Hub : Genes

MCF2L-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.088 0.029 7.7e-04 0.069 0.022 0.065 0.056 0.067 8.5e-09 0.00094 2.2e-08 2.1e-07 1.5e-08
2 GTEx Brain Cerebellar Hemisphere 0.673 0.104 1.3e-05 0.199 NA 0.338 NA 0.391 8.0e-06 NA 1.7e-09 NA 4.5e-11
3 GTEx Skin Not Sun Exposed Suprapubic 0.223 0.067 1.1e-03 -0.004 NA 0.009 NA 0.013 6.9e-01 NA 1.0e-01 NA 6.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 0.8 0.5 -0.9 0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.2 -0.2 -0.5 0.5
Depressed Affect (Nagel 2018) 0.7 1.4 2.5 -0.4 -1.2 -1.6
Depression (Nagel 2018) 1.4 2.1 5.7 -0.7 -2.4 -0.1
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.0 -1.4 -1.4 0.2
Neuroticism (Nagel 2018) 1.1 2.6 5.2 -1.0 -1.3 -2.3
Schizophrenia (2018) 0.1 0.2 0.5 -0.7 -0.1 0.1
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0 0.1
Worry (Nagel 2018) 1.0 2.0 2.6 -1.6 -1.4 -1.2
Alzheimer’s Disease (in mother) 1.3 1.5 2.4 0.8 1.6 1.2
Alzheimer’s Disease (in father) 1.4 1.5 3.3 1.1 1.8 -0.4
Alzheimer’s Disease (including proxy) 2.3 3.4 6.6 1.3 2.6 1.3
Crohns Disease (2017) 0.5 1.1 2.2 -0.3 1.5 1.0
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.2 0.6 0.1
Ulcerative Colitis (UC) 0.1 0.2 0.3 0.5 0.0 -0.5
Major Depression (MDD) 0.1 0.1 0.3 -0.2 0.0 0.6
Reaction Time 1.0 1.9 4.6 0.7 2.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.6 1.5 3.0 -1.7 -1.0 0.8
Breast Cancer 0.2 0.6 0.7 -0.8 0.6 -0.9
Ovarian Cancer 1.8 2.4 5.1 2.2 0.7 1.2
Prostate Cancer 1.7 2.4 4.7 -1.0 1.2 -2.2
Age at First Birth 0.5 0.7 1.0 0.9 -0.6 1.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.9 -0.8 -0.6 1.4
Coronary Artery Disease (CAD) 2.2 2.6 3.7 1.9 -1.3 1.6
Crohns Disease (2012) 0.0 0.1 0.2 -0.4 0.0 -0.1
Mean Putamen Volume 1.0 1.1 2.6 -0.9 -1.6 -0.4
Fasting Glucose 3.3 3.9 6.7 1.6 2.6 1.5
HbA1C 0.5 0.5 1.1 -0.1 -1.1 -0.6
HDL Cholesterol 1.4 2.3 2.7 -1.4 -1.5 -1.6
LDL Cholesterol 0.3 0.5 1.2 1.1 0.1 0.4
Lupus 1.7 2.6 6.2 2.5 0.9 -0.9
Neuroticism (2016) 0.3 0.5 0.7 -0.8 0.6 0.6
Primary Biliary Cirrhosis 0.5 0.7 1.5 -0.7 0.5 -1.2
Rheumatoid Arthritis 1.0 1.3 3.9 -2.0 0.3 0.0
Schizophrenia (2014) 0.1 0.3 0.6 -0.8 0.2 -0.3
Triglycerides 0.0 0.1 0.1 0.2 -0.2 -0.4
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.5 0.7 0.6 0.6
Ulcerative Colitis 0.1 0.1 0.2 -0.2 0.0 -0.5
Blood Eosinophil Count 0.2 1.5 3.3 0.4 1.0 1.8
Blood Platelet Count 0.6 6.8 20.2 -0.2 0.3 4.5
Blood Red Count 0.1 1.0 2.5 -1.6 -0.5 0.7
Blood White Count 0.1 0.9 1.9 0.8 0.5 1.4
Heel T-Score 0.1 0.9 2.5 0.2 -0.1 1.6
BMI 0.1 0.9 1.8 0.0 1.3 0.9
Height 0.4 6.9 11.4 -3.4 -2.2 -2.1
Waist Hip Ratio (WHR) 0.2 1.1 2.8 1.7 -0.1 0.6
Systolic Blood Pressure 5.0 25.0 58.3 7.6 2.8 3.0
Smoking Status 0.1 0.3 0.6 0.8 0.0 -0.5
