Hub : Genes

STYX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0700	0.0280	2.1e-03	0.034	NA	0.034	NA	0.034	8.9e-04	NA	8.5e-04	NA	8.8e-04
2	GTEx	Artery Tibial	0.0899	0.0296	1.1e-04	0.091	NA	0.073	NA	0.084	1.3e-07	NA	2.3e-06	NA	4.2e-07
3	GTEx	Cells EBV-transformed lymphocytes	0.2410	0.0880	4.6e-03	0.150	NA	0.119	NA	0.131	1.4e-05	NA	1.1e-04	NA	4.9e-05
4	GTEx	Cells Transformed fibroblasts	0.3000	0.0500	0.0e+00	0.345	NA	0.344	NA	0.361	8.7e-27	NA	1.1e-26	NA	3.3e-28
5	GTEx	Esophagus Mucosa	0.1660	0.0470	3.5e-06	0.089	NA	0.036	NA	0.022	1.5e-06	NA	1.8e-03	NA	1.2e-02
6	GTEx	Muscle Skeletal	0.0719	0.0266	6.4e-04	0.066	NA	0.040	NA	0.063	4.5e-07	NA	7.4e-05	NA	9.2e-07
7	GTEx	Testis	0.2490	0.0600	1.6e-06	0.263	NA	0.228	NA	0.243	4.8e-12	NA	1.7e-10	NA	3.8e-11
8	NTR	Blood	0.0210	0.0080	4.3e-04	0.011	0.010	0.010	0.011	0.014	1.1e-04	0.00027	1.8e-04	0.00014	2.3e-05
9	TCGA	Breast Invasive Carcinoma	0.0134	0.0083	4.0e-03	0.014	0.010	0.005	NA	0.002	6.7e-04	0.00340	2.7e-02	NA	1.1e-01
10	TCGA	Colon Adenocarcinoma	0.0610	0.0320	8.9e-04	0.074	0.051	0.036	NA	0.057	4.5e-05	0.00062	3.7e-03	NA	3.0e-04
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0398	0.0233	3.3e-03	0.025	0.008	0.021	NA	0.020	6.7e-04	0.03600	1.8e-03	NA	2.0e-03
12	TCGA	Prostate Adenocarcinoma	0.0592	0.0330	3.3e-04	0.004	0.028	0.025	NA	0.016	1.2e-01	0.00054	1.1e-03	NA	7.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.8	1.2	3.8	-0.3	0.8	-1.4	0.5	0.2	-1.4	-1.9	-0.9	-0.1	-1.0	-0.4	-1.9
Bipolar Disorder or Schizophrenia	0.5	1.2	4.5	0.4	-0.3	-1.3	-0.4	-0.5	-1.7	-0.9	0.6	-0.9	-1.5	-0.2	-2.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.6	-0.2	0.1	0.2	0.0	0.5	0.2	0.1	0.1	-0.1	0.2	0.8	-0.5
Depression (Nagel 2018)	1.8	2.8	9.2	-0.1	-0.5	-2.4	-1.1	-0.9	-2.2	-1.0	-0.0	-1.6	-2.1	-1.8	-3.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	0.7	0.9	-0.5	0.7	0.8	-0.4	-1.0	-0.3	0.4	-0.2	0.8	-0.9
Neuroticism (Nagel 2018)	0.1	0.3	1.5	0.5	0.1	-0.7	0.1	0.3	-0.6	-0.5	-0.1	-0.0	-0.5	-0.2	-1.2
Schizophrenia (2018)	0.4	0.9	2.6	0.7	-1.0	-0.6	-0.9	-0.7	-1.0	0.4	1.6	-1.0	-1.1	0.1	-1.2
Schizophrenia vs Biploar Disorder	0.8	1.1	4.7	0.9	-0.1	1.5	0.2	0.4	1.2	0.8	0.3	1.2	1.1	0.2	2.2
Worry (Nagel 2018)	0.6	1.4	3.2	0.1	0.5	-1.8	0.0	-0.1	-1.6	-1.6	-0.9	0.2	-1.4	-1.3	-1.8
Alzheimer’s Disease (in mother)	6.1	7.1	14.5	3.8	3.4	0.9	3.2	3.3	1.0	-3.2	-3.7	3.0	1.6	0.5	0.5
Alzheimer’s Disease (in father)	8.0	8.6	15.3	1.9	2.5	3.7	3.0	3.4	3.8	-0.3	-1.9	2.8	3.9	3.0	3.1
Alzheimer’s Disease (including proxy)	11.8	17.1	30.0	4.3	4.1	4.3	4.7	5.5	4.2	-1.8	-3.7	4.4	4.8	3.4	3.3
Crohns Disease (2017)	0.2	0.4	1.7	-0.3	-0.2	0.8	0.1	-0.3	0.8	0.7	-0.2	0.3	0.6	-0.5	1.3
Irritable Bowel Disease (IBD)	0.6	1.4	3.7	0.8	1.4	0.1	1.3	0.9	0.5	-1.3	-1.5	1.8	0.7	-0.3	1.9
Ulcerative Colitis (UC)	1.8	3.5	8.3	2.1	2.5	-0.7	2.1	1.7	-0.2	-2.9	-2.5	2.5	0.4	-0.2	1.6
Major Depression (MDD)	2.2	2.7	8.3	1.3	1.9	-1.8	1.2	0.3	-1.7	-2.9	-2.2	0.7	-1.3	-1.4	-1.5
Reaction Time	0.7	1.3	3.6	1.6	1.5	-0.5	1.3	1.0	-0.3	-1.9	-1.1	1.5	-0.0	0.4	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.8	0.2	0.6	1.1	0.8	1.3	1.0	0.1	0.3	0.5	1.0	1.9	0.1
Breast Cancer	0.2	0.5	1.7	-0.5	-1.0	-0.1	-0.8	-1.3	-0.3	0.9	1.1	-0.4	-0.4	-0.5	0.2
Ovarian Cancer	0.2	0.3	1.8	-0.2	-0.2	-0.5	-0.4	-1.0	-0.4	0.2	0.2	-0.6	-0.4	0.2	-1.3
Prostate Cancer	2.2	3.0	8.8	-0.2	-1.3	2.6	-0.4	-0.0	2.5	3.0	1.8	-0.6	2.0	1.8	1.3
Age at First Birth	1.8	2.6	8.8	1.4	2.1	-0.4	2.0	1.2	-0.2	-2.6	-3.0	1.7	0.3	-0.8	-0.2
Bipolar Disorder (2011)	1.0	1.0	3.3	1.2	1.3	-0.5	0.9	1.0	-0.7	-1.8	-1.3	0.5	-0.4	0.0	-0.8
Body Mass Index (BMI) (2010)	3.0	4.1	9.3	3.0	1.9	1.9	2.1	2.5	2.1	-0.7	-1.5	1.8	2.2	1.9	1.6
Coronary Artery Disease (CAD)	0.3	0.4	0.8	0.5	-0.2	0.8	0.3	0.7	0.9	0.2	0.2	0.6	0.9	0.8	0.7
Crohns Disease (2012)	0.3	0.6	2.5	0.3	0.3	1.0	0.5	0.4	1.0	0.1	-0.3	0.7	0.9	0.2	1.6
Mean Putamen Volume	0.8	0.9	1.3	1.1	1.1	0.8	1.1	1.1	1.0	-0.6	-1.2	0.7	1.1	0.6	0.8
Fasting Glucose	1.2	1.4	2.8	1.7	1.1	0.4	1.6	1.5	0.7	-1.4	-1.5	1.2	0.9	0.9	0.3
HbA1C	0.1	0.1	0.4	-0.3	-0.4	0.3	0.2	0.0	0.2	0.0	0.1	-0.5	0.2	0.6	-0.5
HDL Cholesterol	0.5	0.9	2.5	-0.1	0.6	-1.2	0.4	0.2	-1.4	-1.6	-0.9	0.2	-1.1	-0.7	-1.1
LDL Cholesterol	0.1	0.1	0.4	-0.2	0.1	-0.6	-0.1	-0.1	-0.4	-0.5	0.1	0.1	-0.2	-0.1	-0.1
