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chr5:130,588,008-132,900,729

Best TWAS P=1.12e-25 · Best GWAS P=8.66e-30 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	7.0	7.2	6.8e-13	0.15	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	KIF3A	0.08	0.07	lasso	3	0.07	1.2e-06	7.2	-7.5	5.5e-14	-0.05	0.95	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	-9.1	8.3	8.6e-17	0.21	0.62	0.03	FALSE
4	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	-8.4	-8.4	3.4e-17	-0.20	0.97	0.00	FALSE
5	GTEx	Artery Aorta	KIF3A	0.13	0.07	enet	7	0.07	6.3e-05	7.2	-7.8	5.7e-15	-0.12	0.92	0.01	FALSE
6	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	5.3	-5.5	3.5e-08	-0.29	0.59	0.11	FALSE
7	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	-8.3	-8.1	5.7e-16	-0.23	0.48	0.02	FALSE
8	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	-8.2	-8.0	1.1e-15	-0.24	1.00	0.00	FALSE
9	GTEx	Artery Tibial	KIF3A	0.11	0.08	lasso	5	0.09	3.2e-07	7.2	-7.8	4.7e-15	-0.10	0.98	0.00	FALSE
10	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	-9.1	10.2	3.1e-24	0.18	1.00	0.00	TRUE
11	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	-8.2	-8.5	1.3e-17	-0.25	1.00	0.00	TRUE
12	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	4.9	-5.4	6.0e-08	-0.30	1.00	0.00	FALSE
13	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	5.4	-6.4	1.5e-10	-0.29	0.52	0.04	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	5.1	-5.3	1.5e-07	-0.29	0.93	0.00	FALSE
15	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	-9.6	5.4	6.6e-08	0.32	0.69	0.02	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	-9.6	8.7	3.2e-18	0.24	0.49	0.03	FALSE
17	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	7.1	7.1	1.6e-12	0.15	0.85	0.01	FALSE
18	GTEx	Cells Transformed fibroblasts	KIF3A	0.15	0.16	enet	7	0.15	2.6e-11	7.2	-7.7	1.7e-14	-0.10	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	SEPT8	0.15	0.12	lasso	4	0.11	6.9e-09	7.1	-7.7	1.9e-14	-0.06	1.00	0.00	FALSE
20	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	8.3	9.7	3.1e-22	0.19	1.00	0.00	FALSE
21	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	5.4	-5.4	7.0e-08	-0.37	0.26	0.12	FALSE
22	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	-9.6	8.3	1.3e-16	0.21	0.56	0.04	FALSE
23	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	5.3	-5.7	1.4e-08	-0.28	0.96	0.00	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	4.4	-5.2	1.7e-07	-0.20	0.67	0.02	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	7.0	8.1	4.8e-16	-0.14	0.10	0.05	FALSE
26	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	-8.4	-8.3	8.4e-17	-0.26	1.00	0.00	FALSE
27	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	-9.6	8.8	1.3e-18	0.25	1.00	0.00	FALSE
28	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	-8.4	-8.5	1.9e-17	-0.25	0.94	0.01	FALSE
29	GTEx	Esophagus Muscularis	KIF3A	0.31	0.17	lasso	5	0.20	2.2e-12	7.1	-7.6	4.1e-14	-0.10	1.00	0.00	FALSE
30	GTEx	Heart Atrial Appendage	KIF3A	0.11	0.00	enet	18	0.01	1.8e-01	6.0	-6.4	1.5e-10	-0.24	0.12	0.11	FALSE
31	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	5.1	-5.4	8.5e-08	-0.37	1.00	0.00	TRUE
32	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	5.3	-5.4	6.1e-08	-0.30	1.00	0.00	FALSE
33	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	-9.6	9.4	6.4e-21	0.30	1.00	0.00	FALSE
34	GTEx	Muscle Skeletal	SLC22A5	0.10	0.01	lasso	3	0.02	6.6e-03	5.4	10.5	1.1e-25	0.53	0.12	0.58	TRUE
35	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	4.9	-6.1	1.1e-09	-0.28	1.00	0.00	FALSE
36	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	7.1	-8.5	1.4e-17	-0.21	0.24	0.05	FALSE
37	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	5.1	-6.4	2.0e-10	-0.30	1.00	0.00	FALSE
38	GTEx	Nerve Tibial	KIF3A	0.23	0.17	lasso	5	0.15	5.3e-11	7.1	-7.6	3.6e-14	-0.12	1.00	0.00	FALSE
39	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	4.8	6.5	9.7e-11	0.02	0.95	0.00	FALSE
40	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	5.1	-5.2	2.0e-07	-0.29	1.00	0.00	FALSE
41	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	-6.2	-6.8	1.3e-11	-0.23	0.98	0.00	FALSE
42	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	4.1	-8.0	1.3e-15	-0.28	0.40	0.12	FALSE
43	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	6.7	-5.6	2.6e-08	-0.16	0.08	0.07	FALSE
44	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	5.3	-5.3	9.0e-08	-0.30	0.97	0.02	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	-9.6	8.8	2.0e-18	0.25	0.56	0.02	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	SEPT8	0.15	0.17	lasso	2	0.17	1.4e-09	7.1	7.6	4.0e-14	0.11	0.99	0.00	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	7.8	7.5	6.2e-14	0.10	0.15	0.06	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	5.1	6.5	9.5e-11	0.33	0.98	0.01	FALSE
49	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	-8.4	8.9	3.6e-19	0.24	1.00	0.00	FALSE
