TWAS hub - C10orf118

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Stomach	0.1560	0.0570	0.0058	0.012	NA	-0.005	NA	0.001	0.085	NA	0.7400	NA	0.280
2	TCGA	Lung Adenocarcinoma	0.0298	0.0179	0.0053	0.011	0.02	0.014	NA	0.008	0.017	0.0019	0.0071	NA	0.038

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Cardiovascular Disease	6.9	22.8	45.6	-0.1	6.8
Vascular/heart problems diagnosed by doctor	6.5	17.7	35.5	0.2	-6.0
Diastolic blood pressure, automated reading	6.4	19.9	39.9	-0.1	6.3
High blood pressure	5.8	16.0	32.0	0.2	5.7
Hypertension (Self-reported)	5.8	16.0	31.5	0.7	5.6
Medication: Amlodipine	5.1	7.1	14.2	0.1	3.8
Systolic Blood Pressure	4.8	23.8	47.3	0.6	6.9
High blood pressure (mother)	4.4	6.2	12.3	0.3	3.5
Medication: Ramipril	4.2	5.4	9.7	-1.1	3.1
Medication: Blood pressure	4.1	7.3	14.5	0.3	3.8
Hair/balding pattern: Pattern 2	3.9	5.0	9.8	3.1	0.5
Medication: Blood pressure	3.9	7.4	14.7	0.3	3.8
Leg predicted mass (right)	3.6	19.5	31.4	-2.8	5.6
Leg fat-free mass (left)	3.5	18.8	30.7	-2.6	5.5
Diverticular disease/diverticulitis (self-reported)	3.5	4.2	8.4	0.1	2.9
Leg predicted mass (left)	3.5	18.5	29.8	-2.7	5.5
Birth weight	3.5	7.6	14.3	0.9	3.8
Leg fat-free mass (right)	3.5	18.9	30.8	-2.6	5.5
High blood pressure (siblings)	3.4	5.0	8.0	1.4	2.8
Medication: Lisinopril	3.2	4.2	4.3	2.0	2.1
Basal metabolic rate	3.2	17.5	29.6	-2.3	5.4
Whole body fat-free mass	3.1	17.6	29.6	-2.4	5.4
Tinnitus: Yes, now most or all of the time	3.0	3.5	4.6	1.6	2.1
Systolic blood pressure, automated reading	2.9	8.4	15.4	1.2	3.9
Pack years adult smoking proportion	2.9	4.4	8.3	-0.6	2.9
Whole body water mass	2.9	16.7	28.2	-2.3	5.3
Medication: Bendroflumethiazide	2.8	4.2	4.4	2.0	2.1
Age started oral contraceptive pill	2.8	3.5	4.8	1.5	-2.2
Medication: Co-codamol	2.6	3.1	5.8	-0.6	-2.4
Illnesses of siblings	2.6	3.7	4.1	-2.0	-1.8
Trunk fat-free mass	2.6	15.1	26.2	-2.0	5.1
Trunk predicted mass	2.6	14.9	25.9	-2.0	5.1
Arm predicted mass (right)	2.6	13.2	21.9	-2.1	4.7
Weight	2.5	12.4	21.6	-1.8	4.6
Hip circumference	2.5	10.7	16.9	-2.1	4.1
Happiness	2.5	3.0	4.8	-1.2	-2.2
Prospective memory result	2.5	3.1	4.2	2.1	-1.4
Arm fat-free mass (right)	2.5	12.6	20.8	-2.1	4.6
Arm fat-free mass (left)	2.5	12.7	21.3	-2.0	4.6
Emphysema/chronic bronchitis	2.4	2.7	5.4	-2.3	0.1
Arm predicted mass (left)	2.4	12.4	21.3	-1.9	4.6
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	4.5	-2.1	-1.0
Father’s age at death	2.3	3.0	3.2	1.8	-1.7
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.2	-2.7	0.2
Illnesses of mother	2.2	2.7	5.2	0.4	-2.3
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	7.2	-0.2	-2.7
Alcohol usually taken with meals	2.1	3.4	6.5	0.5	-2.5
Blood White Count	2.0	14.9	29.6	-0.4	5.4
Waist circumference	2.0	7.5	12.9	-1.4	3.6
Had other major operations	2.0	2.4	4.6	2.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.3	3.9	0.9	-2.0
Fractured/broken bones in last 5 years	2.0	2.6	4.7	0.7	2.2
Crohns Disease (2012)	1.9	3.0	4.0	1.4	-2.0
Medication for hormone replacement therapy	1.9	2.1	3.9	-0.6	-2.0
Arm fat mass (right)	1.9	7.8	13.7	-1.4	3.7
Whole body fat mass	1.9	7.9	13.9	-1.4	3.7
Commuting to job workplace: Cycle	1.9	2.3	4.6	2.1	-0.3
Average weekly spirits intake	1.8	2.2	3.2	1.8	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.4	-1.2	-1.8
Relative age voice broke	1.8	2.8	3.2	-1.8	1.6
Mood swings	1.8	3.3	5.3	-2.3	1.1
Arm fat mass (left)	1.8	7.5	13.0	-1.4	3.6
Prostate Cancer	1.7	2.3	3.0	1.7	-1.3
Angina	1.7	2.3	2.4	-1.6	1.5
