Best TWAS P=9.36e-09 · Best GWAS P=4.66e-08 conditioned to 0.00577
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | AC009228.1 | 0.14 | 0.18 | lasso | 5 | 0.18 | 2.0e-09 | -4.5 | -5.7 | 1.3e-08 | -0.65 | 0.22 | 0.77 | FALSE |
| 2 | GTEx | Colon Transverse | SF3B14 | 0.09 | 0.05 | lasso | 9 | 0.02 | 4.9e-02 | -4.6 | -5.4 | 7.4e-08 | -0.57 | 0.11 | 0.80 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | SF3B14 | 0.10 | 0.01 | lasso | 8 | 0.00 | 3.5e-01 | -4.8 | -5.5 | 3.5e-08 | -0.66 | 0.06 | 0.48 | FALSE |
| 4 | GTEx | Esophagus Muscularis | AC009228.1 | 0.11 | 0.06 | enet | 16 | 0.12 | 9.9e-08 | -5.3 | -5.7 | 9.4e-09 | -0.55 | 0.06 | 0.93 | TRUE |
| 5 | GTEx | Small Intestine Terminal Ileum | UBXN2A | 0.18 | 0.08 | enet | 33 | 0.16 | 2.5e-04 | -4.3 | -5.3 | 1.2e-07 | -0.82 | 0.04 | 0.84 | FALSE |
| 6 | GTEx | Thyroid | ITSN2 | 0.10 | 0.06 | enet | 21 | 0.06 | 3.1e-05 | -5.2 | -5.3 | 9.2e-08 | -0.45 | 0.05 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | C2orf84 | 0.10 | 0.14 | lasso | 8 | 0.15 | 6.2e-17 | -4.4 | -5.1 | 3.1e-07 | -0.46 | 0.13 | 0.84 | FALSE |