Best TWAS P=1.09e-17 · Best GWAS P=3.54e-17 conditioned to 0.000359
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | 6.7 | 7.4 | 1.4e-13 | 0.61 | 0.10 | 0.90 | FALSE |
2 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | 8.4 | 8.2 | 2.9e-16 | 0.86 | 0.02 | 0.91 | FALSE |
3 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | 8.2 | 8.2 | 2.4e-16 | 0.71 | 0.05 | 0.93 | FALSE |
4 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | 8.2 | 7.6 | 2.1e-14 | 0.61 | 0.08 | 0.83 | FALSE |
5 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | 4.5 | 7.8 | 8.4e-15 | 0.76 | 0.02 | 0.93 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | 8.0 | 7.8 | 8.4e-15 | 0.66 | 0.17 | 0.81 | FALSE |
7 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | 8.3 | 8.6 | 1.1e-17 | 0.68 | 0.05 | 0.94 | TRUE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | 8.0 | 8.2 | 2.0e-16 | 0.67 | 0.02 | 0.77 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | 7.9 | 5.6 | 1.9e-08 | 0.54 | 0.02 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | 7.9 | 7.9 | 3.2e-15 | 0.59 | 0.02 | 0.56 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | 8.3 | 7.4 | 1.2e-13 | 0.71 | 0.01 | 0.98 | FALSE |