Hub : Genes

MCF2L-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.088	0.029	7.7e-04	0.069	0.022	0.065	0.056	0.067	8.5e-09	0.00094	2.2e-08	2.1e-07	1.5e-08
2	GTEx	Brain Cerebellar Hemisphere	0.673	0.104	1.3e-05	0.199	NA	0.338	NA	0.391	8.0e-06	NA	1.7e-09	NA	4.5e-11
3	GTEx	Skin Not Sun Exposed Suprapubic	0.223	0.067	1.1e-03	-0.004	NA	0.009	NA	0.013	6.9e-01	NA	1.0e-01	NA	6.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.8	0.5	-0.9	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	-0.2	-0.5	0.5
Depressed Affect (Nagel 2018)	0.7	1.4	2.5	-0.4	-1.2	-1.6
Depression (Nagel 2018)	1.4	2.1	5.7	-0.7	-2.4	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.0	-1.4	-1.4	0.2
Neuroticism (Nagel 2018)	1.1	2.6	5.2	-1.0	-1.3	-2.3
Schizophrenia (2018)	0.1	0.2	0.5	-0.7	-0.1	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.1
Worry (Nagel 2018)	1.0	2.0	2.6	-1.6	-1.4	-1.2
Alzheimer’s Disease (in mother)	1.3	1.5	2.4	0.8	1.6	1.2
Alzheimer’s Disease (in father)	1.4	1.5	3.3	1.1	1.8	-0.4
Alzheimer’s Disease (including proxy)	2.3	3.4	6.6	1.3	2.6	1.3
Crohns Disease (2017)	0.5	1.1	2.2	-0.3	1.5	1.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.2	0.6	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.5	0.0	-0.5
Major Depression (MDD)	0.1	0.1	0.3	-0.2	0.0	0.6
Reaction Time	1.0	1.9	4.6	0.7	2.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.0	-1.7	-1.0	0.8
Breast Cancer	0.2	0.6	0.7	-0.8	0.6	-0.9
Ovarian Cancer	1.8	2.4	5.1	2.2	0.7	1.2
Prostate Cancer	1.7	2.4	4.7	-1.0	1.2	-2.2
Age at First Birth	0.5	0.7	1.0	0.9	-0.6	1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	-0.8	-0.6	1.4
Coronary Artery Disease (CAD)	2.2	2.6	3.7	1.9	-1.3	1.6
Crohns Disease (2012)	0.0	0.1	0.2	-0.4	0.0	-0.1
Mean Putamen Volume	1.0	1.1	2.6	-0.9	-1.6	-0.4
Fasting Glucose	3.3	3.9	6.7	1.6	2.6	1.5
HbA1C	0.5	0.5	1.1	-0.1	-1.1	-0.6
HDL Cholesterol	1.4	2.3	2.7	-1.4	-1.5	-1.6
LDL Cholesterol	0.3	0.5	1.2	1.1	0.1	0.4
Lupus	1.7	2.6	6.2	2.5	0.9	-0.9
Neuroticism (2016)	0.3	0.5	0.7	-0.8	0.6	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.5	-0.7	0.5	-1.2
Rheumatoid Arthritis	1.0	1.3	3.9	-2.0	0.3	0.0
Schizophrenia (2014)	0.1	0.3	0.6	-0.8	0.2	-0.3
Triglycerides	0.0	0.1	0.1	0.2	-0.2	-0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.5	0.7	0.6	0.6
Ulcerative Colitis	0.1	0.1	0.2	-0.2	0.0	-0.5
Blood Eosinophil Count	0.2	1.5	3.3	0.4	1.0	1.8
Blood Platelet Count	0.6	6.8	20.2	-0.2	0.3	4.5
Blood Red Count	0.1	1.0	2.5	-1.6	-0.5	0.7
Blood White Count	0.1	0.9	1.9	0.8	0.5	1.4
Heel T-Score	0.1	0.9	2.5	0.2	-0.1	1.6
BMI	0.1	0.9	1.8	0.0	1.3	0.9
Height	0.4	6.9	11.4	-3.4	-2.2	-2.1
Waist Hip Ratio (WHR)	0.2	1.1	2.8	1.7	-0.1	0.6
Systolic Blood Pressure	5.0	25.0	58.3	7.6	2.8	3.0