Lupus	1.7	2.6	7.8	1.8	2.1	-0.9	1.8	1.5	-0.3	-2.6	-2.8	1.2	0.1	-0.7	-0.9
Neuroticism (2016)	0.1	0.2	1.0	1.0	0.4	-0.3	0.2	-0.1	-0.6	-0.7	-0.4	0.2	-0.5	-0.2	0.1
Primary Biliary Cirrhosis	2.3	3.4	7.0	2.2	2.4	0.5	2.3	2.5	0.7	-2.2	-1.4	1.4	1.1	2.6	-0.2
Rheumatoid Arthritis	0.7	0.9	2.6	-0.7	-0.1	-1.4	-0.4	-0.5	-1.6	-1.0	0.1	-0.2	-1.5	-0.9	-1.3
Schizophrenia (2014)	0.1	0.2	0.8	0.9	0.0	-0.3	-0.0	-0.0	-0.6	-0.4	0.5	0.0	-0.6	0.1	-0.5
Triglycerides	0.4	0.7	1.3	0.6	0.7	0.8	0.8	1.1	0.9	-0.2	-0.9	1.0	0.9	0.3	1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	0.9	0.9	0.7	1.0	0.8	0.8	-0.7	-1.1	1.2	0.9	0.1	1.0
Ulcerative Colitis	2.3	3.4	8.5	2.4	2.4	-0.8	2.1	1.9	-0.3	-2.9	-2.4	2.1	0.2	-0.1	1.3
Blood Eosinophil Count	0.2	1.6	3.4	-0.3	0.2	1.8	0.6	1.1	1.9	1.3	0.6	1.0	1.7	1.6	1.5
Blood Platelet Count	0.6	6.7	15.4	1.5	1.9	2.9	2.3	3.9	3.0	-0.3	-0.1	2.5	3.0	3.9	2.4
Blood Red Count	0.0	0.4	1.1	-0.4	-0.1	-1.0	-0.3	-0.4	-1.1	-0.5	-0.1	-0.1	-1.0	-0.7	-0.5
Blood White Count	0.3	2.1	4.0	0.7	1.3	1.5	1.6	1.9	1.6	-0.6	-1.2	1.9	1.7	0.6	2.0
Heel T-Score	0.4	3.4	26.7	0.9	-0.0	1.4	0.5	0.5	1.6	0.8	0.0	2.3	1.4	-0.1	5.2
BMI	2.5	14.3	23.5	3.9	4.5	2.8	4.7	4.8	3.0	-3.0	-4.0	4.5	3.6	2.9	2.7
Height	0.2	4.4	11.8	0.7	0.6	3.4	1.3	2.6	3.2	1.2	-0.1	0.6	3.0	2.7	1.7
Waist Hip Ratio (WHR)	0.2	1.0	9.7	-3.1	-0.5	-0.5	-0.6	-0.5	-0.6	-0.1	0.8	-0.2	-0.6	-0.2	-0.3
Systolic Blood Pressure	4.9	24.7	38.7	-6.2	-4.4	-5.2	-5.2	-5.2	-5.4	1.2	3.8	-5.1	-5.8	-4.1	-5.8
Smoking Status	1.1	2.7	5.3	0.9	1.2	1.7	1.7	2.3	2.0	-0.3	-0.2	1.5	2.1	2.1	1.8
Allergy or Eczema	1.3	3.4	7.6	-0.3	0.7	2.5	1.3	2.0	2.8	1.0	-0.1	1.4	2.6	2.3	2.4
Cardiovascular Disease	0.5	1.7	4.9	-2.2	-1.3	-0.2	-1.1	-0.5	-0.4	0.9	1.9	-1.6	-0.7	1.0	-1.9
Hypothyroidism (self reported)	1.0	2.2	3.6	0.6	1.6	1.4	1.9	1.9	1.7	-1.0	-1.7	1.3	1.9	1.5	0.8
Respiratory disease	0.2	0.3	1.1	-0.7	-0.1	-1.0	-0.4	-0.4	-0.9	-0.2	0.5	-0.2	-0.9	-0.3	-0.5
Type 2 Diabetes (T2D) (2018)	1.7	3.1	6.1	0.7	2.2	1.2	2.2	2.5	1.5	-1.5	-1.6	2.2	1.7	1.6	1.4
Lung FEV1/FVC ratio	0.4	2.1	7.6	2.8	1.4	-1.1	0.9	0.7	-1.1	-2.3	-1.9	0.6	-0.7	-1.0	-0.9
Lung FVC	0.3	1.7	3.1	-0.1	-0.8	-1.8	-1.1	-1.7	-1.8	-0.3	0.2	-1.0	-1.7	-1.6	-1.6
Neuroticism	0.1	0.2	0.9	-0.6	-0.1	-0.4	-0.3	0.1	-0.3	-0.0	0.6	-0.2	-0.4	0.4	-0.9
Chronotype (morning person)	1.1	2.5	5.4	2.0	2.2	-0.1	2.1	1.5	0.2	-2.3	-2.1	1.6	0.7	1.0	-0.3
Hair Pigment	0.1	3.3	9.0	-0.5	0.0	-3.0	-0.7	-1.3	-2.9	-1.9	-0.2	-0.4	-2.6	-2.1	-2.2
Tanning	0.0	0.2	0.8	-0.1	-0.4	0.9	-0.1	-0.1	0.8	0.2	-0.4	-0.3	0.7	0.7	0.0
Hand grip strength (left)	2.2	5.9	12.1	0.4	2.4	2.7	2.8	3.5	2.9	-0.9	-1.7	1.7	3.2	3.4	0.6
Number of treatments/medications taken	0.3	0.6	1.3	0.4	1.2	0.1	1.1	0.9	0.4	-1.0	-1.0	1.1	0.5	0.4	0.2
Average weekly spirits intake	2.2	2.7	6.4	0.7	1.5	1.9	1.8	2.1	1.9	-0.6	-0.6	1.6	2.1	2.5	1.0
Sensitivity / hurt feelings	0.3	0.6	2.0	-0.6	-0.6	-0.9	-0.7	-0.5	-0.9	0.1	0.7	-0.7	-1.0	-0.2	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.5	-0.3	-0.1	-1.3	-0.4	0.1	-1.0	-0.6	-0.0	-0.7	-1.0	-0.6	-1.6
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.2	0.8	-0.0	0.9	0.5	0.2	-0.5	-1.0	0.8	0.4	-0.1	0.5
Relative age of first facial hair	0.4	0.8	2.8	0.5	0.8	0.6	0.6	1.4	0.8	-0.3	0.1	0.7	0.8	1.7	0.9
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	4.2	2.0	1.6	0.6	1.6	1.5	0.8	-1.4	-1.6	1.2	1.1	0.7	0.3
Ever used hormone-replacement therapy (HRT)	2.2	2.9	9.9	3.1	2.0	-0.1	1.7	1.4	-0.1	-2.2	-2.1	2.1	0.3	-0.0	1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	1.3	0.5	1.1	0.7	0.5	0.9	-0.1	-0.5	1.0	0.9	0.2	1.3
Systolic blood pressure, automated reading	5.2	15.1	22.8	-4.3	-3.3	-4.3	-4.0	-4.1	-4.6	0.5	2.8	-4.0	-4.8	-3.3	-4.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	-0.8	0.7	-0.1	0.6	-0.2	0.0	-0.7	-0.8	0.9	0.1	-0.2	0.2
Angina	0.3	0.4	1.6	0.3	0.7	-0.1	0.6	0.4	0.1	-1.0	-1.3	0.8	0.3	-0.9	0.2
Medication for hormone replacement therapy	1.1	1.2	3.9	0.8	0.9	1.0	0.9	1.3	1.3	-0.2	-0.7	0.9	1.3	0.7	2.0
Vitamin and mineral supplements	1.9	2.6	4.3	-1.2	-1.5	-1.7	-1.8	-2.0	-2.0	0.3	1.2	-1.6	-2.1	-1.7	-1.4
Supplements: Zinc	1.5	1.7	4.4	-1.5	-1.7	0.4	-1.4	-1.4	0.3	2.0	2.1	-1.4	-0.1	0.3	0.2
Medication: Co-codamol	0.1	0.2	0.6	0.5	0.3	0.3	0.4	0.3	0.5	0.1	-0.8	0.2	0.5	-0.1	-0.2
Medication: Metformin	0.8	1.1	2.7	-0.4	0.4	1.3	0.7	1.1	1.5	0.2	-0.2	0.9	1.4	1.2	1.6
