Best TWAS P=2.91e-19 · Best GWAS P=5.98e-33 conditioned to 3.06e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TCF7L2 | 0.19 | 0.09 | lasso | 6 | 0.05 | 1.0e-03 | 5.6 | -5.2 | 1.7e-07 | 0.06 | 0.39 | 0.57 | TRUE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADRB1 | 0.16 | 0.03 | enet | 31 | 0.07 | 4.1e-08 | -11.9 | 9.0 | 2.9e-19 | -0.40 | 0.00 | 0.97 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | C10orf118 | 0.03 | 0.01 | blup | 42 | 0.02 | 1.9e-03 | -4.2 | 6.9 | 6.0e-12 | -0.17 | 0.02 | 0.42 | TRUE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GPAM | 0.04 | 0.02 | enet | 7 | 0.03 | 5.1e-04 | -4.6 | 5.2 | 1.9e-07 | -0.02 | 0.01 | 0.82 | TRUE |