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chr13:112,931,650-115,106,996

Best TWAS P=9.96e-23 · Best GWAS P=1.41e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CDC16	0.05	0.03	bslmm	208	0.04	2.4e-05	9.48	7.9	2.3e-15	0.76	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MCF2L-AS1	0.09	0.07	lasso	3	0.07	1.5e-08	7.36	7.6	2.3e-14	-0.03	0.02	0.98	TRUE
3	CommonMind	Brain Pre-frontal Cortex	UPF3A	0.09	0.04	lasso	6	0.08	1.7e-09	8.97	5.4	6.4e-08	0.31	0.83	0.15	FALSE
4	GTEx	Adipose Subcutaneous	CDC16	0.17	0.17	lasso	4	0.19	3.6e-15	9.11	9.2	4.1e-20	0.99	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	CDC16	0.12	0.11	lasso	4	0.09	1.5e-05	9.52	9.3	2.0e-20	0.98	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	UPF3A	0.33	0.04	enet	31	0.14	1.5e-07	0.95	5.8	8.3e-09	0.37	0.53	0.34	FALSE
7	GTEx	Adrenal Gland	UPF3A	0.17	0.00	enet	27	0.06	3.9e-03	1.00	6.8	9.2e-12	0.44	0.02	0.41	FALSE
8	GTEx	Artery Aorta	CDC16	0.15	0.18	enet	10	0.17	1.6e-09	9.50	8.6	9.4e-18	0.97	0.01	0.99	FALSE
9	GTEx	Artery Aorta	UPF3A	0.38	0.24	enet	18	0.28	9.9e-16	8.97	7.8	5.0e-15	0.65	0.48	0.52	FALSE
10	GTEx	Artery Coronary	CDC16	0.41	0.02	enet	5	0.02	6.9e-02	7.15	8.3	9.6e-17	0.91	0.02	0.95	FALSE
11	GTEx	Artery Coronary	UPF3A	0.25	0.11	lasso	4	0.14	1.5e-05	8.66	7.5	6.2e-14	0.54	0.04	0.76	FALSE
12	GTEx	Artery Tibial	CDC16	0.23	0.26	lasso	8	0.25	2.8e-19	9.17	9.4	8.3e-21	0.99	0.01	0.99	FALSE
13	GTEx	Artery Tibial	UPF3A	0.33	0.25	enet	19	0.29	6.2e-23	8.97	8.7	3.6e-18	0.72	0.40	0.60	FALSE
14	GTEx	Brain Cerebellar Hemisphere	CDC16	0.17	0.10	lasso	9	0.17	3.5e-05	9.11	8.2	3.4e-16	0.92	0.02	0.97	FALSE
15	GTEx	Brain Cerebellum	CDC16	0.18	0.05	lasso	4	0.07	3.4e-03	9.44	8.8	9.7e-19	0.95	0.01	0.96	FALSE
16	GTEx	Breast Mammary Tissue	CDC16	0.25	0.28	lasso	6	0.26	6.9e-14	9.54	8.9	6.7e-19	0.97	0.01	0.99	FALSE
17	GTEx	Breast Mammary Tissue	UPF3A	0.33	0.06	enet	18	0.18	9.7e-10	9.50	7.3	2.9e-13	0.59	0.02	0.98	FALSE
18	GTEx	Breast Mammary Tissue (Male)	CDC16	0.23	0.08	enet	11	0.09	3.8e-03	8.39	8.3	1.1e-16	0.85	0.03	0.85	FALSE
19	GTEx	Breast Mammary Tissue (Female)	CDC16	0.25	0.22	enet	28	0.22	3.6e-07	9.48	8.6	7.9e-18	0.92	0.02	0.98	FALSE
20	GTEx	Breast Mammary Tissue (Female)	UPF3A	0.32	0.16	lasso	13	0.17	1.2e-05	9.51	9.1	7.5e-20	0.91	0.02	0.98	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	CDC16	0.14	0.09	lasso	3	0.10	2.9e-04	9.47	9.7	4.0e-22	0.99	0.01	0.98	FALSE
22	GTEx	Cells Transformed fibroblasts	CDC16	0.17	0.13	lasso	6	0.15	4.6e-11	9.44	9.5	1.4e-21	0.98	0.01	0.99	FALSE
23	GTEx	Cells Transformed fibroblasts	UPF3A	0.49	0.12	lasso	8	0.44	1.3e-35	8.97	6.4	1.7e-10	0.46	0.59	0.41	FALSE
24	GTEx	Colon Sigmoid	UPF3A	0.15	0.10	lasso	8	0.08	8.3e-04	9.50	9.8	1.0e-22	0.97	0.01	0.98	TRUE
25	GTEx	Colon Transverse	CDC16	0.18	0.23	lasso	5	0.21	3.2e-10	9.54	9.5	2.3e-21	0.98	0.01	0.99	FALSE