Diabetes (father)	0.1	0.1	0.7	-0.2	0.1	-0.1	0.2	0.6	0.1	-0.2	0.4	0.4	0.2	0.9	-0.3
Diabetes (mother)	3.0	3.9	7.4	2.3	2.7	-0.1	2.4	2.1	0.3	-2.7	-2.6	2.7	0.8	0.2	1.4
Severe depression (siblings)	0.6	0.6	2.6	-0.7	-0.5	-0.9	-0.6	-0.5	-0.8	0.1	0.3	-0.8	-0.9	-0.7	-1.6
Pack years adult smoking proportion	0.3	0.5	0.8	-0.6	-0.8	-0.6	-0.9	-0.8	-0.7	0.3	0.4	-0.7	-0.8	-0.9	-0.8
Impedance of leg (right)	0.8	3.8	8.0	-1.7	-2.2	-1.6	-2.4	-2.8	-1.8	1.4	1.9	-2.0	-2.0	-1.9	-0.9
Leg fat-free mass (left)	1.5	8.0	14.9	2.6	3.2	2.5	3.5	3.9	2.7	-2.0	-2.8	2.7	3.1	2.6	1.8
Trunk fat percentage	1.1	4.5	7.2	2.0	2.0	2.3	2.2	2.3	2.2	-0.9	-2.2	2.7	2.4	1.1	2.5
Hand grip strength (right)	2.6	7.0	14.6	1.7	3.1	2.3	3.3	3.8	2.6	-1.8	-2.5	2.1	3.0	3.3	0.5
Townsend deprivation index at recruitment	0.3	0.5	1.4	-1.2	-0.3	-1.0	-0.4	-0.5	-0.8	-0.3	0.9	-0.5	-0.8	0.3	-0.6
Current tobacco smoking	1.9	3.2	8.6	1.5	1.2	2.1	1.6	2.1	2.3	-0.1	0.1	1.2	2.4	2.9	1.4
Average weekly fortified wine intake	0.5	0.6	3.9	0.4	0.1	0.8	0.3	0.8	0.6	0.3	0.9	-0.0	0.6	2.0	-0.2
Maternal smoking around birth	0.7	1.0	3.0	-1.7	-1.2	0.2	-1.1	-1.3	0.1	1.4	1.2	-0.8	-0.2	-0.3	0.2
Fed-up feelings	0.4	0.7	3.2	0.1	0.3	1.0	0.5	1.0	1.1	0.4	0.3	-0.0	1.1	1.8	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	6.2	-0.6	-0.2	-1.4	-0.5	-0.2	-1.1	-0.7	0.2	-1.1	-1.1	-0.1	-2.5
Relative age voice broke	0.1	0.2	0.6	0.4	0.3	-0.8	-0.1	0.1	-0.6	-0.7	0.1	0.2	-0.5	-0.2	-0.0
Taking other prescription medications	0.4	0.5	1.7	0.2	0.2	-1.3	-0.0	-0.1	-1.1	-0.8	-0.3	0.3	-1.0	-1.0	-0.9
Age when periods started (menarche)	0.1	0.2	1.6	-0.3	-0.1	0.5	-0.0	-0.3	0.3	0.2	-0.2	0.2	0.2	-0.4	1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	2.9	1.7	0.7	0.0	0.5	0.3	-0.1	-0.6	-0.7	0.3	0.0	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	5.5	0.3	0.2	0.3	0.1	0.7	0.5	0.1	0.0	1.1	0.4	-0.0	2.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.1	-1.4	-1.0	-0.5	-1.2	-1.2	-0.6	1.0	0.9	-1.3	-0.8	-1.0	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	2.3	-1.5	-1.1	0.1	-0.9	-0.9	0.1	1.4	1.1	-0.8	-0.2	-0.1	-0.2
Serious illness, injury or assault to yourself	0.8	1.0	2.2	0.5	1.4	0.8	1.5	1.2	0.8	-1.0	-1.0	1.0	1.0	1.2	0.0
High blood pressure	1.0	2.9	5.9	-2.4	-1.8	-0.9	-1.8	-1.7	-1.1	1.1	2.1	-2.1	-1.4	0.0	-2.3
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.8	-0.5	0.1	1.8	0.5	1.5	1.9	1.3	0.5	0.6	1.8	1.9	1.5
Multivitamins +/- minerals	4.6	5.8	9.7	2.1	2.2	2.4	2.6	2.7	2.7	-0.5	-2.1	2.8	2.9	1.6	3.1
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.2	0.2	0.2	0.3	0.2	0.3	0.2	-0.3	0.3	0.3	-0.3	0.4
Supplements: Glucosamine	0.4	0.5	1.4	1.1	0.6	0.1	0.6	0.3	0.1	-0.8	-1.2	0.9	0.2	-0.5	0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.8	0.9	0.6	0.9	0.8	0.7	0.9	-0.2	-0.4	1.0	0.9	0.7	1.7
Medication: Atenolol	0.1	0.2	0.7	-0.8	0.1	-0.6	-0.1	-0.3	-0.4	-0.5	0.1	0.2	-0.4	-0.2	-0.7
Medication: Levothyroxine sodium	1.1	1.9	4.9	1.0	2.0	0.1	1.8	1.6	0.5	-2.0	-2.2	1.4	0.9	0.5	0.2
Sitting height	0.4	2.8	5.9	1.7	1.7	1.9	1.8	2.4	2.0	-0.5	-1.3	0.3	2.1	2.3	0.3
Chronic bronchitis/emphysema (father)	1.3	1.6	5.2	1.2	1.8	-0.3	1.3	0.8	0.1	-2.0	-2.3	1.4	0.4	-0.2	0.4
High blood pressure (mother)	1.2	1.8	3.3	-1.7	-1.5	-0.7	-1.5	-1.6	-0.8	1.1	1.6	-1.8	-1.1	-0.4	-1.2
Body mass index (BMI)	1.3	5.6	9.0	2.4	2.8	1.6	2.9	2.8	1.7	-2.2	-3.0	2.9	2.2	1.3	1.7
Impedance of leg (left)	0.6	3.1	5.3	-1.9	-2.2	-1.0	-2.2	-2.3	-1.2	1.9	2.2	-1.8	-1.5	-1.2	-0.4
Leg predicted mass (left)	1.5	7.9	15.0	2.5	3.2	2.5	3.5	3.9	2.7	-1.9	-2.8	2.7	3.1	2.7	1.7
Trunk fat mass	1.4	6.0	8.4	2.3	2.5	2.5	2.8	2.9	2.5	-1.3	-2.6	2.9	2.7	1.6	2.4
Waist circumference	1.8	6.6	10.9	1.6	2.5	2.7	2.9	3.3	2.8	-1.2	-2.2	2.9	3.1	2.2	2.6
Number of incorrect matches in round	0.3	0.6	1.1	-0.6	-1.0	-0.3	-1.1	-0.7	-0.6	0.8	1.0	-0.2	-0.8	-0.8	0.6
Past tobacco smoking	0.2	0.4	1.4	0.5	-0.5	1.2	-0.2	-0.3	0.9	1.1	-0.0	-0.1	0.8	0.3	0.3
Alcohol usually taken with meals	3.6	5.8	8.8	2.5	2.5	2.1	2.7	2.4	2.3	-1.5	-2.8	2.7	2.6	1.1	3.0
Nervous feelings	0.5	0.9	2.1	-1.2	-0.8	-0.8	-0.9	-0.9	-1.0	0.4	0.8	-0.8	-1.1	-0.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	5.6	-0.1	-0.1	-0.9	-0.3	-0.3	-0.8	-0.5	0.3	-1.0	-0.8	0.2	-2.4