Smoking Status	0.1	0.3	0.6	0.8	0.0	-0.5
Allergy or Eczema	1.0	2.7	4.6	-1.6	-2.2	-0.9
Cardiovascular Disease	3.5	11.6	24.2	4.9	2.7	1.7
Hypothyroidism (self reported)	0.8	1.7	2.5	-1.1	-1.6	-1.2
Respiratory disease	0.4	0.8	1.1	1.0	0.8	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	0.4	-1.0	0.4
Lung FEV1/FVC ratio	1.0	4.9	8.1	-2.9	-2.4	0.9
Lung FVC	0.4	2.1	6.2	-2.5	0.3	0.2
Neuroticism	0.8	1.9	2.9	-1.4	-0.9	-1.7
Chronotype (morning person)	0.0	0.1	0.2	-0.2	-0.4	-0.2
Hair Pigment	0.1	2.5	5.8	2.4	1.0	0.8
Tanning	0.2	2.8	4.3	-2.1	-0.9	-1.8
Hand grip strength (left)	0.1	0.4	0.9	-0.1	0.4	1.0
Number of treatments/medications taken	0.5	0.9	1.5	1.1	-1.2	0.2
Average weekly spirits intake	0.4	0.5	0.8	-0.9	0.2	-0.8
Sensitivity / hurt feelings	0.4	0.7	1.7	-0.3	0.6	-1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.8	0.4	-1.7	-0.0
Hearing difficulty/problems: Yes	0.4	0.6	1.7	0.2	1.3	-0.4
Relative age of first facial hair	0.3	0.6	1.4	-0.5	-0.2	-1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.6	-0.4	1.2	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.6	-0.8	-0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	0.3	-1.3	-0.1
Systolic blood pressure, automated reading	3.5	10.2	21.7	4.7	1.9	2.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.1	-0.4	-0.3
Angina	1.0	1.3	3.6	1.9	-0.2	0.6
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.3	0.3	0.8
Vitamin and mineral supplements	0.8	1.1	2.8	-0.4	1.7	-0.7
Supplements: Zinc	0.1	0.1	0.1	0.1	0.4	-0.1
Medication: Co-codamol	1.2	1.4	2.2	-1.1	1.5	0.9
Medication: Metformin	0.8	1.1	2.7	1.6	-0.4	0.6
Diabetes (father)	0.1	0.1	0.2	0.1	-0.5	-0.3
Diabetes (mother)	0.5	0.6	1.1	-1.0	-0.7	-0.4
Severe depression (siblings)	0.3	0.3	0.7	0.2	0.4	-0.8
Pack years adult smoking proportion	0.1	0.2	0.3	-0.1	0.6	0.5
Impedance of leg (right)	0.7	3.4	8.5	2.9	0.6	1.2
Leg fat-free mass (left)	0.3	1.4	2.8	-1.7	-0.8	-0.9
Trunk fat percentage	0.0	0.1	0.3	0.2	0.4	0.5
Hand grip strength (right)	0.1	0.2	0.6	0.1	-0.3	0.8
Townsend deprivation index at recruitment	0.3	0.4	0.6	0.3	0.7	-0.7
Current tobacco smoking	0.1	0.1	0.3	-0.5	-0.0	-0.4
Average weekly fortified wine intake	2.9	3.4	6.0	-2.4	-2.0	-0.3
Maternal smoking around birth	3.3	4.7	6.3	2.5	1.8	2.2
Fed-up feelings	0.6	1.2	3.2	-0.2	-0.5	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	3.7	-1.8	-1.9	-0.8
Relative age voice broke	2.1	3.1	8.0	-0.8	-0.9	-2.8
Taking other prescription medications	0.1	0.2	0.3	-0.3	-0.6	-0.5
Age when periods started (menarche)	0.2	0.4	0.5	-0.5	0.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.2	-1.1	-0.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	-1.3	-1.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.7	0.7	-0.2
