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chr14:103,161,201-105,211,221

Best TWAS P=4.26e-11 · Best GWAS P=5.79e-10 conditioned to 0.0326

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PPP1R13B	0.04	0.02	lasso	2	0.01	4.1e-02	5.5	-5.6	1.9e-08	-0.63	0.08	0.72	FALSE
2	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	6.1	5.4	8.3e-08	0.86	0.03	0.89	FALSE
3	GTEx	Adipose Subcutaneous	XRCC3	0.09	0.08	lasso	5	0.07	3.8e-06	5.9	6.0	2.2e-09	0.95	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	APOPT1	0.06	0.02	lasso	5	0.02	8.2e-03	5.4	-6.0	2.3e-09	-0.91	0.04	0.92	FALSE
5	GTEx	Adipose Subcutaneous	RP11-73M18.8	0.14	0.19	lasso	4	0.20	6.4e-16	5.4	5.5	4.1e-08	0.86	0.08	0.92	FALSE
6	GTEx	Adrenal Gland	KLC1	0.15	0.03	lasso	3	0.06	4.6e-03	5.7	5.4	7.9e-08	0.80	0.06	0.65	FALSE
7	GTEx	Artery Aorta	ZFYVE21	0.10	0.09	lasso	4	0.08	2.9e-05	5.8	5.5	3.4e-08	0.64	0.08	0.74	FALSE
8	GTEx	Artery Tibial	XRCC3	0.06	0.08	lasso	3	0.03	1.4e-03	5.7	5.9	4.0e-09	0.74	0.10	0.89	FALSE
9	GTEx	Artery Tibial	RP11-73M18.8	0.09	0.06	lasso	4	0.09	7.4e-08	5.4	6.0	2.6e-09	0.82	0.05	0.95	FALSE
10	GTEx	Artery Tibial	RP11-73M18.6	0.05	0.03	lasso	2	0.02	4.7e-03	5.4	5.2	2.4e-07	0.83	0.05	0.82	FALSE
11	GTEx	Brain Cortex	XRCC3	0.12	0.02	lasso	4	0.01	1.7e-01	5.7	5.8	8.5e-09	0.74	0.08	0.61	FALSE
12	GTEx	Brain Cortex	RP11-73M18.8	0.35	0.13	enet	34	0.25	1.2e-07	5.9	5.5	3.1e-08	0.66	0.03	0.97	FALSE
13	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	5.7	6.0	2.0e-09	0.82	0.06	0.93	FALSE
14	GTEx	Breast Mammary Tissue	XRCC3	0.15	0.01	enet	37	0.01	1.0e-01	5.8	5.2	2.4e-07	0.66	0.07	0.92	FALSE
15	GTEx	Breast Mammary Tissue	RP11-73M18.8	0.19	0.14	enet	21	0.26	2.0e-13	6.2	5.8	5.4e-09	0.85	0.01	0.99	FALSE
16	GTEx	Breast Mammary Tissue (Male)	RP11-73M18.8	0.22	0.12	lasso	4	0.08	7.3e-03	5.8	5.6	2.4e-08	0.74	0.06	0.84	FALSE
17	GTEx	Breast Mammary Tissue (Female)	KLC1	0.09	0.00	lasso	2	0.00	2.4e-01	6.1	6.6	5.2e-11	0.93	0.04	0.64	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	PPP1R13B	0.15	0.08	lasso	4	0.07	2.2e-03	5.8	-6.6	4.3e-11	-0.71	0.07	0.83	TRUE
19	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	6.2	6.0	1.6e-09	0.95	0.02	0.86	FALSE
20	GTEx	Colon Transverse	XRCC3	0.13	0.14	lasso	4	0.11	1.0e-05	5.7	5.8	6.0e-09	0.81	0.07	0.93	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	PPP1R13B	0.09	0.08	lasso	2	0.05	7.9e-03	5.8	-5.9	4.8e-09	-0.67	0.07	0.76	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	RP11-73M18.8	0.14	0.07	enet	10	0.10	2.4e-04	5.4	5.9	2.9e-09	0.79	0.08	0.88	FALSE
23	GTEx	Esophagus Mucosa	KLC1	0.17	0.09	lasso	5	0.12	1.6e-08	5.7	5.9	4.9e-09	0.75	0.08	0.91	FALSE
24	GTEx	Esophagus Mucosa	XRCC3	0.12	0.15	lasso	2	0.13	4.4e-09	5.7	5.7	9.1e-09	0.82	0.10	0.90	FALSE
25	GTEx	Esophagus Muscularis	PPP1R13B	0.12	0.07	lasso	5	0.07	3.9e-05	5.6	-5.8	5.2e-09	-0.67	0.10	0.90	FALSE
26	GTEx	Esophagus Muscularis	KLC1	0.07	0.01	enet	10	0.02	2.6e-02	-3.5	5.8	6.3e-09	0.68	0.11	0.48	FALSE
27	GTEx	Esophagus Muscularis	XRCC3	0.11	0.05	enet	23	0.03	5.2e-03	5.4	5.8	8.4e-09	0.66	0.04	0.86	FALSE
28	GTEx	Esophagus Muscularis	RP11-73M18.8	0.11	0.04	enet	11	0.10	1.9e-06	5.7	5.6	2.4e-08	0.69	0.08	0.88	FALSE
29	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	-3.5	5.2	1.7e-07	0.73	0.40	0.60	FALSE
30	GTEx	Muscle Skeletal	RP11-73M18.8	0.11	0.14	lasso	7	0.13	8.4e-13	5.2	5.8	5.6e-09	0.71	0.15	0.85	FALSE
