Best TWAS P=2.69e-27 · Best GWAS P=3.84e-64 conditioned to 9.36e-28
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GLDC | 0.24 | 0.10 | lasso | 6 | 0.15 | 8.5e-18 | 5.65 | 7.3 | 2.8e-13 | 0.14 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | KIAA1432 | 0.04 | 0.00 | blup | 514 | 0.03 | 2.7e-04 | -0.47 | 10.0 | 2.0e-23 | 0.24 | 0.07 | 0.04 | TRUE |
| 3 | GTEx | Esophagus Muscularis | IL33 | 0.17 | 0.03 | enet | 29 | 0.06 | 1.7e-04 | -5.59 | 8.4 | 5.4e-17 | 0.38 | 0.07 | 0.40 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | KIAA1432 | 0.11 | 0.04 | lasso | 5 | 0.03 | 9.2e-04 | 5.55 | 5.4 | 7.3e-08 | -0.02 | 0.59 | 0.02 | FALSE |
| 5 | GTEx | Testis | RP11-207C16.4 | 0.30 | 0.18 | lasso | 8 | 0.17 | 4.7e-08 | 5.47 | 5.3 | 1.4e-07 | -0.10 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Thyroid | KIAA1432 | 0.08 | 0.04 | enet | 10 | 0.04 | 9.5e-04 | 5.10 | 5.1 | 2.7e-07 | 0.01 | 0.58 | 0.02 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RANBP6 | 0.07 | 0.01 | blup | 396 | 0.02 | 1.7e-03 | 1.08 | 6.9 | 4.1e-12 | -0.03 | 0.89 | 0.00 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | GLDC | 0.11 | 0.00 | enet | 5 | 0.01 | 7.4e-03 | 14.90 | 10.8 | 2.7e-27 | 0.56 | 0.04 | 0.54 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERMP1 | 0.05 | 0.02 | blup | 80 | 0.02 | 3.3e-04 | 7.57 | -5.8 | 6.3e-09 | 0.01 | 0.04 | 0.93 | FALSE |