Best TWAS P=5.9e-09 · Best GWAS P=4e-17 conditioned to 2.29e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | AC004381.6 | 0.09 | 0.04 | enet | 35 | 0.02 | 1.6e-02 | 5.6 | 5.2 | 1.6e-07 | 0.03 | 0.33 | 0.08 | FALSE |
| 2 | GTEx | Brain Cerebellum | AC004381.6 | 0.23 | 0.09 | enet | 18 | 0.12 | 1.9e-04 | 5.6 | 5.7 | 1.6e-08 | 0.03 | 0.28 | 0.06 | FALSE |
| 3 | GTEx | Muscle Skeletal | THUMPD1 | 0.08 | 0.02 | enet | 11 | 0.01 | 4.0e-02 | 5.1 | -5.3 | 1.0e-07 | -0.06 | 0.11 | 0.04 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ACSM1 | 0.07 | 0.06 | lasso | 8 | 0.06 | 1.0e-07 | 5.6 | 5.7 | 1.2e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 5 | YFS | Blood | DCUN1D3 | 0.01 | 0.01 | blup | 353 | 0.01 | 1.4e-03 | 3.1 | 5.8 | 5.9e-09 | 0.01 | 0.60 | 0.01 | TRUE |
| 6 | YFS | Blood | THUMPD1 | 0.03 | 0.03 | lasso | 14 | 0.03 | 5.4e-10 | 5.6 | 5.6 | 2.0e-08 | 0.12 | 1.00 | 0.00 | FALSE |