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chr11:350,917-2,705,175

Best TWAS P=2.19e-50 · Best GWAS P=2.25e-55 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	GTEx	Skin Not Sun Exposed Suprapubic	TNNT3	0.33	0.16	lasso	7	0.17	2.0e-09	14.2	14.9	2.2e-50	0.91	0.00	1.00	TRUE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LSP1	0.07	0.03	lasso	4	0.03	2.4e-04	10.9	-13.4	3.3e-41	-0.35	0.09	0.25	TRUE
31	YFS	Blood	TNNT3	0.02	0.02	lasso	3	0.01	1.9e-05	14.2	-12.6	1.3e-36	-0.81	0.03	0.96	TRUE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TNNI2	0.11	0.09	lasso	2	0.08	4.1e-06	10.9	-10.9	1.1e-27	-0.19	0.64	0.02	TRUE
29	NTR	Blood	TNNT3	0.04	0.02	blup	461	0.02	4.3e-06	12.7	-9.2	5.9e-20	-0.66	0.09	0.91	TRUE
23	GTEx	Skin Sun Exposed Lower leg	TNNT3	0.63	0.02	lasso	20	0.00	3.5e-01	-7.7	7.4	1.1e-13	0.38	0.05	0.04	TRUE
30	ROSMAP	Brain Pre-frontal Cortex	RP13-870H17.3	0.11	0.08	bslmm	382	0.09	9.3e-12	-4.5	-5.7	1.6e-08	0.00	0.02	0.95	TRUE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LSP1	0.12	0.08	lasso	5	0.10	5.0e-11	-13.2	-14.3	3.2e-46	-0.60	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	LSP1	0.21	0.04	enet	28	0.06	3.4e-05	15.7	12.1	1.5e-33	0.72	0.00	1.00	FALSE
8	GTEx	Brain Frontal Cortex BA9	MRPL23-AS1	0.36	0.23	lasso	3	0.21	3.8e-06	11.5	11.5	1.7e-30	0.49	0.34	0.30	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	MRPL23-AS1	0.33	0.19	enet	30	0.21	9.5e-12	10.3	11.2	2.5e-29	0.37	1.00	0.00	FALSE
25	GTEx	Skin Sun Exposed Lower leg	MRPL23-AS1	0.19	0.19	enet	9	0.21	5.3e-17	9.9	10.7	1.3e-26	0.45	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC100133545	0.03	0.01	blup	49	0.01	1.1e-02	10.3	10.7	1.4e-26	0.39	0.00	0.93	FALSE
4	GTEx	Artery Aorta	MRPL23-AS1	0.22	0.07	enet	10	0.12	2.9e-07	11.5	10.3	6.3e-25	0.45	0.97	0.01	FALSE
15	GTEx	Colon Transverse	MRPL23-AS1	0.13	0.03	enet	19	0.03	1.0e-02	9.9	10.2	3.1e-24	0.41	0.12	0.10	FALSE
17	GTEx	Esophagus Muscularis	MRPL23-AS1	0.21	0.07	lasso	4	0.10	1.8e-06	9.9	9.9	2.5e-23	0.44	0.93	0.02	FALSE
20	GTEx	Nerve Tibial	MRPL23-AS1	0.18	0.11	lasso	4	0.16	1.2e-11	10.3	9.8	7.3e-23	0.43	1.00	0.00	FALSE
14	GTEx	Colon Sigmoid	MRPL23-AS1	0.39	0.13	lasso	6	0.23	9.8e-09	9.9	9.8	1.6e-22	0.37	0.92	0.01	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	LSP1	0.06	0.04	enet	6	0.04	3.1e-05	10.9	9.8	1.9e-22	0.11	0.67	0.01	FALSE
7	GTEx	Brain Cerebellum	MRPL23-AS1	0.25	0.14	enet	12	0.18	6.8e-06	9.9	9.5	1.9e-21	0.46	0.27	0.25	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	MRPL23-AS1	0.25	0.07	lasso	5	0.03	6.8e-02	8.5	9.2	2.4e-20	0.40	0.10	0.17	FALSE
