Hub : Genes

THUMPD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0240	4.4e-03	0.005	0.017	0.008	0.017	0.005	6.7e-02	3.4e-03	3.6e-02	3.2e-03	6.2e-02
2	GTEx	Artery Tibial	0.1842	0.0480	2.1e-06	-0.003	NA	0.034	NA	0.026	7.0e-01	NA	1.1e-03	NA	3.9e-03
3	GTEx	Breast Mammary Tissue (Male)	0.1868	0.1091	6.0e-02	-0.010	NA	-0.012	NA	-0.004	6.2e-01	NA	7.9e-01	NA	4.0e-01
4	GTEx	Cells Transformed fibroblasts	0.1340	0.0350	1.5e-07	0.159	NA	0.161	NA	0.159	5.5e-12	NA	4.2e-12	NA	5.2e-12
5	GTEx	Muscle Skeletal	0.0840	0.0410	4.4e-03	0.022	NA	0.009	NA	0.006	2.7e-03	NA	3.9e-02	NA	7.6e-02
6	GTEx	Skin Sun Exposed Lower leg	0.0630	0.0310	2.6e-03	0.007	NA	-0.001	NA	-0.003	8.0e-02	NA	4.5e-01	NA	9.5e-01
7	METSIM	Adipose	0.0335	0.0161	8.3e-04	0.005	0.020	0.003	0.019	0.011	5.2e-02	4.9e-04	9.0e-02	6.4e-04	7.4e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.0814	0.0208	5.9e-11	0.123	0.091	0.121	0.112	0.117	1.7e-15	1.0e-11	3.0e-15	3.0e-14	9.1e-15
9	YFS	Blood	0.0292	0.0097	2.5e-08	0.025	0.027	0.025	0.028	0.029	8.0e-09	2.5e-09	1.1e-08	1.6e-09	5.5e-10
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0306	0.0224	5.8e-03	0.006	0.014	0.021	NA	0.008	6.9e-02	9.5e-03	1.7e-03	NA	3.5e-02
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.0440	0.0290	4.8e-03	0.043	0.034	0.026	NA	0.029	7.1e-04	2.3e-03	6.6e-03	NA	4.8e-03
12	TCGA	Prostate Adenocarcinoma	0.0681	0.0364	2.9e-06	0.060	0.061	0.057	NA	0.059	7.4e-07	5.6e-07	1.2e-06	NA	9.2e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.5	1.6	0.7	-1.0	0.5	-0.7	-0.4	0.0	0.5	0.9	0.1	0.5	-0.6	1.3
Bipolar Disorder or Schizophrenia	0.8	2.0	5.9	0.0	-1.1	-0.3	0.3	-2.1	-2.2	2.4	0.3	1.6	2.0	0.2	0.9
Depressed Affect (Nagel 2018)	0.3	0.5	1.9	-0.5	-0.0	-1.4	0.7	-0.7	-0.7	0.7	-0.6	0.8	0.7	0.9	-0.1
Depression (Nagel 2018)	0.2	0.2	0.6	-0.2	-0.8	-0.5	0.4	0.5	-0.2	0.7	-0.6	0.1	-0.1	0.7	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.4	1.1	-0.6	-1.0	-1.0	1.7	1.9	-0.9	0.5	-1.8	-1.3	-0.4	-0.2
Neuroticism (Nagel 2018)	0.1	0.3	1.2	-0.4	-0.1	-1.1	0.6	0.1	-0.6	-0.3	-0.5	0.4	0.4	0.7	-0.5
Schizophrenia (2018)	1.3	2.6	8.0	-0.5	-0.7	-0.8	0.9	-2.3	-2.8	2.6	-0.4	1.9	2.2	0.7	0.1
Schizophrenia vs Biploar Disorder	1.4	1.8	5.0	-1.3	0.4	-2.0	1.4	-1.4	-2.2	1.1	-1.2	1.3	0.8	1.2	-1.0
Worry (Nagel 2018)	0.3	0.7	2.8	0.3	-0.1	-0.8	0.4	1.7	0.8	-0.7	-0.8	-0.7	-0.5	0.8	-1.3
Alzheimer’s Disease (in mother)	1.5	1.7	5.8	2.4	0.9	-0.5	-1.5	-0.2	1.4	-0.9	1.4	-1.2	-0.7	-1.4	1.7
Alzheimer’s Disease (in father)	0.4	0.4	4.0	-0.5	-2.0	0.3	-0.1	-0.4	0.3	-0.0	0.2	0.1	0.6	-0.0	0.2
Alzheimer’s Disease (including proxy)	1.9	2.7	7.1	2.7	-0.8	-0.1	-2.0	0.8	1.5	-1.7	1.8	-2.0	-0.8	-1.8	1.8
Crohns Disease (2017)	0.9	1.9	4.9	1.9	1.2	0.2	-1.8	1.2	1.4	-1.2	1.2	-2.2	-1.1	-1.6	0.6
Irritable Bowel Disease (IBD)	0.5	1.3	3.5	1.1	1.4	0.1	-1.2	1.1	1.4	-1.6	0.6	-1.9	-0.8	-0.8	0.3
Ulcerative Colitis (UC)	0.5	0.9	3.5	0.5	0.6	0.7	-1.0	0.5	1.3	-1.9	0.8	-1.1	-0.7	-0.7	0.8
Major Depression (MDD)	0.8	0.9	2.0	-1.4	-1.2	0.4	0.1	-1.4	-1.4	-0.6	0.5	1.2	0.2	0.1	1.2
Reaction Time	0.9	1.7	3.5	-0.5	-1.2	-0.2	1.4	-1.4	-0.7	1.6	-1.1	1.9	1.8	1.8	-0.6
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.7	1.9	-0.3	-0.8	-2.0	2.6	1.4	-2.0	1.3	-2.8	-2.3	-1.5	0.8
Breast Cancer	0.9	2.1	4.9	1.3	-0.2	1.8	-1.4	1.4	2.2	-1.5	1.2	-1.2	-2.0	-1.4	0.9
Ovarian Cancer	0.1	0.1	0.8	-0.3	0.2	-0.3	0.3	-0.1	-0.9	0.2	0.2	0.5	0.5	-0.0	0.1
Prostate Cancer	0.4	0.5	2.5	-0.3	0.3	-1.4	-0.2	0.2	0.5	-0.7	0.3	0.0	-1.6	-0.4	0.5
Age at First Birth	0.3	0.4	1.0	0.5	0.1	-0.3	-0.8	0.0	0.6	-0.2	0.8	-1.0	-0.6	-1.0	0.4
Bipolar Disorder (2011)	1.7	1.6	3.9	0.9	-0.2	-1.0	-1.0	2.0	1.9	-1.4	0.4	-1.6	-1.9	-0.9	0.1
Body Mass Index (BMI) (2010)	1.5	2.1	6.8	-0.6	-0.7	-1.3	0.8	-2.0	-2.0	2.6	-0.5	1.6	1.9	0.8	0.2
Coronary Artery Disease (CAD)	2.8	3.4	6.4	-1.8	1.6	-2.5	1.9	-1.3	-1.2	1.9	-1.9	1.8	2.1	1.9	-1.7
Crohns Disease (2012)	2.0	3.2	5.8	2.4	-0.6	1.8	-2.2	1.7	1.6	-1.7	1.8	-2.4	-0.8	-2.1	1.2
Mean Putamen Volume	0.9	1.0	2.3	-0.5	0.4	-0.5	1.2	0.1	-1.0	1.5	-1.2	0.2	0.9	1.3	-1.5
Fasting Glucose	0.7	0.8	4.6	0.2	-0.8	0.4	-0.9	2.1	0.3	-0.5	0.3	-1.4	-0.7	-0.8	-0.0
HbA1C	0.2	0.3	0.8	0.7	-0.0	-0.1	-0.9	-0.2	0.3	-0.3	0.7	-0.6	0.1	-0.9	0.4
HDL Cholesterol	0.7	1.2	3.7	-0.1	-0.7	0.2	1.1	-0.4	-1.9	0.6	-1.3	0.7	1.9	1.2	-1.1
LDL Cholesterol	0.2	0.3	2.5	0.7	-0.7	-0.7	-0.2	0.2	0.2	1.6	0.1	-0.1	0.3	0.0	0.1
