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chr16:74,270,536-76,197,034

Best TWAS P=2.67e-27 · Best GWAS P=9.5e-29 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CFDP1	0.08	0.04	lasso	4	0.04	1.6e-05	-10.8	-10.5	5.5e-26	0.93	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	CFDP1	0.11	0.09	lasso	2	0.09	1.1e-07	-7.0	-7.0	2.1e-12	0.62	0.35	0.64	FALSE
3	GTEx	Adipose Subcutaneous	TMEM170A	0.11	0.00	lasso	5	0.01	6.7e-02	-8.4	-8.5	2.1e-17	0.79	0.03	0.90	FALSE
4	GTEx	Adipose Visceral Omentum	CFDP1	0.20	0.09	lasso	4	0.08	5.2e-05	-6.5	-5.9	4.2e-09	0.58	0.33	0.42	FALSE
5	GTEx	Adrenal Gland	TMEM170A	0.11	0.06	enet	4	0.04	1.7e-02	-10.6	10.8	5.3e-27	-0.95	0.02	0.93	TRUE
6	GTEx	Artery Aorta	BCAR1	0.18	0.13	lasso	3	0.11	9.8e-07	-10.6	10.7	8.2e-27	-0.95	0.02	0.98	FALSE
7	GTEx	Artery Aorta	CFDP1	0.16	0.00	enet	10	0.01	5.3e-02	-6.3	6.0	1.8e-09	-0.41	0.11	0.10	FALSE
8	GTEx	Artery Tibial	BCAR1	0.07	0.06	lasso	1	0.04	2.4e-04	-10.8	10.8	2.7e-27	-0.96	0.02	0.97	FALSE
9	GTEx	Brain Cerebellum	BCAR1	0.18	0.08	enet	12	0.09	1.1e-03	-10.7	-9.0	3.2e-19	0.81	0.02	0.92	FALSE
10	GTEx	Brain Cerebellum	CFDP1	0.25	-0.01	lasso	2	0.05	1.7e-02	-10.6	-8.8	2.1e-18	0.77	0.04	0.82	FALSE
11	GTEx	Brain Cortex	CFDP1	0.18	0.07	lasso	3	0.08	3.4e-03	-6.8	-8.2	2.7e-16	0.75	0.04	0.79	FALSE
12	GTEx	Breast Mammary Tissue (Female)	CFDP1	0.07	0.05	lasso	1	0.05	1.5e-02	-6.7	-6.7	1.9e-11	0.62	0.04	0.59	FALSE
13	GTEx	Breast Mammary Tissue (Female)	ZFP1	0.07	-0.01	enet	12	0.00	4.4e-01	2.8	-5.5	4.5e-08	0.19	0.04	0.10	TRUE
14	GTEx	Cells EBV-transformed lymphocytes	TMEM170A	0.13	0.07	lasso	3	0.02	6.2e-02	-8.9	-8.3	7.2e-17	0.76	0.05	0.69	FALSE
15	GTEx	Cells Transformed fibroblasts	CFDP1	0.17	0.20	enet	10	0.24	9.9e-18	-10.7	-10.6	1.9e-26	0.97	0.01	0.99	FALSE
16	GTEx	Colon Transverse	CFDP1	0.14	0.11	lasso	2	0.08	7.6e-05	-6.8	-5.9	2.8e-09	0.55	0.55	0.04	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	CFDP1	0.31	0.17	lasso	4	0.16	3.0e-06	-6.9	-6.7	2.3e-11	0.62	0.46	0.49	FALSE
18	GTEx	Esophagus Mucosa	BCAR1	0.16	0.13	lasso	8	0.14	1.8e-09	-10.8	-10.2	1.4e-24	0.93	0.04	0.96	FALSE
19	GTEx	Esophagus Muscularis	CFDP1	0.18	0.12	lasso	5	0.09	3.1e-06	-6.8	-6.5	7.4e-11	0.60	0.99	0.00	FALSE
20	GTEx	Muscle Skeletal	CFDP1	0.05	0.05	enet	4	0.04	3.4e-05	-7.0	-7.0	2.6e-12	0.63	0.39	0.57	FALSE
21	GTEx	Nerve Tibial	CFDP1	0.16	0.14	lasso	3	0.12	1.6e-08	-7.0	-8.5	1.4e-17	0.76	0.21	0.79	FALSE