5	GTEx	Artery Tibial	MRPL23-AS1	0.27	0.10	lasso	6	0.19	1.5e-14	5.6	8.9	4.6e-19	0.43	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue	MRPL23-AS1	0.30	0.15	lasso	5	0.19	6.4e-10	8.2	8.7	5.1e-18	0.29	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	LOC100133545	0.09	0.09	enet	8	0.09	3.8e-09	8.5	8.6	7.0e-18	0.39	0.73	0.27	FALSE
12	GTEx	Breast Mammary Tissue (Female)	MRPL23-AS1	0.24	0.06	lasso	4	0.01	1.9e-01	8.2	8.3	8.5e-17	0.29	0.08	0.05	FALSE
19	GTEx	Lung	MRPL23-AS1	0.29	0.09	lasso	7	0.12	1.6e-09	5.6	8.0	1.7e-15	0.41	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC100133545	0.06	0.02	blup	49	0.03	6.7e-03	-6.0	7.9	3.7e-15	0.37	0.09	0.24	FALSE
6	GTEx	Brain Caudate basal ganglia	MRPL23-AS1	0.26	0.07	enet	11	0.10	6.3e-04	5.6	7.7	1.1e-14	0.41	0.24	0.06	FALSE
27	GTEx	Thyroid	MRPL23-AS1	0.20	0.16	lasso	5	0.17	1.0e-12	5.6	7.7	1.7e-14	0.39	1.00	0.00	FALSE
3	GTEx	Artery Aorta	TNNT3	0.21	-0.01	enet	17	0.00	6.4e-01	-3.2	-7.7	2.0e-14	-0.30	0.05	0.06	FALSE
11	GTEx	Breast Mammary Tissue (Male)	MRPL23-AS1	0.34	0.02	enet	23	0.09	4.5e-03	8.2	7.6	2.4e-14	0.23	0.08	0.06	FALSE
1	GTEx	Adipose Subcutaneous	MRPL23-AS1	0.21	0.12	lasso	6	0.16	2.1e-13	5.6	7.3	2.3e-13	0.38	1.00	0.00	FALSE
18	GTEx	Heart Atrial Appendage	MRPL23-AS1	0.17	0.06	lasso	4	0.05	2.2e-03	-5.8	7.1	9.6e-13	0.39	0.36	0.25	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100133545	0.04	0.02	enet	7	0.03	4.4e-07	-6.0	6.9	5.1e-12	0.37	0.96	0.04	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100133545	0.05	0.04	blup	50	0.04	7.1e-06	-6.0	6.7	1.7e-11	0.33	0.76	0.15	FALSE
2	GTEx	Adipose Visceral Omentum	MRPL23-AS1	0.30	0.12	enet	27	0.15	5.3e-08	6.4	6.5	6.2e-11	0.35	0.97	0.00	FALSE
26	GTEx	Stomach	MRPL23-AS1	0.15	0.06	lasso	4	0.04	3.3e-03	5.6	6.5	1.0e-10	0.37	0.32	0.06	FALSE
16	GTEx	Esophagus Mucosa	MRPL23-AS1	0.09	0.10	lasso	3	0.08	7.8e-06	-5.8	6.4	1.3e-10	0.33	0.83	0.01	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPL23	0.04	0.06	lasso	2	0.05	7.5e-07	-6.0	-6.2	7.4e-10	-0.30	0.95	0.00	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC100133545	0.06	0.00	blup	50	0.02	1.5e-03	-6.3	6.0	1.4e-09	0.21	0.08	0.27	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC100133545	0.03	0.01	blup	49	0.02	1.2e-03	-6.0	6.0	1.9e-09	0.20	0.16	0.05	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC100133545	0.08	0.05	blup	49	0.06	2.2e-03	5.5	5.8	6.7e-09	0.25	0.11	0.09	FALSE
28	GTEx	Whole Blood	MRPL23-AS1	0.08	0.08	lasso	2	0.06	6.2e-06	5.6	5.5	2.8e-08	0.38	0.96	0.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	MRPL23	0.09	0.00	lasso	4	0.00	6.5e-01	-6.0	5.5	4.6e-08	0.27	0.20	0.09	FALSE