Lupus	0.8	1.1	3.9	2.0	1.8	0.5	-0.9	0.1	1.5	-0.2	0.7	-1.2	-0.7	-0.8	0.4
Neuroticism (2016)	0.1	0.1	0.5	-0.7	-0.5	-0.6	0.3	0.2	0.3	-0.0	0.1	0.3	-0.5	0.2	0.1
Primary Biliary Cirrhosis	1.0	1.4	4.6	1.4	0.9	-2.1	0.3	1.4	1.6	-0.6	-0.7	-0.9	-0.8	0.4	-1.2
Rheumatoid Arthritis	0.2	0.3	0.7	0.0	0.8	0.6	-0.1	0.8	0.7	-0.4	-0.5	-0.7	-0.8	0.1	-0.5
Schizophrenia (2014)	0.8	1.7	4.9	-0.2	-0.4	-0.6	0.8	-2.1	-2.2	2.2	-0.3	1.7	1.4	0.6	0.2
Triglycerides	0.2	0.3	1.2	-0.2	0.0	-1.0	-0.1	0.7	0.4	0.7	-0.1	-0.6	-1.1	-0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.8	0.7	0.8	-1.7	-0.1	1.0	1.1	-0.5	-0.2	-0.9	-1.1	-0.2	-0.9
Ulcerative Colitis	0.2	0.3	1.2	0.3	0.2	0.2	0.2	0.4	1.1	-0.4	-0.5	-0.5	0.5	0.7	-0.7
Blood Eosinophil Count	0.8	6.0	20.2	-0.8	0.9	0.0	-0.0	4.5	3.9	-2.1	-1.5	-3.0	-3.1	-0.1	-3.0
Blood Platelet Count	0.7	8.3	25.1	-3.2	-1.1	-1.0	2.0	-5.0	-4.8	2.4	-0.3	4.9	1.2	1.0	1.7
Blood Red Count	1.2	11.5	26.5	2.6	1.1	1.6	-2.9	4.1	5.2	-5.1	2.2	-4.3	-4.0	-3.2	0.8
Blood White Count	0.3	1.9	4.1	-2.0	1.6	-1.3	1.4	-1.8	-1.3	1.1	-1.1	1.6	0.5	1.4	-0.5
Heel T-Score	0.9	7.5	16.6	-2.4	-0.5	-0.4	2.5	-3.5	-4.1	3.7	-1.7	3.5	3.5	2.7	-0.9
BMI	0.2	0.9	4.5	1.1	-2.1	0.8	-0.7	-0.2	-0.5	1.6	0.8	-0.1	0.1	-0.4	0.8
Height	1.6	30.2	55.4	6.0	-2.4	2.7	-7.4	4.1	4.2	-5.1	6.9	-6.2	-4.7	-7.3	6.0
Waist Hip Ratio (WHR)	1.2	5.4	13.7	1.2	3.7	-0.3	-2.0	2.1	3.4	-2.6	1.1	-2.8	-3.2	-2.0	0.5
Systolic Blood Pressure	3.1	15.4	31.5	-4.9	2.0	-1.8	4.7	-5.3	-4.5	2.1	-3.5	5.6	3.8	4.2	-1.7
Smoking Status	2.0	4.8	9.5	2.4	-0.3	1.1	-3.1	1.6	2.2	-1.6	2.7	-3.1	-1.5	-2.9	1.9
Allergy or Eczema	0.4	1.0	8.2	-0.3	-0.9	2.9	-0.3	-0.4	-0.6	0.3	0.8	0.4	0.6	-0.4	0.9
Cardiovascular Disease	2.3	7.5	18.0	-4.2	0.2	0.6	3.0	-3.1	-3.6	1.7	-2.3	3.4	3.1	2.9	-1.3
Hypothyroidism (self reported)	0.3	0.6	1.4	-0.9	0.1	-0.8	1.0	-0.1	-1.2	0.6	-0.9	0.5	0.3	1.0	-0.9
Respiratory disease	1.7	3.8	7.0	2.5	-0.2	0.4	-2.5	1.3	1.8	-2.0	2.2	-2.2	-1.7	-2.6	2.0
Type 2 Diabetes (T2D) (2018)	1.9	3.6	11.8	-1.3	0.6	-1.5	2.0	-0.9	-1.6	3.4	-2.1	1.2	2.2	2.2	-2.0
Lung FEV1/FVC ratio	0.3	1.6	7.5	0.9	-2.7	1.1	0.1	0.1	-2.2	1.7	0.1	0.5	1.1	0.3	0.3
Lung FVC	0.6	3.0	7.3	1.1	-0.6	2.1	-2.1	0.2	0.8	-2.7	2.4	-1.2	-0.3	-2.0	2.7
Neuroticism	0.3	0.8	2.5	-1.1	-0.7	-1.6	1.2	-0.3	-0.2	0.6	-1.0	1.0	0.4	1.2	-0.7
Chronotype (morning person)	0.2	0.5	2.1	1.0	1.0	0.1	-0.2	-0.9	0.6	1.4	0.2	0.3	0.1	-0.1	0.0
Hair Pigment	0.0	0.6	3.5	0.2	-1.1	1.9	-0.3	0.1	-0.1	-1.0	0.7	0.0	-0.1	-0.4	0.4
Tanning	0.1	1.2	4.0	1.6	1.0	-1.4	-1.0	0.8	2.0	-0.7	0.8	-0.9	-0.8	-0.9	0.5
Hand grip strength (left)	0.1	0.1	0.4	-0.6	0.7	0.5	0.2	-0.4	0.0	-0.3	-0.3	0.3	-0.2	-0.0	-0.1
Number of treatments/medications taken	0.9	1.7	3.0	-0.6	1.4	0.7	1.6	-1.2	-1.2	1.2	-1.3	1.4	1.5	1.7	-1.1
Average weekly spirits intake	0.4	0.5	3.2	0.1	-0.3	1.8	-0.5	0.6	-0.4	-0.8	0.4	-0.5	-0.3	-0.7	0.1
Sensitivity / hurt feelings	0.5	0.8	2.9	-0.3	-0.2	-0.9	1.1	-0.5	-1.7	0.9	-0.8	0.9	0.9	1.0	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	4.3	-0.5	-2.1	0.1	-0.4	0.3	-0.5	-0.3	0.6	0.1	-0.6	-0.3	0.9
Hearing difficulty/problems: Yes	0.4	0.5	2.4	-1.5	-0.1	-0.9	0.6	0.6	-0.9	0.3	-0.9	0.1	0.5	0.6	-0.6
Relative age of first facial hair	0.5	0.9	4.2	-2.0	0.0	-0.1	1.1	-1.0	0.3	0.5	-1.0	1.5	0.8	0.8	-0.3
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.7	1.3	-1.2	0.8	-1.6	1.5	0.7	-1.8	1.5	-1.5	-2.4	-1.7	1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.7	-0.3	-1.3	0.5	0.7	0.4	-0.7	0.4	-0.6	0.5	0.2	0.8	-0.7
Ever had hysterectomy (womb removed)	0.3	0.4	1.6	0.4	0.0	0.4	-0.6	0.2	-0.1	-1.2	0.7	-0.6	-0.6	-0.6	0.6
Systolic blood pressure, automated reading	0.9	2.6	7.6	-1.0	0.9	-1.3	1.5	-2.8	-2.4	1.1	-1.0	2.4	1.4	1.4	-0.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.9	-0.7	1.3	-0.3	1.2	0.1	1.0	1.8	-1.8	0.1	0.3	1.7	-2.0
Angina	0.9	1.2	5.5	-2.3	-1.0	-0.1	1.0	0.6	-0.4	0.7	-1.5	0.0	-0.6	1.1	-1.5
Medication for hormone replacement therapy	0.5	0.6	3.0	-0.8	0.6	1.0	-0.3	0.6	-0.5	-1.7	0.1	-0.3	-0.9	-0.5	0.2
Vitamin and mineral supplements	0.6	0.8	2.8	-1.0	-0.8	0.4	0.1	-1.7	-1.2	0.6	0.5	1.0	1.3	-0.0	0.8
Supplements: Zinc	0.7	0.8	1.2	-0.9	0.5	-0.7	1.0	-0.7	-1.0	1.1	-1.0	0.9	1.1	0.9	-0.7
Medication: Co-codamol	1.0	1.1	3.2	0.8	-1.8	1.2	-1.2	0.6	-1.4	-0.2	1.2	-0.3	0.6	-0.9	1.2
Medication: Metformin	1.0	1.4	4.0	-0.5	1.5	-0.8	0.9	0.9	0.4	1.6	-1.6	-0.2	0.3	1.4	-2.0
