Hub : Genes

ZNF618

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.150	0.056	5.2e-03	0.045	NA	-0.005	NA	0.012	1.7e-03	NA	9.5e-01	NA	0.06800
2	GTEx	Brain Cerebellar Hemisphere	0.479	0.121	1.6e-03	0.235	NA	0.168	NA	0.110	1.0e-06	NA	4.4e-05	NA	0.00092
3	GTEx	Brain Cerebellum	0.387	0.096	9.2e-05	0.259	NA	0.222	NA	-0.006	2.8e-08	NA	3.5e-07	NA	0.53000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	1.0	-0.2	0.5	1.0
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	0.1	0.3	0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.6	-0.6	-0.4	-1.3
Depression (Nagel 2018)	0.8	1.2	1.8	1.0	-0.9	-1.4
Intelligence (Savage-Jansen 2018)	0.0	0.2	0.3	-0.2	-0.6	-0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.1	-0.5	-0.2	-1.1
Schizophrenia (2018)	0.0	0.0	0.1	0.3	-0.0	-0.2
Schizophrenia vs Biploar Disorder	0.8	1.0	1.9	-0.0	-1.1	-1.4
Worry (Nagel 2018)	0.1	0.3	0.8	-0.9	0.2	-0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.1	-0.2	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.5	-0.2	-0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.0	-0.4	-0.0
Crohns Disease (2017)	1.3	2.9	5.6	0.2	-2.4	-1.7
Irritable Bowel Disease (IBD)	0.3	0.8	2.2	1.5	-0.3	0.1
Ulcerative Colitis (UC)	1.6	3.1	3.5	1.7	1.7	1.9
Major Depression (MDD)	0.2	0.2	0.5	-0.7	-0.3	0.2
Reaction Time	0.2	0.4	1.2	-1.1	-0.1	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.1	-0.8	-1.1	-0.2
Breast Cancer	0.1	0.3	0.6	0.0	0.8	0.5
Ovarian Cancer	1.6	2.1	3.0	0.7	-1.7	-1.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	0.7	0.7	-0.6	-0.8
Bipolar Disorder (2011)	0.5	0.4	1.0	1.0	-0.0	-0.6
Body Mass Index (BMI) (2010)	1.1	1.5	2.5	0.6	-1.6	-1.3
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.4	0.2	-0.2
Crohns Disease (2012)	0.7	1.2	3.2	0.0	-1.8	-0.6
Mean Putamen Volume	0.2	0.2	0.4	-0.1	0.7	0.5
Fasting Glucose	1.3	1.5	1.8	1.1	1.4	1.2
HbA1C	0.2	0.2	0.3	-0.3	-0.5	-0.5
HDL Cholesterol	0.3	0.4	0.8	0.6	0.5	0.9
LDL Cholesterol	0.4	0.6	0.9	-1.0	0.8	0.4
Lupus	2.3	3.5	4.5	1.2	2.1	2.1
Neuroticism (2016)	0.7	1.0	1.9	0.4	-0.9	-1.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.5	0.4	0.1
Rheumatoid Arthritis	0.4	0.6	0.8	0.7	0.7	0.9
Schizophrenia (2014)	0.3	0.7	1.1	0.3	-1.0	-0.9
Triglycerides	0.7	1.1	1.7	-0.4	-1.2	-1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	0.9	0.3	-0.1
Ulcerative Colitis	0.5	0.7	1.7	1.3	0.5	0.6
Blood Eosinophil Count	0.1	0.5	1.4	1.2	0.2	0.3
Blood Platelet Count	0.4	4.3	9.7	3.1	-1.2	-1.2
Blood Red Count	0.1	0.6	1.0	-1.0	-0.6	-0.5
Blood White Count	0.2	1.3	2.3	-0.5	1.5	1.2
Heel T-Score	0.4	3.2	6.6	-1.6	0.5	2.6
BMI	0.4	2.5	3.2	1.2	-1.8	-1.7
Height	0.2	4.8	5.3	2.2	-2.3	-2.0
Waist Hip Ratio (WHR)	0.2	0.9	2.5	-0.2	-1.6	-0.3
Systolic Blood Pressure	4.0	20.2	38.6	-0.2	6.2	4.7