Qualifications: CSEs or equivalent	3.9	5.1	7.9	2.7	2.8	-0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.2	0.7	0.4
High blood pressure	0.8	2.2	4.0	2.0	1.5	0.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.9	-0.2	-2.0	-0.2
Multivitamins +/- minerals	1.0	1.2	1.9	-0.2	-1.3	1.4
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.2	0.3	0.1
Supplements: Glucosamine	0.1	0.1	0.1	-0.0	0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.2	0.1	0.2
Medication: Atenolol	1.8	2.3	5.7	2.4	0.9	0.5
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.6	-0.1	-0.3
Sitting height	0.1	0.7	1.2	-0.9	-1.1	-0.3
Chronic bronchitis/emphysema (father)	1.3	1.6	2.2	-1.5	-1.4	-0.8
High blood pressure (mother)	0.8	1.1	1.7	1.3	-0.6	1.2
Body mass index (BMI)	0.1	0.4	0.9	-0.3	0.9	0.5
Impedance of leg (left)	1.0	5.1	10.9	3.3	0.9	1.8
Leg predicted mass (left)	0.3	1.4	2.6	-1.6	-0.8	-0.9
Trunk fat mass	0.0	0.1	0.1	-0.4	-0.0	0.3
Waist circumference	0.1	0.3	0.8	0.1	0.9	0.3
Number of incorrect matches in round	0.2	0.3	0.8	-0.9	-0.2	0.2
Past tobacco smoking	0.2	0.4	0.8	-0.9	-0.3	-0.4
Alcohol usually taken with meals	2.5	4.1	6.3	-1.4	-2.5	-2.0
Nervous feelings	1.6	3.1	4.7	-1.9	-0.9	-2.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.5	-1.2	-1.6	-0.8
Hearing difficulty/problems with background noise	0.5	0.9	2.5	0.1	1.6	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	-0.1	0.3
Had menopause	0.3	0.4	0.8	0.1	0.9	0.5
Had other major operations	0.3	0.4	0.5	-0.7	0.5	-0.6
Forced vital capacity (FVC)	0.2	0.9	1.4	-1.2	-1.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.3	-1.1	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.5	-2.3	-0.1	-0.7
Qualifications: None of the above	0.1	0.3	0.6	0.5	0.2	0.8
Financial difficulties in last 2 years	2.2	3.0	6.6	-1.5	-2.6	-0.3
Mouth/teeth dental problems	0.2	0.3	0.7	-0.4	-0.2	0.8
Heart attack	0.2	0.3	0.7	0.9	0.3	-0.2
Allergy	0.2	0.4	0.8	-0.3	0.9	-0.5
Pain all over the body in last month	0.5	0.5	1.2	-0.5	-0.4	1.1
Diabetes (self-reported)	0.3	0.4	0.7	0.8	-0.7	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.9	0.7	0.2
Medication: Ramipril	0.8	1.1	3.2	-0.0	0.2	-1.8
Medication: Simvastatin	1.5	2.3	3.8	1.7	1.9	0.1
Fluid intelligence score	1.1	2.4	6.2	-2.5	-0.8	0.5
Illnesses of siblings	1.4	1.9	3.5	-1.9	0.2	-1.5
Neuroticism score	0.8	1.6	3.2	-1.1	0.5	-1.8
Weight	0.1	0.3	0.8	-0.9	0.3	-0.1
Impedance of arm (right)	0.2	1.0	2.9	1.7	0.0	-0.5
Arm fat percentage (right)	0.1	0.2	0.6	-0.1	0.8	-0.1
Trunk fat-free mass	0.2	1.1	2.7	-1.6	-0.5	-0.7
Hip circumference	0.2	0.9	1.8	-1.4	0.5	-0.7
Time employed in main current job	0.7	0.8	1.5	0.6	-0.7	1.2
Alcohol intake versus 10 years previously	0.6	0.9	1.5	1.2	0.3	1.1