Diabetes (father)	0.3	0.4	2.4	-0.3	0.5	-1.6	0.6	0.3	-0.2	-0.1	-0.8	-0.1	-0.4	0.4	-1.0
Diabetes (mother)	1.3	1.6	5.2	-0.2	2.3	-1.6	1.0	-1.8	-0.6	1.2	-1.0	1.1	1.2	1.0	-0.8
Severe depression (siblings)	1.0	1.2	2.9	-0.3	-0.5	0.6	1.0	-1.3	-1.5	1.1	-0.6	1.7	1.7	0.9	-0.4
Pack years adult smoking proportion	0.7	1.0	2.6	-1.0	0.8	0.1	0.2	1.5	0.1	0.2	-1.1	-1.2	-1.5	0.4	-1.6
Impedance of leg (right)	0.4	1.7	9.8	-0.1	3.1	-0.8	0.8	0.1	1.4	-0.1	-1.3	-0.3	1.1	1.2	-1.9
Leg fat-free mass (left)	1.3	6.8	12.3	2.3	-3.5	1.3	-3.4	1.9	0.4	-1.2	3.4	-2.3	-2.5	-3.4	3.3
Trunk fat percentage	0.1	0.6	4.7	0.1	-0.0	0.2	0.0	-0.1	-0.8	2.2	0.0	0.3	1.1	0.4	-0.3
Hand grip strength (right)	0.1	0.3	1.5	-1.2	0.2	0.2	0.6	-0.3	-0.5	-0.1	-0.5	0.6	0.2	0.3	-0.4
Townsend deprivation index at recruitment	0.4	0.5	2.6	-0.1	-0.4	-0.2	-0.7	0.1	1.6	0.0	0.8	-0.4	-1.1	-0.6	0.7
Current tobacco smoking	1.7	2.8	6.0	1.9	-1.6	1.1	-2.2	1.7	1.5	-0.5	1.8	-2.5	-1.6	-1.9	1.0
Average weekly fortified wine intake	0.7	0.8	3.5	-0.4	1.9	-0.4	0.2	1.1	0.7	-1.0	-0.7	-1.0	-1.0	0.1	-1.1
Maternal smoking around birth	3.2	4.7	8.6	1.7	0.4	1.4	-2.6	2.4	1.6	-2.9	2.1	-2.9	-2.4	-2.5	1.7
Fed-up feelings	0.1	0.2	1.5	-0.2	-1.2	-0.3	-0.3	0.3	-0.3	0.1	0.5	0.0	-0.3	-0.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.4	-0.2	-0.8	-0.1	-0.3	0.1	-0.8	-0.4	0.6	0.1	-1.2	-0.4	0.7
Relative age voice broke	0.3	0.4	1.9	-0.2	-1.4	0.3	0.1	-0.6	0.3	0.7	0.1	0.8	0.9	0.3	0.7
Taking other prescription medications	0.1	0.2	0.5	0.5	0.4	-0.6	0.2	-0.6	-0.7	0.7	-0.1	0.2	0.5	0.2	-0.2
Age when periods started (menarche)	1.9	4.5	8.9	-2.5	2.9	-0.6	2.8	-0.6	-0.8	0.5	-3.0	1.8	1.4	2.8	-2.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	5.8	-2.4	-0.9	0.2	1.3	0.7	-1.2	0.1	-1.1	0.7	0.1	1.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	7.5	-0.7	-1.0	-0.2	-0.2	-2.7	-2.1	1.1	1.2	1.9	1.0	-0.3	2.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	4.0	-0.3	-0.6	0.1	-0.2	1.2	-2.0	0.7	-0.5	-0.4	-0.1	0.3	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	1.5	-0.7	1.2	-0.3	0.2	-1.2	-0.2	-0.7	0.5	0.7	0.1	-0.3	0.7
Serious illness, injury or assault to yourself	0.4	0.4	2.6	-0.7	0.1	1.6	0.7	-0.5	-0.3	0.0	-0.5	0.6	-0.3	0.6	-0.3
High blood pressure	2.4	6.6	13.9	-3.3	-0.7	1.2	2.8	-3.0	-3.7	1.5	-2.0	3.3	3.3	2.6	-1.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	8.6	-1.0	-1.1	2.9	-0.2	-0.1	-0.5	-0.0	0.6	0.4	0.7	-0.5	0.9
Multivitamins +/- minerals	0.2	0.2	0.8	0.8	0.2	0.0	0.1	0.8	0.9	-0.0	-0.4	-0.2	-0.4	0.3	-0.5
Stomach or abdominal pain in last month	1.1	1.4	4.4	-0.9	-1.2	-1.0	0.5	-1.4	-1.2	2.1	0.0	1.4	1.7	0.6	0.3
Supplements: Glucosamine	0.7	1.0	2.8	1.4	0.1	1.0	-0.7	1.3	1.7	-0.5	0.1	-1.1	-1.4	-0.4	0.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	6.2	1.2	1.2	-0.4	-1.2	0.9	1.8	-1.4	0.9	-1.5	-2.5	-1.2	0.5
Medication: Atenolol	1.7	2.1	9.5	-3.1	-0.4	0.3	1.7	0.2	-1.1	0.2	-1.9	0.9	0.1	1.7	-1.9
Medication: Levothyroxine sodium	0.8	1.4	4.6	-1.1	0.7	-2.2	1.3	-0.9	-1.7	0.6	-1.2	0.9	-0.4	1.2	-0.8
Sitting height	4.1	28.8	49.8	5.5	-3.5	2.5	-7.1	4.4	4.3	-5.3	6.6	-6.0	-4.3	-7.0	5.7
Chronic bronchitis/emphysema (father)	0.9	1.1	4.3	-0.1	-1.1	0.4	-0.8	-1.3	-1.2	0.4	1.4	0.7	0.3	-1.0	2.1
High blood pressure (mother)	2.2	3.1	8.0	-2.3	0.4	-0.9	1.8	-2.3	-1.5	1.4	-1.4	2.1	2.8	1.9	-0.7
Body mass index (BMI)	0.2	0.8	4.0	-0.0	-1.5	0.2	0.0	-0.5	-1.6	2.0	0.2	0.5	0.3	0.2	0.3
Impedance of leg (left)	0.3	1.4	7.6	0.3	2.8	-0.1	0.2	0.6	2.0	-0.6	-0.8	-0.7	1.1	0.6	-1.4
Leg predicted mass (left)	1.3	6.7	12.6	2.4	-3.5	1.2	-3.4	1.8	0.3	-1.1	3.4	-2.3	-2.4	-3.4	3.3
Trunk fat mass	0.2	0.7	1.7	1.1	-1.1	0.7	-1.1	0.5	-0.3	1.3	1.1	-0.6	0.2	-0.8	0.7
Waist circumference	0.2	0.7	1.5	0.9	-0.5	0.3	-1.1	0.7	0.1	0.9	0.9	-1.0	-1.2	-0.9	0.6
Number of incorrect matches in round	0.7	1.1	2.3	-0.3	-0.3	-0.5	1.5	-1.2	0.1	1.1	-1.1	1.3	1.1	1.4	-1.1
Past tobacco smoking	2.0	3.6	6.1	-0.9	0.5	-2.4	2.2	-1.3	-1.4	2.2	-2.3	2.0	2.1	2.5	-1.9
Alcohol usually taken with meals	0.6	1.0	2.3	0.7	1.1	-1.2	0.2	1.3	1.4	-0.3	-1.0	-1.0	-0.8	0.5	-1.5
Nervous feelings	0.4	0.8	2.5	-0.2	0.1	0.1	0.8	1.6	0.2	-0.7	-1.2	-0.4	-1.1	0.9	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	3.4	0.0	-1.8	-0.2	-0.3	-0.3	-0.6	-0.2	0.9	0.3	0.2	-0.1	1.0
Hearing difficulty/problems with background noise	2.2	3.6	9.2	-2.5	-1.7	-0.7	1.6	-2.2	-3.0	2.0	-0.7	2.6	1.9	1.3	0.5