Hearing difficulty/problems with background noise	0.7	1.1	2.6	1.4	1.6	-0.7	1.2	0.6	-0.3	-1.5	-1.4	1.3	-0.1	-0.5	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.7	0.8	-0.0	-1.3	-0.3	-0.3	-1.1	-0.6	0.1	-0.2	-1.1	-0.8	-0.7
Had menopause	0.4	0.6	1.3	0.3	0.2	-0.9	0.0	-0.7	-1.1	-1.1	-0.7	0.6	-0.9	-1.1	0.2
Had other major operations	0.8	0.9	2.3	1.2	1.4	-0.0	1.3	0.8	-0.0	-1.4	-1.5	0.9	0.2	0.3	-0.3
Forced vital capacity (FVC)	0.1	0.3	1.2	0.4	0.4	0.5	0.4	0.7	0.6	0.0	-0.2	-0.3	0.6	1.1	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	8.9	0.3	-0.3	0.8	-0.2	0.6	0.8	0.7	0.6	1.0	0.6	0.1	3.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.2	-0.7	-0.1	-0.4	-0.4	0.1	-0.2	0.1	0.7	-0.6	-0.3	0.4	-1.1
Qualifications: None of the above	0.1	0.3	0.8	0.1	-0.9	0.4	-0.7	-0.3	0.1	0.9	0.9	-0.4	0.0	-0.3	0.3
Financial difficulties in last 2 years	1.4	1.9	4.4	-0.7	0.6	1.9	1.2	1.2	1.9	0.7	0.1	1.0	1.8	2.1	1.5
Mouth/teeth dental problems	0.1	0.2	0.7	0.3	0.3	-0.4	0.1	-0.2	-0.6	-0.8	-0.6	-0.2	-0.4	-0.7	-0.4
Heart attack	1.5	2.0	6.4	1.2	1.5	-1.7	0.9	0.4	-1.4	-2.5	-1.9	0.7	-1.0	-1.5	-0.7
Allergy	0.5	1.2	2.9	-0.1	-0.4	-1.2	-0.6	-1.4	-1.4	-0.6	-0.4	-0.9	-1.3	-1.7	-1.4
Pain all over the body in last month	0.9	1.0	3.2	-1.0	-0.2	-1.1	-0.5	-0.3	-1.0	-0.4	1.1	-1.0	-0.9	1.2	-1.8
Diabetes (self-reported)	2.5	3.9	6.3	1.0	2.5	1.5	2.5	2.4	1.7	-1.6	-2.1	2.4	2.0	1.6	1.6
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.9	-0.5	-0.1	2.0	0.5	1.3	2.2	1.6	0.4	0.4	2.0	1.8	1.4
Medication: Ramipril	0.5	0.6	1.5	-0.2	0.8	0.5	0.8	1.0	0.7	-0.7	-1.2	0.9	0.8	-0.0	0.8
Medication: Simvastatin	0.5	0.7	1.9	-1.3	-1.2	0.4	-1.0	-0.6	0.3	1.4	1.3	-0.7	-0.0	0.1	0.2
Fluid intelligence score	0.2	0.3	1.2	0.8	0.4	0.7	0.6	0.6	0.6	0.0	-0.1	0.1	0.7	1.1	0.1
Illnesses of siblings	0.4	0.5	2.3	-1.5	-0.7	-0.1	-0.6	-0.3	-0.1	1.0	0.8	-1.0	-0.3	-0.2	0.0
Neuroticism score	0.1	0.3	0.9	-0.9	0.5	-0.6	0.3	0.4	-0.4	-0.7	-0.1	0.2	-0.3	0.4	-1.0
Weight	1.6	8.0	14.0	2.5	3.2	2.5	3.4	3.7	2.6	-2.0	-3.1	2.9	3.0	2.2	2.0
Impedance of arm (right)	0.3	1.5	5.3	-1.0	-1.7	0.5	-1.5	-0.9	0.3	2.3	1.7	-0.6	-0.2	-0.6	1.1
Arm fat percentage (right)	1.1	4.2	6.8	2.0	1.9	2.0	2.2	2.3	2.1	-0.9	-2.3	2.6	2.3	0.8	2.3
Trunk fat-free mass	0.7	3.8	8.1	1.8	2.5	1.3	2.6	2.9	1.5	-1.9	-2.3	1.4	1.9	1.7	0.2
Hip circumference	2.5	10.7	17.3	3.2	3.2	3.4	3.7	4.2	3.5	-1.5	-2.8	3.4	3.8	3.1	2.7
Time employed in main current job	0.7	0.8	2.6	0.0	-0.4	1.6	-0.0	-0.1	1.5	1.3	0.1	0.1	1.3	0.4	0.9
Alcohol intake versus 10 years previously	1.2	1.8	3.3	-1.3	-1.7	-1.1	-1.8	-1.7	-1.2	0.8	1.3	-1.0	-1.3	-1.6	-0.2
Father’s age at death	0.3	0.4	3.0	1.7	0.4	0.2	0.5	0.3	0.1	-0.6	-0.7	0.1	0.2	0.0	-0.4
Worrier / anxious feelings	0.4	0.7	2.5	0.2	0.8	-1.1	0.5	0.3	-0.9	-1.6	-1.0	0.4	-0.7	-0.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.1	-0.1	0.4	-0.9	0.2	0.1	-0.8	-1.0	-0.3	-0.4	-0.6	0.1	-1.4
Falls in the last year	0.0	0.0	0.2	-0.4	0.0	0.2	0.0	-0.2	0.0	0.0	-0.2	0.1	0.1	0.1	0.1
Hair/balding pattern: Pattern 3	0.3	0.4	2.1	1.5	0.3	0.7	0.4	0.6	0.4	-0.2	-0.8	0.3	0.6	-0.1	0.6
Number of live births	0.5	0.7	1.6	-0.9	-1.2	0.2	-1.0	-1.0	0.1	1.2	1.3	-0.5	-0.1	-0.4	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.1	0.9	0.8	0.0	0.8	0.9	0.1	-0.8	-0.7	-0.1	0.2	0.9	-1.0
Pulse rate	1.5	2.6	5.7	2.3	2.1	-0.4	1.8	1.4	0.1	-2.2	-2.4	1.9	0.5	-0.3	0.9
Happiness	0.3	0.4	1.3	-0.1	0.7	0.3	0.7	0.8	0.4	-0.6	-0.4	-0.0	0.5	1.0	-1.1
Noisy workplace	2.0	2.4	4.3	1.4	2.1	1.1	2.0	2.0	1.1	-1.5	-1.4	1.9	1.4	1.6	0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.8	1.7	1.5	-1.1	1.0	0.6	-0.8	-2.2	-2.0	0.8	-0.4	-0.9	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.3	0.5	0.1	0.4	0.5	0.2	-0.4	-0.4	-0.2	0.3	0.5	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.2	-0.2	0.8	0.1	0.1	0.8	0.7	0.4	0.3	0.7	0.6	0.8
Asthma	0.8	1.5	2.9	-1.7	-1.3	-1.1	-1.4	-1.2	-1.2	0.9	1.4	-1.1	-1.4	-0.9	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.7	1.6	1.3	0.2	1.2	1.7	0.1	-1.5	-1.5	1.1	0.4	-0.0	0.6
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.5	-0.5	0.1	-0.5	-0.5	0.0	0.4	0.3	-0.1	-0.1	-0.5	0.2
Depression (self-reported)	0.4	0.5	1.7	-0.4	-0.0	-1.3	-0.2	-0.2	-1.1	-0.7	-0.1	-0.1	-1.1	-0.9	-0.8
Medication: Lansoprazole	0.3	0.3	0.9	0.7	0.4	-0.9	0.2	0.0	-0.8	-0.9	-0.2	0.0	-0.6	-0.3	-0.7
Prospective memory result	0.5	0.6	1.6	-1.2	-0.0	0.8	0.1	1.0	0.8	0.6	0.8	0.3	0.7	1.3	0.6
