Hub : Genes

ITSN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1000 0.0390 4.1e-04 0.036 NA 0.042 NA 0.087 3.0e-03 NA 1.5e-03 NA 6.1e-06
2 GTEx Spleen 0.2270 0.0870 4.7e-03 0.047 NA -0.011 NA 0.001 2.4e-02 NA 8.7e-01 NA 3.1e-01
3 GTEx Thyroid 0.1010 0.0400 2.1e-05 0.063 NA 0.058 NA 0.056 1.4e-05 NA 3.1e-05 NA 4.4e-05
4 NTR Blood 0.0155 0.0089 7.0e-03 -0.001 0.004 0.000 0.006 -0.001 8.8e-01 0.013 2.4e-01 0.0029 9.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.9 3.0 4.8 2.2 1.6 -1.0 1.9
Bipolar Disorder or Schizophrenia 0.1 0.3 0.4 0.6 0.6 0.7 0.0
Depressed Affect (Nagel 2018) 3.5 7.4 11.8 2.8 2.5 3.4 -1.8
Depression (Nagel 2018) 0.2 0.3 0.8 0.2 0.9 0.6 -0.5
Intelligence (Savage-Jansen 2018) 0.9 2.6 6.0 2.5 0.6 -1.0 1.7
Neuroticism (Nagel 2018) 1.0 2.3 3.2 1.5 1.8 1.6 -1.1
Schizophrenia (2018) 0.7 1.5 2.8 -1.0 -0.5 1.7 -1.4
Schizophrenia vs Biploar Disorder 2.3 3.0 7.0 -1.3 -1.1 1.5 -2.6
Worry (Nagel 2018) 0.1 0.2 0.4 -0.2 0.7 0.3 -0.5
Alzheimer’s Disease (in mother) 2.0 2.3 4.4 0.7 1.7 -1.3 2.1
Alzheimer’s Disease (in father) 2.9 3.1 4.0 -2.0 -1.9 -1.9 -1.1
Alzheimer’s Disease (including proxy) 0.9 1.3 3.7 -0.7 0.4 -1.9 0.9
Crohns Disease (2017) 1.8 3.9 8.5 2.9 -0.4 1.2 -2.3
Irritable Bowel Disease (IBD) 1.6 3.9 10.5 3.2 -0.4 0.2 -2.2
Ulcerative Colitis (UC) 0.6 1.2 3.4 1.8 -0.5 -0.4 -1.0
Major Depression (MDD) 0.4 0.5 0.8 0.6 -0.6 0.9 -0.8
Reaction Time 4.5 8.6 28.5 -1.1 -0.3 -5.3 2.1
Verbal and Numeric Reasoning (VNR) 1.0 2.4 3.5 1.9 1.0 -1.6 1.5
Breast Cancer 1.0 2.5 5.5 0.0 -1.1 1.8 -2.4
Ovarian Cancer 0.8 1.0 1.9 0.9 1.1 0.3 1.4
Prostate Cancer 0.6 0.9 3.1 0.2 0.3 -0.5 1.8
Age at First Birth 0.4 0.5 1.4 -0.4 -0.1 1.2 -0.8
Bipolar Disorder (2011) 0.7 0.6 2.1 0.1 0.6 0.1 1.4
Body Mass Index (BMI) (2010) 1.2 1.6 3.5 -0.3 -1.6 -0.7 -1.9
Coronary Artery Disease (CAD) 3.8 4.6 11.0 -1.4 -1.8 1.4 -3.3
Crohns Disease (2012) 1.1 1.7 4.2 2.0 1.2 1.1 -0.3
Mean Putamen Volume 0.5 0.5 1.0 -0.4 -0.9 1.0 0.2
Fasting Glucose 0.5 0.7 1.5 0.5 -0.7 -0.6 -1.2
HbA1C 0.5 0.5 1.0 1.0 0.4 0.8 -0.7
HDL Cholesterol 0.4 0.7 2.2 0.2 1.5 -0.0 0.7
LDL Cholesterol 0.7 1.2 2.2 -0.8 -1.5 0.8 -1.1
Lupus 1.1 1.7 2.9 -1.3 -1.2 -1.7 -0.8
Neuroticism (2016) 0.8 1.2 3.8 0.4 0.8 2.0 -0.3
Primary Biliary Cirrhosis 0.4 0.6 0.9 0.9 -0.7 0.7 -0.6
Rheumatoid Arthritis 0.1 0.1 0.3 0.1 0.6 -0.0 -0.3
Schizophrenia (2014) 0.8 1.7 3.0 -0.5 -1.0 1.6 -1.7
Triglycerides 0.3 0.4 1.7 -0.1 0.1 1.3 0.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.9 -0.1 0.8 -0.9 0.9
Ulcerative Colitis 1.0 1.4 5.4 2.3 0.0 -0.5 -0.3
Blood Eosinophil Count 0.1 0.6 1.8 1.3 -0.4 0.6 0.4