Hair/balding pattern: Pattern 2	0.9	1.1	5.3	0.2	2.3	0.5	-0.3	0.6	2.3	-1.3	0.2	-0.7	0.1	-0.2	-0.3
Had menopause	0.2	0.3	1.3	0.8	-1.1	-0.3	0.0	0.5	0.2	0.5	-0.1	-0.4	0.6	0.5	-0.5
Had other major operations	0.3	0.3	0.9	0.2	-0.9	0.3	-0.6	0.3	0.9	-0.7	0.6	-0.3	-0.6	-0.4	0.7
Forced vital capacity (FVC)	1.8	6.8	15.0	1.5	-2.1	2.9	-3.4	0.5	1.5	-2.6	3.7	-1.9	-1.3	-3.5	3.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	7.1	-0.7	-0.9	-0.7	0.0	-2.7	-2.0	1.6	0.9	1.8	1.7	-0.1	1.6
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.4	0.4	1.3	-1.5	0.5	-1.3	-0.4	1.3	-0.4	0.6	1.4	0.8	-0.3
Qualifications: None of the above	0.1	0.2	1.0	0.3	-0.2	-0.7	-0.5	-0.1	0.3	0.7	0.4	-0.1	-1.0	-0.3	0.5
Financial difficulties in last 2 years	0.9	1.1	4.4	0.8	-0.5	0.6	-1.1	-1.4	-0.2	-0.3	1.8	0.2	-0.5	-1.1	2.1
Mouth/teeth dental problems	0.3	0.5	1.2	-1.0	-0.8	0.5	0.5	1.1	0.3	-0.5	-0.7	-0.2	-0.2	0.4	-1.1
Heart attack	0.7	0.9	5.7	0.3	2.4	-0.9	0.0	0.1	1.4	0.3	-0.4	-1.0	-0.5	0.1	-0.8
Allergy	0.4	1.0	5.2	-0.1	0.5	-2.3	1.0	0.1	-0.3	0.4	-1.3	0.1	-0.2	1.1	-1.4
Pain all over the body in last month	2.3	2.4	4.9	0.9	-2.1	1.6	-1.5	1.2	0.0	-1.9	1.6	-1.0	-2.2	-1.7	1.7
Diabetes (self-reported)	1.1	1.7	8.7	-0.4	0.1	-0.8	1.1	-0.0	-0.4	3.0	-1.5	0.3	1.5	1.5	-1.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.4	-1.8	-0.3	0.2	1.2	-0.6	-1.5	1.1	-1.3	0.9	1.4	1.2	-1.0
Medication: Ramipril	0.4	0.6	2.9	-1.7	-0.6	-0.6	0.6	-0.1	-1.0	-0.3	-0.5	0.6	-0.9	0.6	-0.1
Medication: Simvastatin	0.9	1.3	2.9	-1.6	1.6	0.9	1.2	-0.1	0.6	0.8	-1.5	0.3	0.4	1.2	-1.7
Fluid intelligence score	0.4	0.9	2.5	0.9	-1.0	-0.5	-1.0	1.5	0.3	-0.7	0.7	-1.6	-0.9	-0.5	0.2
Illnesses of siblings	0.9	1.2	3.4	0.5	1.1	-1.3	-1.1	1.4	0.8	-1.4	0.6	-1.8	-1.0	-1.2	0.3
Neuroticism score	0.4	0.7	2.3	-1.1	-0.9	-1.5	1.0	-0.4	-1.0	0.3	-0.6	1.1	-0.2	0.8	-0.3
Weight	0.7	3.7	7.0	2.1	-2.6	1.2	-2.6	1.2	0.2	-0.0	2.6	-1.7	-1.4	-2.5	2.3
Impedance of arm (right)	0.7	3.2	6.5	-2.0	2.5	-1.0	2.4	-0.7	0.1	0.5	-2.2	1.6	1.6	2.2	-2.4
Arm fat percentage (right)	0.4	1.5	6.2	-0.8	-0.3	-0.1	1.1	-0.9	-1.9	2.5	-0.8	1.4	1.1	1.2	-0.7
Trunk fat-free mass	3.1	18.0	30.4	4.4	-4.1	2.1	-5.5	3.1	2.3	-3.7	5.3	-4.5	-4.0	-5.5	4.8
Hip circumference	0.2	0.8	4.4	0.7	-2.1	0.3	-0.7	-0.0	-0.6	1.4	0.9	-0.2	-0.4	-0.6	0.7
Time employed in main current job	0.2	0.2	0.6	-0.3	-0.4	0.1	0.3	0.6	0.2	-0.8	-0.7	-0.2	0.2	0.4	-0.5
Alcohol intake versus 10 years previously	0.6	0.8	2.0	0.5	0.4	-1.4	-0.8	-0.1	0.3	-1.4	0.9	-0.5	-1.3	-0.9	1.1
Father’s age at death	0.2	0.3	0.9	0.9	0.1	-0.8	-0.4	-0.1	0.1	-0.9	0.5	-0.1	-0.1	-0.6	0.4
Worrier / anxious feelings	0.2	0.3	0.9	-0.1	-0.6	0.6	0.5	0.6	0.3	-0.8	-0.3	-0.0	-0.9	0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.7	-1.2	-1.3	-0.2	0.2	-0.4	-1.1	0.6	-0.0	0.5	0.4	0.2	0.5
Falls in the last year	0.6	0.8	3.1	0.7	0.3	0.8	-1.1	-0.6	-0.0	0.0	1.5	-0.2	-0.1	-1.1	1.8
Hair/balding pattern: Pattern 3	1.6	2.5	4.9	1.2	0.7	0.6	-1.6	1.2	2.1	-2.1	1.3	-1.9	-2.2	-1.8	0.7
Number of live births	0.6	0.9	3.6	-0.5	-0.4	-1.2	0.3	-1.9	-1.6	1.2	0.2	1.1	0.4	0.4	0.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	7.8	1.2	-2.4	2.6	-2.3	0.4	0.3	-1.4	2.6	-1.1	-0.4	-2.3	2.8
Pulse rate	0.3	0.6	1.3	0.7	0.2	-1.2	-0.9	-0.1	0.1	-0.5	0.8	-0.5	-0.9	-1.1	1.0
Happiness	0.3	0.4	1.3	-0.3	-1.1	-0.2	0.5	-0.7	-0.9	0.4	-0.2	0.7	0.6	0.6	0.1
Noisy workplace	0.7	0.9	2.8	0.6	-0.3	-0.3	-1.1	0.9	0.9	-1.7	0.9	-0.8	-1.2	-1.1	0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	0.2	-0.2	0.8	-0.5	-0.2	0.3	-0.2	0.5	-0.3	0.7	-0.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.2	-0.7	-0.7	1.0	0.7	-1.1	-1.4	0.9	-0.4	1.3	1.8	0.6	0.2
Mouth/teeth dental problems: Dentures	0.6	1.0	4.3	-0.1	-0.3	-2.1	0.1	-1.3	-1.5	1.3	0.2	0.9	0.6	-0.0	0.7
Asthma	0.6	1.1	2.4	1.6	0.8	0.4	-1.4	0.2	0.8	-0.7	1.3	-0.7	-0.7	-1.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.1	1.8	-0.2	1.5	-0.5	0.7	1.6	-0.5	0.7	-0.4	0.4	-0.4	0.4
Medication: Cholesterol lowering	0.8	1.3	3.8	-0.4	1.9	1.4	1.0	-0.4	0.4	1.3	-1.2	0.3	1.4	1.1	-1.5
Depression (self-reported)	0.2	0.3	0.8	0.1	0.6	0.3	-0.6	0.9	0.1	-0.4	0.5	-0.9	-0.2	-0.5	0.1
Medication: Lansoprazole	0.8	0.9	3.3	-0.4	-1.8	0.5	-0.8	-0.2	-1.3	0.4	1.1	-0.0	-0.9	-1.0	1.2
Prospective memory result	0.5	0.7	3.9	1.2	-0.2	-0.6	0.2	-0.5	-0.5	2.0	-0.3	0.3	1.0	0.8	-0.2