Allergy or Eczema 1.0 2.7 4.6 -1.6 -2.2 -0.9
Cardiovascular Disease 3.5 11.6 24.2 4.9 2.7 1.7
Hypothyroidism (self reported) 0.8 1.7 2.5 -1.1 -1.6 -1.2
Respiratory disease 0.4 0.8 1.1 1.0 0.8 0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 0.4 -1.0 0.4
Lung FEV1/FVC ratio 1.0 4.9 8.1 -2.9 -2.4 0.9
Lung FVC 0.4 2.1 6.2 -2.5 0.3 0.2
Neuroticism 0.8 1.9 2.9 -1.4 -0.9 -1.7
Chronotype (morning person) 0.0 0.1 0.2 -0.2 -0.4 -0.2
Hair Pigment 0.1 2.5 5.8 2.4 1.0 0.8
Tanning 0.2 2.8 4.3 -2.1 -0.9 -1.8
Hand grip strength (left) 0.1 0.4 0.9 -0.1 0.4 1.0
Number of treatments/medications taken 0.5 0.9 1.5 1.1 -1.2 0.2
Average weekly spirits intake 0.4 0.5 0.8 -0.9 0.2 -0.8
Sensitivity / hurt feelings 0.4 0.7 1.7 -0.3 0.6 -1.3
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.8 0.4 -1.7 -0.0
Hearing difficulty/problems: Yes 0.4 0.6 1.7 0.2 1.3 -0.4
Relative age of first facial hair 0.3 0.6 1.4 -0.5 -0.2 -1.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.6 -0.4 1.2 0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 -0.6 -0.8 -0.3
Ever had hysterectomy (womb removed) 0.5 0.6 1.6 0.3 -1.3 -0.1
Systolic blood pressure, automated reading 3.5 10.2 21.7 4.7 1.9 2.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.1 -0.4 -0.3
Angina 1.0 1.3 3.6 1.9 -0.2 0.6
Medication for hormone replacement therapy 0.3 0.3 0.6 -0.3 0.3 0.8
Vitamin and mineral supplements 0.8 1.1 2.8 -0.4 1.7 -0.7
Supplements: Zinc 0.1 0.1 0.1 0.1 0.4 -0.1
Medication: Co-codamol 1.2 1.4 2.2 -1.1 1.5 0.9
Medication: Metformin 0.8 1.1 2.7 1.6 -0.4 0.6
Diabetes (father) 0.1 0.1 0.2 0.1 -0.5 -0.3
Diabetes (mother) 0.5 0.6 1.1 -1.0 -0.7 -0.4
Severe depression (siblings) 0.3 0.3 0.7 0.2 0.4 -0.8
Pack years adult smoking proportion 0.1 0.2 0.3 -0.1 0.6 0.5
Impedance of leg (right) 0.7 3.4 8.5 2.9 0.6 1.2
Leg fat-free mass (left) 0.3 1.4 2.8 -1.7 -0.8 -0.9
Trunk fat percentage 0.0 0.1 0.3 0.2 0.4 0.5
Hand grip strength (right) 0.1 0.2 0.6 0.1 -0.3 0.8
Townsend deprivation index at recruitment 0.3 0.4 0.6 0.3 0.7 -0.7
Current tobacco smoking 0.1 0.1 0.3 -0.5 -0.0 -0.4
Average weekly fortified wine intake 2.9 3.4 6.0 -2.4 -2.0 -0.3
Maternal smoking around birth 3.3 4.7 6.3 2.5 1.8 2.2
Fed-up feelings 0.6 1.2 3.2 -0.2 -0.5 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 3.7 -1.8 -1.9 -0.8
Relative age voice broke 2.1 3.1 8.0 -0.8 -0.9 -2.8
Taking other prescription medications 0.1 0.2 0.3 -0.3 -0.6 -0.5
Age when periods started (menarche) 0.2 0.4 0.5 -0.5 0.7 0.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.2 -1.1 -0.7 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.8 -1.3 -1.0 -0.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 0.7 0.7 -0.2
Qualifications: CSEs or equivalent 3.9 5.1 7.9 2.7 2.8 -0.2