Lung cancer (father)	0.6	0.7	2.7	0.4	0.7	-0.5	0.5	0.1	-0.5	-1.0	-1.6	0.6	-0.4	-1.6	0.1
Illnesses of mother	0.2	0.3	1.1	0.5	0.2	0.6	0.3	0.6	0.5	0.3	0.2	0.4	0.5	0.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.5	1.1	1.0	0.8	1.1	1.2	0.9	-0.6	-1.1	0.3	1.0	1.1	-0.3
Pulse wave Arterial Stiffness index	1.6	1.9	3.3	-1.2	-1.8	-1.0	-1.8	-1.4	-1.0	1.5	1.7	-1.3	-1.3	-1.4	-0.4
Impedance of arm (left)	0.3	1.3	4.4	-0.6	-1.6	0.4	-1.5	-1.1	0.1	2.1	1.7	-0.7	-0.3	-0.5	0.9
Arm fat mass (right)	1.6	6.5	9.9	2.4	2.7	2.2	3.0	3.2	2.3	-1.6	-2.8	3.1	2.7	1.6	2.3
Trunk predicted mass	0.6	3.5	7.5	1.7	2.4	1.1	2.5	2.7	1.4	-1.9	-2.3	1.3	1.7	1.6	0.1
Standing height	0.3	2.8	6.1	0.5	1.1	2.4	1.5	2.4	2.4	0.3	-0.4	0.4	2.3	2.5	0.9
Length of working week for main job	0.1	0.1	0.3	0.6	0.1	0.2	0.2	0.2	0.3	0.1	-0.3	0.0	0.3	-0.1	-0.3
Exposure to tobacco smoke at home	1.5	1.7	3.5	0.1	0.8	1.8	1.0	1.1	1.8	0.2	-0.4	1.0	1.9	1.6	1.8
Breastfed as a baby	0.2	0.2	0.9	0.3	0.3	-0.4	0.2	0.9	-0.4	-0.7	-0.3	0.4	-0.3	-0.3	0.1
Tense / ‘highly strung’	0.6	1.0	2.5	-0.1	1.5	-0.5	1.3	1.4	-0.2	-1.6	-1.1	0.8	0.0	0.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.7	0.2	0.8	-1.2	0.4	0.0	-1.0	-1.3	-0.6	-0.3	-0.8	0.2	-2.2
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	-1.2	-0.4	0.9	-0.2	-0.6	0.8	1.0	0.0	0.2	0.6	-0.8	1.1
Birth weight of first child	3.9	7.0	12.9	3.4	2.2	3.5	2.7	2.5	3.5	-0.1	-2.1	1.9	3.6	2.3	2.2
Peak expiratory flow (PEF)	0.9	2.0	4.5	1.2	1.8	0.8	1.9	2.1	1.0	-1.4	-1.4	1.0	1.2	1.9	-0.3
Pulse wave reflection index	1.0	1.2	3.7	-1.6	-1.3	-0.2	-1.2	-0.7	-0.2	1.5	1.9	-1.3	-0.5	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.2	-0.1	0.7	0.1	0.6	0.7	0.3	-0.5	-0.3	0.2	0.4	0.9	-1.1
Loud music exposure frequency	0.9	1.0	2.2	-0.3	-0.3	-1.5	-0.6	-1.1	-1.4	-0.6	-0.1	-0.7	-1.3	-1.3	-1.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	1.0	0.2	-0.6	-0.0	-0.7	-0.5	-0.6	-0.9	0.2	-0.4	-1.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	-0.6	-0.6	0.9	-0.3	0.3	0.8	1.3	1.0	-0.6	0.6	1.3	0.2
Blood clot in the leg (DVT)	1.2	1.5	2.7	1.3	1.4	1.0	1.4	1.4	1.1	-0.8	-1.0	1.6	1.2	0.9	1.6
Medication: Paracetamol	1.1	1.8	3.4	0.5	0.9	1.8	1.2	1.4	1.7	0.1	-0.2	1.6	1.7	1.4	1.7
Headache pain in last month	1.0	1.7	2.7	1.6	1.6	0.5	1.5	1.6	0.8	-1.1	-1.4	1.6	1.0	0.3	1.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	0.8	1.2	0.2	1.2	1.0	0.4	-0.9	-0.9	1.2	0.6	0.5	0.8
Glaucoma (self-reported)	2.0	2.4	6.6	2.6	1.9	0.7	1.9	1.2	0.7	-1.7	-2.0	1.6	1.1	0.4	1.0
Gout (self-reported)	0.3	0.4	1.2	-1.1	-0.8	0.2	-0.7	-0.3	0.1	0.8	0.9	-0.7	-0.0	-0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.6	0.3	1.3	1.1	1.4	1.6	1.4	-0.7	-1.1	1.1	1.6	1.3	0.8
Medication: Amlodipine	0.7	1.0	2.5	-0.7	-0.7	-1.2	-0.9	-1.0	-1.2	-0.1	0.6	-1.4	-1.2	-0.5	-1.6
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.6	-0.4	0.1	1.1	0.4	0.5	1.0	0.6	0.1	0.9	0.9	0.5	1.3
Birth weight	0.9	1.9	4.5	1.0	0.7	2.1	1.1	1.4	2.1	0.7	-0.2	0.8	2.0	1.9	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	1.0	0.8	-1.2	0.4	-0.2	-1.1	-1.4	-0.9	0.4	-0.8	-0.9	-0.2
High blood pressure (siblings)	0.4	0.5	2.1	0.7	0.9	-0.6	0.6	0.3	-0.4	-1.4	-1.1	0.6	-0.1	-0.2	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	1.7	0.4	0.7	1.1	0.9	1.2	1.3	0.0	-0.7	0.3	1.3	1.2	0.3
Body fat percentage	0.9	3.6	6.3	1.8	1.9	1.8	2.1	1.9	1.8	-1.1	-2.2	2.5	2.0	0.7	2.2
Leg fat percentage (right)	0.5	1.9	4.6	1.7	1.6	0.7	1.6	1.1	0.8	-1.4	-2.1	1.8	1.1	-0.0	1.3
Arm fat-free mass (right)	0.9	4.5	9.1	1.9	2.8	1.3	2.8	3.0	1.5	-2.3	-2.3	1.7	1.9	2.2	0.4
Exposure to tobacco smoke outside home	0.4	0.5	1.2	-0.1	-0.3	-0.9	-0.7	-1.1	-1.1	-0.1	0.5	-0.1	-1.0	-0.8	0.4
Comparative body size at age 10	1.1	3.0	4.9	1.3	1.7	2.0	2.0	1.6	2.1	-0.5	-1.4	1.6	2.2	1.7	2.1
Number of full brothers	0.3	0.4	1.7	-1.3	-0.7	-0.1	-0.7	-0.7	0.0	0.8	1.1	-0.0	-0.1	0.1	0.3
Worry too long after embarrassment	0.2	0.3	0.6	-0.4	-0.1	-0.8	-0.4	-0.2	-0.8	-0.2	0.6	-0.6	-0.8	0.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.1	-0.2	0.7	-1.5	0.2	-0.3	-1.3	-1.4	-1.0	-0.5	-1.2	-0.9	-1.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.9	-0.1	0.4	0.1	0.6	0.7	0.2	-0.2	-0.2	0.8	0.3	0.5	0.9
