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chr15:66,662,107-68,789,191

Best TWAS P=8.62e-39 · Best GWAS P=5.49e-47 conditioned to 0.000438

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AAGAB	0.06	0.05	enet	11	0.05	3.2e-07	-7.5	-7.8	8.8e-15	-0.04	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IQCH	0.13	0.11	bslmm	597	0.10	5.9e-12	-9.1	7.8	4.4e-15	0.06	1.00	0.00	TRUE
3	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-9.1	6.6	4.1e-11	-0.02	0.49	0.03	FALSE
4	GTEx	Cells Transformed fibroblasts	SMAD3	0.12	0.01	lasso	9	0.06	3.6e-05	0.3	-6.6	4.5e-11	-0.05	0.24	0.08	TRUE
5	GTEx	Thyroid	SMAD3	0.19	0.02	enet	3	0.03	2.3e-03	14.4	-11.4	4.1e-30	-0.75	0.00	0.97	TRUE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	-5.0	7.3	2.6e-13	0.00	0.07	0.93	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-9.1	7.8	6.6e-15	-0.01	0.02	0.98	FALSE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-4.9	7.7	1.4e-14	0.00	0.06	0.88	FALSE
9	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-4.9	5.6	2.0e-08	-0.08	0.13	0.76	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCH	0.06	0.04	blup	111	0.03	1.0e-04	-4.9	5.7	9.5e-09	-0.07	0.13	0.75	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQCH	0.12	0.10	enet	22	0.12	4.0e-13	-5.0	5.5	3.3e-08	-0.10	0.99	0.01	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQCH	0.05	0.04	blup	111	0.04	7.7e-06	-5.0	6.5	6.0e-11	-0.05	0.10	0.88	FALSE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-3.0	5.4	5.6e-08	-0.09	0.03	0.94	FALSE
14	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-2.6	6.2	6.2e-10	-0.07	0.22	0.78	FALSE
15	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-5.0	6.9	5.4e-12	-0.06	0.05	0.89	FALSE
16	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-5.0	6.3	2.8e-10	-0.05	0.04	0.64	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	-5.0	6.1	1.4e-09	-0.05	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	SMAD3	0.22	0.12	enet	12	0.11	5.2e-11	12.4	-13.0	8.6e-39	-0.88	0.01	0.99	TRUE