagus Mucosa	FAM114A1	0.14	0.03	lasso	11	0.03	6.6e-03	3.6	-5.5	3.6e-08	0.56	0.34	0.58	FALSE
6	GTEx	Esophagus Muscularis	TLR1	0.21	0.02	enet	46	0.06	2.3e-04	-6.7	6.7	1.9e-11	-0.56	0.07	0.80	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	TLR6	0.29	0.03	lasso	11	0.08	4.8e-05	3.5	7.1	1.2e-12	-0.68	0.12	0.86	FALSE
8	GTEx	Testis	FAM114A1	0.37	0.20	lasso	7	0.20	2.2e-09	-7.4	-7.2	6.0e-13	0.71	0.22	0.77	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	TLR1	0.08	0.02	blup	514	0.03	2.3e-05	-7.2	-5.8	7.7e-09	0.68	0.20	0.76	FALSE
10	YFS	Blood	TLR1	0.08	0.05	bslmm	525	0.07	1.2e-20	-8.0	6.2	4.4e-10	-0.54	0.07	0.93	FALSE
11	YFS	Blood	TLR6	0.05	0.04	bslmm	505	0.06	1.3e-18	-7.6	6.4	1.4e-10	-0.61	0.50	0.50	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TLR6	0.03	0.02	lasso	2	0.01	3.5e-02	-7.3	7.2	5.0e-13	-0.71	0.05	0.20	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TLR1	0.04	0.03	lasso	4	0.03	8.2e-05	-8.0	8.2	2.3e-16	-0.83	0.07	0.93	TRUE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TLR10	0.09	0.06	lasso	2	0.06	2.3e-04	-6.0	6.0	2.3e-09	-0.68	0.12	0.29	FALSE
15	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TLR1	0.14	0.07	enet	12	0.10	1.7e-05	-7.2	7.6	3.7e-14	-0.85	0.01	0.98	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TLR1	0.03	0.03	enet	23	0.03	1.5e-04	-8.0	5.6	1.9e-08	-0.69	0.03	0.91	FALSE
17	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TLR1	0.13	0.13	enet	3	0.08	2.6e-03	-5.6	6.6	5.2e-11	-0.71	0.03	0.53	FALSE