Lung cancer (father)	1.7	2.0	5.7	2.2	0.2	0.6	-1.6	1.6	2.4	-0.5	1.1	-1.9	-1.1	-1.5	0.4
Illnesses of mother	1.5	1.9	7.9	0.3	-1.4	1.4	-1.2	1.7	0.2	-1.4	1.0	-1.2	-2.8	-1.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	7.4	1.4	-1.9	1.6	-2.0	-0.3	-0.3	-0.9	2.4	-0.6	0.7	-2.0	2.7
Pulse wave Arterial Stiffness index	0.2	0.2	1.0	0.0	0.5	-1.0	0.4	0.5	0.0	-0.4	-0.5	-0.1	0.0	0.5	-0.8
Impedance of arm (left)	1.3	6.0	10.3	-2.9	2.9	-1.2	3.2	-1.5	-0.9	1.4	-3.0	2.6	2.5	3.0	-3.0
Arm fat mass (right)	0.2	0.8	2.8	0.6	-1.7	0.4	-0.8	-0.0	-1.3	1.5	0.9	-0.1	0.0	-0.6	0.9
Trunk predicted mass	3.1	17.9	30.4	4.4	-4.0	2.1	-5.5	3.1	2.4	-3.8	5.2	-4.5	-3.9	-5.5	4.7
Standing height	2.1	20.5	36.6	4.8	-2.6	1.9	-6.0	3.7	3.8	-4.4	5.6	-5.1	-3.8	-6.0	4.7
Length of working week for main job	0.7	0.7	2.7	-0.9	-1.3	0.7	-0.5	0.6	0.0	-0.8	0.6	-0.4	-1.6	-0.9	0.7
Exposure to tobacco smoke at home	1.2	1.4	2.9	0.1	-0.1	0.8	-1.4	1.2	1.3	-1.3	1.1	-1.6	-1.7	-1.2	0.8
Breastfed as a baby	1.1	1.4	3.3	-0.1	-1.1	-0.5	1.3	-1.3	0.2	1.8	-0.9	1.5	1.7	1.4	-0.7
Tense / ‘highly strung’	0.2	0.3	1.6	0.6	-0.2	-1.3	-0.4	0.9	-0.2	0.3	0.1	-0.8	0.2	-0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	2.5	-0.1	-1.6	1.5	0.2	-0.1	-0.8	0.2	0.2	0.3	0.9	0.4	-0.1
Hair/balding pattern: Pattern 4	1.1	2.6	10.3	-0.2	-2.0	-1.1	1.2	-1.5	-3.2	2.3	-0.9	1.6	1.1	1.2	-0.0
Birth weight of first child	1.1	2.0	3.6	-1.5	1.3	-0.7	1.9	-0.7	0.3	0.8	-1.5	1.4	1.9	1.7	-1.9
Peak expiratory flow (PEF)	0.4	1.0	5.8	-0.5	-1.6	2.4	-0.2	-0.5	-0.9	0.1	0.5	0.7	0.7	-0.3	0.7
Pulse wave reflection index	1.3	1.5	4.0	-0.7	1.3	-1.8	1.4	-0.2	-0.2	1.0	-1.6	0.7	0.6	1.7	-2.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	0.3	-0.7	1.6	-0.9	-0.1	0.4	-0.5	1.1	-0.6	-0.5	-1.0	1.2
Loud music exposure frequency	1.4	1.6	8.9	-0.0	-3.0	1.6	-0.9	1.4	0.3	-1.3	0.8	-0.9	-0.5	-1.1	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.6	-1.3	0.4	-0.2	0.8	-0.1	-0.1	0.0	-0.8	0.5	0.5	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.7	0.3	1.1	-1.3	-0.0	0.2	0.8	0.0	-0.2	-0.5	0.3	0.3	-0.3
Blood clot in the leg (DVT)	1.9	2.4	6.4	0.4	2.2	-0.6	1.1	-2.3	-0.3	2.1	-0.8	1.6	2.5	1.3	-0.9
Medication: Paracetamol	0.4	0.6	2.1	-1.3	0.1	0.5	1.0	-0.7	-0.4	0.6	-0.5	1.4	0.4	1.0	-0.2
Headache pain in last month	0.3	0.6	3.7	-0.4	-0.0	1.9	0.6	-0.3	-0.1	0.6	-0.4	0.5	1.1	0.7	-0.5
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	5.4	1.3	-2.3	-0.2	-1.9	1.4	1.6	-1.2	1.9	-1.3	-1.9	-1.9	1.9
Glaucoma (self-reported)	2.1	2.4	5.3	1.4	0.3	1.3	-1.7	1.4	2.2	-1.4	1.4	-1.9	-2.3	-1.4	1.3
Gout (self-reported)	1.1	1.5	3.8	1.9	0.3	-0.1	-1.6	1.0	1.4	-0.4	1.3	-1.9	-0.5	-1.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.5	-0.8	0.1	-1.6	0.9	-0.1	-1.3	-0.1	-0.7	0.6	-0.2	0.8	-0.7
Medication: Amlodipine	1.2	1.7	3.8	-1.6	1.0	0.3	1.5	-1.9	-1.6	0.9	-1.1	1.4	1.2	1.2	-0.9
Medication: Ventolin 100micrograms inhaler	1.1	1.5	3.6	1.5	0.1	1.4	-1.5	-0.4	1.1	-0.5	1.9	-0.4	-0.2	-1.7	1.7
Birth weight	1.0	2.2	6.3	2.5	1.0	0.5	-1.8	0.8	1.6	-1.7	1.7	-1.7	-0.2	-1.6	1.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.1	-0.5	-0.1	-0.1	0.5	-0.5	0.5	-0.3	-0.5	0.0	0.1	-0.5
High blood pressure (siblings)	0.7	1.0	3.4	-0.3	0.4	1.8	1.1	-0.7	0.2	0.9	-1.0	1.1	0.9	1.3	-0.8
Forced vital capacity (FVC), Best measure	1.4	5.3	13.4	1.9	-1.7	1.6	-3.1	0.3	0.9	-2.3	3.4	-1.7	-0.5	-3.2	3.7
Body fat percentage	0.2	0.9	5.6	-0.3	0.0	0.1	0.5	-0.4	-1.1	2.4	-0.4	0.7	1.2	0.8	-0.6
Leg fat percentage (right)	0.2	0.8	4.6	-0.3	0.3	-0.2	0.7	-0.5	-0.9	2.1	-0.6	0.7	1.0	1.0	-0.9
Arm fat-free mass (right)	2.7	13.9	25.5	4.1	-4.0	2.1	-5.0	2.8	1.8	-2.5	4.7	-4.0	-2.8	-4.7	4.3
Exposure to tobacco smoke outside home	0.5	0.6	1.9	-1.1	1.1	-1.4	0.7	-0.4	-0.7	0.6	-0.9	0.4	-0.1	0.6	-0.6
Comparative body size at age 10	0.5	1.4	5.8	0.7	-2.4	-1.6	0.0	-1.4	-1.2	1.3	0.5	1.0	-0.8	-0.0	1.0
Number of full brothers	0.7	0.9	4.5	0.3	-2.1	1.2	-0.7	-0.1	-0.8	0.7	1.0	0.3	-0.6	-0.7	1.4
Worry too long after embarrassment	0.1	0.2	0.9	-0.4	0.5	0.1	0.6	-0.3	-0.2	-0.2	-0.3	1.0	-0.2	0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.5	-0.4	1.2	-1.0	0.4	-0.1	-0.1	0.7	-1.0	-0.2	-0.6	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.7	0.4	-0.9	0.5	-0.5	-1.3	-0.5	1.0	0.9	0.5	0.2	-0.6	1.1