Serious illness, injury or assault to yourself 0.2 0.2 0.4 -0.2 0.7 0.4
High blood pressure 0.8 2.2 4.0 2.0 1.5 0.6
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.9 -0.2 -2.0 -0.2
Multivitamins +/- minerals 1.0 1.2 1.9 -0.2 -1.3 1.4
Stomach or abdominal pain in last month 0.0 0.0 0.1 0.2 0.3 0.1
Supplements: Glucosamine 0.1 0.1 0.1 -0.0 0.3 0.4
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.1 -0.2 0.1 0.2
Medication: Atenolol 1.8 2.3 5.7 2.4 0.9 0.5
Medication: Levothyroxine sodium 0.1 0.2 0.4 -0.6 -0.1 -0.3
Sitting height 0.1 0.7 1.2 -0.9 -1.1 -0.3
Chronic bronchitis/emphysema (father) 1.3 1.6 2.2 -1.5 -1.4 -0.8
High blood pressure (mother) 0.8 1.1 1.7 1.3 -0.6 1.2
Body mass index (BMI) 0.1 0.4 0.9 -0.3 0.9 0.5
Impedance of leg (left) 1.0 5.1 10.9 3.3 0.9 1.8
Leg predicted mass (left) 0.3 1.4 2.6 -1.6 -0.8 -0.9
Trunk fat mass 0.0 0.1 0.1 -0.4 -0.0 0.3
Waist circumference 0.1 0.3 0.8 0.1 0.9 0.3
Number of incorrect matches in round 0.2 0.3 0.8 -0.9 -0.2 0.2
Past tobacco smoking 0.2 0.4 0.8 -0.9 -0.3 -0.4
Alcohol usually taken with meals 2.5 4.1 6.3 -1.4 -2.5 -2.0
Nervous feelings 1.6 3.1 4.7 -1.9 -0.9 -2.2
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 2.5 -1.2 -1.6 -0.8
Hearing difficulty/problems with background noise 0.5 0.9 2.5 0.1 1.6 0.2
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.4 -0.1 0.3
Had menopause 0.3 0.4 0.8 0.1 0.9 0.5
Had other major operations 0.3 0.4 0.5 -0.7 0.5 -0.6
Forced vital capacity (FVC) 0.2 0.9 1.4 -1.2 -1.0 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.3 -1.1 -1.0 0.1
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 5.5 -2.3 -0.1 -0.7
Qualifications: None of the above 0.1 0.3 0.6 0.5 0.2 0.8
Financial difficulties in last 2 years 2.2 3.0 6.6 -1.5 -2.6 -0.3
Mouth/teeth dental problems 0.2 0.3 0.7 -0.4 -0.2 0.8
Heart attack 0.2 0.3 0.7 0.9 0.3 -0.2
Allergy 0.2 0.4 0.8 -0.3 0.9 -0.5
Pain all over the body in last month 0.5 0.5 1.2 -0.5 -0.4 1.1
Diabetes (self-reported) 0.3 0.4 0.7 0.8 -0.7 -0.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 0.9 0.7 0.2
Medication: Ramipril 0.8 1.1 3.2 -0.0 0.2 -1.8
Medication: Simvastatin 1.5 2.3 3.8 1.7 1.9 0.1
Fluid intelligence score 1.1 2.4 6.2 -2.5 -0.8 0.5
Illnesses of siblings 1.4 1.9 3.5 -1.9 0.2 -1.5
Neuroticism score 0.8 1.6 3.2 -1.1 0.5 -1.8
Weight 0.1 0.3 0.8 -0.9 0.3 -0.1
Impedance of arm (right) 0.2 1.0 2.9 1.7 0.0 -0.5
Arm fat percentage (right) 0.1 0.2 0.6 -0.1 0.8 -0.1
Trunk fat-free mass 0.2 1.1 2.7 -1.6 -0.5 -0.7
Hip circumference 0.2 0.9 1.8 -1.4 0.5 -0.7
Time employed in main current job 0.7 0.8 1.5 0.6 -0.7 1.2
Alcohol intake versus 10 years previously 0.6 0.9 1.5 1.2 0.3 1.1
Father’s age at death 2.8 3.7 5.9 -2.4 -2.3 0.0