Blood Platelet Count 0.4 5.1 7.8 -2.3 -2.7 -0.6 -2.8
Blood Red Count 1.6 15.0 31.2 4.8 -0.9 5.6 -2.2
Blood White Count 4.6 34.3 78.0 6.2 0.2 8.8 -4.6
Heel T-Score 0.5 3.7 7.0 -2.6 -1.6 -1.6 -1.7
BMI 0.8 4.7 13.4 3.7 -0.9 0.8 -2.0
Height 4.1 79.1 196.0 -3.0 5.9 -8.7 14.0
Waist Hip Ratio (WHR) 0.7 2.9 8.4 2.9 1.0 0.7 1.4
Systolic Blood Pressure 0.9 4.3 12.0 1.3 1.8 -0.3 3.5
Smoking Status 0.7 1.7 4.2 2.1 1.4 0.6 0.7
Allergy or Eczema 0.1 0.2 0.4 0.5 0.6 -0.3 -0.2
Cardiovascular Disease 0.5 1.8 3.0 1.7 -0.7 1.3 1.4
Hypothyroidism (self reported) 0.1 0.1 0.4 0.1 -0.2 0.6 -0.3
Respiratory disease 0.2 0.4 0.9 0.6 -0.3 -0.9 -0.4
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.8 0.5 -0.1 -1.0 2.0
Lung FEV1/FVC ratio 0.1 0.7 1.5 -0.1 -1.2 0.1 -1.2
Lung FVC 0.9 4.5 8.0 -2.8 0.6 -1.7 2.6
Neuroticism 1.9 4.5 9.7 1.8 1.6 3.1 -1.5
Chronotype (morning person) 0.5 1.2 2.9 -1.7 0.2 0.8 -1.0
Hair Pigment 0.1 2.4 5.1 -0.3 0.5 2.1 -2.3
Tanning 0.0 0.4 1.5 0.3 -0.1 1.2 -0.3
Hand grip strength (left) 1.9 5.1 16.9 -4.1 -0.8 1.5 0.8
Number of treatments/medications taken 1.8 3.3 6.3 2.5 1.9 -1.2 1.4
Average weekly spirits intake 1.2 1.5 3.7 0.1 1.5 -0.5 1.9
Sensitivity / hurt feelings 1.3 2.3 4.2 -1.6 -2.1 -0.2 -1.5
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.8 1.7 0.7 1.0 0.2
Hearing difficulty/problems: Yes 1.4 2.2 5.8 1.1 0.9 2.4 -0.9
Relative age of first facial hair 1.0 2.1 4.4 -0.3 -1.1 1.6 -2.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.1 0.1 1.0 -0.5 1.0
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.3 -0.9 -0.4 -1.1 1.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 -0.1 0.4 -0.1 0.8
Systolic blood pressure, automated reading 0.8 2.3 5.1 1.4 1.4 0.3 2.3
Eye problems/disorders: Diabetes related eye disease 3.1 3.4 6.5 0.1 0.9 -2.5 2.5
Angina 1.0 1.4 3.1 0.9 1.2 1.8 -0.2
Medication for hormone replacement therapy 1.9 2.1 3.7 -1.4 -1.9 0.8 -1.5
Vitamin and mineral supplements 0.9 1.3 2.5 1.4 -0.3 1.6 0.6
Supplements: Zinc 3.3 3.6 5.4 -2.3 -1.4 -2.2 -1.4
Medication: Co-codamol 0.5 0.6 1.7 -0.0 0.7 -1.3 -0.4
Medication: Metformin 1.4 2.0 3.8 1.6 1.2 -0.5 1.9
Diabetes (father) 1.1 1.3 2.9 -1.7 -0.7 -0.5 1.3
Diabetes (mother) 0.4 0.5 1.2 -0.7 -1.1 0.6 -0.1
Severe depression (siblings) 0.8 0.8 1.2 0.5 -0.9 -1.1 -1.1
Pack years adult smoking proportion 0.5 0.8 1.3 -0.6 -1.0 1.1 -0.7
Impedance of leg (right) 0.7 3.2 10.1 1.2 -0.0 3.2 -1.0
Leg fat-free mass (left) 1.3 7.0 17.4 -0.0 1.5 -2.9 4.2
Trunk fat percentage 1.7 6.8 23.1 4.8 -0.6 1.2 -1.4
Hand grip strength (right) 1.7 4.7 14.4 -3.8 0.2 1.8 1.1
