Best TWAS P=2.98e-11 · Best GWAS P=7.47e-10 conditioned to 0.229
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AC099850.1 | 0.14 | 0.03 | lasso | 6 | 0.03 | 5.0e-02 | -6.1 | -6.7 | 3.0e-11 | -0.78 | 0.06 | 0.46 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | SKA2 | 0.10 | 0.06 | enet | 4 | 0.04 | 5.5e-03 | -6.1 | -6.0 | 1.7e-09 | -0.69 | 0.03 | 0.86 | FALSE |
| 3 | GTEx | Muscle Skeletal | SKA2 | 0.04 | 0.02 | enet | 12 | 0.04 | 1.0e-04 | 5.7 | -5.2 | 1.9e-07 | -0.57 | 0.07 | 0.84 | FALSE |
| 4 | GTEx | Nerve Tibial | RPS6KB1 | 0.05 | 0.01 | lasso | 4 | 0.00 | 1.6e-01 | 4.7 | -5.5 | 2.9e-08 | -0.04 | 0.04 | 0.47 | TRUE |
| 5 | GTEx | Nerve Tibial | SKA2 | 0.10 | 0.08 | lasso | 6 | 0.09 | 4.4e-07 | 5.4 | -5.2 | 2.5e-07 | -0.65 | 0.06 | 0.94 | FALSE |
| 6 | GTEx | Pituitary | BZRAP1-AS1 | 0.16 | 0.04 | enet | 8 | 0.02 | 8.0e-02 | 4.9 | 5.2 | 1.5e-07 | 0.47 | 0.08 | 0.20 | FALSE |
| 7 | METSIM | Adipose | TEX14 | 0.05 | 0.05 | lasso | 2 | 0.04 | 4.1e-07 | 5.7 | 5.7 | 1.3e-08 | 0.63 | 0.05 | 0.95 | FALSE |