Worrier / anxious feelings 0.7 1.2 2.6 -1.6 0.0 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 -0.5 -0.9 -0.0
Falls in the last year 0.6 0.8 1.4 0.0 0.9 -1.2
Hair/balding pattern: Pattern 3 0.4 0.6 1.8 -0.1 -0.1 1.4
Number of live births 2.4 3.4 10.1 -3.2 0.4 0.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 0.9 -0.9 -0.9 0.7
Pulse rate 0.2 0.4 0.9 -1.0 0.2 0.3
Happiness 1.4 1.8 2.9 -1.1 -1.1 -1.7
Noisy workplace 0.8 1.0 1.5 1.2 0.8 1.0
Qualifications: A levels/AS levels or equivalent 1.1 2.3 4.3 -2.1 -1.5 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.8 3.7 -0.6 -1.9 -1.1
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 -1.3 0.1 -0.3
Asthma 0.8 1.6 3.1 1.8 -0.2 1.3
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.3 1.0 -1.2 1.0
Medication: Cholesterol lowering 0.9 1.4 3.0 1.7 1.0 0.3
Depression (self-reported) 0.8 1.0 2.5 -1.6 -0.7 -0.0
Medication: Lansoprazole 0.3 0.4 0.7 0.2 0.6 -0.8
Prospective memory result 0.5 0.6 1.1 0.8 1.0 0.3
Lung cancer (father) 0.2 0.3 0.7 -0.8 0.4 -0.1
Illnesses of mother 0.3 0.4 0.8 0.1 -0.6 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.3 -1.0 -1.1 0.9
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 -1.1 0.4 0.6
Impedance of arm (left) 0.1 0.6 0.7 0.9 -0.7 -0.7
Arm fat mass (right) 0.1 0.2 0.5 -0.7 0.5 0.1
Trunk predicted mass 0.2 1.1 2.7 -1.6 -0.5 -0.6
Standing height 0.2 1.8 2.3 -1.5 -1.3 -1.1
Length of working week for main job 1.3 1.5 2.2 1.5 -0.9 -1.2
Exposure to tobacco smoke at home 4.7 5.3 7.4 2.7 2.4 1.7
Breastfed as a baby 1.0 1.3 3.0 -0.9 -0.1 1.7
Tense / ‘highly strung’ 0.3 0.4 0.8 -0.1 0.9 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.8 -0.4 -0.9 -0.9
Hair/balding pattern: Pattern 4 0.3 0.6 1.7 -0.5 0.3 1.3
Birth weight of first child 0.6 1.0 2.3 -0.6 -1.5 0.6
Peak expiratory flow (PEF) 0.3 0.7 1.5 -0.4 0.8 1.2
Pulse wave reflection index 0.1 0.1 0.2 0.1 0.4 -0.1
Ever highly irritable/argumentative for 2 days 1.4 1.7 2.8 -1.7 1.0 -1.2
Loud music exposure frequency 0.4 0.4 1.0 0.4 1.0 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.9 -1.0 0.1 0.6
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 2.6 1.1 1.4 1.6
Blood clot in the leg (DVT) 0.9 1.2 2.5 -0.9 -0.5 -1.6
Medication: Paracetamol 0.1 0.2 0.6 -0.2 -0.8 0.3
Headache pain in last month 1.1 1.9 2.9 -1.6 -0.5 -1.7
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 4.7 -2.2 -0.5 -0.9
Glaucoma (self-reported) 0.9 1.0 2.1 -0.9 -0.4 1.4
Gout (self-reported) 0.0 0.0 0.1 0.3 0.1 -0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.6 -0.8 -0.1 -0.6
Medication: Amlodipine 1.3 1.8 4.0 2.0 -1.1 0.1
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.6 0.9 1.1 1.6
Birth weight 0.6 1.4 2.3 -0.7 1.1 -1.5