26	GTEx	Colon Transverse	UPF3A	0.13	0.04	lasso	3	0.04	5.6e-03	6.17	8.4	3.5e-17	0.77	0.03	0.93	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	CDC16	0.09	0.05	lasso	2	0.02	5.7e-02	9.48	9.4	6.2e-21	1.00	0.02	0.90	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	UPF3A	0.20	0.07	lasso	6	0.06	4.5e-03	9.44	9.7	3.6e-22	0.99	0.01	0.95	FALSE
29	GTEx	Esophagus Mucosa	CDC16	0.35	0.46	lasso	6	0.46	1.0e-33	9.54	9.6	1.1e-21	1.00	0.01	0.99	FALSE
30	GTEx	Esophagus Mucosa	UPF3A	0.27	0.04	enet	19	0.21	2.9e-14	8.97	6.4	1.8e-10	0.41	0.38	0.60	FALSE
31	GTEx	Esophagus Muscularis	CDC16	0.12	0.09	lasso	6	0.13	3.2e-08	7.59	7.7	9.7e-15	0.88	0.02	0.98	FALSE
32	GTEx	Esophagus Muscularis	UPF3A	0.43	0.25	enet	33	0.37	8.8e-24	8.97	8.4	5.2e-17	0.66	0.04	0.96	FALSE
33	GTEx	Esophagus Muscularis	RASA3	0.14	0.00	enet	17	0.02	1.8e-02	-3.10	-5.7	1.2e-08	-0.49	0.04	0.50	FALSE
34	GTEx	Lung	CDC16	0.16	0.21	lasso	5	0.19	9.6e-15	9.11	9.2	3.6e-20	0.99	0.01	0.99	FALSE
35	GTEx	Muscle Skeletal	CDC16	0.05	0.06	lasso	1	0.05	9.2e-06	9.17	9.2	4.7e-20	0.99	0.02	0.98	FALSE
36	GTEx	Nerve Tibial	CDC16	0.23	0.23	enet	19	0.26	9.5e-19	9.11	8.3	7.4e-17	0.95	0.01	0.99	FALSE
37	GTEx	Nerve Tibial	UPF3A	0.29	0.06	lasso	7	0.11	2.8e-08	8.97	6.0	2.1e-09	0.37	0.41	0.55	FALSE
38	GTEx	Pancreas	CDC16	0.09	0.14	lasso	3	0.06	1.8e-03	9.52	9.5	1.6e-21	1.00	0.01	0.97	FALSE
39	GTEx	Prostate	CDC16	0.17	0.16	lasso	3	0.11	1.4e-03	9.54	9.5	1.5e-21	1.00	0.01	0.94	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	CDC16	0.35	0.42	enet	33	0.45	7.9e-27	9.47	8.9	5.1e-19	0.96	0.01	0.99	FALSE
41	GTEx	Skin Sun Exposed Lower leg	CDC16	0.31	0.33	lasso	7	0.33	4.1e-28	9.47	8.9	4.4e-19	0.98	0.01	0.99	FALSE
42	GTEx	Small Intestine Terminal Ileum	CDC16	0.16	0.04	lasso	9	0.03	6.1e-02	9.52	7.1	1.7e-12	0.78	0.02	0.78	FALSE
43	GTEx	Spleen	CDC16	0.25	0.19	lasso	7	0.21	4.9e-06	9.51	9.2	2.3e-20	0.98	0.01	0.98	FALSE
44	GTEx	Stomach	CDC16	0.12	0.06	enet	23	0.08	1.6e-04	9.50	7.5	4.9e-14	0.87	0.02	0.98	FALSE
45	GTEx	Testis	CDC16	0.32	0.30	enet	26	0.35	4.4e-16	9.48	8.3	1.1e-16	0.94	0.01	0.99	FALSE
46	GTEx	Thyroid	CDC16	0.12	0.13	lasso	2	0.11	8.2e-09	9.44	9.5	3.4e-21	1.00	0.01	0.99	FALSE
47	GTEx	Thyroid	UPF3A	0.10	0.00	enet	17	0.01	5.7e-02	9.44	8.4	4.4e-17	0.62	0.01	0.77	FALSE
48	GTEx	Whole Blood	CDC16	0.31	0.20	lasso	5	0.20	4.4e-18	9.44	9.0	2.7e-19	0.98	0.01	0.99	FALSE
49	METSIM	Adipose	CDC16	0.18	0.27	enet	18	0.26	6.6e-39	9.52	9.2	3.1e-20	0.96	0.01	0.99	FALSE
50	METSIM	Adipose	UPF3A	0.24	0.12	blup	188	0.19	2.2e-27	8.97	5.9	3.8e-09	0.36	0.60	0.40	FALSE
51	NTR	Blood	CDC16	0.10	0.20	bslmm	209	0.20	3.1e-63	9.50	9.5	1.5e-21	1.00	0.01	0.99	FALSE
52	NTR	Blood	RASA3	0.02	0.00	bslmm	265	0.00	1.5e-02	-1.87	-5.6	2.3e-08	-0.31	0.03	0.06	FALSE
53	YFS	Blood	CDC16	0.28	0.54	enet	30	0.55	1.1e-220	9.49	9.5	2.4e-21	0.99	0.01	0.99	FALSE
