Best TWAS P=2.45e-12 · Best GWAS P=5.04e-17 conditioned to 4.05e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | STYX | 0.07 | 0.03 | enet | 15 | 0.03 | 8.5e-04 | -4.3 | -6.2 | 5.0e-10 | 0.32 | 0.84 | 0.03 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | STYX | 0.24 | 0.15 | lasso | 4 | 0.13 | 4.9e-05 | -5.3 | -5.2 | 2.0e-07 | 0.29 | 0.47 | 0.04 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | STYX | 0.30 | 0.34 | lasso | 4 | 0.36 | 3.3e-28 | -4.5 | -5.2 | 1.5e-07 | 0.36 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Mucosa | STYX | 0.17 | 0.09 | enet | 13 | 0.04 | 1.8e-03 | -4.4 | -5.2 | 2.1e-07 | 0.41 | 0.95 | 0.01 | FALSE |
| 5 | GTEx | Esophagus Mucosa | RP11-841O20.2 | 0.09 | 0.01 | enet | 17 | 0.02 | 8.6e-03 | -7.5 | 7.0 | 2.4e-12 | -0.33 | 0.10 | 0.31 | TRUE |
| 6 | GTEx | Muscle Skeletal | STYX | 0.07 | 0.07 | lasso | 3 | 0.06 | 9.2e-07 | -5.3 | -5.4 | 5.2e-08 | 0.31 | 0.98 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FERMT2 | 0.02 | 0.01 | blup | 63 | 0.00 | 5.1e-02 | -5.9 | -6.8 | 1.1e-11 | 0.41 | 0.08 | 0.08 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STYX | 0.01 | 0.01 | blup | 50 | 0.01 | 3.4e-03 | 4.5 | -5.1 | 2.9e-07 | 0.35 | 0.06 | 0.22 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | STYX | 0.06 | 0.07 | lasso | 2 | 0.06 | 3.0e-04 | -5.3 | -5.8 | 7.5e-09 | 0.34 | 0.01 | 0.93 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STYX | 0.06 | 0.00 | blup | 50 | 0.03 | 5.4e-04 | -5.2 | -5.8 | 5.2e-09 | 0.27 | 0.01 | 0.83 | TRUE |