Number of children fathered	1.0	1.1	3.6	-1.1	-0.1	-1.8	-0.5	-0.1	-1.5	-0.8	0.3	-0.7	-1.4	-0.4	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	1.4	1.2	0.0	0.1	0.0	0.2	-0.0	-0.1	-0.4	0.2	0.0	-0.5	0.2
Age at first live birth	0.7	1.3	3.5	1.1	1.4	0.5	1.5	0.9	0.6	-1.4	-1.9	1.4	0.9	0.1	0.8
Pulse wave peak to peak time	2.2	2.6	4.3	1.4	2.0	1.3	2.1	1.8	1.3	-1.5	-1.8	1.6	1.6	1.7	0.6
Health satisfaction	1.6	2.0	3.4	1.4	1.7	1.3	1.8	1.8	1.4	-1.1	-1.6	1.3	1.6	1.2	0.4
Shortness of breath walking on level ground	0.4	0.4	1.1	1.0	0.7	-0.0	0.7	1.0	0.3	-0.4	-0.3	0.1	0.3	0.7	-1.0
Qualifications: College or University degree	0.4	1.3	2.4	1.1	1.4	0.6	1.5	1.5	0.8	-1.0	-1.5	1.3	1.0	0.7	0.9
Eye problems/disorders: None of the above	2.3	2.7	4.4	-1.3	-2.0	-1.3	-2.1	-1.9	-1.3	1.4	1.9	-2.0	-1.6	-0.9	-1.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	1.3	1.1	0.4	0.9	0.8	0.5	-0.8	-0.7	0.8	0.6	0.6	0.4
Emphysema/chronic bronchitis	0.6	0.6	1.6	0.7	1.0	-0.0	1.0	1.1	0.2	-0.9	-1.1	1.3	0.4	0.1	0.5
Medication for pain relief, constipation, heartburn	3.4	5.7	10.6	-2.8	-3.1	-0.7	-2.9	-3.1	-1.0	2.8	2.5	-3.3	-1.4	-1.3	-2.0
Neck or shoulder pain in last month	1.4	1.9	4.2	1.2	1.7	0.9	1.6	1.5	1.0	-1.1	-1.0	2.0	1.3	1.0	1.8
Medication: Blood pressure	0.5	0.9	1.7	-1.2	-1.3	0.1	-1.1	-1.3	-0.2	1.0	1.0	-1.2	-0.4	-0.3	-0.9
Angina (self-reported)	0.3	0.5	1.5	0.1	0.7	-0.2	0.6	0.4	-0.0	-1.1	-1.2	0.8	0.2	-0.9	0.3
Migraine (self-reported)	0.9	1.1	2.4	1.1	1.1	0.8	1.2	1.1	0.8	-0.7	-1.3	1.3	0.9	0.0	1.6
Medication: Ibuprofen	0.5	0.6	1.7	1.2	1.0	-0.0	0.8	1.3	-0.1	-1.1	-1.0	0.6	0.2	0.1	-0.0
Medication: Allopurinol	0.2	0.3	1.7	-1.3	-0.6	0.5	-0.4	0.0	0.3	0.8	0.6	-0.4	0.2	-0.0	-0.2
Medication: Omeprazole	0.9	1.1	2.6	0.7	1.6	-0.3	1.3	1.3	-0.2	-1.6	-1.2	1.1	0.1	0.8	-0.6
Medication: Seretide 50 evohaler	1.8	2.1	4.7	-2.2	-1.9	-0.6	-1.8	-1.8	-0.8	1.7	1.3	-1.3	-1.1	-1.5	-0.4
Mean time to correctly identify matches	0.5	1.0	3.3	1.3	1.0	-1.0	0.8	0.3	-0.9	-1.8	-1.0	1.2	-0.6	-0.3	-0.2
Heart disease (mother)	0.9	1.1	2.2	-1.1	-0.8	-1.3	-1.0	-1.4	-1.4	-0.1	0.5	-0.3	-1.5	-1.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	-0.4	0.1	0.8	0.2	0.6	0.9	0.6	1.0	0.7	0.8	1.4	1.0
Whole body fat mass	1.5	6.1	9.1	2.3	2.7	2.2	2.9	2.9	2.2	-1.7	-2.8	3.0	2.6	1.5	2.3
Leg fat mass (right)	1.1	4.4	6.2	2.1	2.3	1.8	2.5	2.3	1.8	-1.5	-2.4	2.5	2.2	1.3	2.0
Arm predicted mass (right)	1.1	5.6	10.7	2.0	3.1	1.5	3.1	3.3	1.7	-2.5	-2.6	2.0	2.1	2.3	0.7
Pulse rate, automated reading	1.6	5.1	10.0	3.0	2.9	0.0	2.6	2.1	0.6	-2.7	-3.1	3.2	1.0	-0.3	2.1
Alcohol intake frequency.	0.2	0.5	1.7	0.1	0.8	-0.6	0.6	0.1	-0.6	-1.3	-1.0	0.9	-0.4	-0.6	0.5
Comparative height size at age 10	0.5	2.7	6.2	0.9	0.8	2.5	1.3	2.1	2.4	0.7	0.0	0.6	2.3	2.3	1.2
Number of full sisters	0.5	0.6	1.7	-0.1	0.4	0.6	0.6	1.3	0.9	-0.0	0.4	0.6	0.9	1.1	1.0
Suffer from ‘nerves’	0.7	1.1	3.3	0.4	0.5	-1.8	0.1	-0.2	-1.5	-1.3	-0.2	0.2	-1.3	-0.6	-1.6
Overall health rating	2.1	4.5	9.9	2.0	3.0	-0.0	2.7	2.6	0.4	-3.1	-2.8	2.6	1.0	0.5	0.9
Chest pain or discomfort	0.4	0.6	1.5	-1.0	-0.8	-0.8	-0.8	-0.7	-0.6	0.3	0.8	-0.9	-0.7	-0.5	-1.2
Had major operations	0.2	0.2	0.7	0.2	0.4	-0.0	0.3	0.4	-0.0	-0.5	-0.5	0.8	0.0	-0.3	0.7
Age at last live birth	0.1	0.1	1.0	-0.1	-0.0	0.3	0.2	-0.3	0.1	-0.1	-0.2	0.5	0.2	-0.1	1.0
Family relationship satisfaction	0.6	0.7	1.7	-0.1	0.7	1.1	0.8	1.3	1.1	-0.2	-0.8	0.5	1.1	0.8	0.5
Leg pain on walking	2.0	2.5	5.2	1.5	2.0	1.0	1.9	2.1	1.2	-1.3	-1.0	1.7	1.4	2.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.5	-1.5	-0.5	1.3	-0.1	0.4	1.4	1.6	1.0	-0.2	1.1	1.3	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.2	0.6	0.0	0.2	0.1	0.1	0.3	0.3	-0.0	-0.3	0.3	0.4	-1.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	4.0	0.7	0.2	-1.2	-0.3	-0.7	-1.1	-0.8	-0.7	-0.1	-1.0	-2.0	0.1
Medication: Aspirin	3.4	4.5	7.7	2.5	2.8	0.4	2.7	2.5	1.0	-2.7	-2.5	2.6	1.4	1.1	1.4
Supplements: Vitamin C	0.7	0.8	2.4	-0.4	0.2	1.3	0.4	0.9	1.5	0.6	0.2	0.0	1.3	1.6	-0.0
Knee pain experienced in last month	0.7	1.1	2.1	1.0	1.0	0.9	1.1	1.4	0.9	-0.6	-0.8	1.4	1.1	0.7	1.4
Hypertension (Self-reported)	0.8	2.3	4.7	-2.2	-1.6	-0.9	-1.6	-1.7	-1.1	0.8	1.8	-1.9	-1.3	-0.0	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.9	1.6	1.6	-0.7	1.1	0.5	-0.6	-1.6	-1.7	1.7	-0.3	-1.1	1.2
Illnesses of father: Heart disease	0.9	1.2	3.2	0.4	0.3	-1.8	0.0	-0.4	-1.7	-1.4	-0.7	0.4	-1.5	-1.6	-0.8