Townsend deprivation index at recruitment 0.7 1.0 2.7 1.6 0.4 0.9 0.6
Current tobacco smoking 1.0 1.6 4.2 1.3 0.4 2.1 -0.4
Average weekly fortified wine intake 1.0 1.2 4.5 -0.4 0.0 -2.1 0.1
Maternal smoking around birth 1.0 1.4 2.9 0.8 1.5 1.7 0.2
Fed-up feelings 3.8 6.9 11.6 2.8 1.4 3.4 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 0.1 0.4 0.5 -0.8
Relative age voice broke 0.3 0.5 0.6 0.5 0.7 0.8 -0.8
Taking other prescription medications 2.6 4.0 6.3 2.5 2.2 -0.6 2.1
Age when periods started (menarche) 0.2 0.6 1.9 -1.4 0.5 0.5 -0.1
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 7.6 1.0 1.7 -1.2 2.8
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.4 -0.9 -0.8 -1.2 0.4
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 2.1 1.2 -0.4 1.4 -0.2
Qualifications: CSEs or equivalent 1.6 2.1 7.4 0.1 -0.8 2.7 -0.6
Serious illness, injury or assault to yourself 1.3 1.6 4.7 0.2 0.5 -2.2 1.2
High blood pressure 1.9 5.2 15.2 2.0 1.3 -0.1 3.9
Hayfever, allergic rhinitis or eczema 0.2 0.3 0.4 0.6 0.5 0.5 -0.7
Multivitamins +/- minerals 1.6 2.0 4.0 -2.0 -0.6 -2.0 -0.1
Stomach or abdominal pain in last month 0.4 0.5 0.9 -0.7 -0.6 -1.0 -0.3
Supplements: Glucosamine 1.0 1.3 4.2 -0.3 -0.3 -2.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 1.3 0.8 1.2 -0.4 0.9
Medication: Atenolol 4.3 5.3 8.3 2.9 2.4 0.3 2.7
Medication: Levothyroxine sodium 0.7 1.2 1.9 1.2 1.4 -0.0 1.1
Sitting height 5.7 40.5 62.6 -5.7 2.2 -7.9 7.9
Chronic bronchitis/emphysema (father) 0.8 0.9 1.5 -0.9 -1.2 -0.2 -1.2
High blood pressure (mother) 0.9 1.3 2.7 0.9 1.1 -0.5 1.6
Body mass index (BMI) 1.1 4.6 14.6 3.8 -0.5 1.1 -1.5
Impedance of leg (left) 0.8 3.8 12.4 0.8 -0.3 3.5 -1.5
Leg predicted mass (left) 1.3 6.7 16.6 -0.1 1.5 -2.8 4.1
Trunk fat mass 1.0 4.1 16.4 4.0 0.1 0.3 0.3
Waist circumference 1.3 4.9 18.4 4.3 0.6 0.4 0.7
Number of incorrect matches in round 0.3 0.5 1.0 -0.7 1.0 -0.2 0.8
Past tobacco smoking 0.3 0.5 1.1 -0.5 -0.6 0.4 -1.1
Alcohol usually taken with meals 1.1 1.8 4.0 -2.0 -0.7 -1.6 -0.2
Nervous feelings 0.5 1.0 1.5 -1.2 -0.2 1.0 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.0 1.7 0.5 1.3 -0.8
Hearing difficulty/problems with background noise 1.0 1.6 4.8 1.2 0.2 2.2 -0.3
Hair/balding pattern: Pattern 2 1.1 1.4 2.9 -1.0 -1.7 -1.2 -0.6
Had menopause 0.6 0.7 2.0 0.1 0.6 -0.7 1.4
Had other major operations 1.1 1.3 4.2 0.4 0.5 -0.8 2.0
Forced vital capacity (FVC) 2.2 8.6 16.9 -4.1 0.3 -1.4 3.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.6 0.1 0.4 -1.2 1.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.3 0.6 -0.2 1.1 -1.1