50	GTEx	Skin Sun Exposed Lower leg	KIF3A	0.11	0.04	lasso	4	0.04	6.2e-04	7.2	-7.8	7.8e-15	-0.07	0.63	0.03	FALSE
51	GTEx	Skin Sun Exposed Lower leg	SEPT8	0.46	0.35	lasso	6	0.33	3.2e-28	7.1	7.3	3.1e-13	0.03	1.00	0.00	FALSE
52	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	-9.1	8.8	2.0e-18	0.28	1.00	0.00	FALSE
53	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	-9.6	-8.8	1.9e-18	-0.28	0.38	0.04	FALSE
54	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	9.0	8.0	1.8e-15	0.24	0.16	0.05	FALSE
55	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	4.8	-5.5	3.0e-08	-0.23	1.00	0.00	FALSE
56	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	-8.4	-9.3	1.4e-20	-0.20	0.95	0.00	FALSE
57	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	-8.2	-8.1	6.5e-16	-0.21	0.80	0.01	FALSE
58	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	-6.2	9.0	3.1e-19	0.31	0.45	0.03	FALSE
59	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	4.8	8.9	8.5e-19	0.15	0.96	0.00	FALSE
60	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	-8.2	-8.3	8.9e-17	-0.15	0.74	0.01	FALSE
61	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	8.3	9.2	5.2e-20	0.06	0.60	0.02	FALSE
62	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	-9.6	9.6	6.7e-22	0.27	1.00	0.00	FALSE
63	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	-9.1	9.0	3.4e-19	0.12	0.96	0.00	FALSE
64	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	5.6	-6.1	1.2e-09	0.01	0.56	0.02	FALSE
65	METSIM	Adipose	KIF3A	0.08	0.08	lasso	15	0.07	4.0e-11	6.5	-7.3	3.3e-13	-0.08	1.00	0.00	TRUE
66	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	-8.2	-6.8	8.2e-12	-0.25	1.00	0.00	FALSE
67	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	-6.2	6.3	2.2e-10	0.23	0.91	0.02	FALSE
68	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	-4.4	5.8	7.1e-09	0.09	0.95	0.00	FALSE
69	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	-9.6	9.6	7.0e-22	0.27	1.00	0.00	FALSE
70	NTR	Blood	ACSL6	0.01	0.00	bslmm	399	0.00	2.8e-02	1.3	5.2	2.2e-07	0.06	0.19	0.22	FALSE
71	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	9.5	5.5	4.0e-08	-0.29	0.27	0.02	FALSE
72	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	5.6	-6.8	8.0e-12	0.11	1.00	0.00	FALSE
73	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	-9.8	7.8	4.3e-15	0.16	0.72	0.02	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	7.0	7.1	1.0e-12	0.17	1.00	0.00	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	6.6	6.4	1.4e-10	0.27	0.82	0.04	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	AC034220.3	0.04	0.02	blup	415	0.04	1.3e-05	1.3	-5.8	5.2e-09	-0.63	0.65	0.34	FALSE
77	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	5.1	7.2	5.1e-13	0.37	1.00	0.00	FALSE
78	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	-9.6	8.7	2.9e-18	0.23	1.00	0.00	TRUE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	-8.2	-7.5	5.2e-14	-0.21	0.34	0.58	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	7.0	7.3	4.1e-13	0.15	0.61	0.39	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	-9.6	7.8	4.5e-15	0.34	0.00	0.99	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	4.8	6.1	1.3e-09	0.23	1.00	0.00	TRUE
83	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	5.7	6.8	7.5e-12	0.12	0.16	0.73	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	8.3	8.0	9.2e-16	0.19	0.03	0.91	FALSE
85	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	5.1	6.9	6.0e-12	0.30	0.06	0.94	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	6.7	8.4	5.2e-17	0.12	0.12	0.78	FALSE
87	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	4.8	5.5	3.5e-08	0.21	0.11	0.24	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	5.5	-5.7	1.2e-08	-0.14	0.14	0.13	FALSE
89	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	4.8	5.9	3.0e-09	0.19	0.03	0.50	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	8.3	8.3	1.0e-16	0.08	0.10	0.57	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	5.2	6.8	8.6e-12	0.20	0.03	0.85	FALSE
92	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	4.8	6.6	3.8e-11	0.30	0.06	0.94	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	8.3	6.3	2.7e-10	0.01	0.11	0.60	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	6.7	7.4	1.6e-13	0.17	1.00	0.00	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	5.1	6.7	2.0e-11	0.22	0.09	0.91	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	4.6	5.3	1.1e-07	0.00	0.96	0.00	FALSE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	5.2	6.2	5.9e-10	0.05	0.09	0.12	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	5.4	-7.2	5.4e-13	0.00	0.82	0.08	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	-9.7	-9.1	6.8e-20	-0.28	0.02	0.59	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	-8.2	-8.1	5.4e-16	-0.22	0.50	0.50	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	8.3	8.3	1.2e-16	0.16	0.02	0.70	FALSE