22	GTEx	Nerve Tibial	TMEM170A	0.12	0.09	enet	7	0.11	4.1e-08	-6.4	-9.7	4.5e-22	0.87	0.05	0.95	FALSE
23	GTEx	Pancreas	BCAR1	0.12	0.14	lasso	2	0.09	8.6e-05	-6.3	-6.3	2.4e-10	0.49	0.18	0.24	FALSE
24	GTEx	Pancreas	CFDP1	0.16	0.07	lasso	2	0.12	1.2e-05	-6.7	-6.6	3.3e-11	0.60	0.45	0.21	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	TMEM170A	0.09	0.02	lasso	3	0.05	1.1e-03	-4.7	6.0	1.5e-09	-0.60	0.15	0.64	FALSE
26	GTEx	Skin Sun Exposed Lower leg	CFDP1	0.17	0.13	enet	25	0.11	2.8e-09	-7.0	-5.5	3.3e-08	0.55	0.98	0.02	FALSE
27	GTEx	Skin Sun Exposed Lower leg	TMEM170A	0.13	0.08	lasso	5	0.06	1.2e-05	-8.9	7.9	3.6e-15	-0.74	0.39	0.58	FALSE
28	GTEx	Thyroid	TMEM170A	0.09	0.02	lasso	4	0.00	4.0e-01	-6.5	-6.7	3.0e-11	0.58	0.07	0.73	FALSE
29	METSIM	Adipose	TMEM170A	0.03	0.01	lasso	3	0.02	1.5e-03	-10.9	-9.6	5.7e-22	0.88	0.01	0.98	FALSE
30	YFS	Blood	CFDP1	0.21	0.26	bslmm	396	0.30	1.5e-99	-6.8	-5.9	3.6e-09	0.55	1.00	0.00	FALSE
31	YFS	Blood	WDR59	0.07	0.01	bslmm	422	0.03	6.4e-10	-2.8	-6.7	2.2e-11	0.34	0.82	0.06	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	CFDP1	0.04	0.03	enet	10	0.03	5.2e-07	-7.0	-7.8	9.5e-15	0.64	0.96	0.03	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	CFDP1	0.10	0.04	blup	71	0.06	1.8e-04	-7.0	-5.6	2.5e-08	0.56	0.32	0.15	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CFDP1	0.02	0.02	lasso	4	0.02	1.9e-03	-10.2	-10.0	9.5e-24	0.93	0.02	0.87	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CFDP1	0.03	0.00	blup	71	0.01	1.1e-02	-6.9	-6.0	2.2e-09	0.56	0.09	0.12	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CFDP1	0.13	0.07	enet	10	0.10	2.1e-06	-6.9	-6.2	7.2e-10	0.58	0.38	0.34	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM170A	0.08	0.10	blup	36	0.13	9.1e-08	-7.5	-10.0	2.1e-23	0.89	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	CFDP1	0.04	0.02	lasso	6	0.03	4.0e-04	-6.5	-9.3	1.2e-20	0.86	0.04	0.95	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CFDP1	0.06	0.03	lasso	3	0.03	1.1e-04	-4.9	-6.0	2.4e-09	0.53	0.45	0.17	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CFDP1	0.23	0.00	blup	70	0.02	4.2e-02	-6.9	-8.2	2.5e-16	0.66	0.02	0.31	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CFDP1	0.10	0.00	blup	70	0.04	1.4e-02	-10.2	-9.3	1.6e-20	0.87	0.02	0.44	FALSE
42	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHST6	0.20	0.08	enet	10	0.10	2.2e-04	-9.3	9.0	1.9e-19	-0.85	0.02	0.86	FALSE