Smoking Status	0.0	0.0	0.0	-0.0	-0.2	0.2
Allergy or Eczema	1.1	3.0	3.9	1.8	-2.0	-1.4
Cardiovascular Disease	1.4	4.7	8.8	-0.3	3.0	2.3
Hypothyroidism (self reported)	0.5	1.2	1.8	-1.3	1.2	0.5
Respiratory disease	1.8	4.1	8.3	-0.8	-2.9	-1.9
Type 2 Diabetes (T2D) (2018)	2.0	3.8	7.2	1.0	2.7	1.8
Lung FEV1/FVC ratio	0.4	2.0	3.2	1.6	1.8	0.1
Lung FVC	0.6	3.1	5.3	0.6	-1.9	-2.3
Neuroticism	0.8	1.9	3.4	1.2	-1.0	-1.9
Chronotype (morning person)	3.0	6.9	8.8	-1.8	3.0	2.9
Hair Pigment	0.1	3.1	4.5	-0.9	2.0	2.1
Tanning	0.3	3.6	6.9	-0.6	-2.6	-1.9
Hand grip strength (left)	0.2	0.6	1.5	-0.1	-1.2	-0.5
Number of treatments/medications taken	0.2	0.4	1.1	1.1	-0.2	0.2
Average weekly spirits intake	1.0	1.3	3.8	0.0	-2.0	0.0
Sensitivity / hurt feelings	0.2	0.3	0.5	0.1	-0.5	-0.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	1.7	1.3	-0.9	-1.3
Hearing difficulty/problems: Yes	0.3	0.4	0.6	-0.8	-0.6	-0.4
Relative age of first facial hair	1.0	2.1	3.2	1.8	-0.7	-1.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	1.2	0.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.2	0.6	-0.2
Ever had hysterectomy (womb removed)	2.1	2.4	4.5	0.1	2.1	1.6
Systolic blood pressure, automated reading	2.7	7.9	14.6	-0.7	3.8	2.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	-0.1	0.9	0.5
Angina	0.3	0.4	0.9	0.0	1.0	0.6
Medication for hormone replacement therapy	0.3	0.4	0.6	0.7	0.8	0.2
Vitamin and mineral supplements	1.1	1.5	2.1	1.3	-0.8	-1.5
Supplements: Zinc	0.6	0.7	1.5	0.5	0.4	1.2
Medication: Co-codamol	0.5	0.5	1.2	1.1	0.6	0.0
Medication: Metformin	2.1	3.0	4.8	1.3	2.2	1.6
Diabetes (father)	0.9	1.1	1.7	0.3	1.2	1.3
Diabetes (mother)	0.6	0.8	1.2	-0.5	-1.0	-1.1
Severe depression (siblings)	0.2	0.2	0.7	0.2	-0.8	-0.1
Pack years adult smoking proportion	1.2	1.9	2.2	1.3	1.5	1.2
Impedance of leg (right)	0.3	1.2	2.0	-1.4	1.0	0.8
Leg fat-free mass (left)	1.3	6.8	8.8	3.0	-2.1	-2.7
Trunk fat percentage	0.1	0.2	0.4	0.6	0.4	0.2
Hand grip strength (right)	0.6	1.7	4.5	-0.2	-2.1	-0.9
Townsend deprivation index at recruitment	0.8	1.1	1.9	0.4	1.1	1.4
Current tobacco smoking	0.5	0.8	1.7	-0.4	-1.3	-0.6
Average weekly fortified wine intake	0.2	0.2	0.4	0.1	-0.6	-0.5
Maternal smoking around birth	0.2	0.2	0.6	0.2	-0.3	-0.8
Fed-up feelings	0.4	0.8	2.1	-1.5	0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.0	0.9	-0.9	-1.4
Relative age voice broke	0.6	0.9	2.0	1.4	-0.3	-0.9
Taking other prescription medications	0.6	0.9	2.0	0.4	-0.8	-1.4
Age when periods started (menarche)	0.3	0.6	0.9	-0.5	-0.9	-0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.8	0.9	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	-1.4	-0.5	0.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.6	1.6	-0.8	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.8	0.0	-0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.7	0.5	-0.4