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.8 0.4 0.9 0.2
High blood pressure (siblings) 3.2 4.6 7.5 2.7 1.5 2.0
Forced vital capacity (FVC), Best measure 0.2 0.8 1.4 -1.2 -1.0 0.3
Body fat percentage 0.1 0.3 0.3 0.5 0.5 0.5
Leg fat percentage (right) 0.2 0.9 0.9 0.9 1.0 0.9
Arm fat-free mass (right) 0.2 1.0 2.5 -1.6 -0.7 -0.3
Exposure to tobacco smoke outside home 0.5 0.7 2.0 -0.1 1.4 0.1
Comparative body size at age 10 0.5 1.3 1.8 1.1 1.0 1.4
Number of full brothers 1.4 1.8 3.9 2.0 0.9 0.7
Worry too long after embarrassment 0.1 0.2 0.5 -0.2 0.7 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.1 -0.2 -1.1 -0.6
Wheeze or whistling in the chest in last year 0.4 0.8 1.1 0.9 1.0 -0.7
Number of children fathered 0.7 0.8 2.1 0.4 -0.5 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.4 -0.5 -0.7 -0.5
Age at first live birth 0.1 0.2 0.6 -0.8 0.3 0.2
Pulse wave peak to peak time 0.4 0.5 0.8 0.9 -0.4 -0.8
Health satisfaction 0.5 0.6 1.4 1.2 0.5 0.6
Shortness of breath walking on level ground 0.9 1.0 3.1 -0.1 1.8 -0.0
Qualifications: College or University degree 0.7 2.1 5.3 -2.3 -0.9 -0.2
Eye problems/disorders: None of the above 0.2 0.2 0.5 -0.3 0.7 -0.2
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.4 1.9 -0.6 -0.4
Emphysema/chronic bronchitis 3.0 3.4 7.8 0.3 2.8 1.5
Medication for pain relief, constipation, heartburn 2.2 3.8 7.1 -1.8 1.0 -2.7
Neck or shoulder pain in last month 0.3 0.4 1.1 0.1 0.1 -1.0
Medication: Blood pressure 1.2 2.0 5.1 2.3 0.6 0.9
Angina (self-reported) 0.9 1.2 2.9 1.7 -0.1 0.8
Migraine (self-reported) 0.2 0.3 0.7 0.3 0.8 -0.1
Medication: Ibuprofen 1.0 1.2 1.7 1.1 -1.3 0.8
Medication: Allopurinol 0.1 0.2 0.3 -0.6 -0.2 -0.3
Medication: Omeprazole 0.1 0.2 0.3 -0.2 -0.4 -0.6
Medication: Seretide 50 evohaler 1.6 1.9 2.8 1.0 1.7 1.3
Mean time to correctly identify matches 0.9 1.7 4.9 0.4 2.2 -0.4
Heart disease (mother) 1.8 2.1 5.0 0.6 1.0 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.7 0.0 -0.9 0.4
Whole body fat mass 0.0 0.1 0.1 -0.2 0.4 0.2
Leg fat mass (right) 0.0 0.1 0.3 -0.0 0.4 0.5
Arm predicted mass (right) 0.2 1.1 3.0 -1.7 -0.5 -0.1
Pulse rate, automated reading 0.3 1.1 2.5 -1.6 -0.6 -0.5
Alcohol intake frequency. 0.4 1.0 1.6 -0.8 -1.3 -0.8
Comparative height size at age 10 0.2 0.9 1.9 -1.4 -0.6 0.7
Number of full sisters 0.1 0.2 0.3 -0.6 0.2 0.3
Suffer from ‘nerves’ 0.6 1.0 1.7 -1.1 0.2 -1.3
Overall health rating 0.2 0.5 1.3 1.1 -0.3 0.2
Chest pain or discomfort 0.3 0.4 0.6 0.8 0.5 0.5
Had major operations 0.4 0.4 0.8 -0.9 0.5 -0.5
Age at last live birth 0.8 1.2 2.1 -1.5 1.2 0.0
Family relationship satisfaction 3.9 4.8 6.7 -1.6 -2.6 -2.2
