Best TWAS P=9.01e-15 · Best GWAS P=4.69e-19 conditioned to 2.31e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TSNARE1 | 0.26 | 0.10 | lasso | 3 | 0.14 | 1.1e-11 | -5.3 | -5.5 | 4.2e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Hypothalamus | THEM6 | 0.21 | 0.13 | lasso | 3 | 0.02 | 1.4e-01 | 7.1 | 6.7 | 2.3e-11 | 0.63 | 0.07 | 0.18 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | TSNARE1 | 0.26 | 0.12 | enet | 21 | 0.11 | 2.5e-06 | -5.2 | -5.3 | 1.1e-07 | -0.12 | 0.95 | 0.00 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | TSNARE1 | 0.17 | 0.07 | lasso | 4 | 0.07 | 9.7e-03 | -5.1 | -5.3 | 1.5e-07 | -0.12 | 0.05 | 0.10 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | TSNARE1 | 0.07 | 0.11 | lasso | 3 | 0.09 | 1.3e-03 | -5.2 | -5.2 | 1.9e-07 | -0.14 | 0.07 | 0.06 | FALSE |
| 6 | GTEx | Colon Sigmoid | SLC45A4 | 0.22 | 0.16 | lasso | 9 | 0.14 | 8.3e-06 | -5.9 | -6.1 | 8.1e-10 | 0.02 | 0.03 | 0.94 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | TSNARE1 | 0.22 | 0.10 | lasso | 6 | 0.03 | 3.2e-02 | -4.9 | -5.5 | 4.3e-08 | -0.06 | 0.15 | 0.04 | FALSE |
| 8 | GTEx | Liver | CASC7 | 0.12 | 0.11 | enet | 8 | 0.01 | 1.4e-01 | 5.1 | 5.2 | 1.9e-07 | -0.01 | 0.25 | 0.04 | TRUE |
| 9 | GTEx | Nerve Tibial | TSNARE1 | 0.24 | 0.18 | lasso | 3 | 0.23 | 2.3e-16 | -5.2 | -5.3 | 9.1e-08 | -0.14 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Spleen | TSNARE1 | 0.40 | 0.39 | lasso | 4 | 0.38 | 8.9e-11 | -4.3 | -5.3 | 1.4e-07 | -0.07 | 0.92 | 0.00 | FALSE |
| 11 | GTEx | Stomach | TSNARE1 | 0.27 | 0.09 | lasso | 3 | 0.09 | 6.7e-05 | -5.2 | -5.2 | 1.9e-07 | -0.14 | 0.96 | 0.00 | FALSE |
| 12 | GTEx | Thyroid | TSNARE1 | 0.33 | 0.26 | lasso | 5 | 0.26 | 2.6e-20 | -5.3 | -5.3 | 1.5e-07 | -0.14 | 1.00 | 0.00 | FALSE |
| 13 | METSIM | Adipose | ARC | 0.04 | 0.00 | blup | 416 | 0.01 | 3.9e-03 | -6.1 | -7.8 | 9.0e-15 | -0.72 | 0.04 | 0.92 | TRUE |
| 14 | NTR | Blood | DENND3 | 0.03 | 0.01 | lasso | 2 | 0.01 | 7.9e-05 | 6.2 | -6.3 | 2.9e-10 | 0.01 | 0.00 | 1.00 | TRUE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | DENND3 | 0.10 | 0.05 | bslmm | 451 | 0.05 | 2.5e-07 | -2.4 | -5.8 | 5.2e-09 | 0.02 | 0.20 | 0.79 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | PTK2 | 0.05 | 0.07 | lasso | 4 | 0.07 | 5.4e-09 | 5.1 | -5.2 | 2.0e-07 | -0.01 | 0.23 | 0.77 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSNARE1 | 0.09 | 0.02 | blup | 104 | 0.04 | 1.1e-05 | -3.6 | 5.7 | 1.0e-08 | 0.07 | 0.08 | 0.87 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSNARE1 | 0.02 | 0.00 | blup | 103 | 0.00 | 2.1e-01 | -5.1 | 6.1 | 1.0e-09 | 0.09 | 0.04 | 0.42 | TRUE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSNARE1 | 0.03 | 0.02 | blup | 104 | 0.02 | 7.6e-04 | -5.1 | 5.4 | 6.4e-08 | 0.12 | 0.04 | 0.86 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DENND3 | 0.07 | 0.01 | blup | 98 | 0.05 | 3.3e-06 | 3.5 | -5.3 | 1.4e-07 | 0.03 | 0.10 | 0.83 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC45A4 | 0.04 | 0.05 | lasso | 1 | 0.03 | 1.3e-04 | -5.8 | -5.8 | 8.7e-09 | 0.03 | 0.01 | 0.99 | FALSE |