54	YFS	Blood	UPF3A	0.21	0.17	enet	38	0.25	2.4e-82	8.97	7.9	2.1e-15	0.62	0.60	0.40	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC16	0.08	0.11	lasso	5	0.12	4.3e-10	9.52	9.3	1.8e-20	0.99	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UPF3A	0.21	0.07	blup	32	0.14	7.6e-12	8.66	6.6	5.6e-11	0.46	0.39	0.61	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC16	0.01	0.01	blup	49	0.01	1.1e-03	9.17	9.3	1.5e-20	0.97	0.01	0.96	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	CDC16	0.06	0.04	lasso	5	0.03	5.9e-03	7.00	8.3	7.8e-17	0.88	0.02	0.90	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	UPF3A	0.37	0.12	blup	32	0.14	2.9e-08	8.66	6.4	2.0e-10	0.39	0.57	0.36	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDC16	0.05	0.08	lasso	4	0.08	7.2e-09	9.49	9.3	9.3e-21	0.99	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UPF3A	0.13	0.03	enet	16	0.11	1.9e-12	8.97	6.2	4.8e-10	0.43	0.42	0.53	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC16	0.05	0.04	blup	49	0.05	2.0e-06	9.11	9.4	4.8e-21	0.95	0.01	0.98	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UPF3A	0.20	0.11	enet	12	0.17	4.3e-19	8.97	6.8	7.9e-12	0.50	0.60	0.40	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC16	0.04	0.01	blup	49	0.03	7.7e-03	9.54	8.4	4.2e-17	0.96	0.01	0.95	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UPF3A	0.24	0.08	blup	32	0.16	2.6e-09	9.11	7.0	2.3e-12	0.59	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	UPF3A	0.10	0.00	blup	32	0.05	3.6e-06	8.97	5.4	7.7e-08	0.28	0.07	0.32	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDC16	0.03	0.04	lasso	3	0.04	1.3e-05	8.66	9.7	3.2e-22	0.90	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UPF3A	0.19	0.07	enet	15	0.16	4.4e-18	8.97	6.4	1.3e-10	0.42	0.74	0.26	FALSE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDC16	0.11	0.09	blup	49	0.09	1.8e-04	9.11	9.3	1.4e-20	0.98	0.01	0.97	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UPF3A	0.31	0.08	enet	13	0.17	1.1e-07	8.97	7.4	2.0e-13	0.54	0.03	0.59	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDC16	0.07	0.03	blup	49	0.05	6.3e-03	9.52	9.5	1.3e-21	0.93	0.01	0.86	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UPF3A	0.10	0.09	lasso	1	0.08	3.8e-04	8.97	9.0	3.0e-19	0.76	0.02	0.53	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDC16	0.08	0.07	blup	49	0.08	1.2e-08	7.28	7.7	1.3e-14	0.90	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	UPF3A	0.14	0.06	blup	32	0.10	3.9e-10	8.97	8.7	4.3e-18	0.70	0.20	0.80	FALSE
75	The Cancer Genome Atlas	Rectum Adenocarcinoma	UPF3A	0.25	-0.01	blup	32	-0.01	5.1e-01	8.66	6.8	8.8e-12	0.51	0.01	0.26	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	CDC16	0.06	0.09	lasso	3	0.09	3.3e-09	9.52	9.7	2.6e-22	0.98	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	UPF3A	0.14	0.11	enet	9	0.15	1.7e-14	8.97	8.9	3.7e-19	0.77	0.06	0.94	FALSE