31	GTEx	Nerve Tibial	KLC1	0.07	0.00	enet	22	0.01	8.5e-02	4.7	6.4	1.8e-10	0.73	0.07	0.78	FALSE
32	GTEx	Nerve Tibial	XRCC3	0.08	0.06	lasso	3	0.05	3.5e-04	5.4	5.7	1.3e-08	0.85	0.05	0.95	FALSE
33	GTEx	Nerve Tibial	APOPT1	0.10	0.08	lasso	5	0.06	7.8e-05	6.1	-6.0	1.7e-09	-0.98	0.01	0.99	FALSE
34	GTEx	Nerve Tibial	RP11-73M18.8	0.08	0.13	lasso	4	0.10	7.4e-08	5.4	5.4	7.0e-08	0.84	0.15	0.85	FALSE
35	GTEx	Ovary	RP11-73M18.8	0.19	0.20	lasso	5	0.14	2.4e-04	5.4	5.6	1.6e-08	0.80	0.06	0.74	FALSE
36	GTEx	Pituitary	RP11-73M18.8	0.23	0.17	lasso	2	0.13	3.6e-04	5.4	5.4	5.4e-08	0.85	0.05	0.66	FALSE
37	GTEx	Prostate	RP11-73M18.8	0.15	0.29	lasso	1	0.25	5.2e-07	5.7	5.7	1.5e-08	0.82	0.06	0.85	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	KLC1	0.11	0.09	lasso	4	0.10	4.1e-06	5.7	5.9	4.1e-09	0.64	0.10	0.87	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	XRCC3	0.14	0.03	lasso	14	0.03	1.3e-02	5.7	6.2	5.1e-10	0.80	0.05	0.94	FALSE
40	GTEx	Skin Sun Exposed Lower leg	XRCC3	0.09	0.10	enet	16	0.09	6.3e-08	5.8	5.5	4.3e-08	0.76	0.06	0.94	FALSE
41	GTEx	Skin Sun Exposed Lower leg	RP11-73M18.8	0.11	0.11	lasso	4	0.12	5.1e-10	5.4	5.2	2.5e-07	0.72	0.08	0.92	FALSE
42	GTEx	Small Intestine Terminal Ileum	ZFYVE21	0.16	0.10	lasso	2	0.13	7.7e-04	4.0	5.2	2.1e-07	0.61	0.07	0.45	FALSE
43	GTEx	Spleen	XRCC3	0.28	0.19	lasso	3	0.24	8.7e-07	5.7	5.3	1.2e-07	0.77	0.04	0.94	FALSE
44	GTEx	Testis	KLC1	0.17	0.17	lasso	2	0.15	4.4e-07	5.7	6.1	1.2e-09	0.82	0.10	0.89	FALSE
45	GTEx	Testis	RP11-73M18.8	0.16	0.12	lasso	4	0.12	4.0e-06	5.7	6.0	2.4e-09	0.82	0.09	0.89	FALSE
46	GTEx	Thyroid	KLC1	0.12	0.03	enet	22	0.03	3.6e-03	5.1	5.7	1.0e-08	0.61	0.12	0.73	FALSE
47	GTEx	Thyroid	APOPT1	0.11	0.12	lasso	1	0.10	1.9e-08	5.9	-5.9	3.8e-09	-0.97	0.01	0.99	FALSE
48	GTEx	Whole Blood	KLC1	0.16	0.13	lasso	3	0.11	3.6e-10	5.7	5.7	1.2e-08	0.83	0.11	0.89	FALSE
49	GTEx	Whole Blood	XRCC3	0.08	0.12	lasso	3	0.10	1.3e-09	5.7	5.8	8.5e-09	0.82	0.10	0.90	FALSE
50	METSIM	Adipose	MARK3	0.03	0.02	lasso	6	0.03	6.3e-05	5.9	-5.3	1.4e-07	-0.87	0.06	0.93	FALSE
51	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	6.1	-5.4	5.3e-08	-0.81	0.01	0.99	FALSE
52	METSIM	Adipose	XRCC3	0.13	0.20	lasso	7	0.22	6.2e-33	5.7	5.5	3.7e-08	0.76	0.10	0.90	FALSE
53	YFS	Blood	BAG5	0.01	0.01	bslmm	350	0.00	1.9e-02	6.2	5.8	5.6e-09	0.73	0.01	0.92	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRCC3	0.03	0.04	enet	3	0.04	6.1e-05	5.7	6.0	2.7e-09	0.82	0.02	0.97	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XRCC3	0.06	0.07	lasso	4	0.05	4.6e-04	5.7	5.6	2.4e-08	0.80	0.02	0.80	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	6.1	-5.4	5.1e-08	-0.84	0.00	0.95	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-3.4	-5.3	1.3e-07	-0.79	0.02	0.94	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C14orf153	0.15	0.03	blup	37	0.03	1.6e-02	5.4	-5.6	2.3e-08	-0.91	0.01	0.78	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	XRCC3	0.02	0.01	blup	46	0.01	3.0e-02	5.3	5.7	1.3e-08	0.67	0.02	0.56	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	6.1	6.1	1.2e-09	0.86	0.02	0.86	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1R13B	0.04	0.04	lasso	2	0.03	7.9e-04	5.7	5.8	6.0e-09	0.73	0.04	0.90	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	XRCC3	0.08	0.07	lasso	4	0.08	1.8e-08	5.7	5.4	5.3e-08	0.76	0.02	0.98	FALSE