Qualifications: None of the above 0.3 0.6 1.2 0.6 0.4 1.0 -1.1
Financial difficulties in last 2 years 1.3 1.8 3.8 -0.9 -1.0 2.0 -1.2
Mouth/teeth dental problems 1.5 2.3 6.1 -2.5 -1.2 0.5 -1.3
Heart attack 0.4 0.4 1.0 0.5 1.0 -0.7 0.3
Allergy 0.1 0.1 0.5 -0.1 -0.0 -0.0 0.7
Pain all over the body in last month 0.2 0.2 0.6 -0.3 0.8 0.3 0.0
Diabetes (self-reported) 1.8 2.8 5.6 1.6 1.6 -0.6 2.4
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.7 1.5 1.7 0.3 0.9
Medication: Ramipril 5.2 6.7 11.4 2.4 2.9 1.1 3.4
Medication: Simvastatin 0.4 0.6 1.2 0.8 0.7 -0.2 1.1
Fluid intelligence score 1.2 2.5 3.5 1.7 1.1 -1.9 1.5
Illnesses of siblings 0.6 0.8 1.3 -1.1 -1.1 -0.8 -0.3
Neuroticism score 1.7 3.6 8.8 1.3 0.9 3.0 -1.7
Weight 0.7 3.2 6.5 2.2 0.8 -0.8 2.5
Impedance of arm (right) 0.1 0.5 1.4 1.2 -0.6 -0.2 -0.6
Arm fat percentage (right) 1.9 7.4 25.3 5.0 -0.6 1.0 -1.7
Trunk fat-free mass 2.6 14.8 43.7 -1.1 2.7 -2.6 6.6
Hip circumference 0.7 3.1 11.0 3.3 0.5 -0.3 1.1
Time employed in main current job 0.2 0.3 0.5 -0.2 -0.6 -0.7 -0.3
Alcohol intake versus 10 years previously 0.5 0.8 1.6 0.5 0.1 1.1 -1.3
Father’s age at death 1.1 1.5 5.5 -0.4 0.3 -2.3 0.6
Worrier / anxious feelings 0.3 0.6 1.1 -1.1 0.1 -0.9 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 6.0 2.5 1.3 0.7 -0.0
Falls in the last year 0.3 0.4 0.8 0.9 0.7 -0.4 0.4
Hair/balding pattern: Pattern 3 0.7 1.0 1.5 1.0 1.2 1.2 -0.4
Number of live births 0.7 1.0 1.8 1.2 0.8 -0.2 1.3
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 12.0 -3.5 0.1 -1.2 2.9
Pulse rate 1.0 1.7 2.5 1.4 1.4 -0.5 1.6
Happiness 0.4 0.5 0.7 -0.4 -0.8 0.9 -0.7
Noisy workplace 0.6 0.7 1.5 -1.2 -1.0 -0.4 0.0
Qualifications: A levels/AS levels or equivalent 1.6 3.5 6.6 -0.3 0.9 -2.6 2.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.5 0.7 0.3 -0.1 -1.2
Mouth/teeth dental problems: Dentures 1.4 2.4 6.1 2.5 0.8 -0.9 1.4
Asthma 0.2 0.4 1.2 0.2 -0.2 -1.1 0.4
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 4.9 1.4 2.0 2.2 0.9
Medication: Cholesterol lowering 1.7 2.7 7.0 1.8 0.6 2.6 -0.5
Depression (self-reported) 0.0 0.1 0.1 0.1 -0.1 -0.3 -0.3
Medication: Lansoprazole 1.2 1.4 4.0 1.2 0.1 2.0 0.4
Prospective memory result 1.3 1.6 3.3 0.1 -1.3 1.3 -1.8
Lung cancer (father) 0.8 0.9 1.4 -1.2 -1.0 -0.2 -1.0
Illnesses of mother 1.5 1.9 2.6 -1.5 -1.3 1.0 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.3 8.0 -2.8 0.7 -1.0 2.8
Pulse wave Arterial Stiffness index 1.5 1.7 4.4 -2.1 -0.6 -1.3 0.7
Impedance of arm (left) 0.1 0.5 1.6 1.2 -0.2 -0.1 -0.7
Arm fat mass (right) 0.9 3.8 15.0 3.9 0.1 0.3 0.2
