[Hub]/) : Traits : Systolic Blood Pressure :

chr8:140,840,550-144,515,639

Best TWAS P=9.01e-15 · Best GWAS P=4.69e-19 conditioned to 2.31e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TSNARE1 0.26 0.10 lasso 3 0.14 1.1e-11 -5.3 -5.5 4.2e-08 -0.12 1.00 0.00 FALSE
2 GTEx Brain Hypothalamus THEM6 0.21 0.13 lasso 3 0.02 1.4e-01 7.1 6.7 2.3e-11 0.63 0.07 0.18 FALSE
3 GTEx Breast Mammary Tissue TSNARE1 0.26 0.12 enet 21 0.11 2.5e-06 -5.2 -5.3 1.1e-07 -0.12 0.95 0.00 FALSE
4 GTEx Breast Mammary Tissue (Male) TSNARE1 0.17 0.07 lasso 4 0.07 9.7e-03 -5.1 -5.3 1.5e-07 -0.12 0.05 0.10 FALSE
5 GTEx Breast Mammary Tissue (Female) TSNARE1 0.07 0.11 lasso 3 0.09 1.3e-03 -5.2 -5.2 1.9e-07 -0.14 0.07 0.06 FALSE
6 GTEx Colon Sigmoid SLC45A4 0.22 0.16 lasso 9 0.14 8.3e-06 -5.9 -6.1 8.1e-10 0.02 0.03 0.94 FALSE
7 GTEx Esophagus Gastroesophageal Junction TSNARE1 0.22 0.10 lasso 6 0.03 3.2e-02 -4.9 -5.5 4.3e-08 -0.06 0.15 0.04 FALSE
8 GTEx Liver CASC7 0.12 0.11 enet 8 0.01 1.4e-01 5.1 5.2 1.9e-07 -0.01 0.25 0.04 TRUE
9 GTEx Nerve Tibial TSNARE1 0.24 0.18 lasso 3 0.23 2.3e-16 -5.2 -5.3 9.1e-08 -0.14 1.00 0.00 FALSE
10 GTEx Spleen TSNARE1 0.40 0.39 lasso 4 0.38 8.9e-11 -4.3 -5.3 1.4e-07 -0.07 0.92 0.00 FALSE
11 GTEx Stomach TSNARE1 0.27 0.09 lasso 3 0.09 6.7e-05 -5.2 -5.2 1.9e-07 -0.14 0.96 0.00 FALSE
12 GTEx Thyroid TSNARE1 0.33 0.26 lasso 5 0.26 2.6e-20 -5.3 -5.3 1.5e-07 -0.14 1.00 0.00 FALSE
13 METSIM Adipose ARC 0.04 0.00 blup 416 0.01 3.9e-03 -6.1 -7.8 9.0e-15 -0.72 0.04 0.92 TRUE
14 NTR Blood DENND3 0.03 0.01 lasso 2 0.01 7.9e-05 6.2 -6.3 2.9e-10 0.01 0.00 1.00 TRUE
15 ROSMAP Brain Pre-frontal Cortex DENND3 0.10 0.05 bslmm 451 0.05 2.5e-07 -2.4 -5.8 5.2e-09 0.02 0.20 0.79 FALSE
16 ROSMAP Brain Pre-frontal Cortex PTK2 0.05 0.07 lasso 4 0.07 5.4e-09 5.1 -5.2 2.0e-07 -0.01 0.23 0.77 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TSNARE1 0.09 0.02 blup 104 0.04 1.1e-05 -3.6 5.7 1.0e-08 0.07 0.08 0.87 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma TSNARE1 0.02 0.00 blup 103 0.00 2.1e-01 -5.1 6.1 1.0e-09 0.09 0.04 0.42 TRUE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TSNARE1 0.03 0.02 blup 104 0.02 7.6e-04 -5.1 5.4 6.4e-08 0.12 0.04 0.86 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma DENND3 0.07 0.01 blup 98 0.05 3.3e-06 3.5 -5.3 1.4e-07 0.03 0.10 0.83 FALSE
21 The Cancer Genome Atlas Prostate Adenocarcinoma SLC45A4 0.04 0.05 lasso 1 0.03 1.3e-04 -5.8 -5.8 8.7e-09 0.03 0.01 0.99 FALSE