Best TWAS P=5.83e-16 · Best GWAS P=4.17e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | YES1 | 0.18 | 0.10 | lasso | 11 | 0.16 | 1.8e-19 | -5.6 | -6.3 | 2.5e-10 | 0.50 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | RP11-672L10.6 | 0.12 | 0.08 | lasso | 5 | 0.08 | 4.4e-06 | -5.6 | 5.5 | 4.1e-08 | -0.51 | 0.86 | 0.08 | FALSE |
| 3 | GTEx | Esophagus Muscularis | YES1 | 0.13 | 0.10 | lasso | 2 | 0.07 | 4.0e-05 | -8.1 | -8.1 | 5.8e-16 | 0.99 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Muscle Skeletal | ENOSF1 | 0.19 | 0.10 | lasso | 11 | 0.16 | 3.6e-15 | 3.5 | 5.5 | 3.4e-08 | -0.42 | 0.99 | 0.01 | FALSE |
| 5 | GTEx | Muscle Skeletal | RP11-672L10.6 | 0.11 | 0.10 | lasso | 3 | 0.07 | 1.5e-07 | 4.5 | 5.3 | 1.3e-07 | -0.32 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Thyroid | RP11-672L10.6 | 0.12 | 0.04 | lasso | 5 | 0.06 | 1.3e-05 | -6.3 | 6.8 | 1.4e-11 | -0.61 | 0.18 | 0.78 | FALSE |
| 7 | METSIM | Adipose | ENOSF1 | 0.11 | 0.08 | enet | 30 | 0.10 | 1.6e-14 | -4.0 | -5.1 | 3.0e-07 | 0.54 | 1.00 | 0.00 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | TYMS | 0.14 | 0.04 | bslmm | 600 | 0.08 | 2.3e-10 | 4.7 | -5.4 | 7.8e-08 | 0.23 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | YES1 | 0.05 | 0.05 | lasso | 2 | 0.05 | 2.3e-04 | 6.0 | 6.1 | 1.2e-09 | -0.45 | 0.24 | 0.19 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | YES1 | 0.08 | 0.04 | lasso | 5 | 0.08 | 5.1e-08 | 3.3 | -7.2 | 6.0e-13 | 0.64 | 0.03 | 0.97 | TRUE |