Trunk predicted mass 2.6 14.7 43.2 -1.2 2.7 -2.6 6.6
Standing height 3.1 30.6 84.8 -3.0 3.2 -4.3 9.2
Length of working week for main job 0.4 0.4 0.7 0.7 0.8 -0.1 0.7
Exposure to tobacco smoke at home 0.4 0.5 1.0 0.2 0.8 1.0 0.6
Breastfed as a baby 1.1 1.3 3.3 -0.3 -0.0 -1.8 1.4
Tense / ‘highly strung’ 0.1 0.2 0.6 -0.7 -0.1 -0.2 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.8 0.1 -0.3 1.7 -1.2
Hair/balding pattern: Pattern 4 0.5 1.1 2.8 0.7 -0.0 1.7 -1.1
Birth weight of first child 0.7 1.3 4.3 0.1 0.9 -0.3 2.1
Peak expiratory flow (PEF) 0.7 1.7 4.4 -2.1 -0.9 -0.6 1.0
Pulse wave reflection index 1.8 2.3 4.8 -1.3 -2.2 0.8 -1.4
Ever highly irritable/argumentative for 2 days 1.2 1.4 4.4 -0.0 -0.8 0.7 -2.1
Loud music exposure frequency 1.2 1.3 2.8 -0.3 0.0 1.7 -1.5
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 5.8 -0.1 0.8 -2.4 1.9
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.0 0.5 0.4 1.4 -0.4
Blood clot in the leg (DVT) 0.6 0.7 1.5 -1.2 -0.7 -0.8 -0.4
Medication: Paracetamol 1.9 3.2 6.4 2.5 2.3 0.4 0.9
Headache pain in last month 1.1 1.9 4.5 1.7 2.1 0.5 0.5
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 2.4 -1.3 -0.9 -1.6 -0.8
Glaucoma (self-reported) 1.4 1.6 3.5 1.9 1.4 -1.0 0.3
Gout (self-reported) 0.6 0.8 1.7 -0.7 0.7 -1.3 0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.2 0.5 1.1 0.2 0.2
Medication: Amlodipine 1.4 2.0 3.2 1.3 1.3 -1.2 1.8
Medication: Ventolin 100micrograms inhaler 1.5 1.9 2.8 1.1 1.6 -0.9 1.7
Birth weight 2.3 5.0 16.1 0.1 1.8 -0.8 4.0
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.8 0.6 1.7 1.1 0.3
High blood pressure (siblings) 0.3 0.4 1.0 0.6 0.6 -0.2 1.0
Forced vital capacity (FVC), Best measure 1.8 6.7 13.2 -3.6 0.7 -1.2 3.4
Body fat percentage 2.1 8.3 25.3 5.0 -0.7 1.8 -2.1
Leg fat percentage (right) 3.2 11.4 26.4 5.1 -1.0 3.0 -3.1
Arm fat-free mass (right) 1.4 7.4 22.1 -0.6 2.1 -1.6 4.7
Exposure to tobacco smoke outside home 0.7 0.9 1.8 1.4 0.5 1.1 0.6
Comparative body size at age 10 4.7 12.9 38.1 6.2 0.9 3.3 -1.5
Number of full brothers 0.4 0.5 0.7 -0.1 -0.8 -0.7 -0.8
Worry too long after embarrassment 0.3 0.6 1.4 0.1 -0.1 1.2 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.0 -1.4 -0.8 -0.8 -1.1
Wheeze or whistling in the chest in last year 0.4 0.8 1.8 1.3 0.7 0.3 0.8
Number of children fathered 0.6 0.7 1.4 -1.2 0.9 -0.3 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 4.9 -0.6 1.8 -0.5 2.2
Age at first live birth 0.3 0.6 0.8 -0.9 0.5 -0.8 0.8
Pulse wave peak to peak time 1.0 1.2 3.0 1.7 0.8 1.0 0.0
Health satisfaction 0.4 0.5 1.3 -0.7 -1.2 -0.6 -0.2