Illnesses of siblings: Diabetes	1.2	1.5	3.3	1.2	-0.1	1.8	0.3	0.8	1.8	1.1	0.5	0.8	1.7	1.4	1.5
Smoking status: Previous	0.5	0.7	2.1	-1.0	0.0	-1.4	-0.4	-0.4	-1.4	-0.8	0.1	-0.1	-1.3	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.5	0.8	1.0	0.5	1.0	1.2	0.6	-0.8	-0.8	0.4	0.7	0.9	0.0
Whole body fat-free mass	1.0	5.9	12.2	2.1	2.9	1.9	3.1	3.5	2.1	-2.0	-2.6	2.0	2.5	2.3	0.9
Leg fat-free mass (right)	1.7	8.8	17.8	2.5	3.2	2.9	3.6	4.2	3.0	-1.7	-2.7	2.7	3.3	3.0	2.0
Arm fat percentage (left)	1.1	4.3	7.0	2.2	2.1	1.9	2.3	2.3	1.9	-1.2	-2.5	2.7	2.2	0.9	2.2
Average weekly red wine intake	2.2	3.3	6.2	0.3	1.6	2.3	2.1	1.8	2.4	-0.2	-1.6	1.7	2.5	1.8	1.9
Handedness (chirality/laterality): Left-handed	1.9	2.3	6.3	0.6	0.4	2.1	0.8	1.3	2.2	0.9	0.2	1.3	2.0	1.8	2.5
Mood swings	0.3	0.5	1.7	-1.2	-0.4	-0.7	-0.3	-0.0	-0.6	0.0	0.6	-0.9	-0.6	0.4	-1.3
Loneliness, isolation	0.4	0.5	2.0	-1.1	0.1	0.8	0.3	0.6	0.9	0.5	0.4	0.2	0.8	1.4	-0.5
Long-standing illness, disability or infirmity	0.9	1.3	3.4	1.2	1.6	-0.1	1.4	1.0	0.2	-1.8	-1.4	1.3	0.5	0.8	-0.7
Ever had bowel cancer screening	0.3	0.4	1.6	-0.9	-0.0	-0.7	-0.3	-0.5	-0.5	-0.3	-0.4	0.5	-0.4	-1.3	0.9
Diabetes diagnosed by doctor	2.7	4.4	7.2	0.9	2.3	1.7	2.5	2.6	2.0	-1.5	-2.1	2.7	2.2	1.5	2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	6.2	1.3	0.8	1.2	1.0	1.1	1.1	-0.2	0.4	0.3	1.1	2.5	0.1
Friendships satisfaction	0.6	0.7	3.3	0.2	0.7	1.0	0.8	1.0	1.0	-0.3	-0.2	0.4	1.0	1.8	-0.2
Qualifications: nursing, teaching	0.2	0.3	1.5	0.9	-0.3	-0.6	-0.3	-0.2	-0.6	-0.1	-0.3	0.0	-0.7	-1.2	0.3
Commuting to job workplace: Walk	0.4	0.5	1.9	-0.3	0.7	-0.3	0.6	0.4	-0.2	-0.8	-1.4	0.5	-0.0	-1.0	0.7
Eye problems/disorders: Cataract	1.4	1.6	3.2	0.9	1.4	1.2	1.4	1.8	1.3	-0.5	-1.1	1.2	1.4	1.2	1.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	-0.2	0.1	0.6	0.2	0.1	0.8	0.5	-0.4	0.2	0.7	-0.1	0.2
Medication for cholesterol	0.5	0.7	2.4	1.6	0.4	1.3	0.7	0.8	1.0	0.4	-0.4	0.5	1.0	0.9	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.8	1.2	1.1	1.1	1.1	1.2	1.3	-0.5	-0.7	1.1	1.4	1.2	0.9
Back pain experienced in last month	0.5	0.7	1.9	0.5	1.1	-0.9	0.7	0.9	-0.6	-1.4	-1.1	0.6	-0.4	-0.6	-0.3
Mineral and other dietary supplements	0.9	1.2	2.9	-0.6	-0.5	-1.7	-0.9	-1.0	-1.7	-0.6	0.8	-0.9	-1.6	-0.8	-1.2
Breast cancer (self-reported)	0.6	0.8	2.4	-0.6	-1.0	-0.5	-0.9	-0.6	-0.7	0.5	0.7	-1.5	-0.8	-0.2	-1.5
Asthma (self-reported)	0.7	1.4	2.6	-1.6	-1.1	-1.3	-1.3	-1.1	-1.3	0.5	1.2	-1.0	-1.5	-1.0	-0.8
Osteoporosis (self-reported)	0.7	0.9	2.1	0.4	1.4	0.0	1.3	1.4	0.4	-1.0	-0.8	1.0	0.6	1.1	0.2
Osteoarthritis (self-reported)	0.9	1.2	3.2	1.1	0.3	-1.8	-0.0	-0.1	-1.6	-1.5	-0.6	0.0	-1.3	-1.0	-1.6
Medication: Aspirin	2.9	3.8	6.5	2.5	2.5	0.5	2.5	2.2	1.0	-2.3	-2.2	2.4	1.3	1.1	1.3
Medication: Gliclazide	1.4	1.6	4.4	-0.2	1.2	1.2	1.3	1.1	1.2	-0.6	-1.3	1.9	1.3	0.4	2.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.4	-0.6	0.1	-0.4	-0.8	-0.1	0.6	0.1	-0.3	-0.2	-0.9	0.4
Smoking status: Current	2.3	3.6	10.6	1.4	1.1	2.3	1.6	2.3	2.5	0.2	0.3	1.1	2.5	3.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.9	-0.6	-0.3	0.0	-0.1	-0.4	-0.1	0.1	-0.5	-0.3	-0.1	-0.5	-0.9
Whole body water mass	1.0	5.9	12.3	2.0	2.9	2.0	3.1	3.5	2.2	-2.0	-2.6	2.0	2.6	2.4	1.0
Leg predicted mass (right)	1.7	9.1	18.1	2.5	3.3	2.9	3.6	4.3	3.1	-1.7	-2.7	2.8	3.4	3.1	2.1
Arm fat mass (left)	1.6	6.6	10.3	2.5	2.9	2.1	3.1	3.2	2.3	-1.9	-2.9	3.0	2.6	1.6	2.2
Number of self-reported non-cancer illnesses	1.0	1.7	4.3	1.4	1.9	-0.4	1.6	1.3	-0.0	-2.1	-1.6	1.8	0.3	0.3	0.3
Average weekly champagne plus white wine intake	1.2	1.6	3.0	1.7	1.4	1.0	1.4	1.4	0.9	-1.1	-1.4	1.3	1.2	0.6	1.5
Miserableness	0.6	1.1	3.1	-1.7	-0.9	-0.2	-0.9	-0.1	-0.2	1.0	1.5	-1.3	-0.4	0.9	-1.5
Guilty feelings	0.5	0.8	1.7	-0.4	0.8	1.0	0.9	1.3	1.0	0.0	-0.4	1.0	1.0	0.8	1.2
Wears glasses or contact lenses	0.7	0.8	1.7	0.9	-0.6	-0.9	-0.8	-1.3	-1.2	-0.2	0.3	-0.7	-1.1	-1.1	-0.6
Ever taken oral contraceptive pill	1.2	1.4	3.2	-0.1	0.9	1.5	1.1	1.5	1.7	0.2	-0.5	0.6	1.7	1.8	0.4
Hearing aid user	0.8	0.9	2.6	-1.1	-1.2	0.7	-0.9	-0.8	0.4	1.3	1.6	-0.7	0.3	0.7	0.1
Mother’s age at death	0.3	0.3	0.8	0.3	0.2	0.9	0.5	0.3	0.9	0.0	-0.3	-0.1	0.9	0.6	0.8
Financial situation satisfaction	0.8	1.0	2.2	-1.4	-0.7	1.2	-0.3	0.0	1.2	1.5	1.1	-0.7	0.9	1.4	-0.3