Father’s age at death	2.8	3.7	5.9	-2.4	-2.3	0.0
Worrier / anxious feelings	0.7	1.2	2.6	-1.6	0.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.5	-0.9	-0.0
Falls in the last year	0.6	0.8	1.4	0.0	0.9	-1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	-0.1	-0.1	1.4
Number of live births	2.4	3.4	10.1	-3.2	0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	0.9	-0.9	-0.9	0.7
Pulse rate	0.2	0.4	0.9	-1.0	0.2	0.3
Happiness	1.4	1.8	2.9	-1.1	-1.1	-1.7
Noisy workplace	0.8	1.0	1.5	1.2	0.8	1.0
Qualifications: A levels/AS levels or equivalent	1.1	2.3	4.3	-2.1	-1.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	3.7	-0.6	-1.9	-1.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.7	-1.3	0.1	-0.3
Asthma	0.8	1.6	3.1	1.8	-0.2	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.3	1.0	-1.2	1.0
Medication: Cholesterol lowering	0.9	1.4	3.0	1.7	1.0	0.3
Depression (self-reported)	0.8	1.0	2.5	-1.6	-0.7	-0.0
Medication: Lansoprazole	0.3	0.4	0.7	0.2	0.6	-0.8
Prospective memory result	0.5	0.6	1.1	0.8	1.0	0.3
Lung cancer (father)	0.2	0.3	0.7	-0.8	0.4	-0.1
Illnesses of mother	0.3	0.4	0.8	0.1	-0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.3	-1.0	-1.1	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-1.1	0.4	0.6
Impedance of arm (left)	0.1	0.6	0.7	0.9	-0.7	-0.7
Arm fat mass (right)	0.1	0.2	0.5	-0.7	0.5	0.1
Trunk predicted mass	0.2	1.1	2.7	-1.6	-0.5	-0.6
Standing height	0.2	1.8	2.3	-1.5	-1.3	-1.1
Length of working week for main job	1.3	1.5	2.2	1.5	-0.9	-1.2
Exposure to tobacco smoke at home	4.7	5.3	7.4	2.7	2.4	1.7
Breastfed as a baby	1.0	1.3	3.0	-0.9	-0.1	1.7
Tense / ‘highly strung’	0.3	0.4	0.8	-0.1	0.9	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.8	-0.4	-0.9	-0.9
Hair/balding pattern: Pattern 4	0.3	0.6	1.7	-0.5	0.3	1.3
Birth weight of first child	0.6	1.0	2.3	-0.6	-1.5	0.6
Peak expiratory flow (PEF)	0.3	0.7	1.5	-0.4	0.8	1.2
Pulse wave reflection index	0.1	0.1	0.2	0.1	0.4	-0.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.8	-1.7	1.0	-1.2
Loud music exposure frequency	0.4	0.4	1.0	0.4	1.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-1.0	0.1	0.6
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	2.6	1.1	1.4	1.6
Blood clot in the leg (DVT)	0.9	1.2	2.5	-0.9	-0.5	-1.6
Medication: Paracetamol	0.1	0.2	0.6	-0.2	-0.8	0.3
Headache pain in last month	1.1	1.9	2.9	-1.6	-0.5	-1.7
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.7	-2.2	-0.5	-0.9
Glaucoma (self-reported)	0.9	1.0	2.1	-0.9	-0.4	1.4
Gout (self-reported)	0.0	0.0	0.1	0.3	0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.8	-0.1	-0.6
Medication: Amlodipine	1.3	1.8	4.0	2.0	-1.1	0.1
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.6	0.9	1.1	1.6