High blood pressure	1.2	3.3	6.0	0.1	2.4	2.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.7	-0.6	-0.3
Multivitamins +/- minerals	3.4	4.3	6.0	-2.5	1.4	2.2
Stomach or abdominal pain in last month	0.3	0.4	0.9	1.0	0.5	0.3
Supplements: Glucosamine	0.1	0.1	0.4	-0.1	-0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.1	-0.3
Medication: Atenolol	2.1	2.6	4.4	-1.3	2.1	1.4
Medication: Levothyroxine sodium	1.1	1.9	3.1	-0.7	1.4	1.8
Sitting height	1.0	7.0	7.8	2.8	-2.3	-2.8
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.5	0.1	0.2
High blood pressure (mother)	0.7	1.0	2.2	1.5	0.5	-0.7
Body mass index (BMI)	0.1	0.3	0.8	0.9	0.0	-0.4
Impedance of leg (left)	0.3	1.6	2.8	-1.7	0.8	1.1
Leg predicted mass (left)	1.3	6.8	8.8	3.0	-2.1	-2.7
Trunk fat mass	0.2	0.8	1.8	1.3	-0.3	-0.7
Waist circumference	0.1	0.3	0.6	0.3	-0.5	-0.8
Number of incorrect matches in round	0.3	0.5	1.2	1.1	0.2	0.5
Past tobacco smoking	0.1	0.1	0.3	-0.1	-0.6	-0.3
Alcohol usually taken with meals	0.1	0.2	0.5	-0.2	-0.1	0.7
Nervous feelings	0.3	0.5	1.4	-1.2	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.4	0.6	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.9	-0.5	0.1
Hair/balding pattern: Pattern 2	1.6	2.0	4.2	-2.1	-1.3	0.1
Had menopause	2.3	2.8	6.7	-2.6	1.0	1.0
Had other major operations	1.0	1.2	2.1	-1.5	1.0	0.7
Forced vital capacity (FVC)	2.3	8.8	12.4	1.5	-3.5	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.5	-2.1	-0.1	1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.1	-1.5	-0.6	-0.8
Qualifications: None of the above	0.9	2.0	2.5	-1.3	1.6	1.3
Financial difficulties in last 2 years	0.3	0.5	1.0	0.6	-1.0	0.1
Mouth/teeth dental problems	0.8	1.2	2.1	-1.5	0.8	0.8
Heart attack	1.0	1.2	2.9	-0.3	1.7	0.8
Allergy	0.6	1.5	2.8	-1.0	1.7	0.8
Pain all over the body in last month	0.0	0.1	0.1	-0.2	0.3	0.0
Diabetes (self-reported)	2.3	3.5	6.8	0.0	2.6	1.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	0.2	0.9	1.1
Medication: Ramipril	1.4	1.9	2.9	-1.3	1.7	1.0
Medication: Simvastatin	0.5	0.8	1.5	-1.2	1.0	-0.0
Fluid intelligence score	0.2	0.3	0.6	-0.5	-0.8	-0.4
Illnesses of siblings	2.6	3.6	8.5	-0.3	-2.9	-1.5
Neuroticism score	0.5	0.9	2.3	0.1	-0.7	-1.5
Weight	0.6	2.9	3.4	1.9	-1.4	-1.8
Impedance of arm (right)	0.3	1.6	2.5	-1.6	0.6	1.3
Arm fat percentage (right)	0.0	0.2	0.2	0.4	0.5	0.4
Trunk fat-free mass	1.9	11.2	15.4	3.0	-3.0	-3.9
Hip circumference	0.2	1.0	2.3	0.3	-0.8	-1.5
Time employed in main current job	0.6	0.7	0.8	-0.8	0.7	0.9
Alcohol intake versus 10 years previously	0.9	1.4	2.8	0.4	1.1	1.7
Father’s age at death	0.7	0.9	2.4	-0.6	-1.6	-0.1