Leg pain on walking 0.4 0.5 1.2 0.0 1.1 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.1 -0.3 0.3 0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.3 1.2 -0.8 0.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 0.7 0.4 1.1
Medication: Aspirin 1.2 1.6 3.7 1.9 0.1 1.0
Supplements: Vitamin C 0.2 0.2 0.5 -0.0 -0.4 -0.7
Knee pain experienced in last month 1.1 1.7 3.6 1.9 0.9 -0.8
Hypertension (Self-reported) 0.9 2.5 4.7 2.2 1.7 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.5 4.0 1.9 -0.4 -2.0
Illnesses of father: Heart disease 2.7 3.8 6.0 0.1 -2.5 -2.3
Illnesses of siblings: Diabetes 1.1 1.4 2.3 0.1 1.5 1.4
Smoking status: Previous 0.8 1.3 2.4 1.5 0.3 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 4.7 2.2 -1.2 -1.1
Whole body fat-free mass 0.2 1.0 2.4 -1.6 -0.5 -0.7
Leg fat-free mass (right) 0.2 1.2 2.3 -1.5 -0.7 -0.8
Arm fat percentage (left) 0.0 0.1 0.2 -0.4 0.4 -0.2
Average weekly red wine intake 0.1 0.1 0.1 -0.4 -0.3 0.1
Handedness (chirality/laterality): Left-handed 0.8 0.9 1.6 -0.8 -0.7 -1.3
Mood swings 0.7 1.2 2.9 -0.5 0.7 -1.7
Loneliness, isolation 1.7 2.4 5.9 -0.9 0.5 -2.4
Long-standing illness, disability or infirmity 0.9 1.4 2.3 -1.2 -0.7 1.5
Ever had bowel cancer screening 0.5 0.6 1.1 -0.9 0.0 1.1
Diabetes diagnosed by doctor 0.2 0.3 0.5 0.5 -0.7 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.6 0.0 -0.8 -0.8
Friendships satisfaction 2.0 2.5 3.6 -1.4 -1.9 -1.4
Qualifications: nursing, teaching 0.5 0.8 1.4 0.7 0.7 1.2
Commuting to job workplace: Walk 0.7 0.7 1.9 -0.1 1.4 0.4
Eye problems/disorders: Cataract 0.7 0.8 1.3 1.2 0.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 6.2 0.3 0.5 -2.5
Medication for cholesterol 1.0 1.5 2.3 -1.5 -1.0 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.6 0.2 -0.8 0.7
Back pain experienced in last month 0.6 0.9 2.5 -0.4 0.4 1.6
Mineral and other dietary supplements 0.2 0.2 0.6 -0.3 0.8 0.0
Breast cancer (self-reported) 0.4 0.5 1.3 0.1 -1.2 -0.3
Asthma (self-reported) 0.8 1.6 3.3 1.8 -0.1 1.2
Osteoporosis (self-reported) 0.8 1.0 2.3 -0.9 -0.1 1.5
Osteoarthritis (self-reported) 0.7 0.9 1.5 0.8 0.6 1.2
Medication: Aspirin 1.2 1.6 4.1 2.0 0.3 0.7
Medication: Gliclazide 0.1 0.1 0.2 0.2 -0.5 0.1
Illnesses of father: None of the above (group 1) 0.7 0.9 1.6 0.9 1.3 0.6
Smoking status: Current 0.3 0.5 0.9 -0.8 -0.1 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.1 0.0 -1.0 0.3
Whole body water mass 0.2 1.1 2.7 -1.6 -0.4 -0.7
Leg predicted mass (right) 0.2 1.2 2.4 -1.6 -0.8 -0.8
Arm fat mass (left) 0.1 0.2 0.5 -0.7 0.5 0.1
Number of self-reported non-cancer illnesses 0.8 1.4 2.1 1.5 0.5 1.3
Average weekly champagne plus white wine intake 2.4 3.3 5.1 -2.3 -2.1 0.4
Miserableness 0.9 1.5 3.2 1.8 -0.0 -1.1
Guilty feelings 1.4 2.1 3.6 -1.9 -0.1 -1.7