Birth weight	0.6	1.4	2.3	-0.7	1.1	-1.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	0.4	0.9	0.2
High blood pressure (siblings)	3.2	4.6	7.5	2.7	1.5	2.0
Forced vital capacity (FVC), Best measure	0.2	0.8	1.4	-1.2	-1.0	0.3
Body fat percentage	0.1	0.3	0.3	0.5	0.5	0.5
Leg fat percentage (right)	0.2	0.9	0.9	0.9	1.0	0.9
Arm fat-free mass (right)	0.2	1.0	2.5	-1.6	-0.7	-0.3
Exposure to tobacco smoke outside home	0.5	0.7	2.0	-0.1	1.4	0.1
Comparative body size at age 10	0.5	1.3	1.8	1.1	1.0	1.4
Number of full brothers	1.4	1.8	3.9	2.0	0.9	0.7
Worry too long after embarrassment	0.1	0.2	0.5	-0.2	0.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.2	-1.1	-0.6
Wheeze or whistling in the chest in last year	0.4	0.8	1.1	0.9	1.0	-0.7
Number of children fathered	0.7	0.8	2.1	0.4	-0.5	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.4	-0.5	-0.7	-0.5
Age at first live birth	0.1	0.2	0.6	-0.8	0.3	0.2
Pulse wave peak to peak time	0.4	0.5	0.8	0.9	-0.4	-0.8
Health satisfaction	0.5	0.6	1.4	1.2	0.5	0.6
Shortness of breath walking on level ground	0.9	1.0	3.1	-0.1	1.8	-0.0
Qualifications: College or University degree	0.7	2.1	5.3	-2.3	-0.9	-0.2
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.3	0.7	-0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.4	1.9	-0.6	-0.4
Emphysema/chronic bronchitis	3.0	3.4	7.8	0.3	2.8	1.5
Medication for pain relief, constipation, heartburn	2.2	3.8	7.1	-1.8	1.0	-2.7
Neck or shoulder pain in last month	0.3	0.4	1.1	0.1	0.1	-1.0
Medication: Blood pressure	1.2	2.0	5.1	2.3	0.6	0.9
Angina (self-reported)	0.9	1.2	2.9	1.7	-0.1	0.8
Migraine (self-reported)	0.2	0.3	0.7	0.3	0.8	-0.1
Medication: Ibuprofen	1.0	1.2	1.7	1.1	-1.3	0.8
Medication: Allopurinol	0.1	0.2	0.3	-0.6	-0.2	-0.3
Medication: Omeprazole	0.1	0.2	0.3	-0.2	-0.4	-0.6
Medication: Seretide 50 evohaler	1.6	1.9	2.8	1.0	1.7	1.3
Mean time to correctly identify matches	0.9	1.7	4.9	0.4	2.2	-0.4
Heart disease (mother)	1.8	2.1	5.0	0.6	1.0	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	0.0	-0.9	0.4
Whole body fat mass	0.0	0.1	0.1	-0.2	0.4	0.2
Leg fat mass (right)	0.0	0.1	0.3	-0.0	0.4	0.5
Arm predicted mass (right)	0.2	1.1	3.0	-1.7	-0.5	-0.1
Pulse rate, automated reading	0.3	1.1	2.5	-1.6	-0.6	-0.5
Alcohol intake frequency.	0.4	1.0	1.6	-0.8	-1.3	-0.8
Comparative height size at age 10	0.2	0.9	1.9	-1.4	-0.6	0.7
Number of full sisters	0.1	0.2	0.3	-0.6	0.2	0.3
Suffer from ‘nerves’	0.6	1.0	1.7	-1.1	0.2	-1.3
Overall health rating	0.2	0.5	1.3	1.1	-0.3	0.2
Chest pain or discomfort	0.3	0.4	0.6	0.8	0.5	0.5
Had major operations	0.4	0.4	0.8	-0.9	0.5	-0.5
Age at last live birth	0.8	1.2	2.1	-1.5	1.2	0.0
Family relationship satisfaction	3.9	4.8	6.7	-1.6	-2.6	-2.2