Worrier / anxious feelings	1.3	2.4	5.5	-2.4	1.2	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.8	0.3	-1.5	-2.2
Falls in the last year	0.9	1.2	3.3	1.8	0.4	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.5	-0.8	-0.1
Number of live births	2.1	3.0	4.0	-1.2	2.0	1.9
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	8.1	1.3	-2.2	-2.8
Pulse rate	0.8	1.4	3.8	1.9	-0.4	-0.6
Happiness	0.5	0.6	1.5	1.2	-0.3	-0.4
Noisy workplace	1.5	1.8	2.7	1.1	-1.2	-1.6
Qualifications: A levels/AS levels or equivalent	1.8	4.1	6.0	1.3	-2.5	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.2	0.3	2.1	1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	1.1	-1.1	1.0	1.0
Asthma	1.0	2.0	3.8	-0.8	-1.9	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-0.8	-1.1	0.3
Medication: Cholesterol lowering	0.3	0.5	1.0	0.7	1.0	-0.1
Depression (self-reported)	0.3	0.4	0.7	-0.8	-0.5	0.3
Medication: Lansoprazole	0.2	0.2	0.6	0.1	-0.1	-0.8
Prospective memory result	1.8	2.2	3.4	-0.9	1.6	1.8
Lung cancer (father)	3.1	3.6	5.6	1.0	-2.4	-2.1
Illnesses of mother	1.1	1.4	3.5	-0.8	0.3	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	5.2	1.7	-1.6	-2.3
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	1.5	0.9	0.7
Impedance of arm (left)	0.2	0.8	1.3	-0.9	0.4	1.2
Arm fat mass (right)	0.2	1.0	1.8	1.3	-0.6	-0.9
Trunk predicted mass	2.0	11.2	15.4	3.0	-3.0	-3.9
Standing height	1.1	10.6	13.3	2.5	-3.5	-3.6
Length of working week for main job	0.6	0.7	1.3	-0.6	-1.2	-0.6
Exposure to tobacco smoke at home	0.1	0.2	0.3	0.5	-0.4	0.3
Breastfed as a baby	5.7	7.0	9.7	2.2	-2.6	-3.1
Tense / ‘highly strung’	0.9	1.5	2.6	-1.6	0.9	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.4	-2.1	-0.4	-0.2
Hair/balding pattern: Pattern 4	0.7	1.7	2.5	-1.1	-1.2	-1.6
Birth weight of first child	3.3	5.9	10.5	-0.7	-3.2	-2.6
Peak expiratory flow (PEF)	1.8	4.3	7.4	-0.7	-2.2	-2.7
Pulse wave reflection index	0.2	0.3	0.7	0.1	0.4	0.8
Ever highly irritable/argumentative for 2 days	2.5	3.0	5.7	-0.1	-1.9	-2.4
Loud music exposure frequency	5.3	5.8	11.0	1.6	-1.9	-3.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.9	0.2	-1.7	-1.1
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	8.4	2.9	-1.4	-1.1
Blood clot in the leg (DVT)	0.7	0.9	1.4	-0.1	1.1	1.2
Medication: Paracetamol	0.5	0.8	2.2	1.5	0.4	-0.1
Headache pain in last month	0.4	0.7	1.3	0.1	1.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	-0.1	-1.4	-0.7
Glaucoma (self-reported)	2.0	2.3	4.8	1.4	2.2	0.0
Gout (self-reported)	0.8	1.2	2.5	-0.9	-1.6	-0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.1	-0.9	1.4	1.3
Medication: Amlodipine	0.1	0.1	0.2	-0.3	-0.4	-0.1
Medication: Ventolin 100micrograms inhaler	2.6	3.3	6.7	-0.8	-2.6	-1.6