Shortness of breath walking on level ground 0.7 0.9 3.0 1.7 0.7 -0.1 0.2
Qualifications: College or University degree 0.8 2.7 6.5 -1.2 0.8 -2.5 1.5
Eye problems/disorders: None of the above 2.3 2.6 3.6 -0.8 -1.8 1.9 -1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 1.0 0.5 0.5 -0.3
Emphysema/chronic bronchitis 1.5 1.7 5.8 0.3 0.8 -2.4 0.3
Medication for pain relief, constipation, heartburn 3.6 6.2 11.2 -3.3 -3.0 -0.8 -2.0
Neck or shoulder pain in last month 1.5 2.2 3.4 1.6 1.6 1.9 0.4
Medication: Blood pressure 2.5 4.4 11.2 1.3 2.1 0.6 3.3
Angina (self-reported) 1.0 1.3 2.9 0.9 1.0 1.7 -0.5
Migraine (self-reported) 0.1 0.2 0.6 0.3 0.8 0.2 0.2
Medication: Ibuprofen 3.1 3.7 6.0 1.8 2.4 1.9 1.4
Medication: Allopurinol 0.8 1.0 2.5 -0.9 0.4 -1.6 0.8
Medication: Omeprazole 1.6 1.9 4.3 2.1 1.3 0.2 1.2
Medication: Seretide 50 evohaler 4.2 4.9 13.4 -0.4 1.2 -3.7 2.1
Mean time to correctly identify matches 4.2 7.9 26.6 -0.9 -0.4 -5.2 2.0
Heart disease (mother) 0.8 1.0 3.3 1.8 0.7 0.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.4 0.5 -1.5 -0.8 0.8
Whole body fat mass 0.9 3.8 15.1 3.9 0.0 0.4 -0.0
Leg fat mass (right) 1.3 5.1 18.1 4.3 0.0 1.4 -0.6
Arm predicted mass (right) 1.6 8.2 24.9 -0.4 2.3 -1.5 5.0
Pulse rate, automated reading 1.3 4.4 8.9 1.3 1.9 -1.8 3.0
Alcohol intake frequency. 2.6 6.1 13.5 0.1 -1.7 3.7 -2.8
Comparative height size at age 10 3.6 19.9 67.1 -0.6 2.8 -2.1 8.2
Number of full sisters 0.6 0.7 2.4 0.0 0.5 1.5 0.4
Suffer from ‘nerves’ 0.4 0.6 1.4 0.4 -0.5 1.2 -0.8
Overall health rating 0.4 0.8 2.1 1.5 -0.1 -0.1 1.0
Chest pain or discomfort 0.2 0.3 0.8 0.9 0.6 -0.3 -0.1
Had major operations 3.2 3.8 7.6 -2.8 -0.3 -2.7 0.1
Age at last live birth 0.3 0.5 0.7 -0.7 0.1 -0.9 0.7
Family relationship satisfaction 0.2 0.3 0.5 -0.7 0.3 -0.6 0.5
Leg pain on walking 0.2 0.3 1.0 -0.0 -0.1 -0.5 -1.0
Qualifications: NVQ or HND or HNC or equivalent 2.4 2.9 5.0 -1.0 -1.7 2.2 -1.6
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.7 -0.6 0.7 0.8 0.4
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 4.7 -0.6 0.8 -1.2 2.2
Medication: Aspirin 0.1 0.2 0.3 0.6 0.1 -0.4 0.5
Supplements: Vitamin C 0.7 0.9 1.7 -0.7 -0.5 -1.3 -1.0
Knee pain experienced in last month 0.2 0.3 0.9 0.0 0.5 0.3 0.9
Hypertension (Self-reported) 2.1 5.9 16.5 2.2 1.5 -0.2 4.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 0.6 0.6 -0.3 0.4
Illnesses of father: Heart disease 0.7 1.0 2.3 0.8 1.5 -0.4 0.9
Illnesses of siblings: Diabetes 0.6 0.7 1.3 0.8 -0.2 -1.1 1.0
Smoking status: Previous 0.5 0.8 1.7 0.2 0.3 -1.3 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.0 -1.2 -0.1 0.7 1.4