Number of children fathered	1.2	1.4	6.0	-0.3	-0.2	2.4	-0.1	-1.6	-1.0	0.1	1.1	1.3	-0.4	-0.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.1	-0.5	-0.3	-0.3	0.9	-2.3	-1.8	0.6	-0.3	2.0	1.3	0.9	0.7
Age at first live birth	0.3	0.5	1.1	-0.5	0.3	1.0	0.5	0.9	0.6	-0.4	-1.0	-0.3	-1.0	0.4	-1.0
Pulse wave peak to peak time	0.3	0.4	1.6	0.1	-0.6	1.3	-0.6	-0.3	0.2	-0.0	0.7	-0.1	-0.3	-0.7	1.0
Health satisfaction	0.6	0.8	4.0	-1.1	-2.0	1.0	0.3	-0.2	-0.2	0.9	-0.1	0.5	-1.1	0.3	0.5
Shortness of breath walking on level ground	0.3	0.4	1.6	-0.2	-0.2	0.4	-0.6	-0.1	-0.2	-0.5	0.7	-0.3	-1.3	-0.9	1.0
Qualifications: College or University degree	0.2	0.5	2.0	-0.7	-0.6	1.4	0.2	-1.2	-0.1	0.4	0.4	0.7	0.7	-0.2	0.3
Eye problems/disorders: None of the above	0.5	0.6	1.6	-1.1	-0.4	-0.3	0.8	0.1	-1.3	-1.0	-0.6	0.7	0.8	0.6	-0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.7	-0.8	1.6	-0.7	0.4	-1.4	0.2	0.8	-0.4	0.4	-0.5	0.3	-0.2
Emphysema/chronic bronchitis	1.1	1.2	3.9	0.1	-0.4	-0.6	-1.3	0.8	0.2	-1.3	1.2	-1.2	-2.0	-1.4	1.0
Medication for pain relief, constipation, heartburn	0.5	0.8	4.9	0.7	0.2	-2.2	-0.4	0.6	-0.3	-1.0	0.1	-0.8	-1.4	-0.5	-0.1
Neck or shoulder pain in last month	0.3	0.4	1.3	-0.3	0.1	1.1	-0.8	0.4	0.1	-0.0	0.7	-0.8	-0.2	-0.7	0.8
Medication: Blood pressure	1.8	3.2	9.8	-2.0	1.3	-0.2	1.8	-2.4	-3.1	0.7	-1.2	2.0	2.1	1.6	-0.8
Angina (self-reported)	1.0	1.3	4.6	-2.1	-0.7	-0.4	1.0	0.8	-0.2	0.7	-1.7	-0.1	-0.7	1.2	-1.8
Migraine (self-reported)	0.3	0.3	1.9	-1.4	0.1	0.4	0.4	0.2	-1.0	-0.1	-0.4	0.2	-0.1	0.4	-0.4
Medication: Ibuprofen	0.8	0.9	5.6	2.4	0.3	0.9	-0.5	0.4	1.5	-0.6	0.8	-0.4	0.4	-0.3	0.6
Medication: Allopurinol	0.3	0.4	1.5	0.8	1.1	-0.3	-0.1	0.3	1.2	-0.3	-0.1	-0.7	0.1	0.1	-0.4
Medication: Omeprazole	0.3	0.4	1.9	-0.2	-0.1	0.9	0.4	-0.4	1.4	0.6	-0.5	0.2	-0.2	0.7	-0.4
Medication: Seretide 50 evohaler	0.9	1.0	2.8	1.7	0.0	1.0	-1.1	0.5	1.6	-0.0	1.1	-0.7	-0.8	-1.0	1.0
Mean time to correctly identify matches	0.6	1.1	2.5	0.3	-0.5	-1.0	1.0	-1.1	-0.2	1.4	-0.8	1.3	1.6	1.5	-0.6
Heart disease (mother)	1.4	1.7	4.5	-1.1	0.6	-0.5	1.3	-1.3	-2.0	0.9	-1.0	1.6	2.1	1.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.7	-1.4	-0.1	-0.1	1.8	-0.4	-1.4	1.5	-1.8	1.6	1.0	1.9	-1.7
Whole body fat mass	0.2	0.7	2.0	1.0	-1.2	0.4	-0.9	0.3	-0.6	1.4	1.0	-0.4	0.2	-0.6	0.7
Leg fat mass (right)	0.1	0.5	1.8	0.8	-1.1	0.3	-0.8	0.4	-0.3	1.4	0.9	-0.5	-0.1	-0.5	0.6
Arm predicted mass (right)	2.6	13.5	25.2	4.0	-3.8	2.1	-5.0	2.7	1.7	-2.4	4.7	-3.9	-2.8	-4.7	4.3
Pulse rate, automated reading	0.2	0.5	2.7	1.3	1.7	-0.2	-0.4	0.1	0.9	-0.4	0.2	-0.6	0.0	-0.4	0.1
Alcohol intake frequency.	0.2	0.4	3.8	-0.5	-0.1	-1.9	0.2	0.3	0.5	-0.2	-0.4	-0.1	-0.3	0.5	-0.5
Comparative height size at age 10	3.1	17.0	30.8	4.7	-2.9	0.9	-5.5	3.0	3.3	-3.4	5.2	-4.4	-3.6	-5.5	4.4
Number of full sisters	0.2	0.3	0.9	0.0	-0.7	0.3	0.7	-0.4	0.3	-0.2	-0.3	0.6	1.0	0.7	-0.5
Suffer from ‘nerves’	0.3	0.5	2.4	-0.1	-1.6	-1.1	-0.4	0.3	-0.5	-0.2	0.6	0.1	-0.6	-0.3	0.8
Overall health rating	0.2	0.4	1.6	-0.8	-1.3	1.0	-0.1	1.1	0.2	0.2	-0.1	-0.5	-0.6	0.3	-0.3
Chest pain or discomfort	0.2	0.3	1.0	-0.6	-0.4	-0.5	0.2	-0.1	-0.8	1.0	-0.1	0.3	0.7	0.1	-0.3
Had major operations	2.0	2.3	5.2	1.1	-1.2	2.3	-1.6	-0.3	0.5	-0.9	2.1	-0.7	-1.7	-1.9	2.3
Age at last live birth	0.3	0.5	3.5	-0.9	-0.2	0.2	0.1	0.6	0.1	-0.7	-0.3	-0.1	-1.9	-0.1	-0.4
Family relationship satisfaction	0.5	0.6	1.9	-0.1	-0.9	1.4	0.7	-0.3	-1.0	0.9	-0.5	0.5	1.1	0.6	-0.4
Leg pain on walking	0.2	0.2	0.6	0.1	-0.2	-0.2	0.6	0.0	0.6	-0.0	-0.6	0.3	0.0	0.8	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	5.1	-2.3	-0.1	-0.7	1.5	-1.3	-2.1	1.3	-1.2	1.7	1.3	1.4	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	-0.2	0.3	0.0	-0.2	-0.7	-0.9	-0.3	0.4	0.3	-0.4	-0.8	1.0
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	12.6	1.9	0.1	0.5	-1.5	3.6	2.8	-1.8	0.3	-2.9	-1.6	-0.9	-0.9
Medication: Aspirin	0.6	0.8	3.0	-1.7	-0.3	1.2	0.5	-0.7	-1.0	1.3	-0.5	0.6	0.9	0.4	0.0
Supplements: Vitamin C	0.9	1.1	2.4	0.5	-0.0	-1.0	-1.5	0.2	-0.5	-0.2	1.2	-1.1	-1.5	-1.6	1.3
Knee pain experienced in last month	0.7	1.0	2.4	0.3	1.6	0.4	0.9	-1.0	0.6	1.0	-0.9	1.0	1.5	1.4	-0.6
Hypertension (Self-reported)	2.1	5.8	11.4	-3.0	-0.4	0.7	2.6	-2.5	-3.4	1.6	-2.1	2.7	3.3	2.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.9	1.4	-0.9	0.8	-0.6	-0.2	-0.4	0.5	0.8	-0.3	0.9	-0.4	0.8