Tinnitus: Yes, now most or all of the time	3.3	3.9	7.8	2.8	2.1	1.8	2.3	2.2	1.9	-1.1	-1.3	1.9	2.1	2.2	1.2
Commuting to job workplace: Public transport	0.0	0.0	0.2	-0.0	0.2	-0.2	0.1	0.2	-0.2	-0.4	-0.2	0.3	-0.2	-0.1	0.1
Eye problems/disorders: Glaucoma	2.8	3.4	7.4	2.7	2.2	1.3	2.4	1.9	1.3	-1.6	-2.0	1.7	1.7	1.4	0.9
Medication: Blood pressure	0.9	1.7	2.8	-1.5	-0.9	-1.7	-1.3	-1.6	-1.6	-0.3	0.8	-1.1	-1.6	-1.2	-1.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.5	0.5	0.0	0.5	0.3	-0.0	-0.5	-0.1	0.3	0.1	0.3	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	1.2	0.3	1.1	0.4	0.5	1.1	0.5	-0.5	0.6	1.0	0.3	1.2
High cholesterol (Self-reported)	1.3	2.3	5.5	-2.3	-2.0	-0.7	-2.0	-1.3	-0.7	1.7	2.0	-1.7	-1.1	-0.9	-0.4
Medication: Bendroflumethiazide	0.7	1.1	2.1	0.8	1.4	0.5	1.3	1.0	0.6	-1.5	-1.1	1.4	0.8	1.0	0.4
Medication: Paracetamol	0.6	0.9	1.7	0.8	0.9	1.2	0.9	0.8	1.0	-0.1	-0.1	1.1	1.0	1.3	1.1
Medication: Lisinopril	2.6	3.3	7.0	-2.6	-2.4	-0.5	-2.2	-2.1	-1.0	1.7	2.5	-1.9	-1.3	-0.2	-1.3
Medication: Atorvastatin	0.1	0.1	0.3	-0.0	0.5	0.2	0.5	0.2	0.2	-0.5	-0.6	0.3	0.3	-0.1	0.2
Illnesses of father: High blood pressure	0.5	0.7	1.4	-1.0	-0.6	-0.7	-0.9	-0.9	-0.7	0.3	0.9	-1.2	-0.8	-0.1	-1.0
Alcohol drinker status: Never	0.2	0.2	0.5	-0.3	-0.5	-0.3	-0.6	-0.7	-0.5	0.3	0.5	-0.4	-0.6	-0.1	-0.6
Ever smoked	0.2	0.3	1.1	-0.2	0.3	-1.1	0.1	0.3	-0.9	-1.0	0.1	-0.1	-0.7	-0.0	-0.5
Basal metabolic rate	1.2	6.6	13.0	2.2	3.0	2.1	3.2	3.6	2.3	-2.0	-2.7	2.3	2.7	2.4	1.2
Leg fat percentage (left)	0.7	2.4	4.6	1.7	1.8	1.0	1.8	1.5	1.1	-1.3	-2.1	2.1	1.4	0.3	1.7
Arm fat-free mass (left)	1.0	4.9	10.3	1.7	2.7	1.7	2.9	3.2	2.0	-1.9	-2.3	1.8	2.3	2.3	0.8
Number of operations (self-reported)	1.5	2.2	5.1	1.6	2.2	0.2	2.0	1.4	0.3	-2.1	-2.2	1.6	0.6	0.3	0.4
Average weekly beer plus cider intake	3.0	4.3	12.8	-3.6	-2.5	-1.0	-2.6	-2.0	-1.2	2.0	2.5	-2.3	-1.6	-1.2	-0.9
Irritability	0.7	1.2	3.5	1.1	1.3	-0.9	0.9	0.4	-0.8	-1.9	-1.8	0.4	-0.5	-0.9	-1.3
Risk taking	1.3	1.9	4.5	0.8	-0.2	2.1	0.5	1.1	2.1	1.3	0.7	0.2	1.9	2.0	1.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	-0.0	0.4	1.0	0.6	0.7	1.1	0.3	-0.6	0.4	1.0	0.4	1.1
Fractured/broken bones in last 5 years	2.8	3.6	8.7	2.9	2.6	-0.3	2.3	1.7	-0.0	-3.0	-2.5	2.1	0.5	0.4	0.6
Age started oral contraceptive pill	0.9	1.1	2.8	0.6	0.0	-1.5	-0.3	-0.9	-1.7	-1.0	-0.2	-0.1	-1.5	-1.2	-1.2
Diastolic blood pressure, automated reading	1.2	3.8	6.8	-2.1	-1.3	-2.4	-1.9	-1.6	-2.6	-0.2	1.3	-2.0	-2.6	-1.4	-2.4
Ever depressed for a whole week	0.5	0.7	2.1	-0.2	1.1	0.3	1.0	1.0	0.4	-0.8	-0.4	0.2	0.5	1.4	-1.0
Unable to work because of sickness or disability	0.3	0.4	1.0	1.0	0.8	-0.2	0.6	0.7	0.1	-1.0	-1.0	0.4	0.2	-0.2	0.0
Commuting to job workplace: Cycle	0.1	0.1	0.5	-0.3	0.3	-0.2	0.2	0.4	-0.3	-0.7	-0.4	0.2	-0.1	0.0	-0.2
Myopia	2.8	4.1	9.0	-1.5	-1.7	-2.2	-2.0	-2.1	-2.3	0.5	1.1	-2.3	-2.4	-2.2	-3.0
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.0	2.2	1.7	1.4	1.9	1.9	1.5	-0.6	-1.8	1.9	1.7	0.6	2.2
Cholesterol lowering medication	0.2	0.2	0.8	-0.9	0.3	-0.6	0.2	0.7	-0.3	-0.8	-0.3	0.1	-0.2	-0.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.6	0.5	1.4	-0.3	1.2	1.1	-0.4	-1.6	-1.3	0.9	-0.0	0.4	-0.6
Pain experienced in last month	1.4	2.4	4.4	-1.3	-2.0	-0.9	-1.9	-2.1	-1.3	1.0	1.3	-2.1	-1.5	-1.2	-1.3
Supplements: Calcium	0.5	0.5	1.4	-1.2	-0.9	-0.4	-0.8	-0.9	-0.3	1.0	1.0	-0.5	-0.4	-0.2	-0.6
Basal cell carcinoma (self-reported)	0.3	0.4	1.2	-0.5	0.1	-1.1	-0.2	-0.4	-1.0	-0.7	0.6	0.1	-0.9	0.3	-0.3
Heart attack/myocardial infarction (self-reported)	1.8	2.4	7.6	1.4	1.7	-1.9	1.0	0.5	-1.5	-2.8	-2.0	0.8	-1.0	-1.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	4.0	1.3	1.6	1.1	1.6	1.6	1.2	-0.9	-1.1	1.9	1.3	0.9	2.0
Heart disease (siblings)	0.2	0.3	0.9	0.3	0.6	0.3	0.6	0.5	0.3	-0.6	-0.5	0.9	0.5	0.3	0.5
Alcohol drinker status: Previous	2.4	2.7	4.1	1.2	2.0	1.3	2.0	1.7	1.5	-1.3	-1.9	2.0	1.7	1.2	1.8
Pack years of smoking	0.6	0.9	1.9	-0.6	-0.8	-1.0	-1.0	-1.1	-1.2	0.1	0.4	-0.7	-1.2	-1.4	-0.8
Impedance of whole body	0.5	2.6	5.7	-1.6	-2.2	-0.2	-2.1	-1.9	-0.5	2.4	2.3	-1.5	-0.9	-0.8	0.2
Leg fat mass (left)	1.2	4.9	6.8	2.1	2.4	2.0	2.6	2.6	2.0	-1.4	-2.4	2.6	2.4	1.4	2.2
Arm predicted mass (left)	1.1	5.4	10.8	1.7	2.8	1.8	3.0	3.3	2.0	-2.1	-2.5	2.0	2.4	2.3	0.9