Impedance of leg (right)	1.7	8.1	10.2	2.4	-3.2
Fed-up feelings	1.7	3.1	6.2	-2.5	0.1
Trunk fat mass	1.7	7.2	13.0	-1.2	3.6
Number of children fathered	1.7	1.9	3.5	-1.9	-0.6
Breast Cancer	1.6	3.9	4.1	-1.9	2.0
Sitting height	1.6	11.3	21.3	-1.2	4.6
Impedance of leg (left)	1.6	7.9	10.7	2.3	-3.3
Leg fat mass (right)	1.6	6.0	11.1	-1.0	3.3
Pack years of smoking	1.6	2.4	4.6	-0.3	2.1
Leg fat mass (left)	1.6	6.3	11.1	-1.2	3.3
HDL Cholesterol	1.5	2.4	3.0	1.7	1.4
Medication: Atenolol	1.5	1.9	2.8	-1.7	1.0
Angina (self-reported)	1.5	2.0	2.2	-1.3	1.5
Mineral and other dietary supplements	1.5	2.0	4.0	0.2	2.0
Basal cell carcinoma (self-reported)	1.5	1.8	3.6	-0.2	-1.9
Bipolar Disorder (2011)	1.4	1.4	1.8	1.3	1.0
Mean time to correctly identify matches	1.4	2.7	3.5	1.9	-1.4
Friendships satisfaction	1.4	1.7	3.3	-0.4	-1.8
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.5	1.9	0.2
Average weekly beer plus cider intake	1.4	2.0	3.8	-1.9	-0.4
Depression (Nagel 2018)	1.3	2.0	2.9	-1.1	-1.7
Chronic bronchitis/emphysema (father)	1.3	1.5	3.0	1.7	0.2
Noisy workplace	1.3	1.7	2.2	-1.1	-1.5
Knee pain experienced in last month	1.3	2.0	3.8	2.0	-0.4
Loneliness, isolation	1.3	1.9	3.5	-1.9	-0.4
Mother’s age at death	1.3	1.6	2.0	-1.1	-1.4
Heart disease (siblings)	1.3	1.6	3.1	1.8	0.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.4	-1.6	-1.0
Body mass index (BMI)	1.2	5.1	8.5	-1.4	2.9
Neuroticism score	1.2	2.5	4.1	-2.0	1.0
Arm fat percentage (right)	1.2	4.8	8.4	-1.1	2.9
Medication: Gliclazide	1.2	1.3	1.6	-1.0	-1.3
Illnesses of father: High blood pressure	1.2	1.5	2.5	-1.6	0.7
Risk taking	1.2	1.7	1.8	1.3	1.3
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.2	-0.8	1.5
Impedance of whole body	1.2	6.2	8.3	2.0	-2.9
Alzheimer’s Disease (in father)	1.1	1.2	2.2	0.4	-1.5
Mean Putamen Volume	1.1	1.3	1.3	1.1	-1.1
Rheumatoid Arthritis	1.1	1.5	2.2	-1.5	-0.9
BMI	1.1	6.6	12.2	-0.9	3.5
Hair/balding pattern: Pattern 3	1.1	1.6	3.2	-1.8	0.1
Standing height	1.1	10.5	19.4	-1.3	4.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	3.8	-0.9	2.0
Ever had bowel cancer screening	1.1	1.3	2.6	1.6	0.1
Osteoporosis (self-reported)	1.1	1.3	2.5	0.4	-1.6
Miserableness	1.1	1.9	2.7	-1.1	1.6
Irritability	1.1	1.9	3.4	-1.8	0.6
Blood Eosinophil Count	1.0	7.6	14.6	-0.8	3.8
Chronotype (morning person)	1.0	2.2	3.9	0.7	-2.0
Had menopause	1.0	1.2	2.1	0.6	-1.4
Lung cancer (father)	1.0	1.1	1.8	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.0	-1.7	0.3
Comparative height size at age 10	1.0	5.4	10.7	0.1	3.3
Illnesses of siblings: Diabetes	1.0	1.2	2.1	-0.5	1.5
Arm fat percentage (left)	1.0	4.0	7.1	-1.0	2.7
Long-standing illness, disability or infirmity	1.0	1.5	3.0	0.2	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.0	-0.4	-2.0
Average weekly champagne plus white wine intake	1.0	1.3	2.5	0.5	-1.6
Financial situation satisfaction	1.0	1.3	2.5	-1.6	-0.2
Number of operations (self-reported)	1.0	1.4	2.7	1.6	-0.4
Ever depressed for a whole week	1.0	1.2	1.5	-1.2	-0.9
Crohns Disease (2017)	0.9	2.0	3.7	0.5	-1.9
Reaction Time	0.9	1.8	2.3	1.1	-1.5
Body Mass Index (BMI) (2010)	0.9	1.2	2.1	-1.4	0.6
Primary Biliary Cirrhosis	0.9	1.3	1.7	1.3	1.0
Severe depression (siblings)	0.9	1.1	2.1	1.5	-0.0
Average weekly fortified wine intake	0.9	1.1	2.0	1.4	0.4
Medication: Simvastatin	0.9	1.4	2.8	0.1	1.7
Depression (self-reported)	0.9	1.1	1.9	-0.6	-1.4
Breastfed as a baby	0.9	1.1	2.2	-0.2	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.6	-1.3	-0.8