Illnesses of father: Heart disease	0.3	0.4	2.2	-1.5	-0.5	-0.3	0.5	-0.0	-0.5	-0.8	-0.1	0.6	-0.2	0.2	0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.4	0.6	-0.6	0.9	-0.3	0.4	0.6	-0.7	0.8	0.2	0.6	-0.9
Smoking status: Previous	1.3	2.0	4.1	0.3	-0.3	2.0	-1.6	0.5	0.7	-1.7	1.9	-1.0	-1.1	-1.9	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.5	1.0	-1.4	1.5	-1.7	0.2	0.9	-1.2	2.0	-0.8	-0.6	-2.1	2.0
Whole body fat-free mass	2.5	14.2	24.5	3.8	-4.1	2.0	-5.0	2.7	1.6	-2.8	4.8	-3.8	-3.4	-4.9	4.4
Leg fat-free mass (right)	1.4	7.4	12.9	2.5	-3.6	1.5	-3.5	2.0	0.5	-1.4	3.6	-2.4	-2.5	-3.6	3.4
Arm fat percentage (left)	0.7	2.8	9.3	-1.4	-0.2	-0.4	1.6	-1.2	-2.4	3.0	-1.3	1.9	1.6	1.7	-1.2
Average weekly red wine intake	2.2	3.3	7.2	2.2	-0.1	0.7	-2.2	2.0	2.0	-2.1	1.7	-2.7	-1.2	-2.1	0.8
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.5	0.6	0.2	0.8	-0.4	0.2	0.8	-0.8	0.3	0.2	0.6	-1.0
Mood swings	0.0	0.0	0.1	0.4	0.1	0.1	-0.1	-0.4	0.3	0.1	0.3	0.1	-0.1	-0.0	0.3
Loneliness, isolation	0.1	0.2	1.3	0.1	-0.5	-0.2	-0.0	0.4	-0.0	-0.5	0.1	-0.1	-1.1	-0.2	0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.8	-0.6	-0.5	0.3	0.3	0.9	-0.3	0.2	-0.6	-0.3	-0.6	0.5	-0.8
Ever had bowel cancer screening	0.7	0.8	4.8	-1.3	0.2	0.4	0.8	-0.6	-2.2	0.4	-0.5	0.7	0.6	0.6	-0.5
Diabetes diagnosed by doctor	1.9	3.2	12.3	-1.3	0.7	-0.9	1.8	-0.4	-0.7	3.5	-2.2	0.9	1.9	2.2	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	4.5	0.7	-0.8	-0.2	-0.1	-0.6	-2.1	1.7	0.3	0.7	0.4	-0.2	0.4
Friendships satisfaction	0.6	0.7	2.9	0.9	-1.7	1.0	-0.4	1.1	0.7	0.9	0.1	-0.9	0.7	0.0	-0.3
Qualifications: nursing, teaching	0.1	0.2	1.4	-0.5	-0.1	1.2	-0.0	-0.2	0.1	-0.1	0.0	-0.2	0.5	-0.2	-0.3
Commuting to job workplace: Walk	0.1	0.2	0.7	0.7	0.3	0.2	-0.2	0.0	-0.2	0.6	0.1	-0.3	0.8	0.2	-0.0
Eye problems/disorders: Cataract	0.8	0.9	2.7	1.3	1.4	-0.3	0.5	-1.1	0.7	1.7	-0.5	0.1	1.0	0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.2	1.5	-0.5	2.1	-1.1	-0.1	1.3	-0.2	1.2	-0.7	-0.6	-1.2	1.4
Medication for cholesterol	1.6	2.4	7.5	2.7	-0.9	-1.4	-1.9	1.1	1.5	-0.3	1.8	-1.6	-0.8	-1.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	1.4	-0.1	0.3	-1.2	-0.1	0.4	-0.4	1.1	-0.7	0.2	-1.1	1.1
Back pain experienced in last month	0.2	0.3	0.7	-0.7	-0.8	0.5	0.5	-0.6	-0.7	0.1	-0.2	0.7	-0.1	0.8	0.3
Mineral and other dietary supplements	0.3	0.4	2.1	-0.8	-1.4	-0.3	-0.2	1.0	-0.0	-0.4	0.2	-0.6	-0.3	-0.3	-0.3
Breast cancer (self-reported)	1.1	1.4	5.1	-0.2	1.6	-2.3	1.0	-0.6	-0.2	1.3	-1.3	0.7	0.8	1.1	-1.2
Asthma (self-reported)	0.9	1.9	4.2	1.8	0.3	0.4	-1.9	0.3	0.8	-0.9	1.8	-1.0	-1.0	-2.0	2.0
Osteoporosis (self-reported)	0.3	0.3	1.1	1.1	-0.8	-0.1	-0.3	-0.5	-0.4	-0.3	0.6	0.3	-0.6	-0.5	0.6
Osteoarthritis (self-reported)	0.2	0.3	1.3	0.7	0.4	0.3	-0.3	1.1	0.7	0.0	-0.2	-0.7	-0.4	0.1	-0.5
Medication: Aspirin	0.5	0.6	2.3	-1.5	-0.1	0.9	0.4	-0.6	-0.9	1.1	-0.5	0.6	0.9	0.4	-0.1
Medication: Gliclazide	1.7	1.9	4.5	-1.0	2.1	-1.8	1.2	-0.6	-0.7	2.1	-1.5	0.9	0.7	1.4	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	3.4	1.7	1.6	0.4	-0.4	0.9	1.8	0.4	-0.1	-1.0	-0.4	-0.1	-0.8
Smoking status: Current	1.6	2.6	5.8	1.9	-1.3	0.9	-2.2	1.5	1.4	-0.5	1.8	-2.4	-1.4	-1.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.0	0.6	-1.5	0.2	-0.3	-1.0	-1.7	-0.1	0.6	0.6	1.2	-0.2	1.2
Whole body water mass	2.4	14.0	24.3	3.8	-4.0	2.0	-4.9	2.7	1.6	-2.7	4.8	-3.8	-3.4	-4.9	4.4
Leg predicted mass (right)	1.4	7.3	12.8	2.4	-3.5	1.4	-3.5	2.0	0.5	-1.4	3.5	-2.4	-2.5	-3.6	3.4
Arm fat mass (left)	0.2	0.8	3.4	0.0	-1.5	0.2	-0.2	-0.3	-1.6	1.8	0.5	0.4	0.5	-0.1	0.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	-0.7	0.8	0.1	0.9	-0.1	-1.0	0.1	-1.0	0.3	0.3	1.1	-1.1
Average weekly champagne plus white wine intake	1.4	1.9	4.9	-1.0	0.2	-1.2	1.7	0.5	-0.0	1.5	-2.1	0.7	0.9	2.0	-2.2
Miserableness	0.3	0.6	2.0	-1.1	0.2	-1.1	0.3	-1.1	-1.4	0.0	0.0	0.9	0.1	0.2	0.7
Guilty feelings	0.8	1.2	3.5	-1.9	-0.5	-0.7	1.1	-1.7	-1.7	0.1	-0.3	1.6	0.7	0.6	0.1
Wears glasses or contact lenses	0.8	0.9	1.9	0.4	-0.9	1.2	-1.2	1.0	0.1	-0.8	0.9	-1.1	-1.1	-1.4	0.6
Ever taken oral contraceptive pill	0.3	0.3	1.6	-0.2	-0.5	0.9	0.0	1.3	0.6	-0.1	-0.3	-0.3	-0.1	0.2	-0.5
Hearing aid user	1.2	1.4	3.6	0.4	0.2	0.9	-1.3	1.1	1.6	-1.2	0.9	-1.6	-1.9	-1.2	0.6
Mother’s age at death	0.7	0.9	2.2	1.5	-1.3	1.1	-0.9	1.1	1.1	-0.3	0.8	-0.8	-0.1	-0.7	0.6
Financial situation satisfaction	1.1	1.3	3.4	0.7	-1.4	0.9	-1.3	1.2	1.0	-0.9	1.1	-1.3	-1.9	-1.1	0.7