Leg pain on walking	0.4	0.5	1.2	0.0	1.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	1.2	-0.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	0.7	0.4	1.1
Medication: Aspirin	1.2	1.6	3.7	1.9	0.1	1.0
Supplements: Vitamin C	0.2	0.2	0.5	-0.0	-0.4	-0.7
Knee pain experienced in last month	1.1	1.7	3.6	1.9	0.9	-0.8
Hypertension (Self-reported)	0.9	2.5	4.7	2.2	1.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	4.0	1.9	-0.4	-2.0
Illnesses of father: Heart disease	2.7	3.8	6.0	0.1	-2.5	-2.3
Illnesses of siblings: Diabetes	1.1	1.4	2.3	0.1	1.5	1.4
Smoking status: Previous	0.8	1.3	2.4	1.5	0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	4.7	2.2	-1.2	-1.1
Whole body fat-free mass	0.2	1.0	2.4	-1.6	-0.5	-0.7
Leg fat-free mass (right)	0.2	1.2	2.3	-1.5	-0.7	-0.8
Arm fat percentage (left)	0.0	0.1	0.2	-0.4	0.4	-0.2
Average weekly red wine intake	0.1	0.1	0.1	-0.4	-0.3	0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	-0.8	-0.7	-1.3
Mood swings	0.7	1.2	2.9	-0.5	0.7	-1.7
Loneliness, isolation	1.7	2.4	5.9	-0.9	0.5	-2.4
Long-standing illness, disability or infirmity	0.9	1.4	2.3	-1.2	-0.7	1.5
Ever had bowel cancer screening	0.5	0.6	1.1	-0.9	0.0	1.1
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.5	-0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	0.0	-0.8	-0.8
Friendships satisfaction	2.0	2.5	3.6	-1.4	-1.9	-1.4
Qualifications: nursing, teaching	0.5	0.8	1.4	0.7	0.7	1.2
Commuting to job workplace: Walk	0.7	0.7	1.9	-0.1	1.4	0.4
Eye problems/disorders: Cataract	0.7	0.8	1.3	1.2	0.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	6.2	0.3	0.5	-2.5
Medication for cholesterol	1.0	1.5	2.3	-1.5	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	0.2	-0.8	0.7
Back pain experienced in last month	0.6	0.9	2.5	-0.4	0.4	1.6
Mineral and other dietary supplements	0.2	0.2	0.6	-0.3	0.8	0.0
Breast cancer (self-reported)	0.4	0.5	1.3	0.1	-1.2	-0.3
Asthma (self-reported)	0.8	1.6	3.3	1.8	-0.1	1.2
Osteoporosis (self-reported)	0.8	1.0	2.3	-0.9	-0.1	1.5
Osteoarthritis (self-reported)	0.7	0.9	1.5	0.8	0.6	1.2
Medication: Aspirin	1.2	1.6	4.1	2.0	0.3	0.7
Medication: Gliclazide	0.1	0.1	0.2	0.2	-0.5	0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	0.9	1.3	0.6
Smoking status: Current	0.3	0.5	0.9	-0.8	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.0	-1.0	0.3
Whole body water mass	0.2	1.1	2.7	-1.6	-0.4	-0.7
Leg predicted mass (right)	0.2	1.2	2.4	-1.6	-0.8	-0.8
Arm fat mass (left)	0.1	0.2	0.5	-0.7	0.5	0.1
Number of self-reported non-cancer illnesses	0.8	1.4	2.1	1.5	0.5	1.3
Average weekly champagne plus white wine intake	2.4	3.3	5.1	-2.3	-2.1	0.4
Miserableness	0.9	1.5	3.2	1.8	-0.0	-1.1
Guilty feelings	1.4	2.1	3.6	-1.9	-0.1	-1.7