Number of self-reported non-cancer illnesses	0.9	1.5	3.0	0.2	1.7
Wears glasses or contact lenses	0.9	1.1	2.1	1.5	-0.1
Ovarian Cancer	0.8	1.1	2.1	-1.4	-0.3
Fasting Glucose	0.8	0.9	1.6	0.5	-1.2
Lupus	0.8	1.2	2.0	0.7	1.4
Ulcerative Colitis	0.8	1.1	2.3	-1.5	0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.0	1.0	-0.9
Supplements: Glucosamine	0.8	1.0	2.0	-0.1	-1.4
Hair/balding pattern: Pattern 4	0.8	1.9	3.5	-1.9	0.5
Exposure to tobacco smoke outside home	0.8	1.0	2.0	-0.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.8	1.3	0.0
Medication for pain relief, constipation, heartburn	0.8	1.4	2.4	-0.7	-1.5
Leg pain on walking	0.8	1.0	1.9	1.4	0.3
Osteoarthritis (self-reported)	0.8	1.0	1.5	-0.8	-1.2
Bipolar Disorder (2018)	0.7	1.1	1.9	0.4	-1.4
Depressed Affect (Nagel 2018)	0.7	1.6	2.7	-1.6	0.7
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.9	2.0	0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.7	-1.6	-0.1
Number of treatments/medications taken	0.7	1.2	1.7	1.3	0.8
Sensitivity / hurt feelings	0.7	1.2	1.7	-0.9	1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	-1.2	-0.3
Trunk fat percentage	0.7	2.8	5.3	-0.6	2.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.0	-0.7	1.0
Pain all over the body in last month	0.7	0.8	1.4	0.4	1.2
Medication: Lansoprazole	0.7	0.8	1.6	1.3	0.1
Impedance of arm (left)	0.7	3.4	5.0	1.3	-2.2
Tense / ‘highly strung’	0.7	1.2	1.9	-1.4	0.6
Headache pain in last month	0.7	1.2	1.6	1.3	1.0
Gout (self-reported)	0.7	1.0	2.0	-1.4	-0.1
Body fat percentage	0.7	2.7	5.0	-0.6	2.2
Average weekly red wine intake	0.7	1.0	2.0	1.4	0.2
Medication: Paracetamol	0.7	1.2	1.2	1.1	1.1
Major Depression (MDD)	0.6	0.8	1.5	-1.2	-0.3
Coronary Artery Disease (CAD)	0.6	0.8	1.4	1.2	0.4
Schizophrenia (2014)	0.6	1.3	1.9	-0.9	-1.4
Triglycerides	0.6	0.9	1.4	-0.7	1.2
Smoking Status	0.6	1.5	2.4	-0.8	1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	0.2	-1.2
Forced vital capacity (FVC)	0.6	2.3	3.4	-1.1	1.9
Diabetes (self-reported)	0.6	0.9	1.3	-1.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	3.2	-1.1	1.8
Birth weight of first child	0.6	1.0	1.4	-0.8	1.2
Wheeze or whistling in the chest in last year	0.6	1.0	1.7	-1.3	0.6
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.5	-1.1
Medication: Omeprazole	0.6	0.7	1.0	-0.6	1.0
Overall health rating	0.6	1.2	1.8	-1.4	0.8
Medication for cholesterol	0.6	0.9	1.7	0.2	-1.3
Ever taken oral contraceptive pill	0.6	0.7	1.4	-1.2	-0.1
Medication: Atorvastatin	0.6	0.7	1.2	0.5	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.2	2.4	-0.2	-1.5
Ulcerative Colitis (UC)	0.5	0.9	1.7	-1.3	0.1
Relative age of first facial hair	0.5	1.0	1.0	-1.0	1.0
Supplements: Zinc	0.5	0.5	0.8	0.5	-0.9
Medication: Metformin	0.5	0.7	1.4	-1.2	0.0
Hand grip strength (right)	0.5	1.4	2.4	-0.7	1.6
Current tobacco smoking	0.5	0.8	1.0	-0.8	1.0
Peak expiratory flow (PEF)	0.5	1.2	2.4	-0.3	1.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	1.0	0.4
Qualifications: College or University degree	0.5	1.6	2.0	1.0	-1.4
Medication: Ibuprofen	0.5	0.5	0.8	0.9	-0.5
Medication: Allopurinol	0.5	0.7	1.4	-1.2	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.7	0.9	-1.0	-0.6
Diabetes diagnosed by doctor	0.5	0.9	1.7	-1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	1.1	-0.3
Smoking status: Current	0.5	0.8	0.9	-0.8	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.0	-0.6	-1.0
Supplements: Calcium	0.5	0.6	1.1	1.0	-0.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.1	-1.1	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	0.2	-0.9
