Best TWAS P=6.05e-18 · Best GWAS P=5.05e-16 conditioned to 1.89e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CTD-3203P2.1 | 0.12 | 0.01 | lasso | 7 | 0.02 | 9.2e-03 | 4.6 | -5.5 | 3.6e-08 | -0.52 | 0.32 | 0.25 | FALSE |
| 2 | GTEx | Nerve Tibial | CTD-3203P2.1 | 0.21 | 0.05 | lasso | 6 | 0.09 | 8.5e-07 | 6.3 | -7.3 | 3.0e-13 | -0.46 | 0.75 | 0.07 | FALSE |
| 3 | NTR | Blood | IL4R | 0.03 | 0.01 | enet | 10 | 0.01 | 8.1e-04 | 6.8 | -7.6 | 3.2e-14 | -0.61 | 0.33 | 0.55 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | NSMCE1 | 0.07 | 0.03 | bslmm | 510 | 0.02 | 3.1e-03 | 5.9 | 5.7 | 9.9e-09 | 0.41 | 0.20 | 0.75 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CTD-3203P2.1 | 0.14 | 0.07 | enet | 24 | 0.07 | 2.3e-09 | 6.3 | -6.0 | 1.6e-09 | -0.46 | 1.00 | 0.00 | FALSE |
| 6 | YFS | Blood | IL4R | 0.13 | 0.04 | enet | 35 | 0.10 | 2.0e-32 | 7.1 | -8.6 | 6.1e-18 | -0.45 | 0.86 | 0.14 | TRUE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | JMJD5 | 0.04 | 0.04 | blup | 67 | 0.02 | 3.5e-03 | 6.3 | -7.1 | 1.3e-12 | -0.46 | 0.00 | 1.00 | FALSE |