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chr8:37,329,315-38,989,813

Best TWAS P=8.95e-15 · Best GWAS P=1.59e-14 conditioned to 0.048

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DDHD2	0.04	0.04	bslmm	286	0.04	2.0e-05	7.7	7.0	3.4e-12	0.93	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STAR	0.05	0.00	blup	247	0.02	1.2e-03	5.7	5.9	3.8e-09	0.76	0.08	0.76	FALSE
3	GTEx	Adrenal Gland	DDHD2	0.25	0.21	lasso	2	0.19	1.7e-07	7.5	7.4	9.7e-14	0.98	0.03	0.97	FALSE
4	GTEx	Adrenal Gland	LSM1	0.17	0.10	enet	22	0.17	1.1e-06	7.5	-6.5	1.0e-10	-0.80	0.04	0.94	FALSE
5	GTEx	Adrenal Gland	RP11-90P5.2	0.18	0.18	enet	24	0.22	2.0e-08	6.3	-5.7	9.7e-09	-0.75	0.04	0.94	FALSE
6	GTEx	Artery Aorta	DDHD2	0.16	0.04	enet	22	0.05	6.1e-04	7.5	6.8	7.5e-12	0.75	0.02	0.97	FALSE
7	GTEx	Artery Tibial	DDHD2	0.07	0.07	lasso	2	0.05	7.3e-05	7.5	7.6	3.7e-14	0.99	0.03	0.96	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RP11-350N15.4	0.28	-0.01	enet	23	-0.01	7.3e-01	1.2	-5.6	2.6e-08	-0.50	0.04	0.40	FALSE
9	GTEx	Brain Cerebellum	DDHD2	0.18	0.05	lasso	7	0.05	1.5e-02	7.6	7.0	3.4e-12	0.84	0.03	0.90	FALSE
10	GTEx	Breast Mammary Tissue	RP11-350N15.5	0.08	0.03	enet	12	0.02	1.9e-02	4.4	-6.7	1.9e-11	-0.89	0.04	0.88	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RP11-350N15.5	0.12	0.10	lasso	2	0.07	3.9e-03	7.5	-7.6	4.2e-14	-0.98	0.03	0.83	FALSE
12	GTEx	Cells Transformed fibroblasts	RP11-90P5.2	0.07	0.02	lasso	3	0.04	4.0e-04	2.0	-6.3	3.7e-10	-0.53	0.04	0.64	FALSE
13	GTEx	Colon Sigmoid	DDHD2	0.15	0.15	lasso	3	0.12	7.5e-05	7.7	7.6	2.1e-14	0.96	0.02	0.96	FALSE
14	GTEx	Esophagus Mucosa	DDHD2	0.09	0.02	lasso	3	0.02	8.4e-03	7.5	7.8	9.0e-15	0.86	0.03	0.93	TRUE
15	GTEx	Esophagus Muscularis	DDHD2	0.12	0.13	lasso	2	0.12	5.7e-08	7.5	7.5	8.0e-14	0.93	0.03	0.97	FALSE
16	GTEx	Liver	DDHD2	0.29	0.01	lasso	5	-0.01	5.4e-01	7.4	7.1	1.4e-12	0.89	0.03	0.63	FALSE
17	GTEx	Nerve Tibial	DDHD2	0.15	0.16	enet	26	0.16	2.3e-11	7.6	6.9	5.2e-12	0.92	0.02	0.98	FALSE
18	GTEx	Pituitary	DDHD2	0.25	0.22	lasso	3	0.17	3.9e-05	7.4	7.1	1.2e-12	0.93	0.03	0.90	FALSE
19	GTEx	Prostate	DDHD2	0.38	0.18	lasso	7	0.17	5.4e-05	7.5	7.4	1.2e-13	0.94	0.02	0.97	FALSE
20	GTEx	Skin Sun Exposed Lower leg	WHSC1L1	0.06	0.01	enet	19	0.01	3.8e-02	7.5	-5.2	2.3e-07	-0.70	0.04	0.78	FALSE
21	GTEx	Spleen	DDHD2	0.17	0.17	lasso	2	0.11	7.8e-04	7.5	7.6	4.1e-14	0.99	0.03	0.90	FALSE
22	GTEx	Stomach	DDHD2	0.13	0.06	lasso	2	0.06	1.1e-03	7.1	7.2	6.1e-13	0.96	0.04	0.89	FALSE
23	GTEx	Testis	PPAPDC1B	0.11	0.02	lasso	2	0.07	6.6e-04	5.0	5.1	3.0e-07	0.66	0.04	0.43	FALSE
24	GTEx	Thyroid	DDHD2	0.11	0.10	lasso	4	0.09	3.8e-07	7.5	7.4	1.3e-13	0.94	0.03	0.97	FALSE
25	GTEx	Thyroid	RP11-90P5.2	0.09	0.00	enet	12	0.01	1.1e-01	6.8	-6.9	6.2e-12	-0.82	0.03	0.87	FALSE
26	GTEx	Whole Blood	BAG4	0.10	0.02	enet	21	0.03	9.7e-04	7.5	5.6	2.5e-08	0.71	0.02	0.94	FALSE
27	NTR	Blood	BAG4	0.01	0.01	blup	253	0.01	3.9e-03	7.5	-7.2	4.4e-13	-0.94	0.03	0.96	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	DDHD2	0.05	0.01	lasso	5	0.02	1.6e-03	7.5	7.2	6.7e-13	0.79	0.03	0.95	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	PPAPDC1B	0.06	0.08	enet	14	0.09	4.0e-11	7.5	7.3	2.9e-13	0.98	0.05	0.95	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	LSM1	0.09	0.16	lasso	6	0.16	7.3e-20	7.5	-7.5	5.1e-14	-0.95	0.03	0.97	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	RPS20P22	0.04	0.00	blup	267	0.02	2.9e-03	7.4	7.0	2.2e-12	0.75	0.03	0.85	FALSE
32	YFS	Blood	BAG4	0.01	0.01	bslmm	234	0.00	2.6e-02	6.3	7.1	1.0e-12	0.83	0.03	0.85	FALSE
33	YFS	Blood	LSM1	0.02	0.00	bslmm	218	0.01	4.1e-04	4.0	-6.9	4.4e-12	-0.82	0.05	0.92	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	DDHD2	0.01	0.01	blup	21	0.01	2.3e-03	7.5	7.6	2.5e-14	0.97	0.01	0.80	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BAG4	0.04	0.03	lasso	1	0.02	1.6e-03	6.3	-6.3	3.1e-10	-0.87	0.04	0.67	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDHD2	0.03	0.03	blup	21	0.03	3.5e-04	7.1	7.6	3.0e-14	0.98	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPAPDC1B	0.02	0.00	blup	18	0.01	4.2e-02	7.7	7.5	6.8e-14	0.96	0.01	0.59	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DDHD2	0.07	0.05	blup	21	0.05	2.7e-03	7.7	7.6	2.3e-14	0.96	0.01	0.82	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PPAPDC1B	0.14	0.06	enet	15	0.08	2.7e-04	7.7	6.2	6.8e-10	0.75	0.01	0.92	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDHD2	0.11	0.08	lasso	3	0.08	1.9e-08	7.7	7.6	2.0e-14	0.96	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	DDHD2	0.02	0.01	blup	21	0.01	2.4e-02	7.5	7.6	3.2e-14	0.98	0.02	0.75	FALSE