Birth weight	1.3	2.8	5.8	0.1	-2.4	-1.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.6	0.7	-1.0	-1.3
High blood pressure (siblings)	3.2	4.6	8.3	-1.1	2.9	2.0
Forced vital capacity (FVC), Best measure	1.3	4.7	7.0	1.2	-2.4	-2.6
Body fat percentage	0.1	0.3	0.4	0.5	0.6	0.5
Leg fat percentage (right)	0.1	0.2	0.6	-0.2	0.8	0.1
Arm fat-free mass (right)	1.5	7.9	11.3	3.4	-1.9	-2.9
Exposure to tobacco smoke outside home	0.2	0.3	0.8	0.9	0.1	-0.2
Comparative body size at age 10	0.3	0.9	1.8	1.3	-0.2	-0.9
Number of full brothers	0.3	0.4	0.8	0.1	0.9	0.6
Worry too long after embarrassment	0.3	0.5	0.9	0.9	0.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.5	-0.2	-0.6	-1.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	-0.1	-1.3	0.2
Number of children fathered	0.9	1.0	1.4	-0.5	1.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.2	1.1	1.0	0.9
Age at first live birth	0.1	0.2	0.5	0.7	-0.1	-0.2
Pulse wave peak to peak time	1.0	1.1	1.5	-1.2	-1.0	-0.9
Health satisfaction	0.6	0.8	1.3	-0.1	-1.1	-1.0
Shortness of breath walking on level ground	0.2	0.2	0.3	0.5	-0.6	-0.4
Qualifications: College or University degree	1.0	3.2	5.4	2.3	-1.4	-1.4
Eye problems/disorders: None of the above	1.5	1.8	3.4	-1.8	0.3	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.2	0.9	-0.2
Emphysema/chronic bronchitis	2.1	2.4	5.2	-0.2	-2.3	-1.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.8	0.4	0.5
Neck or shoulder pain in last month	2.9	4.1	8.4	-0.1	2.0	2.9
Medication: Blood pressure	0.7	1.3	1.5	-1.1	1.2	1.0
Angina (self-reported)	0.2	0.3	0.6	0.0	0.8	0.5
Migraine (self-reported)	0.4	0.5	0.9	-0.1	-0.9	-0.8
Medication: Ibuprofen	0.5	0.5	0.9	-0.4	-0.8	0.9
Medication: Allopurinol	1.1	1.5	3.8	-0.2	-1.9	-0.8
Medication: Omeprazole	0.8	0.9	1.4	0.9	-0.7	-1.2
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.0	0.0	1.1
Mean time to correctly identify matches	0.3	0.5	1.6	-1.2	-0.0	0.3
Heart disease (mother)	0.3	0.4	0.6	-0.6	0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.0	7.8	-0.7	-2.8	-1.9
Whole body fat mass	0.1	0.6	1.4	1.2	-0.2	-0.5
Leg fat mass (right)	0.1	0.4	0.9	1.0	0.1	-0.5
Arm predicted mass (right)	1.5	7.9	9.9	3.1	-2.1	-3.0
Pulse rate, automated reading	0.6	1.9	5.4	2.3	-0.1	-0.5
Alcohol intake frequency.	0.9	2.1	3.3	0.7	-1.8	-1.5
Comparative height size at age 10	1.3	7.2	13.4	0.9	-3.7	-2.7
Number of full sisters	0.6	0.7	2.0	-1.4	0.0	0.1
Suffer from ‘nerves’	0.6	1.0	1.7	-0.4	-1.0	-1.3
Overall health rating	0.1	0.3	0.6	0.4	-0.1	-0.8
Chest pain or discomfort	0.2	0.4	1.0	-1.0	-0.1	0.1
Had major operations	0.5	0.6	0.8	-0.9	-0.9	-0.3
Age at last live birth	1.1	1.6	2.6	0.0	1.6	1.5
Family relationship satisfaction	1.1	1.3	1.8	0.7	-1.3	-1.4
