Best TWAS P=5.36e-18 · Best GWAS P=4e-40 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WDR36 | 0.05 | 0.03 | enet | 13 | 0.01 | 1.0e-02 | -2.9 | -6.3 | 2.3e-10 | 0.38 | 0.16 | 0.37 | TRUE |
| 2 | GTEx | Brain Cerebellar Hemisphere | WDR36 | 0.32 | 0.12 | lasso | 7 | 0.17 | 4.8e-05 | -4.8 | -7.9 | 3.3e-15 | 0.54 | 0.01 | 0.89 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | WDR36 | 0.17 | 0.09 | lasso | 6 | 0.08 | 2.6e-05 | -5.0 | -5.2 | 2.2e-07 | 0.25 | 0.59 | 0.33 | FALSE |
| 4 | GTEx | Testis | WDR36 | 0.61 | 0.37 | lasso | 10 | 0.34 | 5.7e-16 | -4.9 | -6.1 | 1.3e-09 | 0.20 | 1.00 | 0.00 | TRUE |
| 5 | METSIM | Adipose | CAMK4 | 0.05 | 0.01 | bslmm | 518 | 0.03 | 8.3e-05 | 5.6 | 6.8 | 8.7e-12 | -0.05 | 0.32 | 0.02 | TRUE |
| 6 | METSIM | Adipose | TSLP | 0.16 | 0.18 | lasso | 7 | 0.18 | 8.5e-26 | -8.7 | 8.6 | 5.4e-18 | -0.09 | 1.00 | 0.00 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | TSLP | 0.13 | 0.08 | enet | 14 | 0.09 | 4.1e-11 | -8.0 | 6.3 | 3.4e-10 | 0.05 | 1.00 | 0.00 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CAMK4 | 0.10 | 0.03 | lasso | 4 | 0.04 | 7.8e-06 | 5.3 | -5.4 | 7.9e-08 | 0.13 | 0.98 | 0.00 | FALSE |
| 9 | YFS | Blood | SLC25A46 | 0.03 | 0.02 | enet | 12 | 0.02 | 9.5e-07 | 4.3 | -7.9 | 2.3e-15 | 0.16 | 0.93 | 0.02 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSLP | 0.03 | 0.03 | lasso | 2 | 0.03 | 5.5e-07 | -8.7 | 7.2 | 6.8e-13 | -0.02 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSLP | 0.08 | 0.01 | blup | 39 | 0.03 | 5.4e-03 | -8.3 | 6.7 | 1.7e-11 | 0.02 | 0.04 | 0.04 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSLP | 0.05 | 0.02 | blup | 39 | 0.02 | 7.9e-04 | -8.3 | 8.4 | 6.7e-17 | -0.10 | 0.24 | 0.02 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSLP | 0.06 | 0.07 | blup | 39 | 0.06 | 6.4e-07 | -8.3 | 7.5 | 6.5e-14 | -0.08 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSLP | 0.02 | 0.02 | blup | 39 | 0.02 | 1.9e-03 | -8.7 | 6.8 | 1.0e-11 | -0.03 | 0.05 | 0.03 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSLP | 0.04 | 0.03 | enet | 6 | 0.02 | 1.6e-03 | -8.6 | 7.8 | 8.8e-15 | -0.06 | 0.14 | 0.03 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TSLP | 0.03 | 0.01 | blup | 39 | 0.02 | 2.7e-03 | -5.3 | 5.3 | 1.2e-07 | 0.06 | 0.08 | 0.03 | FALSE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TSLP | 0.12 | 0.11 | lasso | 3 | 0.08 | 6.9e-04 | -8.7 | 8.4 | 4.0e-17 | -0.09 | 0.11 | 0.05 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | TSLP | 0.13 | 0.14 | blup | 39 | 0.15 | 1.4e-14 | -8.3 | 6.2 | 4.5e-10 | -0.08 | 1.00 | 0.00 | FALSE |