Allergy or Eczema	0.4	1.0	1.9	-0.2	-1.4
Diabetes (father)	0.4	0.5	0.7	-0.8	-0.6
Multivitamins +/- minerals	0.4	0.6	0.7	-0.7	0.8
Number of incorrect matches in round	0.4	0.7	1.3	1.1	-0.2
Falls in the last year	0.4	0.5	0.6	-0.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	1.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.4	-1.0	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.4	1.2	0.0
Medication: Paracetamol	0.4	0.7	1.2	1.1	0.5
Forced vital capacity (FVC), Best measure	0.4	1.6	2.2	-1.0	1.5
Comparative body size at age 10	0.4	1.1	2.1	-1.5	-0.1
Number of full brothers	0.4	0.5	0.6	0.6	0.8
Worry too long after embarrassment	0.4	0.6	0.6	0.8	0.8
Heart disease (mother)	0.4	0.5	0.7	-0.5	0.8
Family relationship satisfaction	0.4	0.5	0.9	-0.9	0.3
Back pain experienced in last month	0.4	0.5	0.8	0.5	0.9
Guilty feelings	0.4	0.6	0.6	-0.7	-0.8
Myopia	0.4	0.6	1.1	-0.1	1.1
Cholesterol lowering medication	0.4	0.6	1.1	-0.3	1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-0.0	1.0
Schizophrenia (2018)	0.3	0.5	0.7	-0.6	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	1.2	-0.3
Neuroticism (2016)	0.3	0.4	0.6	-0.8	-0.4
Blood Red Count	0.3	2.5	3.7	1.1	1.9
Height	0.3	5.3	9.9	-0.9	3.1
Lung FVC	0.3	1.4	1.8	-1.4	-0.9
Maternal smoking around birth	0.3	0.4	0.4	0.6	0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.9	0.0
Serious illness, injury or assault to yourself	0.3	0.4	0.8	0.9	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	-0.7	-0.9
Medication: Levothyroxine sodium	0.3	0.6	0.9	0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.6	-0.6	-0.8
Allergy	0.3	0.7	0.8	0.7	0.9
Impedance of arm (right)	0.3	1.4	1.6	1.1	-1.3
Time employed in main current job	0.3	0.3	0.6	-0.1	-0.8
Worrier / anxious feelings	0.3	0.5	1.1	-0.0	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	0.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.6	0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.8	0.5
Loud music exposure frequency	0.3	0.3	0.6	-0.8	0.2
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.0	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.0	-0.8
Eye problems/disorders: None of the above	0.3	0.4	0.4	0.7	0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.5	0.7	0.5
Migraine (self-reported)	0.3	0.4	0.7	0.9	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.8	0.4
Pulse rate, automated reading	0.3	1.0	2.0	-1.4	0.2
Age at last live birth	0.3	0.5	0.9	-1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	-0.8	-0.4
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.9	0.2
Qualifications: nursing, teaching	0.3	0.5	0.8	0.5	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.0	-0.8
Breast cancer (self-reported)	0.3	0.4	0.6	0.8	0.5
Medication: Aspirin	0.3	0.4	0.7	0.1	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.8	-0.4
Hearing aid user	0.3	0.4	0.8	-0.0	0.9
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.2	0.8
Unable to work because of sickness or disability	0.3	0.3	0.6	0.3	0.8
Pain experienced in last month	0.3	0.6	1.1	-1.1	-0.1
Alcohol drinker status: Previous	0.3	0.3	0.5	0.7	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	0.5	-0.5	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.4	-0.9
HbA1C	0.2	0.2	0.4	0.2	-0.6
Hypothyroidism (self reported)	0.2	0.5	0.9	-0.9	0.2
Respiratory disease	0.2	0.3	0.6	-0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.4	0.6
Vitamin and mineral supplements	0.2	0.3	0.6	0.8	0.0