Leg pain on walking	0.1	0.1	0.3	0.2	0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.6	0.0	-0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.5	-0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.3	-1.1	-0.0	0.2
Medication: Aspirin	0.2	0.3	0.7	-0.8	-0.1	-0.5
Supplements: Vitamin C	0.2	0.2	0.4	0.2	-0.4	-0.6
Knee pain experienced in last month	3.0	4.6	6.2	2.2	2.5	1.7
Hypertension (Self-reported)	0.7	2.1	3.8	-0.3	1.9	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.4	-0.5	-1.1
Illnesses of father: Heart disease	0.1	0.1	0.2	0.1	0.3	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.4	0.5	0.4
Smoking status: Previous	2.1	3.1	5.2	0.3	2.3	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	6.8	1.0	-2.0	-2.6
Whole body fat-free mass	1.7	9.4	12.1	3.0	-2.7	-3.5
Leg fat-free mass (right)	1.2	6.6	8.3	2.9	-2.2	-2.6
Arm fat percentage (left)	0.1	0.4	0.9	0.9	0.4	0.3
Average weekly red wine intake	0.4	0.6	1.6	0.1	1.3	0.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.1	-0.3	1.5	1.3
Mood swings	0.3	0.5	1.1	0.4	1.1	0.2
Loneliness, isolation	0.6	0.8	1.3	1.0	0.1	-1.1
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.6	-0.1	-0.4
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	-0.3	-0.3
Diabetes diagnosed by doctor	3.2	5.2	10.0	0.7	3.2	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.6	1.1	-2.1	0.2
Friendships satisfaction	0.2	0.2	0.4	-0.4	0.1	-0.6
Qualifications: nursing, teaching	0.7	1.0	3.0	1.7	-0.1	-0.3
Commuting to job workplace: Walk	1.2	1.3	2.9	-0.7	0.6	1.7
Eye problems/disorders: Cataract	1.4	1.6	2.5	0.5	-1.4	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.0	1.0	-0.6	-0.8
Medication for cholesterol	1.3	2.0	3.3	0.0	-1.8	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	2.7	-1.4	1.6	1.0
Back pain experienced in last month	0.7	1.1	2.3	1.5	0.5	0.8
Mineral and other dietary supplements	0.3	0.4	0.8	0.6	0.2	-0.9
Breast cancer (self-reported)	0.2	0.3	0.8	-0.9	0.1	0.2
Asthma (self-reported)	1.1	2.2	4.0	-0.5	-2.0	-1.5
Osteoporosis (self-reported)	2.6	3.2	5.2	-0.6	2.0	2.3
Osteoarthritis (self-reported)	1.2	1.5	2.7	0.5	1.3	1.6
Medication: Aspirin	0.2	0.3	0.6	-0.7	-0.2	-0.5
Medication: Gliclazide	1.1	1.2	1.9	-0.4	1.4	1.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.3	1.1	-1.0	-0.6
Smoking status: Current	0.8	1.3	2.7	-0.2	-1.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.2	0.4	-1.4	-1.5
Whole body water mass	1.6	9.4	11.9	3.1	-2.6	-3.4
Leg predicted mass (right)	1.2	6.6	7.9	2.8	-2.3	-2.6
Arm fat mass (left)	0.3	1.4	2.9	1.7	-0.6	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	0.8	0.4	0.1
Average weekly champagne plus white wine intake	0.3	0.5	1.1	1.1	-0.2	0.5
Miserableness	1.7	2.9	4.5	0.0	-2.0	-2.1
Guilty feelings	0.8	1.2	2.0	1.0	-0.8	-1.4