Whole body fat-free mass 1.9 10.9 31.2 -0.9 2.2 -2.6 5.6
Leg fat-free mass (right) 1.3 6.9 16.6 -0.6 1.4 -3.0 4.1
Arm fat percentage (left) 1.9 7.7 25.2 5.0 -0.6 1.1 -2.0
Average weekly red wine intake 2.1 3.1 5.3 -0.6 1.4 -2.2 2.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 0.1 1.1 -0.6 0.7
Mood swings 1.4 2.5 6.1 1.3 0.8 2.5 -1.3
Loneliness, isolation 1.5 2.0 4.1 1.2 0.8 2.0 -1.4
Long-standing illness, disability or infirmity 1.1 1.6 3.0 1.7 1.7 -0.1 0.8
Ever had bowel cancer screening 2.7 3.1 5.6 1.3 2.4 -1.1 2.0
Diabetes diagnosed by doctor 2.0 3.3 6.6 1.4 1.6 -1.4 2.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.8 -0.9 -0.4 0.7 -0.9
Friendships satisfaction 1.2 1.5 3.0 -1.7 -0.2 -1.6 0.7
Qualifications: nursing, teaching 0.8 1.2 3.0 1.1 -0.1 -1.7 0.6
Commuting to job workplace: Walk 1.2 1.3 1.4 1.2 1.1 -1.1 1.2
Eye problems/disorders: Cataract 0.6 0.7 1.0 0.7 0.8 -0.9 1.0
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.3 0.4 0.0 -1.3 2.1
Medication for cholesterol 0.7 1.0 2.5 -1.6 -0.3 0.0 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 4.0 -0.7 1.2 -2.0 1.7
Back pain experienced in last month 0.3 0.5 1.2 0.4 0.7 1.1 0.3
Mineral and other dietary supplements 0.7 1.0 3.3 0.8 0.2 1.8 -0.2
Breast cancer (self-reported) 0.5 0.5 1.3 -0.5 -0.5 -0.6 1.1
Asthma (self-reported) 0.1 0.2 0.7 -0.0 -0.3 -0.8 0.3
Osteoporosis (self-reported) 0.4 0.5 1.9 0.1 0.4 1.4 0.1
Osteoarthritis (self-reported) 3.7 4.8 9.8 3.1 2.4 0.1 1.9
Medication: Aspirin 0.4 0.5 1.1 0.7 0.1 -0.7 1.1
Medication: Gliclazide 1.4 1.6 2.7 0.6 0.9 -1.6 1.6
Illnesses of father: None of the above (group 1) 1.0 1.2 1.9 1.1 0.4 1.4 -1.2
Smoking status: Current 1.1 1.7 3.9 1.5 0.6 2.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.1 -1.5 0.4 -1.2 1.3
Whole body water mass 1.9 11.1 32.1 -0.8 2.2 -2.6 5.7
Leg predicted mass (right) 1.4 7.4 17.3 -0.7 1.5 -3.1 4.2
Arm fat mass (left) 0.8 3.4 13.5 3.7 0.1 0.4 0.1
Number of self-reported non-cancer illnesses 1.3 2.2 2.8 1.5 1.5 -1.3 1.7
Average weekly champagne plus white wine intake 1.6 2.2 5.4 0.7 0.7 -2.3 1.5
Miserableness 3.4 6.0 10.4 2.8 1.8 3.2 -1.5
Guilty feelings 2.6 3.9 7.2 2.1 0.9 2.7 -1.8
Wears glasses or contact lenses 0.2 0.3 0.9 0.1 -0.3 0.0 -1.0
Ever taken oral contraceptive pill 0.5 0.5 1.7 -0.5 0.0 -1.3 0.4
Hearing aid user 0.2 0.2 0.5 0.7 0.2 0.4 0.1
Mother’s age at death 0.3 0.4 0.6 0.8 0.2 0.7 -0.5
Financial situation satisfaction 0.9 1.1 3.9 0.6 -0.1 2.0 -0.3
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.1 0.0 -0.3 -0.0 -0.3
