Best TWAS P=5.11e-09 · Best GWAS P=4.38e-10 conditioned to 1.14e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PPP2R2D | 0.21 | 0.21 | lasso | 4 | 0.20 | 2.1e-11 | 5.8 | -5.8 | 5.1e-09 | -0.03 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Male) | PPP2R2D | 0.22 | 0.09 | lasso | 5 | 0.13 | 6.1e-04 | 5.7 | -5.8 | 7.1e-09 | -0.02 | 0.01 | 0.90 | FALSE |
| 3 | GTEx | Lung | PPP2R2D | 0.18 | 0.06 | enet | 11 | 0.10 | 2.6e-08 | 5.8 | -5.2 | 2.5e-07 | -0.01 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | PPP2R2D | 0.20 | 0.08 | lasso | 6 | 0.11 | 2.1e-06 | 5.9 | -5.3 | 1.4e-07 | -0.03 | 0.00 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPP2R2D | 0.05 | 0.02 | blup | 18 | 0.03 | 8.7e-04 | -4.3 | -5.4 | 5.5e-08 | 0.01 | 0.01 | 0.81 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP2R2D | 0.09 | 0.05 | lasso | 4 | 0.06 | 6.7e-07 | -5.1 | -5.4 | 5.4e-08 | 0.02 | 0.03 | 0.97 | FALSE |