Wears glasses or contact lenses	1.0	1.2	3.2	1.8	-0.4	-0.5
Ever taken oral contraceptive pill	4.3	4.8	9.2	-0.1	-3.0	-2.3
Hearing aid user	0.8	0.9	1.4	1.0	1.2	0.7
Mother’s age at death	1.0	1.3	3.6	-1.9	-0.4	-0.2
Financial situation satisfaction	0.1	0.1	0.3	-0.3	-0.5	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	0.1	-1.0	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.1	-0.5	0.1
Eye problems/disorders: Glaucoma	2.2	2.6	4.0	2.0	2.0	-0.3
Medication: Blood pressure	0.8	1.6	2.2	0.6	1.5	1.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	1.4	0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.7	-1.3	0.3	0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	0.3	0.4	0.1
Medication: Bendroflumethiazide	1.7	2.5	3.0	-1.7	1.7	1.3
Medication: Paracetamol	0.7	1.1	2.9	1.7	0.5	-0.1
Medication: Lisinopril	1.0	1.3	1.5	1.2	1.0	1.2
Medication: Atorvastatin	0.4	0.5	1.4	1.2	0.3	0.3
Illnesses of father: High blood pressure	2.6	3.2	5.7	-0.5	2.4	1.9
Alcohol drinker status: Never	0.3	0.3	0.9	1.0	-0.0	-0.0
Ever smoked	0.1	0.2	0.5	-0.2	-0.2	-0.7
Basal metabolic rate	1.4	8.0	9.8	2.9	-2.4	-3.1
Leg fat percentage (left)	0.1	0.3	0.6	-0.3	0.8	0.6
Arm fat-free mass (left)	1.2	5.9	7.8	2.3	-2.1	-2.8
Number of operations (self-reported)	0.1	0.1	0.3	-0.6	-0.1	-0.2
Average weekly beer plus cider intake	0.5	0.7	1.4	0.4	0.7	1.2
Irritability	2.2	3.7	6.0	-0.3	-2.2	-2.4
Risk taking	1.6	2.3	4.4	0.2	1.6	2.1
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.0	1.2	0.1	-1.4
Fractured/broken bones in last 5 years	0.6	0.8	1.2	0.6	0.9	1.1
Age started oral contraceptive pill	0.4	0.5	0.9	-0.6	0.5	0.9
Diastolic blood pressure, automated reading	0.5	1.7	2.4	0.7	1.6	1.5
Ever depressed for a whole week	2.1	2.6	4.8	-2.2	-0.8	-1.6
Unable to work because of sickness or disability	0.2	0.3	0.6	0.2	0.7	0.5
Commuting to job workplace: Cycle	0.7	0.8	1.0	-1.0	0.9	0.9
Myopia	0.2	0.4	0.6	0.1	0.7	0.8
Vascular/heart problems diagnosed by doctor	1.5	4.1	8.3	0.2	-2.9	-2.0
Cholesterol lowering medication	3.0	4.5	6.8	-1.5	2.0	2.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.6	-0.6	-1.0
Pain experienced in last month	2.0	3.3	4.1	-1.7	-2.0	-1.7
Supplements: Calcium	2.3	2.5	3.8	-1.6	1.2	1.9
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-0.3	-1.1	-1.0
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.9	-0.4	2.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.2	0.8	0.7
Heart disease (siblings)	1.7	2.0	5.7	0.3	2.4	0.5
Alcohol drinker status: Previous	0.4	0.4	0.9	-0.2	-0.9	-0.6
Pack years of smoking	1.1	1.6	1.8	1.4	1.3	1.1
Impedance of whole body	0.3	1.6	2.1	-1.5	0.8	1.5
Leg fat mass (left)	0.1	0.4	1.0	1.0	0.1	-0.3
Arm predicted mass (left)	1.2	5.9	8.0	2.3	-2.1	-2.8