Tinnitus: Yes, now most or all of the time	1.5	1.8	6.3	1.4	-1.9	2.5	-1.2	0.5	1.3	-0.2	1.4	-0.5	0.4	-1.1	1.6
Commuting to job workplace: Public transport	0.9	1.1	4.2	-1.1	-1.3	-0.2	0.8	-0.9	-2.0	0.8	-0.1	1.5	1.1	0.7	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.3	0.7	0.7	-0.1	-0.8	0.6	1.5	-0.1	0.5	-1.0	-1.4	-0.4	0.6
Medication: Blood pressure	1.0	1.8	6.0	-2.4	-1.4	1.4	1.2	-0.8	-2.1	0.7	-1.0	1.3	0.9	1.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.0	0.4	-1.4	0.8	-0.9	0.3	-0.7	0.4	1.0	-0.1	0.3	-0.8	1.3
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.1	0.7	1.0	0.2	-0.3	-0.8	-0.1	-0.2	0.5	0.2	-0.8	-0.5	0.8
High cholesterol (Self-reported)	0.3	0.6	3.8	0.8	1.9	1.0	0.3	-0.5	0.6	0.3	-0.3	0.1	0.6	0.5	-0.5
Medication: Bendroflumethiazide	1.1	1.7	3.5	-1.9	0.7	-0.1	1.6	-1.6	-1.1	0.8	-1.3	1.4	1.3	1.6	-1.1
Medication: Paracetamol	0.4	0.5	1.3	-0.3	0.9	0.2	0.9	-0.8	-0.1	0.7	-0.5	1.2	0.9	1.0	-0.3
Medication: Lisinopril	1.4	1.9	4.0	-2.0	0.3	0.3	1.6	-1.1	-1.8	1.2	-1.4	1.4	1.3	1.7	-1.1
Medication: Atorvastatin	0.7	0.9	2.2	-0.4	1.4	-0.6	1.2	-0.2	0.4	0.3	-1.2	0.5	0.6	1.5	-1.5
Illnesses of father: High blood pressure	0.6	0.7	2.9	-1.2	0.1	-0.2	-0.4	-0.6	-1.1	-1.7	0.8	0.0	-0.2	-0.6	1.0
Alcohol drinker status: Never	0.2	0.2	1.9	-0.5	-0.0	-1.4	0.3	-0.1	-0.2	0.0	-0.2	0.2	-0.2	0.5	-0.4
Ever smoked	2.5	4.3	8.1	1.3	-1.4	2.8	-2.5	1.5	1.1	-1.9	2.5	-2.4	-2.1	-2.7	1.8
Basal metabolic rate	2.1	11.4	20.2	3.4	-3.8	1.9	-4.5	2.4	1.2	-2.1	4.4	-3.3	-3.0	-4.4	4.1
Leg fat percentage (left)	0.2	0.6	3.8	-0.2	-0.1	0.3	0.4	-0.3	-0.8	2.0	-0.3	0.5	0.9	0.7	-0.6
Arm fat-free mass (left)	3.0	15.3	27.7	4.3	-3.9	2.1	-5.3	2.7	1.9	-2.7	5.0	-4.1	-3.3	-5.0	4.6
Number of operations (self-reported)	0.2	0.3	0.8	-0.2	-0.2	0.8	-0.1	-0.7	-0.5	0.1	0.4	0.5	-0.7	-0.3	0.9
Average weekly beer plus cider intake	0.9	1.3	6.4	0.0	-2.5	-0.1	-1.0	0.2	-1.0	-0.7	1.3	-0.1	-1.0	-1.1	1.5
Irritability	0.3	0.6	1.9	0.1	-1.2	-0.3	-0.6	1.4	0.4	-0.9	0.4	-1.0	-0.8	-0.6	0.2
Risk taking	0.9	1.3	4.3	0.4	-0.8	1.1	-1.0	-1.3	-1.0	-0.2	1.8	0.3	0.5	-1.4	2.1
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.2	1.4	1.5	0.6	-0.7	-0.1	-0.2	0.3	0.7	-0.4	1.1	-0.7	0.6
Fractured/broken bones in last 5 years	1.9	2.5	4.8	-1.6	2.2	-1.3	2.1	-1.7	-0.3	0.5	-1.8	1.8	1.1	1.8	-1.5
Age started oral contraceptive pill	0.9	1.2	4.9	0.8	0.2	-0.4	0.5	-0.6	-0.7	2.1	-0.7	0.3	2.2	1.1	-1.0
Diastolic blood pressure, automated reading	2.0	6.2	11.7	-2.7	1.8	-1.1	2.9	-3.3	-2.7	1.6	-2.3	3.4	2.7	2.7	-1.2
Ever depressed for a whole week	0.5	0.6	2.4	-0.1	1.0	-0.3	0.4	-1.6	-0.4	0.9	0.1	0.9	1.3	0.5	0.2
Unable to work because of sickness or disability	0.4	0.5	3.1	-0.9	-1.8	0.8	-0.2	0.7	-0.2	0.6	0.0	-0.3	-0.5	0.1	0.1
Commuting to job workplace: Cycle	0.3	0.4	1.1	0.0	-0.4	-0.8	0.1	1.1	-0.3	0.6	-0.6	-0.6	-0.4	0.4	-1.1
Myopia	0.2	0.3	0.8	-0.9	-0.5	0.7	0.2	0.8	-0.6	-0.0	-0.3	-0.0	0.9	0.5	-0.6
Vascular/heart problems diagnosed by doctor	2.1	5.7	13.4	3.3	0.3	-1.1	-2.4	3.0	3.7	-1.5	1.8	-2.9	-2.7	-2.3	1.0
Cholesterol lowering medication	0.3	0.4	1.1	-0.9	0.9	-0.1	0.4	0.2	-0.1	0.1	-0.8	-0.2	-1.1	0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.3	0.7	0.2	1.0	-0.6	-0.1	1.5	0.3	0.5	-0.7	-0.4	-0.5	0.4
Pain experienced in last month	0.3	0.4	1.2	0.5	0.2	-0.5	-0.6	0.7	1.1	-0.4	0.6	-0.7	-0.6	-1.0	0.3
Supplements: Calcium	1.1	1.2	3.6	-0.4	0.2	0.4	0.5	-1.9	-1.5	1.6	-0.0	1.5	1.6	0.7	0.6
Basal cell carcinoma (self-reported)	1.7	2.0	5.3	0.2	-1.4	2.2	-1.0	-1.3	-1.4	0.4	1.9	0.5	1.4	-1.3	2.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	4.5	0.4	2.1	-0.9	-0.1	0.2	1.2	0.2	-0.2	-1.1	-0.6	-0.0	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	5.5	0.3	1.9	-0.6	1.0	-2.3	-0.5	2.1	-0.7	1.6	2.3	1.2	-0.8
Heart disease (siblings)	1.6	2.0	4.1	-0.6	-0.9	0.2	1.8	-0.4	-1.3	1.7	-1.4	1.7	2.0	2.0	-1.4
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.2	-0.9	-0.7	-0.5	0.4	-0.5	-0.3	0.5	-0.5	0.2	-0.5	0.2
Pack years of smoking	0.7	1.0	2.6	-0.6	1.0	-0.1	0.1	1.6	0.3	0.4	-1.1	-1.3	-1.5	0.3	-1.6
Impedance of whole body	0.6	2.8	8.8	-1.3	3.0	-0.6	1.8	-0.3	0.6	0.5	-2.0	0.9	2.0	2.0	-2.5
Leg fat mass (left)	0.2	0.6	1.7	0.9	-1.3	0.5	-1.0	0.6	-0.3	1.2	1.0	-0.6	-0.1	-0.7	0.7
Arm predicted mass (left)	3.1	15.7	28.6	4.3	-3.8	2.4	-5.3	2.9	2.1	-2.8	5.0	-4.3	-3.3	-5.1	4.6