Townsend deprivation index at recruitment	0.2	0.3	0.3	0.6	0.5
Past tobacco smoking	0.2	0.4	0.7	0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.5	-0.7	0.5
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	0.3
Mouth/teeth dental problems	0.2	0.4	0.7	-0.8	0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.4	0.7
Number of live births	0.2	0.3	0.6	0.8	0.2
Pulse rate	0.2	0.3	0.6	-0.8	0.3
Asthma	0.2	0.4	0.7	0.4	-0.8
Length of working week for main job	0.2	0.3	0.3	-0.4	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.3	-0.5	-0.6
Leg fat percentage (right)	0.2	0.9	1.7	0.3	1.3
Health satisfaction	0.2	0.2	0.2	0.5	-0.5
Suffer from ‘nerves’	0.2	0.4	0.7	-0.8	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.2	0.7
Supplements: Vitamin C	0.2	0.2	0.4	-0.6	-0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.6	-0.2
Leg fat percentage (left)	0.2	0.8	1.6	0.0	1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	0.6	0.4
Age at First Birth	0.1	0.1	0.2	-0.4	0.3
LDL Cholesterol	0.1	0.1	0.2	-0.4	0.1
Waist Hip Ratio (WHR)	0.1	0.7	0.8	0.7	0.9
Lung FEV1/FVC ratio	0.1	0.4	0.8	-0.2	0.9
Neuroticism	0.1	0.2	0.3	-0.5	0.2
Hair Pigment	0.1	2.7	5.4	0.2	-2.3
Hand grip strength (left)	0.1	0.3	0.7	0.1	0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	-0.3
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.3
Taking other prescription medications	0.1	0.1	0.2	-0.2	0.4
Age when periods started (menarche)	0.1	0.3	0.4	0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.5	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.1	0.6
Heart attack	0.1	0.2	0.3	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.1	0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	0.2	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	0.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.5	-0.3
Age at first live birth	0.1	0.2	0.4	0.1	0.6
Pulse wave peak to peak time	0.1	0.1	0.1	-0.1	0.4
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.1	0.6
Alcohol intake frequency.	0.1	0.1	0.3	-0.1	0.5
Number of full sisters	0.1	0.2	0.3	0.5	0.3
Chest pain or discomfort	0.1	0.2	0.4	0.1	0.6
Had major operations	0.1	0.1	0.2	0.5	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	-0.2
Medication: Aspirin	0.1	0.2	0.2	0.3	0.5
Smoking status: Previous	0.1	0.1	0.1	-0.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.3	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.2	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.2	0.5
Asthma (self-reported)	0.1	0.2	0.4	-0.1	-0.6
High cholesterol (Self-reported)	0.1	0.1	0.2	0.2	0.4
Ever smoked	0.1	0.1	0.2	-0.0	0.5
Worry (Nagel 2018)	0.0	0.0	0.1	-0.2	0.2
Alzheimer’s Disease (in mother)	0.0	0.1	0.1	-0.3	0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	-0.0
Blood Platelet Count	0.0	0.2	0.3	-0.5	0.4
Heel T-Score	0.0	0.0	0.0	-0.2	-0.0
Tanning	0.0	0.2	0.4	-0.2	0.7
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.2	0.2
Nervous feelings	0.0	0.1	0.2	-0.1	-0.4
Qualifications: None of the above	0.0	0.1	0.1	0.2	0.2
Fluid intelligence score	0.0	0.1	0.1	0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	0.2	-0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.1	0.3
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	-0.2
Pulse wave reflection index	0.0	0.0	0.0	-0.2	-0.0
Commuting to job workplace: Public transport	0.0	0.1	0.1	0.2	-0.2
Alcohol drinker status: Never	0.0	0.0	0.0	-0.1	0.1

Hub : Genes

C10orf118

Models

Trait associations