Best TWAS P=3.83e-19 · Best GWAS P=2.27e-27 conditioned to 7.74e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DEXI | 0.17 | 0.02 | enet | 27 | 0.03 | 1.3e-02 | -7.1 | -5.3 | 9.3e-08 | 0.53 | 0.07 | 0.85 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-876N24.5 | 0.11 | 0.08 | lasso | 2 | 0.10 | 6.0e-06 | -7.9 | -7.8 | 5.6e-15 | 0.68 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | RMI2 | 0.48 | 0.31 | lasso | 9 | 0.40 | 1.7e-10 | -3.2 | -5.2 | 1.6e-07 | 0.34 | 0.69 | 0.03 | TRUE |
| 4 | GTEx | Breast Mammary Tissue | DEXI | 0.12 | 0.07 | enet | 14 | 0.08 | 6.9e-05 | -7.4 | -7.3 | 2.9e-13 | 0.72 | 0.06 | 0.89 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | RP11-876N24.5 | 0.15 | 0.11 | enet | 19 | 0.12 | 1.4e-06 | -7.4 | -8.7 | 5.1e-18 | 0.73 | 0.28 | 0.70 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | DEXI | 0.18 | 0.04 | lasso | 3 | -0.01 | 4.9e-01 | -6.7 | -7.0 | 2.6e-12 | 0.63 | 0.03 | 0.64 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | RP11-876N24.5 | 0.16 | 0.24 | lasso | 2 | 0.21 | 1.5e-05 | -5.3 | -5.2 | 1.9e-07 | 0.36 | 0.07 | 0.22 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | DEXI | 0.13 | 0.06 | lasso | 2 | 0.04 | 2.0e-02 | -8.3 | -8.3 | 1.1e-16 | 0.79 | 0.05 | 0.52 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | RP11-876N24.5 | 0.22 | 0.14 | enet | 11 | 0.13 | 1.0e-04 | -6.5 | -7.7 | 1.1e-14 | 0.77 | 0.14 | 0.75 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | DEXI | 0.12 | 0.05 | lasso | 5 | 0.08 | 9.6e-07 | -6.1 | -7.5 | 7.3e-14 | 0.72 | 0.17 | 0.82 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | RP11-876N24.4 | 0.12 | 0.04 | lasso | 5 | 0.08 | 2.1e-06 | -6.1 | -7.5 | 5.2e-14 | 0.73 | 0.17 | 0.82 | FALSE |
| 12 | GTEx | Nerve Tibial | DEXI | 0.11 | 0.05 | enet | 7 | 0.07 | 1.7e-05 | -7.4 | -8.4 | 5.5e-17 | 0.81 | 0.64 | 0.28 | FALSE |
| 13 | GTEx | Pancreas | DEXI | 0.13 | 0.06 | lasso | 4 | 0.07 | 5.7e-04 | -6.9 | -7.3 | 3.6e-13 | 0.67 | 0.18 | 0.68 | FALSE |
| 14 | GTEx | Pancreas | RP11-876N24.4 | 0.11 | 0.05 | lasso | 3 | 0.04 | 8.6e-03 | -6.9 | -7.3 | 3.1e-13 | 0.67 | 0.15 | 0.67 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | DEXI | 0.05 | 0.06 | lasso | 2 | 0.03 | 7.8e-04 | -6.9 | -6.6 | 4.5e-11 | 0.65 | 0.70 | 0.21 | FALSE |
| 16 | GTEx | Testis | CLEC16A | 0.15 | 0.00 | enet | 20 | 0.01 | 1.2e-01 | -7.5 | -8.9 | 3.8e-19 | 0.71 | 0.02 | 0.92 | TRUE |
| 17 | GTEx | Testis | DEXI | 0.21 | 0.11 | lasso | 3 | 0.08 | 2.1e-04 | -7.8 | -7.3 | 2.2e-13 | 0.68 | 0.29 | 0.32 | FALSE |
| 18 | GTEx | Testis | RP11-876N24.4 | 0.21 | 0.06 | lasso | 5 | 0.07 | 6.0e-04 | -7.8 | -7.7 | 1.7e-14 | 0.70 | 0.21 | 0.30 | FALSE |
| 19 | GTEx | Thyroid | DEXI | 0.08 | 0.00 | enet | 18 | 0.03 | 1.8e-03 | -6.9 | -6.7 | 2.8e-11 | 0.53 | 0.18 | 0.65 | FALSE |
| 20 | GTEx | Thyroid | RP11-876N24.4 | 0.06 | 0.00 | enet | 17 | 0.02 | 1.5e-02 | 2.4 | -5.4 | 7.7e-08 | 0.43 | 0.18 | 0.33 | FALSE |
| 21 | GTEx | Thyroid | RP11-396B14.2 | 0.12 | 0.01 | lasso | 6 | 0.01 | 4.0e-02 | -7.6 | 8.2 | 2.7e-16 | -0.80 | 0.01 | 0.96 | TRUE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | DEXI | 0.12 | 0.12 | lasso | 6 | 0.13 | 5.9e-16 | -6.5 | -7.1 | 1.0e-12 | 0.70 | 1.00 | 0.00 | FALSE |
| 23 | YFS | Blood | DEXI | 0.11 | 0.15 | enet | 29 | 0.16 | 2.6e-51 | -6.5 | -6.2 | 4.3e-10 | 0.66 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DEXI | 0.04 | 0.02 | blup | 49 | 0.04 | 8.6e-08 | -7.9 | -6.9 | 4.6e-12 | 0.66 | 0.03 | 0.97 | FALSE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DEXI | 0.05 | 0.02 | lasso | 4 | 0.03 | 1.7e-04 | -5.7 | -6.2 | 4.4e-10 | 0.64 | 0.02 | 0.84 | FALSE |