Wears glasses or contact lenses 2.1 2.4 5.1 -2.3 -1.2 -0.8
Ever taken oral contraceptive pill 0.6 0.7 1.9 -1.4 -0.2 0.4
Hearing aid user 0.1 0.1 0.3 -0.5 0.2 0.1
Mother’s age at death 1.2 1.5 4.3 -2.1 0.1 -0.5
Financial situation satisfaction 1.7 2.1 3.1 0.7 -1.7 -1.8
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.9 -0.0 -0.2 -2.0
Commuting to job workplace: Public transport 2.0 2.4 5.0 -1.4 -0.5 -2.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 -0.8 -0.4 1.0
Medication: Blood pressure 1.7 3.2 4.4 2.1 2.1 0.9
Pain type(s) experienced in last month: Hip pain 0.4 0.6 1.6 -0.1 1.3 0.3
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.0 0.1 -0.1 -0.2
High cholesterol (Self-reported) 1.0 1.7 2.5 1.6 1.4 0.8
Medication: Bendroflumethiazide 1.0 1.5 2.9 1.7 0.7 1.0
Medication: Paracetamol 0.1 0.2 0.3 0.1 -0.6 0.6
Medication: Lisinopril 1.6 2.0 4.5 1.2 2.1 -0.4
Medication: Atorvastatin 0.3 0.4 0.6 0.8 -0.6 0.4
Illnesses of father: High blood pressure 1.3 1.6 3.0 0.2 1.7 1.3
Alcohol drinker status: Never 0.6 0.8 1.4 -0.4 -1.2 -0.9
Ever smoked 0.1 0.2 0.4 0.6 0.6 0.0
Basal metabolic rate 0.1 0.7 1.6 -1.3 -0.3 -0.5
Leg fat percentage (left) 0.4 1.5 2.0 1.2 1.1 1.4
Arm fat-free mass (left) 0.1 0.4 1.2 -1.1 0.2 -0.3
Number of operations (self-reported) 0.4 0.6 1.4 -1.2 0.5 0.1
Average weekly beer plus cider intake 2.6 3.8 9.7 3.1 1.1 0.7
Irritability 0.9 1.5 4.0 -0.6 0.0 -2.0
Risk taking 0.4 0.6 0.8 0.9 0.9 -0.6
Ever had prostate specific antigen (PSA) test 3.9 4.5 6.2 -2.4 -1.3 -2.5
Fractured/broken bones in last 5 years 0.9 1.1 3.3 0.2 0.2 -1.8
Age started oral contraceptive pill 0.4 0.4 1.3 -1.1 -0.2 0.2
Diastolic blood pressure, automated reading 0.9 2.9 4.9 2.2 0.8 1.8
Ever depressed for a whole week 2.9 3.6 8.9 -3.0 -1.3 -0.4
Unable to work because of sickness or disability 0.5 0.7 1.9 -0.4 0.0 -1.4
Commuting to job workplace: Cycle 1.2 1.4 2.5 -1.0 -0.9 -1.6
Myopia 0.2 0.3 0.8 -0.5 -0.9 -0.1
Vascular/heart problems diagnosed by doctor 1.1 3.0 5.8 -2.4 -1.6 -0.7
Cholesterol lowering medication 0.8 1.2 3.3 1.8 0.3 0.5
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.1 -0.5 -0.6
Pain experienced in last month 0.2 0.3 0.7 0.1 0.6 0.8
Supplements: Calcium 0.4 0.4 1.2 -0.1 -0.3 1.1
Basal cell carcinoma (self-reported) 0.6 0.7 2.1 -0.1 0.3 -1.5
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.6 0.8 0.5 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.4 -0.7 -0.2 -1.2
Heart disease (siblings) 0.7 0.9 2.5 0.5 -1.6 0.1
Alcohol drinker status: Previous 1.3 1.5 3.2 -1.2 -1.8 -0.1
Pack years of smoking 0.2 0.3 0.4 -0.4 0.6 0.6
Impedance of whole body 0.3 1.4 4.2 2.0 0.1 0.4
Leg fat mass (left) 0.1 0.2 0.5 0.1 0.4 0.7
Arm predicted mass (left) 0.1 0.5 1.4 -1.2 0.2 -0.4