Wears glasses or contact lenses	2.1	2.4	5.1	-2.3	-1.2	-0.8
Ever taken oral contraceptive pill	0.6	0.7	1.9	-1.4	-0.2	0.4
Hearing aid user	0.1	0.1	0.3	-0.5	0.2	0.1
Mother’s age at death	1.2	1.5	4.3	-2.1	0.1	-0.5
Financial situation satisfaction	1.7	2.1	3.1	0.7	-1.7	-1.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.9	-0.0	-0.2	-2.0
Commuting to job workplace: Public transport	2.0	2.4	5.0	-1.4	-0.5	-2.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.8	-0.4	1.0
Medication: Blood pressure	1.7	3.2	4.4	2.1	2.1	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.6	-0.1	1.3	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.1	-0.1	-0.2
High cholesterol (Self-reported)	1.0	1.7	2.5	1.6	1.4	0.8
Medication: Bendroflumethiazide	1.0	1.5	2.9	1.7	0.7	1.0
Medication: Paracetamol	0.1	0.2	0.3	0.1	-0.6	0.6
Medication: Lisinopril	1.6	2.0	4.5	1.2	2.1	-0.4
Medication: Atorvastatin	0.3	0.4	0.6	0.8	-0.6	0.4
Illnesses of father: High blood pressure	1.3	1.6	3.0	0.2	1.7	1.3
Alcohol drinker status: Never	0.6	0.8	1.4	-0.4	-1.2	-0.9
Ever smoked	0.1	0.2	0.4	0.6	0.6	0.0
Basal metabolic rate	0.1	0.7	1.6	-1.3	-0.3	-0.5
Leg fat percentage (left)	0.4	1.5	2.0	1.2	1.1	1.4
Arm fat-free mass (left)	0.1	0.4	1.2	-1.1	0.2	-0.3
Number of operations (self-reported)	0.4	0.6	1.4	-1.2	0.5	0.1
Average weekly beer plus cider intake	2.6	3.8	9.7	3.1	1.1	0.7
Irritability	0.9	1.5	4.0	-0.6	0.0	-2.0
Risk taking	0.4	0.6	0.8	0.9	0.9	-0.6
Ever had prostate specific antigen (PSA) test	3.9	4.5	6.2	-2.4	-1.3	-2.5
Fractured/broken bones in last 5 years	0.9	1.1	3.3	0.2	0.2	-1.8
Age started oral contraceptive pill	0.4	0.4	1.3	-1.1	-0.2	0.2
Diastolic blood pressure, automated reading	0.9	2.9	4.9	2.2	0.8	1.8
Ever depressed for a whole week	2.9	3.6	8.9	-3.0	-1.3	-0.4
Unable to work because of sickness or disability	0.5	0.7	1.9	-0.4	0.0	-1.4
Commuting to job workplace: Cycle	1.2	1.4	2.5	-1.0	-0.9	-1.6
Myopia	0.2	0.3	0.8	-0.5	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	1.1	3.0	5.8	-2.4	-1.6	-0.7
Cholesterol lowering medication	0.8	1.2	3.3	1.8	0.3	0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.1	-0.5	-0.6
Pain experienced in last month	0.2	0.3	0.7	0.1	0.6	0.8
Supplements: Calcium	0.4	0.4	1.2	-0.1	-0.3	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	-0.1	0.3	-1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	0.8	0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.4	-0.7	-0.2	-1.2
Heart disease (siblings)	0.7	0.9	2.5	0.5	-1.6	0.1
Alcohol drinker status: Previous	1.3	1.5	3.2	-1.2	-1.8	-0.1
Pack years of smoking	0.2	0.3	0.4	-0.4	0.6	0.6
Impedance of whole body	0.3	1.4	4.2	2.0	0.1	0.4
Leg fat mass (left)	0.1	0.2	0.5	0.1	0.4	0.7
Arm predicted mass (left)	0.1	0.5	1.4	-1.2	0.2	-0.4