Commuting to job workplace: Public transport 0.8 1.0 1.5 1.1 0.9 -1.2 -0.4
Eye problems/disorders: Glaucoma 1.3 1.6 2.6 1.5 1.6 -0.7 0.9
Medication: Blood pressure 2.3 4.3 7.6 2.7 1.4 -0.6 2.8
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.0 1.4 0.3 0.9 0.7
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.3 -1.3 -1.1 -1.5 -0.6
High cholesterol (Self-reported) 1.5 2.7 7.8 1.6 -0.3 2.8 -0.5
Medication: Bendroflumethiazide 3.8 5.8 9.0 3.0 2.1 1.2 2.9
Medication: Paracetamol 2.2 3.4 8.1 2.9 2.1 0.7 0.6
Medication: Lisinopril 0.4 0.5 1.7 -0.6 -0.2 -0.0 1.3
Medication: Atorvastatin 1.1 1.4 3.6 1.9 1.3 -0.2 -0.4
Illnesses of father: High blood pressure 0.8 0.9 3.5 -0.0 0.5 -0.1 1.9
Alcohol drinker status: Never 0.8 0.9 1.6 1.1 1.0 1.3 0.3
Ever smoked 0.2 0.3 0.6 0.1 0.6 0.5 0.8
Basal metabolic rate 1.4 7.8 23.4 -0.1 1.8 -2.1 4.8
Leg fat percentage (left) 2.9 10.4 23.4 4.8 -1.0 2.8 -3.0
Arm fat-free mass (left) 1.4 7.1 22.6 -0.5 1.8 -1.5 4.8
Number of operations (self-reported) 1.5 2.2 5.5 -0.2 0.2 -1.8 2.3
Average weekly beer plus cider intake 0.3 0.5 1.0 0.9 0.4 1.0 -0.3
Irritability 0.4 0.7 2.1 1.4 0.7 0.4 -0.2
Risk taking 1.3 1.9 3.2 -0.8 1.2 -1.8 1.5
Ever had prostate specific antigen (PSA) test 2.6 3.1 7.2 -1.8 -0.8 -2.7 -1.0
Fractured/broken bones in last 5 years 0.7 0.8 2.3 0.5 0.7 1.5 0.5
Age started oral contraceptive pill 0.1 0.2 0.3 -0.6 0.1 -0.5 -0.2
Diastolic blood pressure, automated reading 0.5 1.6 2.4 1.4 1.4 0.4 1.5
Ever depressed for a whole week 0.5 0.6 1.6 0.5 0.3 0.6 -1.3
Unable to work because of sickness or disability 0.3 0.3 0.6 0.8 -0.8 -0.3 -0.4
Commuting to job workplace: Cycle 0.5 0.6 1.4 -0.1 -1.2 -0.9 0.0
Myopia 0.3 0.4 0.6 -0.5 0.5 -0.6 0.8
Vascular/heart problems diagnosed by doctor 1.6 4.3 12.0 -1.6 -1.6 0.4 -3.5
Cholesterol lowering medication 0.5 0.8 1.5 -0.5 0.1 -1.1 1.2
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 4.7 2.2 1.2 0.7 0.8
Pain experienced in last month 0.3 0.6 1.1 -0.0 -0.9 -1.0 -0.5
Supplements: Calcium 0.3 0.4 1.0 -0.2 0.1 1.0 -0.6
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.2 -0.3 -0.8 -0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.9 0.4 1.0 -0.8 0.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.6 -1.3 -0.6 -1.0 -0.0
Heart disease (siblings) 0.2 0.3 0.6 -0.2 -0.1 0.6 -0.8
Alcohol drinker status: Previous 2.1 2.4 6.4 -0.7 -0.8 2.5 -1.4
Pack years of smoking 0.2 0.3 0.6 -0.3 -0.6 0.7 -0.3
Impedance of whole body 0.3 1.4 2.5 0.6 -0.6 1.6 -1.6
Leg fat mass (left) 1.2 4.7 16.6 4.1 0.0 1.4 -0.7
Arm predicted mass (left) 1.5 7.9 25.5 -0.4 1.9 -1.4 5.0